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Scanning electron microscopy image of the engineered 3D bone marrow tissue colonized with human blood cells (red). Image Credit: Andrés García-García, University of Basel, Department of Biomedicine |
Our body’s “blood factory” consists of specialized tissue made up of bone cells, blood vessels, nerves and other cell types. Now, researchers have succeeded for the first time in recreating this cellular complexity in the laboratory using only human cells. The novel system could reduce the need for animal experiments for many applications.
The bone marrow usually works quietly in the background. It only comes into focus when something goes wrong, such as in blood cancers. In these cases, understanding exactly how blood production in our body works, and how this process fails, becomes critical.
Typically, bone marrow research relies heavily on animal models and oversimplified cell cultures in the laboratory. Now, researchers from the Department of Biomedicine at the University of Basel and University Hospital Basel have developed a realistic model of bone marrow engineered entirely from human cells. This model may become a valuable tool not only for blood cancer research, but also for drug testing and potentially for personalized therapies, as reported by a team of researchers led by Professor Ivan Martin and Dr Andrés García-García in the journal Cell Stem Cell.