. Scientific Frontline

Tuesday, February 13, 2024

Satellites unveil the size and nature of the world’s coral reefs

A satellite photo from the Allen Coral Atlas showing shallow coral reefs off Fiji
Image Credit: Courtesy of Allen Coral Atlas

University of Queensland-led research has shown there is more coral reef area across the globe than previously thought, with detailed satellite mapping helping to conserve these vital ecosystems.

Dr Mitchell Lyons from UQ’s School of the Environment, working as part of the Allen Coral Atlas project, said scientists have now identified 348,000 square kilometers of shallow coral reefs, up to 20-30 meters deep.

“This revises up our previous estimate of shallow reefs in the world’s oceans,” Dr Lyons said.

“Importantly, the high-resolution, up-to-date mapping satellite technology also allows us to see what these habitats are made from.

“We’ve found 80,000 square kilometers of reef have a hard bottom, where coral tends to grow, as opposed to soft bottom like sand, rubble or seagrass.

Discovery of Unexpected Ultramassive Galaxies May Not Rewrite Cosmology, But Still Leaves Questions

Infrared view of the universe captured by the James Webb Space Telescope.
Image Credit: NASA, ESA, CSA and STScI.

Ever since the James Webb Space Telescope (JWST) captured its first glimpse of the early universe, astronomers have been surprised by the presence of what appear to be more “ultramassive” galaxies than expected. Based on the most widely accepted cosmological model, they should not have been able to evolve until much later in the history of the universe, spurring claims that the model needs to be changed.

This would upend decades of established science.

“The development of objects in the universe is hierarchical. You start small and get bigger and bigger,” said Julian Muñoz, an assistant professor of astronomy at The University of Texas at Austin and co-author of a recent paper that tests changes to the cosmological model. The study concludes that revising the standard cosmological model is not necessary. However, astronomers may have to revisit what they understand about how the first galaxies formed and evolved.

Cosmology studies the origin, evolution and structure of our universe, from the Big Bang to the present day. The most widely accepted model of cosmology is called the Lambda Cold Dark Matter (ΛCDM) model or the “standard cosmological model.” Although the model is very well informed, much about the early universe has remained theoretical because astronomers could not observe it completely, if at all.

Concordia researchers identify a decline in microbial genetic richness in the western Arctic Ocean

With the warming and freshening of the Arctic Ocean comes a decrease of nutrients that are important for photosynthesis
Photo Credit: Davide Cantelli

The Arctic region is experiencing climate change at a much faster rate than the rest of the world. Melting ice sheets, runoff from thawing permafrost and other factors are rapidly changing the composition of the Arctic Ocean’s water. And that change is being experienced all the way down to the microbial level.

In a Concordia-led study published in the journal ISME Communications, researchers analyzed archival samples of bacteria and archaea populations taken from the Beaufort Sea, bordering northwest Canada and Alaska. The samples were collected between 2004 and 2012, a period that included two years — 2007 and 2012 — in which the sea ice coverage was historically low. The researchers looked at samples taken from three levels of water: the summer mixed layer, the upper Arctic water below it and the Pacific-origin water at the deepest level.

The study examined the microbes’ genetic composition using bioinformatics and statistical analysis across the nine-year time span. Using this data, the researchers were able to see how changing environmental conditions were influencing the organisms’ structure and function.

The researchers found subtle but statistically significant changes in the communities they studied.

Sandalwood oil by-product prevents prostate cancer development in mice

Ajay Bommareddy, Ph.D., senior author and an associate professor of pharmacology in the Department of Biomedical Science, FAU Schmidt College of Medicine.
Photo Credit: Courtesy of Florida Atlantic University

Extracted from the core of sandalwood trees (santalum album tree), sandalwood oil has been used for many centuries by several cultures throughout the world for perfume, soaps, incense and candles. With its earthy sweet scent, this essential oil is also used in the food industry and topically in various cosmetic preparations.

Importantly, this natural oil is known for its health benefits and medicinal applications from antibacterial to anticancer because of its phytochemical constituents. In addition to containing esters, free acids, aldehydes, ketones and santenone, sandalwood oil primarily (90 percent or more) constitutes santalol – equal amounts of two compounds, alpha and beta-santalol.

Now, researchers from Florida Atlantic University’s Schmidt College of Medicine and collaborators are the first to demonstrate in vivo the chemo-preventive properties of alpha-santalol against prostate cancer development using a transgenic mouse model.

Study finds childhood bullying linked to distrust and mental health problems in adolescence

Photo Credit: Mikhail Nilov

A new study, co-led by UCLA Health and the University of Glasgow, found that young teenagers who develop a strong distrust of other people as a result of childhood bullying are substantially more likely to have significant mental health problems as they enter adulthood compared to those who do not develop interpersonal trust issues.

The study, published in the journal Nature Mental Health on Feb. 13, is believed to be the first to examine the link between peer bullying, interpersonal distrust, and the subsequent development of mental health problems, such as anxiety, depression, hyperactivity and anger. 

Researchers used data from 10,000 children in the United Kingdom who were studied for nearly two decades as part of the Millennium Cohort Study. From these data, the researchers found that adolescents who were bullied at age 11 and in turn developed greater interpersonal distrust by age 14 were around 3.5 times more likely to experience clinically significant mental health problems at age 17 compared to those who developed less distrust.

Bruised and bleeding: New materials show where they’re hurt

Sandia National Laboratories materials chemist Cody Corbin works in a glove box, preparing a container filled with bead bits that will turn brown if someone attempts to tamper with the container’s contents.
Photo Credit: Craig Fritz

Every over-the-counter medication bottle sports a protective seal, usually a plastic wrap or foam layer, or both. These seals offer signs of tampering attempts. In a parallel concern, the International Atomic Energy Agency relies on tamper-indicating devices to make sure it knows if containers of nuclear material have been opened or tampered with.

However, just as a medication bottle might be opened and the tamper seals carefully reattached by a bad guy, the IAEA is concerned its devices could be bypassed and repaired or counterfeited. A possible solution? Engineers at Sandia National Laboratories have developed a groundbreaking prototype using “bruising” materials. Their innovation doesn’t just detect tampering; the new device boldly displays the evidence, like battle scars.

“Our first idea was to create a ‘bleeding’ material where it was extremely obvious that it had been tampered with,” said Heidi Smartt, a Sandia electrical engineer and project lead. “Then we made a new device using these materials where the damage is obvious for people to see. No one has ever done this sort of concept for international nuclear safeguards before.”

Desert Ants: The Magnetic Field Calibrates the Navigation System

The desert ant Cataglyphis nodus at its nest entrance - an inconspicuous hole in the ground that cannot be seen from the ant's perspective. To find its way back there, the ant uses the earth's magnetic field during its learning walks.
Photo Credit: Robin Grob

Desert ants find their way during an early learning phase with the help of the Earth's magnetic field. The associated learning process leaves clear traces in their nervous system. This is shown in a new study by a Würzburg research team.

They are only a few centimeters tall and their brains have a comparatively simple structure with less than one million neurons. Nevertheless, desert ants of the Cataglyphis genus possess abilities that distinguish them from many other creatures: The animals are able to orient themselves to the Earth's magnetic field.

Visible Changes in the Nervous System

A research team from Julius-Maximilians-Universität Würzburg (JMU) discovered this a few years ago. However, it was previously unknown where in the ants' brains the magnetic information is processed. This has now changed: In a new study published in the journal PNAS - Proceedings of the National Academy of Sciences, the team shows that information about the Earth's magnetic field is primarily processed in the ants' internal compass, the so-called central complex, and in the mushroom bodies, the animals' learning and memory centers.

Immunotherapy before surgery leads to promising long-term survival in sarcoma patients

From Left to Right Christina Roland, M.D. and Neeta Somaiah, M.D.
Image Credit: Courtesy of University of Texas MD Anderson Cancer Center

Patients with soft-tissue sarcoma treated with neoadjuvant, or pre-surgical, immunotherapy had very little residual tumor at the time of surgery and promising long-term survival, according to Phase II trial results published today in Nature Cancer by researchers at The University of Texas MD Anderson Cancer Center.

After treatment with a combination of immunotherapy and radiation followed by surgical removal of the residual mass, 90% of patients with undifferentiated pleomorphic sarcoma (UPS) had less than 15% viable tumor cells remaining, better than what has historically been seen with radiation alone. The overall survival (OS) rate at two years after first treatment was 82% in resectable retroperitoneal dedifferentiated liposarcoma (DDLPS) and 90% in UPS.

“These results demonstrate the role immunotherapy treatment can have on soft-tissue sarcomas and how the neoadjuvant treatment platform can help identify novel treatment options for patients,” said co-principal investigator Christina Roland, M.D., associate professor of Surgical Oncology. “Sarcoma patients have limited systemic therapy options to consider, and this trial offers data to support the use of immunotherapy in their treatment.”

Monday, February 12, 2024

Genetic analysis and archaeological insight combine to reveal the ancient origins of the fallow deer

Fallow deer
Photo Credit: Nick Fewings

Scientific Frontline: "At a Glance" Summary

  • Main Discovery: Genetic and archaeological analysis reveals that fallow deer were first introduced to Britain by the Romans rather than the Normans, with their subsequent global spread driven by British colonial expansion and cultural symbolism.
  • Methodology: Researchers combined zooarchaeological records with the DNA sequencing of several hundred ancient and modern specimens to reconstruct an evolutionary history spanning 10,000 years.
  • Key Data: The study successfully sequenced a 130,000-year-old sample and identified two distinct European lineages: a Balkan group spread during the Roman Empire and an Anatolian group introduced to Britain around 1000 AD.
  • Significance: These findings challenge standard conservation classifications by demonstrating that modern deer populations are artifacts of human history, rendering terms like "wild," "domestic," or "invasive" inadequate for management decisions.
  • Future Application: Conservation policies must be revised to incorporate biocultural heritage rather than relying solely on native status, particularly for populations like those in Barbuda where the deer is the national animal yet lacks legal protection.
  • Branch of Science: Bioarchaeology and Molecular Ecology
  • Additional Detail: The earliest evidence of fallow deer outside the Mediterranean was identified at a Roman palace in Fishbourne, West Sussex, confirming their presence centuries before the Norman Conquest.

Researchers identify brain hub with key role in learned response to direct and indirect threats

Diagram of mouse prefrontal cortex showing neural projections to the midbrain (purple) and the amygdala (green), pathways involved in learning about threat.
Image Credit: National Institute on Alcohol Abuse and Alcoholism

NIH-supported study in mice could inform treatments of trauma- and stress-related psychiatric conditions.

Scientists have identified an area within the brain’s frontal cortex that may coordinate an animal’s response to potentially traumatic situations. Understanding where and how neural circuits involving the frontal cortex regulate such functions, and how such circuits could malfunction, may provide insight about their role in trauma-related and stress-related psychiatric disorders in people. The study, led by scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), a part of the National Institutes of Health, was published in Nature.

“Experiencing traumatic events is often at the root of trauma-related and stress-related psychiatric conditions, including alcohol use disorder (AUD),” said the study’s senior author, Andrew Holmes, Ph.D., senior investigator in NIAAA’s Laboratory of Behavioral and Genomic Neuroscience. “Additionally, witnessing others experience traumatic events can also contribute to these disorders.”

SwRI Scientists Identify Water Molecules on Asteroids for the First Time

NASA’s Stratospheric Observatory for Infrared Astronomy
Image Credit: NASA/Carla Thomas/SwRI

Using data from the retired Stratospheric Observatory for Infrared Astronomy (SOFIA) — a joint project of NASA and the German Space Agency at DLR — Southwest Research Institute scientists have discovered, for the first time, water molecules on the surface of an asteroid. Scientists looked at four silicate-rich asteroids using the FORCAST instrument to isolate the mid-infrared spectral signatures indicative of molecular water on two of them.

“Asteroids are leftovers from the planetary formation process, so their compositions vary depending on where they formed in the solar nebula,” said SwRI’s Dr. Anicia Arredondo, lead author of a Planetary Science Journal paper about the discovery. “Of particular interest is the distribution of water on asteroids, because that can shed light on how water was delivered to Earth.”

Anhydrous, or dry, silicate asteroids form close to the Sun while icy materials coalesce farther out. Understanding the location of asteroids and their compositions tells us how materials in the solar nebula were distributed and have evolved since formation. The distribution of water in our solar system will provide insight into the distribution of water in other solar systems and, because water is necessary for all life on Earth, will drive where to look for potential life, both in our solar system and beyond.

Research makes key advance for capturing carbon from the air

Vanadium, one of the CO2 capture materials, displaying a brilliant deep purple color
Image Credit: May Nyman, chemistry professor, OSU College of Science

A chemical element so visually striking it was named for a goddess that shows a “Goldilocks” level of reactivity – neither too much nor too little – that makes it a strong candidate as a carbon scrubbing tool.

The element is vanadium, and research by Oregon State University scientists has demonstrated the ability of vanadium peroxide molecules to react with and bind carbon dioxide – an important step toward improved technologies for removing carbon dioxide from the atmosphere.

The study is part of a $24 million federal effort to develop new methods for direct air capture, or DAC, of carbon dioxide, a greenhouse gas that’s produced by the burning of fossil fuels and is associated with climate change.

Facilities that filter carbon from the air have begun to spring up around the globe but they’re still in their infancy. Technologies for mitigating carbon dioxide at the point of entry into the atmosphere, such as at power plants, are more well developed. Both types of carbon capture will likely be needed if the Earth is to avoid the worst outcomes of climate change, scientists say.

Riverine fish numbers increase amidst environmental challenges

Surprising trends in the abundance and species richness of riverine fish across the globe have been unveiled in a new study.
Photo Credit: Brandon

A new study, conducted by scientists at the University of Sheffield, has found a significant increase in the number and diversity of riverine fish species across the planet over the past 30 years

Contrary to conventional expectations, increases in fish species that live in rivers are concentrated in the most degraded areas

Although researchers found positive trends in riverine fish communities, a surge in the prevalence of non-native species poses a threat to the delicate balance of native fish

Surprising trends in the abundance and species richness of riverine fish across the globe have been unveiled in a new study. 

Until now, it was a common scientific belief that increases in species richness and abundance in freshwater ecosystems were as a result of the recent improvement of water quality in historically industrialized regions.

Researchers identify a new mechanism that could improve the efficiency of diabetes treatments

The study led by the UB and CIBERDEM reveals new strategies to inhibit glucose synthesis in the liver and reduce levels in patients affected by metabolic pathologies.
Image Credit: Gemini Advance AI

A study led by the University of Barcelona and the Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM) reveals how a new mechanism could improve the efficiency of currently available treatments for diabetes. The study, carried out on mice and cell cultures, may open up new ways of approaching metabolic diseases that are a global health problem.

The study, published in the journal Metabolism, focuses on the GDF15 protein, a factor that is expressed at high levels in many diseases, such as heart failure, cancer and fatty liver disease. Obese patients also have elevated levels of this protein, but its function is altered and those affected may develop resistance to GDF15 — that is, a reduction in the effectiveness of its activity.

The study is led by Professor Manuel Vázquez-Carrera, from the Faculty of Pharmacy and Food Sciences of the UB, the Institute of Biomedicine of the UB (IBUB), the Sant Joan de Déu Research Institute (IRSJD) and CIBERDEM. The study also highlights the participation of researchers Patricia Rada and Ángela María Valverde, also collaborators at CIBERDEM, the Spanish National Research Council (CSIC) and the Autonomous University of Madrid (UAM). The work has the collaboration of Professor Walter Wahli of the University of Lausanne (Switzerland), among other experts.

Artificial cartilage with the help of 3D printing

The spheroids in which living cells are grown, can be assembled into almost any shape.
Image Credit: Technische Universität Wien

A new approach to producing artificial tissue has been developed at TU Wien: Cells are grown in microstructures created in a 3D printer.

Is it possible to grow tissue in the laboratory, for example to replace injured cartilage? At TU Wien (Vienna), an important step has now been taken towards creating replacement tissue in the lab - using a technique that differs significantly from other methods used around the world.

A special high-resolution 3D printing process is used to create tiny, porous spheres made of biocompatible and degradable plastic, which are then colonized with cells. These spheroids can then be arranged in any geometry, and the cells of the different units combine seamlessly to form a uniform, living tissue. Cartilage tissue, with which the concept has now been demonstrated at TU Wien, was previously considered particularly challenging in this respect.

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