OHSU researchers identify protective properties of amniotic fluid

A multidisciplinary team of OHSU researchers collaborates to better understand the mechanism of amniotic fluid’s role in fetal development. Their goal is to identify how its properties can be harnessed to address prenatal health concerns.
Photo Credit: Christine Torres Hicks/OHSU

Researchers at Oregon Health & Science University have made new discoveries about amniotic fluid, a substance historically not well understood in medical research due to the difficulty in obtaining it during pregnancy, especially across gestation.

Amniotic fluid is the vital fluid that surrounds and protects a fetus during pregnancy. In addition to providing much-needed cushion and protection for the fetus, it also aids in development of vital organs — especially the lungs, digestive tract and skin— and stabilizes the temperature inside the womb.

The new study, published in the journal Research and Practice in Thrombosis and Haemostasis, found that the addition of amniotic fluid to plasma — the liquid portion of blood — improves the blood’s ability to thicken and clot, which is a critical and likely a protective function throughout pregnancy and during delivery for both the birthing parent and the baby.

The mechanism of amniotic fluid’s role in fetal development is not well understood and is understudied: The OHSU study is one of the first to identify how the features and properties of amniotic fluid change over time, especially those properties that play a role in thickening the blood, and how those changes can affect how maternal blood coagulates. If a pregnant person’s blood does not clot properly, it can create life-threatening complications for the fetus and birthing parent, including excessive bleeding during pregnancy and delivery.  

Cold Waves in the Rainforest: What They Mean for Wild Animals

Typical animals in the lowland rainforest of the Amazon: On the left, the palm-sized dung beetle Coprophanaeus lancifer, which appears to be sensitive to low temperatures. On the right, the Brazilian wandering spider Phoneutria boliviensis, which also grows to the size of a palm. The spider can often be seen at night, but during the cold wave it was nowhere to be seen.
Photo Credit: Kim Lea Holzmann / Universität Würzburg

It's not always cozy and warm in the Amazon rainforest: cold waves can cause temperatures to drop drastically. Würzburg researchers have investigated how animals react to this.

Anyone conducting research in the tropical rainforest does not necessarily have a winter jacket and warm socks with them. After all, this region of the world is considered to have a consistently pleasant temperature. But this is not the case, as Kim Lea Holzmann and Pedro Alonso-Alonso have found out for themselves. Both are doing their doctoral theses at the University of Würzburg's Biocentre and both spent almost the whole of 2023 in the Amazon region in southern Peru to study biodiversity.

It happened on 13 June: a cold spell caused temperatures to plummet from an average of 23.9 to 10.5 degrees Celsius. The cool period lasted almost a week. ‘A year before, we had already experienced a day when it was only 18 degrees,’ says Kim Lea Holzmann. But such severe and prolonged cold seemed strange to them. The local field assistants, on the other hand, were not really surprised. They explained to the Würzburg team that cold spells lasting several days are not that rare in the Amazon.

Ancient Antarctic ice loss offers insights into future climate scenarios

Photo Credit: University of Cambridge / British Antarctic Survey.

Scientists from the University of Cambridge and British Antarctic Survey have used ice core records to draw new conclusions about how Antarctica was affected by increased global temperatures over 100,000 years ago. The new paper, published today in the journal Nature, shows that large parts of the West Antarctic Ice Sheet were lost, contributing to significant sea level rise. However, the data also suggests that the nearby Ronne Ice Shelf – which climate models project could be lost under future warming scenarios – survived this period of global heating.

Greenhouse gas emissions are warming the Earth at an unprecedented speed and scale. While anthropogenic warming has no direct historical parallel, warm episodes in Earth’s history can offer clues to the future.

A team of ice core scientists, led by Eric Wolff from Cambridge University, wanted to find out what happened to the West Antarctic Ice Sheet during the Last Interglacial, when the polar regions were about 3°C warmer than present and sea levels were significantly higher. This period of Earth’s history is considered comparable to conditions we might see within decades.

How rapid temperature changes influence biodiversity

Image Credit: Scientific Frontline stock image

Biodiversity has changed faster in places where temperatures have also changed quickly. This is the result of a new study published in the scientific journal Nature. Researchers from the Martin Luther University Halle-Wittenberg (MLU), the German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig and Friedrich Schiller University Jena were also involved in the work.

The study focused on how the composition of species in an ecosystem - rather than the number of species - has shifted over time. The researchers found that faster temperature changes sped up shifts in species composition, meaning species identities changed more rapidly in those areas.

The results also suggest that behavioral adaptation and changing species interactions are not enough to preserve species composition in the face of higher rates of temperature fluctuations. 

"It's like shuffling a deck of cards, and temperature change now is shuffling that deck faster and faster," said lead author Dr Malin Pinsky, associate professor of ecology and evolutionary biology at UC Santa Cruz. Pinsky was hosted at iDiv as a sabbatical researcher in 2020. "The worry is that eventually you start to lose some cards," he said.

Conservation paradox: Invasive species are often threatened in their native range

The wild rabbit is endangered in its native Europe. In other parts of the world, such as Australia, this species has been introduced and has large populations.
Photo Credit: ©Alexis Lours

Non-native animals are a threat to biodiversity, yet many are themselves threatened with extinction in their areas of origin

Non-native species introduced by humans are among the main causes of global species decline – they were partly responsible for 60 percent of the species that have become extinct worldwide in recent decades. In Central Europe, non-native mammals include species such as the Norway rat, the mouflon and the mink. Now a study led by biologists from the University of Vienna and La Sapienza University in Rome shows that some of these species introduced by humans are themselves endangered in their native range. The study has been published in the current issue of the journal Conservation Letters.

The globalization of the earth is contributing to the introduction of many animal and plant species into new parts of the world. Invasive species can displace native species through competition or transmit new diseases. At the same time, however, some of these non-native species are threatened with extinction in their native ranges. This creates a conservation paradox – because the question now is, should non-native occurrences of species that are endangered in their native range be protected or controlled? However, it was previously unknown how many non-native mammal species this paradox actually applies to. In the new study, the scientists have now quantified this in order to come one step closer to an answer to this paradox.

Demystifying Space Weather

SDO 304Å

Space weather has become increasingly important in our modern world due to our growing reliance on technology. It can impact various aspects of our daily lives, from communication and navigation systems to power grids and even astronaut safety. In this deep dive, we'll explore the intricacies of space weather, its causes, its effects, and why understanding it is crucial in our technology-dependent society.

Space weather is a dynamic and ever-changing phenomenon that has significant implications for our technology-dependent world. From disrupting communication and navigation systems to causing power outages and posing radiation hazards to astronauts, space weather events can have far-reaching consequences. While predicting space weather accurately remains a challenge, ongoing research and improved monitoring capabilities are crucial for mitigating potential risks. By understanding the causes and effects of space weather, we can better prepare for these events and protect our critical infrastructure and space-based assets. As we continue to explore and utilize space, space weather awareness and preparedness will become increasingly important for ensuring the safety and sustainability of our technological advancements and space exploration endeavors.

Chemical looping turns environmental waste into fuel

As scientists search for sustainable alternatives to typical waste disposal methods, chemical looping technology promises to spawn a new energy cycle.
Photo Credit: Chokniti Khongchum

Turning environmental waste into useful chemical resources could solve many of the inevitable challenges of our growing amounts of discarded plastics, paper and food waste, according to new research. 

In a significant breakthrough, researchers from The Ohio State University have developed a technology to transform materials like plastics and agricultural waste into syngas, a substance most often used to create chemicals and fuels like formaldehyde and methanol. 

Using simulations to test how well the system could break down waste, scientists found that their approach, called chemical looping, could produce high-quality syngas in a more efficient manner than other similar chemical techniques. Altogether, this refined process saves energy and is safer for the environment, said Ishani Karki Kudva, lead author of the study and a doctoral student in chemical and biomolecular engineering at Ohio State. 

Sikorsky Begins Black Hawk® Ground Runs With U.S. Army T901 Improved Turbine Engines

Sikorsky started ground runs on a UH-60M Black Hawk equipped with two Improved Turbine Engines. This engine increases the Black Hawk's combat capabilities.
Photo Credit: Courtesy Sikorsky, a Lockheed Martin company. ©Lockheed Martin Corporation.

Sikorsky, a Lockheed Martin company started its first-ever ground runs on a UH-60M Black Hawk® helicopter equipped with two GE Aerospace T901 Improved Turbine Engines (ITE). During this test, the T901 engine demonstrated its capabilities through a series of rigorous procedures. The initial light off and ground runs were executed by a combined U.S. Army and industry test team and operated by Army and Sikorsky pilots.

“Soldiers will rely on Black Hawk helicopters well into the future, and upgrades to the aircraft today will pay dividends for decades, enabling new missions such as deploying and managing launched effects,” said Hamid Salim, vice president of Army and Air Force Systems at Sikorsky. “A modernized Black Hawk fleet will create new operational opportunities for the Army by extending the capabilities of a proven, fielded fleet to travel farther on less fuel and with more troops and cargo.”

First flight of the ITE-equipped Black Hawk is anticipated this year.

Even Quantum Physics Obeys the Law of Entropy

Image Credit: Courtesy of Technische Universität Wien

Is there a contradiction between quantum theory and thermodynamics? On the surface, yes - but at TU Wien, researchers have now shown how the two fit together perfectly.

It is one of the most important laws of nature that we know: The famous second law of thermodynamics says that the world gets more and more disordered when random chance is at play. Or, to put it more precisely: That entropy must increase in every closed system. Ordered structures lose their order, regular ice crystals turn into water, porcelain vases are broken up into shards. At first glance, however, quantum physics does not really seem to adhere to this rule: Mathematically speaking, entropy in quantum systems always remains the same.

A research team at TU Wien has now taken a closer look at this apparent contradiction and has been able to show: It depends on what kind of entropy you look at. If you define the concept of entropy in a way that it compatible with the basic ideas of quantum physics, then there is no longer any contradiction between quantum physics and thermodynamics. Entropy also increases in initially ordered quantum systems until it reaches a final state of disorder.

Blood-powered toes give salamanders an arboreal edge

Wandering salamanders are known for gliding high through the canopies of coastal redwood forests, but how the small amphibians stick their landing and take-off with ease remains something of a mystery.

A new study in the Journal of Morphology reveals the answer may have a lot to do with a surprising mechanism: blood-powered toes. The Washington State University-led research team discovered that wandering salamanders (Aneides vagrans) can rapidly fill, trap, and drain the blood in their toe tips to optimize attachment, detachment and general locomotion through their arboreal environment.

The research not only uncovers a previously unknown physiological mechanism in salamanders but also has implications for bioinspired design. Insights into salamander toe mechanics could ultimately inform the development of adhesives, prosthetics, and even robotic appendages.

“Gecko-inspired adhesives already allow surfaces to be reused without losing stickiness,” said Christian Brown, lead author of the study and an integrative physiology and neuroscience postdoctoral researcher at WSU. “Understanding salamander toes could lead to similar breakthroughs in attachment technologies.”

Hidden ‘highways’ connect Brazil’s rainforests

An Inga tree (I. affinis) growing alongside a river in the Cerrado savanna region of central Brazil.
Photo Credit RT Pennington

Forests flanking Brazil’s rivers act as “highways” that have allowed tree species to move between the Amazon and Atlantic rainforests for millions of years, new research shows.

The two rainforests are separated by hundreds of miles of dry forest and savanna, where most rainforest trees cannot survive.

Until now, it was thought that tree species only passed between the Amazon and the Atlantic forests during periods long ago when the climate was wetter and much of South America was covered in rainforest.

But the new study – led by the Royal Botanic Garden Edinburgh (RBGE) and the University of Exeter – reveals a different story.

“Rather than tree species being exchanged during specific wetter periods in the past, we found that species have dispersed consistently over time,” said Dr James Nicholls, of RBGE.

“This probably happens slowly, by generations of trees growing along the ‘highways’ provided by rivers that run through Brazil’s dry ecosystems.”

UQ team finds relative of deadly Hendra virus in the US

A northern short-tailed shrew
Photo Credit: RPN

Researchers at The University of Queensland have identified the first henipavirus in North America. 

Dr Rhys Parry from the School of Chemistry and Molecular Biosciences said Camp Hill virus was confirmed in shrews in the US state of Alabama.

“Henipaviruses have caused serious disease and death in people and animals in other regions,” Dr Parry said

“One of the most dangerous is the Hendra virus, which was first detected in Brisbane, Australia and has a fatality rate of 70 per cent.

“Another example is Nipah virus which has recorded fatality rates between 40 and 75 per cent in outbreaks in South-East Asia, including in Malaysia and Bangladesh.

“The discovery of a henipavirus in North America is highly significant, as it suggests these viruses may be more globally distributed than previously thought.”

Neutrons reveal lithium flow could boost performance in solid-state battery

Scientists from Duke University and ORNL used neutron scattering to see how lithium ions, represented by the glowing orbs, move through a diffusion gate, represented by the gold triangle, in a solid-state electrolyte.
Image Credit: Phoenix Pleasant/ORNL, U.S. Dept. of Energy

A team of scientists led by a professor from Duke University discovered a way to help make batteries safer, charge faster and last longer. They relied on neutrons at the Department of Energy’s Oak Ridge National Laboratory to understand at the atomic scale how lithium moves in lithium phosphorus sulfur chloride (Li6PS5Cl), a promising new type of solid-state battery material known as a superionic compound. 

Using neutrons at ORNL’s Spallation Neutron Source (SNS), and machine-learned molecular dynamics simulations at the National Energy Research Scientific Computing Center at Lawrence Berkeley National Laboratory, they found that lithium ions easily diffused in the solid material, as they do in liquid electrolytes, allowing faster, safer charging. The results, published in Nature Physics, could bring the best of both worlds for solid-state electrolytes, or SSEs, enabling next-generation batteries.  

“Our research was about figuring out what is going on inside these materials using the power of neutron scattering and large-scale computer simulations,” said Olivier Delaire, associate professor of mechanical engineering, materials science, chemistry and physics at Duke University. Delaire arrived at ORNL in 2008 as a Clifford G. Shull Fellow and won DOE’s Office of Science Early Career Award in 2014. Today, he leads a research group at Duke dedicated to investigating the atomic structure and dynamics of energy materials.

Plant-based substitute for fossil fuels developed for plastic foams

Ziqi Yu (Postdoc), Isaac Nartey Oduro (PhD student) and Daniela Gonzalez- Sepulveda (undergraduate RA) are examining lignin-based polyurethane samples.
Photo Credit: Courtesy of Washington State University

An environmentally-friendly preparation of plant material from pine could serve as a substitute for petroleum-based chemicals in polyurethane foams.

The innovation could lead to more environmentally friendly versions of foams used ubiquitously in products such as kitchen sponges, foam cushions, coatings, adhesives, packaging and insulation. The global market for polyurethane totaled more than $75 billion in 2022.

A Washington State University-led research team used an environmentally-friendly preparation of lignin as a substitute for 20% of the fossil fuel-based chemicals in the foam. The bio-based foam was as strong and flexible as typical polyurethane foam. They report on their work in the journal, ACS Sustainable Chemistry and Engineering.

 “It’s quite novel in terms of the material we generate and the process we have,” said Xiao Zhang, corresponding author on the paper and professor in the Gene and Linda Voiland School of Chemical Engineering and Bioengineering. “Our extracted lignin offers a new class of renewable building blocks for the development of bio-based value-added products.”

Regulatory T Cells Found to Safeguard Brain Health, Memory Formation

Differences in neuronal activation in mice with intact Tregs (left) and depleted Tregs (right). The finding demonstrates that Tregs play a role in ensuring healthy neuronal activity under normal conditions.
Image Credit: Mathis/Benoist Lab

Immune cells called regulatory T cells have long been known for their role in countering inflammation. In the setting of infection, these so-called Tregs restrain the immune system to ensure it doesn’t go into overdrive and mistakenly attack the body’s own organs.

Now scientists at Harvard Medical School have discovered a distinct population of Tregs dwelling in the protective layers of the brains of healthy mice with a repertoire much broader than inflammation control.

The research, published Jan. 28 in Science Immunology, shows that these specialized Tregs not only control access to the inner regions of the brain but also ensure the proper renewal of nerve cells in an area of the brain where short-term memories are formed and stored.

The research, funded in part by the National Institutes of Health, represents an important step toward untangling the complex interplay of immune cells in the brain. If replicated in further animal studies and confirmed in humans, the research could open up new avenues for averting or mitigating disease-fueling inflammation in the brain.