Whack-a-mole vaping policies do not protect youth

New flavored vaping products have been developed
that aren't regulated by current legislative restrictions,
Stanford Medicine researchers report.
Courtesy of the Stanford Tobacco Prevention Toolkit

The Food and Drug Administration’s approach to controlling specific e-cigarette devices and flavors has failed to prevent teens and young adults from vaping, according to a Stanford Medicine study. Instead, young people are migrating to widely available flavored vaping products, including new products that circumvent FDA policies.

The findings, which will be published online Nov. 30 in the journal Addictive Behaviors, suggest that, rather than adopting policies that target particular device types and flavors, the FDA should implement comprehensive regulations covering all tobacco and nicotine-containing products to reduce nicotine use by young people.

“Our goal was to understand, in a time after policies were announced, which tobacco products and flavors youth were able to access and use,” said the study’s senior author, Bonnie Halpern-Felsher, PhD, a professor of pediatrics at Stanford Medicine.

“What we found was exactly what we were afraid of: Some young people were still using flavors and products that were purportedly restricted, and even more were using products that were completely uncontrolled,” she said. “Unless we regulate all vaping products — and all nontobacco flavors of products, including menthol — young people will simply go to another nicotine-based product.”

The study’s lead author is Shivani Gaiha, PhD, instructor of pediatrics at Stanford Medicine.

Stemming the tide of invasive weeds with world-first herbicide capsules

An innovative herbicide delivery system could revolutionize the way agricultural and environmental managers battle invasive weeds.

The ingenious method uses herbicide-filled capsules drilled into the stems of invasive woody weeds and is safer, cleaner and as effective as herbicide sprays, which can have negative health impacts on workers and surrounding areas.

PhD candidate Amelia Limbongan from The University of Queensland’s School of Agriculture and Food Sciences said the method was highly effective against a wide variety of weed species, which pose a major threat to farming and grazing systems.

“Woody weeds such as Mimosa bush stifle pasture growth, impede mustering and cause physical and financial damage to animals and property,” Ms Limbongan said.

“This method of weed control is practical, portable and far more convenient than other methods and we’ve already seen several professional operators and councils adopting the approach.”

The portability and convenience of the system, coupled with its proven efficacy and safety, meant the encapsulated herbicide could be used in a variety of settings and locations worldwide.

“This method uses 30 per cent less herbicide to kill weeds, and is just as effective as more labor-intensive approaches, which will save valuable time and money for farmers and foresters,” Ms Limbongan said.

Texas Astronomers Discover Strangely Massive Black Hole in Milky Way Satellite Galaxy

McDonald Observatory astronomers have found that Leo I (inset), a tiny satellite galaxy of the Milky Way (main image), has a black hole nearly as massive as the Milky Way's. Leo I is 30 times smaller than the Milky Way. The result could signal changes in astronomers' understanding of galaxy evolution. Credit: ESA/Gaia/DPAC; SDSS (inset) McDonald Observatory astronomers have found that Leo I (inset), a tiny satellite galaxy of the Milky Way (main image), has a black hole nearly as massive as the Milky Way's. Leo I is 30 times smaller than the Milky Way. The result could signal changes in astronomers' understanding of galaxy evolution.
Credit: ESA/Gaia/DPAC; SDSS (inset)

Astronomers at The University of Texas at Austin’s McDonald Observatory have discovered an unusually massive black hole at the heart of one of the Milky Way’s dwarf satellite galaxies, called Leo I. Almost as massive as the black hole in our own galaxy, the finding could redefine our understanding of how all galaxies — the building blocks of the universe — evolve. The work is published in a recent issue of The Astrophysical Journal.

The team decided to study Leo I because of its peculiarity. Unlike most dwarf galaxies orbiting the Milky Way, Leo I does not contain much dark matter. Researchers measured Leo I’s dark matter profile — that is, how the density of dark matter changes from the outer edges of the galaxy all the way into its center. They did this by measuring its gravitational pull on the stars: The faster the stars are moving, the more matter there is enclosed in their orbits. In particular, the team wanted to know whether dark matter density increases toward the galaxy’s center. They also wanted to know whether their profile measurement would match previous ones made using older telescope data combined with computer models.

Particle accelerator magnet sets record using high-temperature superconductor

Henryk Piekarz of Fermilab’s Accelerator Division
controls the flow of cryogens in the high-temperature
superconductor magnet prototype.
Photo: Ryan Postel, Fermilab

Cost- and energy-efficient rapid cycling magnets for particle accelerators are critical for particle physics research. Their performance determines how frequently a circular particle accelerator can receive a bunch of particles, propel them to higher energy, send them to an experiment or target station, and then repeat all over again.

A small team of physicists, engineers and technicians at the U.S. Department of Energy’s Fermi National Particle Accelerator Laboratory, led by Henryk Piekarz, just demonstrated the world’s fastest magnetic ramping rates for particle accelerator magnets. Noteworthy, they achieved this record by using magnets made with energy-efficient, high-temperature superconducting material.

What is the best conductor?

Despite the many attractive features of superconducting wire, the fastest-ramping high-energy particle accelerators still use magnets with copper conductors operating at room temperature. Examples include the 3 GeV proton ring at JPARC in Japan, which features a magnetic field that changes at a rate of 70 tesla per second (T/s) and reaches a peak magnetic field of 1.1 tesla, and the 8 GeV Booster ring at Fermilab, which achieves a ramping rate of 30 T/s and a peak field of 0.7 tesla.

Most of the powerful superconducting magnets employed in modern-day particle accelerators are relatively slow when it comes to increasing the magnetic field. Their main goal is to ramp up to a high peak magnetic field to steer particles around a ring while electric fields propel the particles to higher and higher energy. The higher the energy, the stronger the magnetic field must be to keep the particles in their track as they go around the ring.

KvarkenSat, the first small satellite in the Kvarken region

KvarkenSat is a joint small satellite between the Ostrobothnian provinces and Västerbotten, which is due to be launched into space in just over a year.

The design and implementation of the KvarkenSat small satellite is part of the 'New Space Digital Economy Innovation Center' project funded by the EU's Interreg Botnia-Atlantica programme, the Regional Council of Ostrobothnia and the province of Västerbotten. The project is abbreviated as KvarkenSpaceEco.

KvarkenSpaceEco is a project focusing on the new space economy, implemented by 10 universities and research institutes on both sides of the Kvarken. The actors in the project are involved in developing an ecosystem around space data and economy in the Kvarken region, as well as the Kvarken Space Center.

'The project will make space data available to the region's residents, companies, schools and other actors, as well as introduce them to the opportunities brought by the new space economy,' says the director responsible for the project, Professor Heidi Kuusniemi from the University of Vaasa.

In the KvarkenSpaceEco project, a ground station has been built on the university campus in Vaasa, which receives data transmitted by satellites and, in time, will control the region's own small satellite. The ground station will become part of the space data laboratory of the University of Vaasa to be built in the Technobothnia research center.

Evol­ution happens faster than ex­pec­ted

A microscopic image of a ciliate
Credit: B. Sonntag

It is a relatively new finding that evolution occurs fast enough to play an important role in population dynamics. Some recently published research shows how prey organisms adapt evolutionarily to escape predation pressure. But how important is this process? New research at the University of Innsbruck's Research Department for Limnology in Mondsee demonstrates that in predator-prey dynamics, not only does the prey adapt through evolution, but so do the predators. The study was published in the journal Ecology and Evolution and funded by the University of Innsbruck's Young Investigator Grant.

The classic predator-prey model

Individuals of the same species who live and reproduce together in a relatively enclosed area form a population. The size of this population can be subject to gentle or extreme fluctuations, due to various environmental influences. This decrease and increase in individuals over time is called population dynamics.

Population dynamics are often explained in terms of purely ecological processes, as can be seen in the example of predator-prey relationships. Here, population dynamics are primarily determined by prey growth rates and predator feeding rates.

Classical predator-prey models assume that prey organisms evolve unaffected until a predator arrives and decimates the prey. Predators find abundant food and also become more abundant. Increased predation pressure reduces prey densities, which causes predator densities to decrease until prey recovers. Thus, when prey is depleted by the predator, an overall population collapse occurs. This model only represents ecological dynamics. However, predator-prey relationships are also an important cause of evolutionary adaptation.

Origins of Earth’s water could be solved in space dust analysis

Meteorites on their way to earth and breaking through atmosphere.
Elements of this image furnished by NASA- earthmap for 3Drender

A key mystery about the origins of Earth’s water may have been solved after an international team of scientists uncovered persuasive new evidence pointing to an unlikely culprit—the Sun.

In a paper published in Nature Astronomy, a team of researchers, including two from the University of Hawaiʻi at Mānoa School of Ocean and Earth Science and Technology (SOEST), describe how analysis of dust grains from the surface of an ancient asteroid suggests that extraterrestrial dust grains from asteroids and comets carried water to the surface of the early Earth. The water in the grains is produced by space weathering, a process by which charged particles from the Sun, known as solar wind, altered the chemical composition of the grains to produce water molecules.

The finding could answer the longstanding question about the sources of the water that covers 70% of Earth’s surface—far more than any other rocky planet in our Solar System. Planetary scientists have been puzzled for decades over the source of Earth’s oceans. One theory suggests that comets and asteroids brought the water to the planet in the final stages of its formation 4.6 billion years ago.

Researchers discover a potential new therapeutic pathway to clear chronic viral infections

A recent study in mice has uncovered the role of a
protein, called BMI-1, in chronic viral infections.

Chronic infectious diseases have a devastating effect on global health. When someone is suffering from a chronic viral infection such as HIV or hepatitis C, their B cells get altered resulting in low-quality antibodies that are not strong enough to help the body clear the infection.

A recent study in mice, conducted by the Monash Biomedicine Discovery Institute (BDI), has uncovered that during chronic viral infection, a protein called BMI-1 gets turned on too early in B cells and messes up the delicate balance of gene expression, resulting in antibodies that are unsuccessful in their endeavor to clear the virus from the body.

However, when this protein is targeted, the nature of the B cell can be changed to produce a higher quality antibody that accelerates clearance of a virus and may provide a new therapeutic pathway to help improve and regulate the body’s antibody response to achieve better outcomes.

The findings have now been published in Nature Immunology.

B cells, a type of white blood cell, respond to infection and can eventually turn into plasma cells. It is the plasma cells that make and secrete antibodies. During an infection, some of the B cells that become activated can quickly become plasma cells and start to produce antibodies in the first few days of the body’s immune response. While these antibodies are helpful, they are typically lower in quality and do not clear the infection. However, they do give the immune system some time to allow other B cells to undergo a "training period" to become high-quality memory B cells and plasma cells for immunity.

Miniature grinding mill closes in on the details of ‘green’ chemical reactions

Credit: Photo by Chokniti Khongchum from Pexels

The study, published in Nature Communications and led by Cambridge Earth Sciences’ Dr Giulio Lampronti, observed reactions as materials were pulverized inside a miniaturized grinding mill — providing new detail on the structure and formation of crystals.

Knowledge of the structure of these newly-formed materials, which have been subjected to considerable pressures, helps scientists unravel the kinetics involved in mechanochemistry. But they are rarely able to observe it at the level of detail seen in this new work.

The study also involved Dr Ana Belenguer and Professor Jeremy Sanders from Cambridge’s Yusuf Hamied Department of Chemistry.

Mechanochemistry is touted as a ‘green’ tool because it can make new materials without using bulk solvents that are harmful to the environment. Despite decades of research, the process behind these reactions remains poorly understood.

To learn more about mechanochemical reactions, scientists usually observe chemical transformations in real time, as ingredients are churned and ground in a mill — like mixing a cake — to create complex chemical components and materials.

Study aims to understand why COVID-19 vaccines can lead to very rare blood clotting with low platelets

A group of 11 institutions, led by the University of Liverpool and including the University of Bristol, is seeking to understand the very rare, but very serious, condition of blood clotting with low platelets in the general population, in COVID-19 infection, and potentially following vaccination.

The vast majority of people who experience a side effect from COVID-19 vaccination have only mild reactions lasting for two or three days. However, in March 2021 reports of small numbers of people being admitted to hospital predominantly after the Oxford/AstraZeneca vaccine with what could potentially be a very rare side effect of vaccination began to emerge. These people had blood clots in the major veins in the brain, abdomen, or elsewhere in the body, but at the same time a low level of platelets – which are responsible for clotting – in the blood.

The group of researchers, supported by a wide range of collaborators within the NHS and national agencies, will work together to study the mechanisms underlying the occurrence of blood clots with low platelets – known as thrombotic thrombocytopenia syndrome (TTS). This project is supported by the National Institute for Health Research and backed by £1.6 million of government funding from the Vaccine Taskforce.

Bristol's involvement in the study, led by Professor Jonathan Sterne, will be to look at the association of COVID-19 vaccination with cardiovascular events after vaccination by analyzing very large (population-level) datasets.