Does herpes simplex virus change during transmission?

A new study offers clues as to how herpes simplex virus (HSV) genetic diversity is shared between transmission partners. The authors used viral genome sequencing to follow oral and genital samples of HSV, collected over a year of each partner's infection. Often, the same viral variants were observed in both partners within a transmission pair. Occasionally these variants developed into viral genome differences between partners. This is the first study to compare HSV-1 genomes between adult sexual transmission partners. Image created with BioRender.com.
Credit: Moriah Szpara, Penn State / Penn State

A new study helps explain how the virus that causes herpes might change during transmission between partners and over time during a long-term infection within a human host, which could have implications for future treatment strategies. The study, by a team of researchers from Penn State and the University of Washington, is the first to track genetic differences of the herpes simplex virus (HSV-1) as it moves between adult sexual transmission partners. Their findings revealed that viral population movement between partners has a strong impact on whether genetic differences appear at the start of new infections.

A paper describing this work appears online in the journal PLoS Pathogens.

“Hundreds of minor differences in the genome of HSV-1 have been documented around the world, and many of these differences — called variants — can be detected within a single human host,” said Molly Rathbun, graduate student in biochemistry and molecular biology at Penn State and the lead author of the paper. “How often these variants are transmitted and how quickly they evolve within a person has remained elusive until now. Improving our understanding of these processes might help us understand why individuals vary so much in the severity and frequency of their symptoms.”

Climate change on course to hit U.S. Corn Belt especially hard

Climate change will make the U.S. Corn Belt unsuitable for cultivating corn by 2100 without major technological advances in agricultural practices, an Emory University study finds.

Environmental Research Letters published the research, which adds to the evidence that significant agricultural adaptation will be necessary and inevitable in the Central and Eastern United States. It is critical that this adaptation includes diversification beyond the major commodity crops that now make up the bulk of U.S. agriculture, says Emily Burchfield, author of the study and assistant professor in Emory’s Department of Environmental Sciences.

“Climate change is happening, and it will continue to shift U.S. cultivation geographies strongly north,” Burchfield says. “It’s not enough to simply depend on technological innovations to save the day. Now is the time to envision big shifts in what and how we grow our food to create more sustainable and resilient forms of agriculture.”

Burchfield’s research combines spatial-temporal social and environmental data to understand the future of food security in the United States, including the consequences of a changing climate.

Pets or threats? Goldfish might be harmful for biodiversity

Invasive species are one of the leading causes of global biodiversity loss, and the pet trade is responsible for a third of all aquatic invasive species. Pet owners releasing unwanted pets into the wild is a major problem. Whilst many believe this is a humane option, new research suggests that attempting to ‘save’ the life of a goldfish could in fact lead to catastrophic outcomes for native biodiversity.

To better understand the ecological risks posed by species within the pet trade, the researchers focused on the two most commonly traded fish species in Northern Ireland: goldfish and the white cloud mountain minnow.

The globally popular goldfish was first domesticated over a thousand years ago and has since established non-native populations around the world. The white cloud mountain minnow on the other hand is a species with a limited invasion history to date.

Koalas exposed to double whammy health threat

Credit: Tara Gatehouse

An AIDS-like virus that is plaguing Australia’s koala population is leaving them more vulnerable to chlamydia and other threatening health conditions, University of Queensland research has found.

One of UQ’s leading COVID-19 vaccine researchers, Associate Professor Keith Chappell, has discovered that the chlamydia epidemic plaguing endangered koala populations in Queensland and NSW is linked to a common virus that likely suppresses koalas’ immune systems.

Dr Chappell and Dr Michaela Blyton, from UQ’s Australian Institute for Bioengineering and Nanotechnology and School of Chemistry and Molecular Biosciences, made this discovery after studying more than 150 koalas admitted to Currumbin Wildlife Hospital.

Dr Chappell said this study could have far reaching impacts and lead to better protective measures like breeding programs and new anti-viral medications.

“We know Queensland and NSW koala populations are heavily impacted by chlamydia infections and a retrovirus, but until now a clear link between the two has not been conclusively established,” Professor Chappell said.

“Our research has found that the amount of retrovirus circulating within an animal’s blood was strongly associated with chlamydia and symptoms like cystitis and conjunctivitis, as well as overall poor health.

“It’s a double whammy for already-endangered koalas.”

Secret to treating ‘Achilles’ heel’ of alternatives to silicon solar panels revealed

Solar panels 
Credit: Alachua County

The researchers used a combination of techniques to mimic the process of aging under sunlight and observe changes in the materials at the nanoscale, helping them gain new insights into the materials, which also show potential for optoelectronic applications such as energy-efficient LEDs and X-ray detectors, but are limited in their longevity.

Their results, reported in the journal Nature, could significantly accelerate the development of long-lasting, commercially available perovskite photovoltaics.

Perovksites are abundant and much cheaper to process than crystalline silicon. They can be prepared in liquid ink that is simply printed to produce a thin film of the material.

While the overall energy output of perovskite solar cells can often meet or – in the case of multi-layered ‘tandem’ devices – exceed that achievable with traditional silicon photovoltaics, the limited longevity of the devices is a key barrier to their commercial viability.

A typical silicon solar panel, like those you might see on the roof of a house, typically lasts about 20-25 years without significant performance losses.

Building a Pipeline of Space Cyber Defenders

Source/Credit: Pacific Northwest National Laboratory

Cybercrime is a growing threat to critical space-based technologies—from the satellites that feed communication devices to the global positioning systems that enable military operations. And as the United States continues to expand capabilities in space, the need to secure and protect space-based assets from hackers and other malicious actors has never been greater.

But finding cybersecurity professionals is tough. Currently, there are 600,000 open cybersecurity jobs in the United States, but only enough qualified workers to fill 400,000 of them. This deep shortage of cybersecurity talent not only puts a strain on employers, but it leaves crucial digital systems—both on Earth and in space—vulnerable to cyberattacks.

In an effort to grow the cybersecurity workforce needed to build more resilient and secure space systems, Pacific Northwest National Laboratory (PNNL) has teamed up with U.S. Space Force’s Space Systems Command to create the Cyber Halo Innovation Research Program—or CHIRP.

AI reveals unsuspected math underlying search for exoplanets

Artist’s concept of a sun-like star (left) and a rocky planet about 60% larger than Earth in orbit in the star’s habitable zone. Gravitational microlensing has the ability to detect such planetary systems and determine the masses and orbital distances, even though the planet itself is too dim to be seen. 
Image credit: NASA Ames/JPL-Caltech/T. Pyle

Artificial intelligence (AI) algorithms trained on real astronomical observations now outperform astronomers in sifting through massive amounts of data to find new exploding stars, identify new types of galaxies and detect the mergers of massive stars, accelerating the rate of new discovery in the world’s oldest science.

But AI, also called machine learning, can reveal something deeper, University of California, Berkeley, astronomers found: unsuspected connections hidden in the complex mathematics arising from general relativity — in particular, how that theory is applied to finding new planets around other stars.

In a paper appearing this week in the journal Nature Astronomy, the researchers describe how an AI algorithm developed to more quickly detect exoplanets when such planetary systems pass in front of a background star and briefly brighten it — a process called gravitational microlensing — revealed that the decades-old theories now used to explain these observations are woefully incomplete.

‘Beam Me Up:’ Nation’s First Quantum Drone Provides Unrivaled Security

Hacked bank and Twitter accounts, malicious power outages and attempts to tamper with medical records threaten the security of the nation’s health, money, energy, society and infrastructure. Harnessing the laws of nature – namely quantum physics – cutting–edge teleportation technology is taking cybersecurity to new, “unhackable” heights using miniscule particles of light or “beams.”

Florida Atlantic University’s Warner A. Miller, Ph.D., in concert with Qubitekk and L3Harris, is leading the United States’ efforts to deliver the first drone-based, mobile quantum network to seamlessly maneuver around buildings, inclement weather and terrain and quickly adapt to changing environments such as warfare.

Together with Qubitekk, an award-winning leader in manufacturing entangled photon sources and other hardware for networking quantum processors and sensors, FAU has been entrusted by the U.S. Office of the Secretary of Defense to develop the project.

The network includes a ground station, drones, lasers and iber optics to share quantum-secured information. Today’s telecommunication networks use fiber optics, connected by laser beams from the ground and between planes and satellites — called fiber and free space optical networks. Drones are used to save lives, secure infrastructure, help the environment and thwart hostile military advances such as the war between Russia and Ukraine.

Population-scale study highlights ongoing risk of COVID-19 in some cancer patients despite vaccination

Illustration of the coronavirus
Credit: Gerd Altmann

A study co-led by the Universities of Oxford, Birmingham and Southampton and the UK Health Security Agency (UKHSA), published in Lancet Oncology today by the UK Coronavirus Cancer Evaluation Project, has found that while COVID-19 vaccination is effective in most cancer patients, the level of protection against COVID-19 infection, hospitalization and death offered by the vaccine is less than in the general population and vaccine effectiveness wanes more quickly.

Dr Lennard Lee, Department of Oncology, University of Oxford who led the study said: ‘We know that people with cancer have a higher risk of severe COVID-19 disease and that the immune response in cancer patients following COVID-19 vaccination is lower. However, no study has looked at vaccine effectiveness and its waning in cancer patients at a population level. We have undertaken the largest real-world health system evaluation of COVID-19 in cancer patients globally.’

This study analyzed 377,194 individuals with active or recent cancer who had received two doses of the COVID-19 vaccine and undergone a SARS-CoV-2 PCR test in England. The numbers of breakthrough COVID-19 infections and COVID-19-associated hospitalizations and deaths in this cohort of cancer patients were compared to a control population without active or recent cancer.

New tool measures atomic scale defects, identifies transistor limitations

Engineering science and mechanics doctoral student Fedor Sharov adjusts settings in a very low frequency EDMR spectrometer.
Credit: Kelby Hochreither/Penn State

A new technique for studying defects in semiconductor materials could lead to improved speed, power and performance of electronic devices by revealing the atomic-level limitations of advanced materials.

Developed by a Penn State-led team of researchers and lead by former Penn State graduate student James Ashton, the analytic tool makes use of extremely small magnetic fields and frequencies far smaller than those typically used in such measurements to detect and measure imperfections in new materials, providing structural information about the magnetic interactions between electrons and nearby magnetic nuclei in a simpler way than previously possible.

The approach was published as a cover article in Applied Physics Letters. According to Patrick Lenahan, distinguished professor of engineering science and mechanics at Penn State and Ashton’s doctoral thesis adviser, the tool allows researchers to take a big step toward solving a variety of faults in next-generation devices.