Reduce alcohol consumption by exercising

Photo Credit: KoolShooters

Researchers at Karolinska Institutet present new findings on reduced alcohol consumption through exercise. The three related publications, published in Drug and Alcohol Dependence, present results from the randomized controlled trial, FitForChange.

Alcohol consumption is the seventh leading risk factor for both deaths and functionally adjusted years of life globally - this new study can help improve global public health by broadening the range of effective non-stigmatizing treatments available to people with alcohol abuse.

Common barriers to seeking help

Most people with alcohol abuse never seek or receive treatment despite negative consequences for both mental and physical health. According to the researchers, perceived stigma and dissatisfaction with available treatments are common barriers to seeking help. Therefore, more effective and non-stigmatizing treatments for alcohol abuse are needed.

Current treatments include psychological therapies and medication. These are effective, but relapse rates remain high, and these treatments do not directly address the somatic health problems commonly seen in those with AUD. To address this, we invested the effects on alcohol consumption of aerobic exercise - which is recommended for general health - and yoga, an increasingly popular form of exercise which may be suitable for people with AUD, says Mats Hallgren, Project Manager, Department of Global Public Health.

No Fib: NIST Unmasks a Superfast Process for Nanoscale Machining

NIST researchers have demonstrated that a focused ion beam (FIB) can fabricate microscopic devices with fine resolution and without sacrificing high speed. Left: The conventional FIB process requires a narrow, low-current ion beam to fabricate a miniature version of a lighthouse lens in silica glass with fine resolution. Because the beam has a low current of ions, the method is time consuming. Right: Placing a protective layer of chromium oxide over the silica glass enables machinists to use a much higher-current ion beam, allowing them to fabricate the same lenses 75 times faster. 
Credit: Andrew C. Madison, Samuel M. Stavis/NIST

Cutting intricate patterns as small as several billionths of a meter deep and wide, the focused ion beam (FIB) is an essential tool for deconstructing and imaging tiny industrial parts to ensure they were fabricated correctly. When a beam of ions, typically of the heavy metal gallium, bombards the material to be machined, the ions eject atoms from the surface—a process known as milling—to sculpt the workpiece.

Beyond its traditional uses in the semiconductor industry, the FIB has also become a critical tool for fabricating prototypes of complex three-dimensional devices, ranging from lenses that focus light to conduits that channel fluid. Researchers also use the FIB to dissect biological and material samples to image their internal structure.

Machine learning algorithm predicts how to get the most out of electric vehicle batteries

Credit: (Joenomias) Menno de Jong from Pixabay 

The researchers, from the University of Cambridge, say their algorithm could help drivers, manufacturers and businesses get the most out of the batteries that power electric vehicles by suggesting routes and driving patterns that minimize battery degradation and charging times.

The team developed a non-invasive way to probe batteries and get a holistic view of battery health. These results were then fed into a machine learning algorithm that can predict how different driving patterns will affect the future health of the battery.

"This method could unlock value in so many parts of the supply chain, whether you’re a manufacturer, an end user, or a recycler, because it allows us to capture the health of the battery beyond a single number"

Alpha Lee

If developed commercially, the algorithm could be used to recommend routes that get drivers from point to point in the shortest time without degrading the battery, for example, or recommend the fastest way to charge the battery without causing it to degrade. The results are reported in the journal Nature Communications.

The health of a battery, whether it’s in a smartphone or a car, is far more complex than a single number on a screen. “Battery health, like human health, is a multi-dimensional thing, and it can degrade in lots of different ways,” said first author Penelope Jones, from Cambridge’s Cavendish Laboratory. “Most methods of monitoring battery health assume that a battery is always used in the same way. But that’s not how we use batteries in real life. If I’m streaming a TV show on my phone, it’s going to run down the battery a whole lot faster than if I’m using it for messaging. It’s the same with electric cars – how you drive will affect how the battery degrades.”

Revealed missing step in lipid formation could enable detection of past climate

A team from Penn State and the University of Illinois Urbana-Champaign has determined the missing step in the formation of a molecule called GDGT, which is a promising candidate for use as an indicator of past climate. The team determined the X-ray crystal structure of an enzyme that facilitates this process called GDGT/MAS—shown here bound to additional cofactors.
Credit: Booker Lab | Pennsylvania State University

The missing step in the formation of a lipid molecule that allows certain single-celled organisms to survive the most extreme environments on Earth has now been deciphered. This new understanding, uncovered by a team of biochemists from Penn State and the University of Illinois Urbana-Champaign, could improve the ability of the lipids to be used as an indicator of temperature across geological time.

The lipid, called glycerol dibiphytanyl glycerol tetraether (GDGT), is found in the cell membrane of some species of archaea, single-celled organisms that were originally thought to be bacteria but now are considered a separate group. This lipid provides the stability for some species to thrive in environments with extremely high temperatures, salinity or acidity, like thermal vents in the ocean, hot springs and hypersaline waters. The unique stability of GDGT also allows it to be detected hundreds or even thousands of years after the organism dies. Because these organisms tend to produce more GDGT at higher temperatures, it is considered a promising candidate for estimating temperature over geologic time.

“For GDGT to be accurately used as a proxy to reconstruct changes in geological temperatures, scientists need to better understand how it is made, what genes code for it, and which species can create it,” said Squire Booker, a biochemist at Penn State, an investigator with the Howard Hughes Medical Institute, and leader of the research team. “But, until now, there has been a missing step in the formation of this lipid. We used imaging techniques coupled with chemical and biochemical methods to deconstruct the chemical pathway for this missing step.”

COVID-19 pandemic fallout worse for women

Dr Terry Fitzsimmons, Lead author
Credit: University of Queensland

Researchers from The University of Queensland have found the COVID-19 pandemic in Australia has had a greater financial and psychological impact on women than men.

A study conducted by the UQ Business School shows women have experienced more significant impacts on their overall employment, hours of work, domestic labor and mental health and wellbeing.

Lead researcher Dr Terry Fitzsimmons said one reason was the over-representation of women in industries most affected by lockdowns.

“Women are also more likely to be casual, part-time or contract workers which were among the first to lose their jobs as businesses struggled in response to lockdown,” Dr Fitzsimmons said.

Additionally, the study found women were less likely to be considered ‘essential workers’, so bore a greater share of caring responsibilities including home schooling, when schools and child care centers closed.

“Women either reduced their work hours or stopped working altogether and took on more domestic labor than their male counterparts while at home with their children,” Dr Fitzsimmons said.

Researchers develop the first AI-based method for dating archaeological remains

Credit: Unsplash

By analyzing DNA with the help of artificial intelligence (AI), an international research team led by Lund University in Sweden has developed a method that can accurately date up to ten-thousand-year-old human remains.

Accurately dating ancient humans is key when mapping how people migrated during world history.

The standard dating method since the 1950s has been radiocarbon dating. The method, which is based on the ratio between two different carbon isotopes, has revolutionized archaeology. However, technology is not always completely reliable in terms of accuracy, making it complicated to map ancient people, how they moved and how they are related.

In a new study published in Cell Reports Methods, a research team has developed a dating method that could be of great interest to archaeologists and paleognomicists.

“Unreliable dating is a major problem, resulting in vague and contradictory results. Our method uses artificial intelligence to date genomes via their DNA with great accuracy, says Eran Elhaik, researcher in molecular cell biology at Lund University.

Increasing use of hazardous preservatives - measures are needed to protect health and the environment

Credit: Pixabay

The use of hazardous preservatives in chemical products has increased dramatically during the years 1995–2018. Several of these are highly allergenic and can cause lifelong allergies that affect work ability and quality of life. A new study from the Institute of Environmental Medicine (IMM) highlights the need for measures to protect human health and the environment.

Many preservatives and other biocides are highly allergenic in skin contact. Several are also harmful to the environment. Allergy is lifelong and anyone who has become allergic must avoid skin contact with the substance in order not to become ill in allergic contact dermatitis that adversely affects work ability and quality of life.

Significantly increased use

The purpose of the current study was to increase knowledge about how EU chemicals legislation and the use of the most problematic preservatives in chemical products have evolved over time, while the use in cosmetics is more widely known. The results show that the use of the most problematic substances has increased very significantly. The study also shows that information on the content of preservatives is often missing due to the design of the regulations. The only products that today must have a declaration of preservatives on the packaging are cosmetics and detergents. Some preservatives, especially isothiazolinones, have caused massive outbreaks of contact allergy due to extensive use. Therefore, it is often difficult to avoid risky contact and skin disease. Color, adhesive and putty are examples of products that often contain these harmful chemicals.

‘Drug factory’ implants eliminate mesothelioma tumors in mice

Tiny alginate bead implants invented in the laboratory of Rice University bioengineer Omid Veiseh can be loaded with cells that produce cytokine, proteins that play a major role in immune response. A new study found a treatment combining the implants and checkpoint inhibitor drugs eradicated advanced mesothelioma tumors in all seven mice in which it was tested.
Photo credit: Jeff Fitlow/Rice University

Rice University and Baylor College of Medicine researchers have shown they can eradicate advanced-stage mesothelioma tumors in mice in just a few days with a treatment combining Rice’s cytokine “drug factory” implants and a checkpoint inhibitor drug.

The researchers administered the drug-producing beads, which are no larger than the head of a pin, next to tumors where they could produce continuous, high doses of interleukin-2 (IL-2), a natural compound that activates white blood cells to fight cancer.

The study, published online today in Clinical Cancer Research, is the latest in a string of successes for the drug-factory technology invented in the lab of Rice bioengineer Omid Veiseh, including Food and Drug Administration (FDA) approval to begin clinical trials of the technology this fall in ovarian cancer patients.

“From the beginning, our objective was to develop a platform therapy that can be used for multiple different types of immune system disorders or different types of cancers,” said Rice graduate student Amanda Nash, who spent several years developing the implant technology with study co-lead author Samira Aghlara-Fotovat, a fellow student in Veiseh’s lab.

Boeing Delivers Two Commercial Satellites to SES for ULA Launch

Two C-band satellites enable SES to provide rapid broadcast and radio services, and critical network communications, to the United States
Credit: Boeing 

Boeing has delivered two satellites for leading global content connectivity service provider SES to their launch site in Cape Canaveral, Florida, ahead of the upcoming launch of the twin spacecraft on a United Launch Alliance (ULA) Atlas V rocket.

“SES-20 and SES-21 are the first commercial satellites we’ve delivered since the start of the global pandemic,” said Ryan Reid, president of Boeing Satellite Systems International. “It was challenging, but we found ways to be responsive to emerging customer demands and timelines. As a result, we went from contract signing to delivery of two satellites in little over two years.”

The pair of all-electric 702SP (small platform) satellites are equipped with C-band payloads that will operate over the continental United States and help usher in the Federal Communications Commission’s 5G Fast initiative, which requires satellite operators such as SES to transition services from the lower 300 MHz to the upper 200 MHz of C-band spectrum for 5G mobile services.

Study paves way for widespread architectural use of end-of-life tires

'Earthship' built from recycled tires at Ironbank, SA. 
Credit: Earthship Ironbank

A new study by The University of South Australia published in the journal Engineering Structures has tested and verified the structural integrity of walls constructed from tires packed with earth, with the results potentially providing new opportunities for the reuse of end-of-life tires in the construction industry.

Tire waste represents a major sustainability challenge globally, with Australia alone generating an average of 55 million (450,000 tons) end-of-life tires each year.

While earth-packed tire walls have been used in niche construction scenarios for decades, there has previously been no strong empirical data available to support their use, a fact that has limited their wider uptake by architects and engineers.

Supported by Tire Stewardship Australia, a UniSA team consisting of Yachong Xu, Martin Freney, Reza Hassanli, Yan Zhuge, Mizanur Rahman and Rajibul Karim, has rigorously assessed the structural integrity of a test tire wall to examine how the structure performed under various stressors.

According to Dr. Martin Freney, the wall proved to be as structurally sound as conventional walls used in residential applications.

“The wall we tested was the first of its kind to be scientifically tested in this fashion, and all the data indicates tire walls can be extremely strong and safe structures,” Dr. Freney says.