Ruptured ACLs can heal without surgery

A new study challenges the common notion that an ACL injury cannot heal.
Photo Credit:  kinkate

Anterior cruciate ligament (ACL) ruptures can heal without surgery and this could be key to better patient outcomes, according to new findings challenging the common notion that an ACL injury cannot heal.

Published in the British Journal of Sports Medicine, the study analysed trial data and found some ruptured ACLs healed after exercise-based rehabilitation, and that this healing was associated with better patient-reported outcomes compared with ACL reconstruction surgery.

The study, led by physiotherapist and Senior Research Fellow at the University of Melbourne, Dr Stephanie Filbay, undertook a secondary analysis of data from the KANON randomized controlled trial - the first to randomize people with ACL rupture to either management with early ACL reconstruction, or rehabilitation and optional delayed surgery. Participants in the trial were active adults – not professional athletes - aged 18-35 years.

The study found 53 per cent of trial participants whose ACL ruptures were managed with rehabilitation only, and did not decide to have surgery, had a healed ACL on MRI two years after injury. Signs of ACL healing were observed as early as three months after injury on MRI in this group.

Participants in this group reported better sport and recreational function and quality of life two years post-injury, compared to the non-healed, early ACL reconstruction surgery and delayed ACL reconstruction surgery groups.

Surfing scientists conduct 3D reef research at epic surf break

MEGA Lab Research Technician Kailey Pascoe mapping Cloudbreak in Fiji
Resized Image using AI by SFLORG
Credit: Source University of Hawaiʻi

With more than 80% of the world’s oceans left unexplored, untouched and unseen by humans, researchers know more about the surface of Mars than the ocean. A University of Hawaiʻi at Hilo professor is helping to fill that knowledge gap by leading a team of scientists to 3D map the planet’s premier surf breaks to help better protect reefs around the world.

Professors John H.R. Burns (UH Hilo), Haunani Kane (Arizona State University) and Cliff Kapono (Arizona State University) recently mapped the reef at Kurukuru Mailani in Fiji, also known as Cloudbreak, which is home to some of the biggest and best waves in the world. The team takes high resolution images of the reef and uses a technique called photogrammetry to create 3D reconstructions that can be studied to help provide a better understanding of reef systems.

“These models will help us to understand the composition, characteristics and ecology of the reef and these waves that will help us to protect them in the face of disturbances such as sea level rise,” said Burns, an associate professor of marine science.

Boeing-Built X-37B Completes Sixth Mission, Sets New Endurance Record

The Boeing-built X-37B Orbital Test Vehicle (OTV) landed at NASA’s Kennedy Space Center in Florida at 5:22 a.m. ET, November 12, 2022.
Photo Credit: Boeing / U.S. Space Force

The Boeing built X-37B Orbital Test Vehicle (OTV) set a new endurance record after spending 908 days in orbit before landing at NASA’s Kennedy Space Center in Florida at 5:22 a.m. ET, November 12, 2022. This surpasses its previous record of 780 days on-orbit.

With the successful completion of its sixth mission the reusable spaceplane has now flown over 1.3 billion miles and spent a total of 3,774 days in space where it conducts experiments for government and industry partners with the ability to return them to Earth for evaluation.

For the first time, the vehicle carried a service module to augment the number of payloads it can haul. The module separated from the OTV prior to de-orbiting ensuring a safe and successful landing.

“This mission highlights the Space Force's focus on collaboration in space exploration and expanding low-cost access to space for our partners, within and outside of the Department of the Air Force (DAF),” said Gen. Chance Saltzman, Chief of Space Operations.

Synthetic black holes radiate like real ones

To make a synthetic black hole, just take a chain of atoms (green), and change how easy it is for an electron to jump between each atomic site, represented here by the color and width of the blue interatomic bonds. The varied bond strength in the lower chain mimics the warping of spacetime in the presence of a black hole. This way, the incredible physics of black holes can be explored in a lab on Earth.
Source/Credit:  Universiteit van Amsterdam

Black holes are the most extreme objects in the universe, packing so much mass into so little space that nothing – not even light – can escape their gravitational pull once it gets close enough.

Understanding black holes is key to unraveling the most fundamental laws governing the cosmos, because they represent the limits of two of the best-tested theories of physics: the theory of general relativity, which describes gravity as resulting from the (large-scale) warping of spacetime by massive objects, and the theory of quantum mechanics, which describes physics at the smallest length scales. To fully describe black holes, we would need to stitch these two theories together and form a theory of quantum gravity.

Radiating black holes

To achieve this goal, we might want to look at what manages to escape from black holes, rather than what gets swallowed. The event horizon is an intangible boundary around each black hole, beyond which there is no way of getting out. However, Stephen Hawking famously discovered that every black hole must emit a small amount of thermal radiation due to small quantum fluctuations around its horizon.

Altered cell behavior behind resistance in neuroblastoma

Credit: National Cancer Institute

Researchers at Lund University in Sweden have identified one of the reasons why the childhood cancer neuroblastoma becomes resistant to chemotherapy. The findings are significant for how future treatments should be designed. The results have been published in Science Advances.

Neuroblastoma is an aggressive cancer of the sympathetic nervous system, especially of the adrenal gland. Despite intense treatment with chemotherapy, the disease can be difficult to cure and the prognosis is poor for children who have the aggressive variant. One of the reasons is that the tumor often develops resistance to drugs. In order to understand what happens when the tumor becomes resistant, good disease models are needed that can mimic the complex drug treatment given to patients today:

“Tumors from patients with neuroblastoma look very different, and it is difficult to produce a model that is representative of many patients. This type of challenge often limits medical research”, explains the study's first author, Adriana Mañas, child cancer researcher at Lund University.

Probiotic ‘backpacks’ show promise for treating inflammatory bowel diseases

Probiotic bacteria (teal) coated in a layer of biomaterial as they travel through a human intestine. Attached to the bacteria are reactive oxygen species nano-scavengers.
Image Credit: Quanyin Hu

Like elite firefighters headed into the wilderness to combat an uncontrolled blaze, probiotic bacteria do a better job quelling gut inflammation when they’re equipped with the best gear.

A new study by researchers at the University of Wisconsin–Madison demonstrates just how much promise some well-equipped gut-friendly bacteria hold for improving treatments of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis.

Led by Quanyin Hu, a biomedical engineer and professor in the UW–Madison School of Pharmacy, the research builds on technology the team had previously designed. That prior technology encases beneficial bacteria within a very thin protective shell to help them survive an onslaught of stomach acids and competing microbes long enough to establish and multiply in the guts of mice.

While the technology makes orally administered probiotics more effective, IBD is a complex disease that usually involves more than gut microbial communities that are out of whack.

“IBD is a complicated disease, and you need to attack it at different angles,” says Hu.

So, Hu and his colleagues devised specialized nanoparticles to neutralize molecules implicated in IBD. They’ve also figured out a way of attaching these nanoparticle “backpacks” to beneficial bacteria after encasing them in the protective coating.

Researchers Solve Hundred-Year-Old Botanical Mystery that was Key to the Spread of Plant Life on Land

Plant material from Yale-Myers Forest and YSE greenhouses were used to study how their vascular systems are constructed and how they compare to the extinct plants from the fossil record. Without developing their vascular systems, plants would largely still look like mosses. Shown here: Huperzia lucidula, also known as Shining club-moss.
Photo Credit: courtesy of Craig Brodersen Lab.

The earliest land plants were small — just a few centimeters tall at most — and restricted to moist, boggy habitats around streams and ponds. Around 400 million years ago, however, plants developed vascular systems to extract water more efficiently from the soil and use it for photosynthesis, a transition that would forever alter the Earth’s atmosphere and ecosystems. A team of researchers have now solved a 100-year-old paleontology mystery: How did ancient plants emerge from swamps and riverbanks to new habitats with limited access to water?

In a new paper published in Science, YSE Professor of Plant Physiological Ecology Craig Brodersen and his research team, including lead author Martin Bouda ’17 PhD, ’12 MPhil and Kyra A. Prats ’22 PhD, ’16 MFS, discovered that a simple change in the vascular system of plants made them more drought-resistant, which opened up new landscapes for exploration.

The research was spurred by a century-long debate about why the simple, cylindrical vascular system of the earliest land plants rapidly changed to more complex shapes. In the 1920s, scientists noted this increasing complexity in the fossil record but were not able to pinpoint the reason — if there even was one — for the evolutionary changes.

New pterosaur species found in sub-Saharan Africa

SMU paleontologists helped find a new species of pterosaurs in Angola, where fossils of other large marine animals have been found. E. otyikokolo can be seen flying above the ocean in the ancient picture.
Artwork Credit: Karen Carr Studio.

With wings spanning nearly 16 feet, a new species of pterosaurs has been identified from the Atlantic coast of Angola.

An international team, including two vertebrate paleontologists from SMU, named the new genus and species Epapatelo otyikokolo. This flying reptile of the dinosaur age was found in the same region of Angola as fossils from large marine animals currently on display at the Smithsonian’s National Museum of Natural History.

Pterosaur fossils that date back to the Late Cretaceous are extremely rare in sub-Saharan Africa, said team member Michael J. Polcyn, research associate in the Huffington Department of Earth Sciences and senior research fellow, ISEM at SMU (Southern Methodist University).

“This new discovery gives us a much better understanding of the ecological role of the creatures that were flying above the waves of Bentiaba, on the west coast of Africa, approximately 71.5 million years ago,” Polcyn said.

Renowned paleontologist Louis L. Jacobs, SMU professor emeritus of earth sciences and president of ISEM, an interdisciplinary institute at the university, also collaborated on the research. The team’s findings were published in the journal Diversity.

Alzheimer's disease can be diagnosed before symptoms emerge

Oskar Hansson, Professor of Neurology Lund University 
Photo Credit: Kennet Ruona

A large study led by Lund University in Sweden has shown that people with Alzheimer's disease can now be identified before they experience any symptoms. It is now also possible to predict who will deteriorate within the next few years. The study is published in Nature Medicine, and is very timely in light of the recent development of new drugs for Alzheimer's disease.

It has long been known that there are two proteins linked to Alzheimer’s – beta-amyloid, which forms plaques in the brain, and tau, which at a later stage accumulates inside brain cells. Elevated levels of these proteins in combination with cognitive impairment have previously formed the basis for diagnosing Alzheimer's.

“Changes occur in the brain between ten and twenty years before the patient experiences any clear symptoms, and it is only when tau begins to spread that the nerve cells die and the person in question experiences the first cognitive problems. This is why Alzheimer's is so difficult to diagnose in its early stages”, explains Oskar Hansson, senior physician in neurology at Skåne University Hospital and professor at Lund University.

He has now led a large international research study that was carried out with 1,325 participants from Sweden, the US, the Netherlands and Australia. The participants did not have any cognitive impairment at the beginning of the study. By using PET scans, the presence of tau and amyloid in the participants' brains could be visualized. The people in whom the two proteins were discovered were found to be at a 20-40 times higher risk of developing the disease at follow-up a few years later, compared to the participants who had no biological changes.

Friendly monkeys have friendly microbes

More sociable monkeys have a higher abundance of certain beneficial gut bacteria, and a lower abundance of potentially disease-causing bacteria, new research has found.

The study involved analyzing social network data from a population of non-captive macaques on the island of Cayo Santiago, off Puerto Rico, and combining this with sequencing data to assess their individual gut microbiota.

The researchers found that monkeys that engage in social interactions were more likely to have an abundance of gut microbes that are known to benefit the immune system, and were less likely to have an abundance of potentially harmful bacteria. The analyses controlled for other factors that could affect the microbiome, including age, season, sex and rank within the group’s hierarchy.

The study was conducted by Dr Katerina Johnson at the University of Oxford's Department of Psychiatry, in collaboration with Dr Karli Watson from the University of Colorado Boulder, alongside Oxford professors Robin Dunbar and Philip Burnet.