Studies find Omicron related hospitalizations lower in severity than Delta and Pfizer-BioNTech COVID vaccine remains effective in preventing hospitalizations

Photo Credit: Fernando Zhiminaicela

Adult hospitalizations from Omicron-related SARS-CoV-2 (COVID-19) were less severe than Delta and the Pfizer-BioNTech vaccine (also known as Comirnaty and BNT162b2*) remains effective in preventing not only hospitalization, but severe patient outcomes associated with COVID-19, two new research studies have found.

The University of Bristol-led research, funded and conducted in collaboration with Pfizer Inc., as part of AvonCAP, is published in The Lancet Regional Health – Europe.

AvonCAP records adults who are admitted to Bristol’s two hospital Trusts – North Bristol NHS Trust (NBT) and University Hospitals Bristol and Weston NHS Foundation Trust (UHBW) with possible respiratory infection.

In the first paper ‘Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalized adults: a prospective cohort study in Bristol, United Kingdom’ researchers assessed whether Delta SARS-CoV-2 infection resulted in worse patient outcomes than Omicron SARS-CoV-2 infection, in hospitalized patients

The study aimed to provide more detailed data on patient outcomes, such as the need for respiratory support.

Sandia, Intel seek novel memory tech to support stockpile mission

Developed at Sandia National Laboratories, a high-fidelity simulation of the hypersonic turbulent flow over a notional hypersonic flight vehicle, colored grey, depicts the speed of the air surrounding the body, with red as high and blue as low. The turbulent motions that impose harsh, unsteady loading on the vehicle body are depicted in the back portion of the vehicle. Accurately predicting these loads are critical to vehicle survivability, and for practical applications, billions of degrees of freedom are required to predict physics of interest, inevitably requiring massive computing capabilities for realistic turnaround times. The work conducted as part of this research and development contract targets improving memory performance characteristics that can greatly benefit this and other mission applications.
Simulation Credit: Cory Stack

In pursuit of novel advanced memory technologies that would accelerate simulation and computing applications in support of the nation’s stockpile stewardship mission, Sandia National Laboratories, in partnership with Los Alamos and Lawrence Livermore national labs, has announced a research and development contract awarded to Intel Federal LLC, a wholly owned subsidiary of Intel Corporation.

Funded by the National Nuclear Security Administration’s Advanced Simulation and Computing program, the three national labs will collaborate with Intel Federal LLC on the project.

“ASC’s Advanced Memory Technology research projects are developing technologies that will impact future computer system architectures for complex modeling and simulation workloads,” said ASC program director Thuc Hoang. “We have selected several technologies that have the potential to deliver more than 40 times the application performance of our forthcoming NNSA Exascale systems.”

Sandia project lead James H. Laros III, a Distinguished Member of Technical Staff, said “this effort will focus on improving bandwidth and latency characteristics of future memory systems, which should have a direct impact on application performance for a wide range of ASC mission codes.”

What is driving the high suicide rate among farmers?

Mental health outreach programs geared toward farmers also need to provide services for their teens, who have similar rates of anxiety and depression, said agricultural and biological engineering professor Josie Rudolphi. The co-director of the North Central Farm and Ranch Stress Assistance Center, Rudolphi is conducting a five-year study on the mental health needs of people who live and work on farms. 
Photo Credit: Fred Zwicky

Josie Rudolphi is a professor of agricultural and biological engineering at the University of Illinois Urbana-Champaign whose research examined suicide among farmers and ranchers, as well as the mental health of their children. She is the co-director of the North Central Farm and Ranch Stress Assistance Center, a 12-state, 15-partner collaborative based in Illinois Extension that offers stress management and mental health interventions. Rudolphi spoke with News Bureau research editor Sharita Forrest about the mental health needs of people in the farming industry.

Recent data from the U.S. Centers for Disease Control and Prevention indicated that farmers are twice as likely as people in other occupations to die by suicide. What are the unique stressors affecting the mental health of farmers?

While most farmers in the Midwest had a good harvest this year and commodity prices are strong, they are faced with incredibly high input costs. Unpredictable commodity prices have so much impact on the viability of a farm. There’s a lot to celebrate, but the future is so uncertain.

Fossil-Sorting Robots Will Help Researchers Study Oceans, Climate

Researchers have developed and demonstrated a robot capable of sorting, manipulating, and identifying microscopic marine fossils. The new technology automates a tedious process that plays a key role in advancing our understanding of the world’s oceans and climate – both today and in the prehistoric past.

“The beauty of this technology is that it is made using relatively inexpensive off-the-shelf components, and we are making both the designs and the artificial intelligence software open source,” says Edgar Lobaton, co-author of a paper on the work and an associate professor of electrical and computer engineering at North Carolina State University. “Our goal is to make this tool widely accessible, so that it can be used by as many researchers as possible to advance our understanding of oceans, biodiversity and climate.”

The technology, called Forabot, uses robotics and artificial intelligence to physically manipulate the remains of organisms called foraminifera, or forams, so that those remains can be isolated, imaged and identified.

Forams are protists, neither plant nor animal, and have been prevalent in our oceans for more than 100 million years. When forams die, they leave behind their tiny shells, mostly less than a millimeter wide. These shells give scientists insights into the characteristics of the oceans as they existed when the forams were alive. For example, different types of foram species thrive in different kinds of ocean environments, and chemical measurements can tell scientists about everything from the ocean’s chemistry to its temperature when the shell was being formed.

Antibody discovery paves way for new therapies against group A streptococcal infections

Pontus Nordenfelt Associate Professor, Infection Medicine Lund University
Source: Lund University

Researchers at Lund University in Sweden have discovered an antibody with the potential to protect against Strep A infection, as well as a rare form of antibody binding, that leads to an effective immune response against bacteria. The discovery could explain why so many Group A strep vaccines have failed.

The results are published in EMBO Molecular medicine.

Group A streptococci have several ways in which they evade the body's immune system and, when they infect us, can cause both common throat infections (strep throat), scarlet fever, sepsis, swine pox and skin infections. So far, antibiotics work against these bacteria, but should they become resistant, they will pose a major public health threat.

One strategy that the scientific community uses to find new ways of fighting bacterial infections is to create target-seeking antibodies. First, the antibodies that the body's immune system produces in the event of an infection are mapped, and then their effect on the immune system is studied. In this way, antibodies can be identified that can be used both for preventive treatment and for treatment during an ongoing infection. However, it's a challenging process, and many attempts to develop antibody-based treatments against Strep A have failed.

Molecules found in mucus could prevent cholera infection

Scanning electron microscope image of Vibrio cholerae bacteria, which infects the digestive system.
Image Credit: Zeiss DSM 962 SEM T.J. Kirn, M.J. Lafferty, C.M.P Sandoe and R.K. Taylor,

MIT researchers have identified molecules found in mucus that can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state.

These protective molecules, known as glycans, are a major constituent of mucins, the gel-forming polymers that make up mucus. The MIT team identified a specific type of glycan that can prevent Vibrio cholerae from producing the toxin that usually leads to severe diarrhea.

If these glycans could be delivered to the site of infection, they could help strengthen the mucus barrier and prevent cholera symptoms, which affect up to 4 million people per year. Because glycans disarm bacteria without killing them, they could be an attractive alternative to antibiotics, the researchers say.

“Unlike antibiotics, where you can evolve resistance pretty quickly, these glycans don’t actually kill the bacteria. They just seem to shut off gene expression of its virulence toxins, so it’s another way that one could try to treat these infections,” says Benjamin Wang PhD ’21, one of the lead authors of the study.

Scientists Have Created New Substance to Treat Neurological Disorders

Scientists used a set of 1,2,3-triazole derivatives and modeled the structure of the putative inhibitor.
 Photo Credit: Andrey Fomin

The international team of scientists, including chemists from the Ural Federal University, has developed a substance that may become the basis for drugs that suppress or alleviate a number of neurological disorders. These include, for example, psychosis, schizophrenia, Parkinson's and Huntington's diseases, etc. The scientists reported the development and first results of the study in the Journal of Biomolecular Structure and Dynamics. The study was supported by a grant from the Ministry of Science and Higher Education of the Russian Federation (Project No. 075-15-2020-777).

"We found that the enzyme Phosphodiesterase 10A, which is produced in the body, is directly linked to neurological disorders. If you inhibit this enzyme, you can significantly slow down or even suppress the disease. For this purpose, we used a set of derivatives of 1,2,3-triazole, a pharmacophore whose fragments are contained in many drugs, and modeled the structure of the putative TP-10 inhibitor. We hypothesize that it would have a positive effect on conditions associated with brain dysfunction by reducing the activity of the Phosphodiesterase 10A enzyme. Other inhibitors developed by foreign companies still have no reliable antipsychotic efficacy so far," notes Dhananjay Bhattacherjee, senior researcher at the Department of Organic and Biomolecular Chemistry at UrFU.

Monash researchers on the front line in fight against fungal infections

The fungal pathogen Candida albicans transformed with a green fluorescence protein (GFP) tagged iron sensor is engulfed by macrophages. Upon iron starvation induced by macrophages Candida will express GFP and make hyphal projections thereby escaping immune cells.
Source: Monash University

With fungal infections killing 1.5 million people each year, Monash University researchers are playing an important role as the World Health Organization recognizes this growing threat.

The world-leading Monash experts are among a small but determined group of researchers working to curb the growing impact of potentially dangerous fungal infections.

In late October, 2022, WHO published a report highlighting the first list of fungal "priority pathogens" – a catalogue of the 19 fungi that represent the greatest threat to public health.

The premise behind the publication is twofold: fungi are a significant and increasing threat to public health, and because there is little global research and development into fungi or their treatment.

Professor Ana Traven, from the Monash Biomedicine Discovery Institute, said fungi could range from benign (skin and nail infections and vaginal thrush) to the deadly (Candida, Aspergillus).

Researchers kick goals with soccer findings

Photo Credit: Joshua Hoehne

University of Queensland scientists have developed a model that gives soccer players their best chance of kicking a penalty goal.

After analyzing strategies used by penalty shot kickers and goalkeepers, researchers developed a model that coaches can use to identify the best shooting strategy against a particular goalkeeper.

Professor Robbie Wilson, head of the UQ Football Research Group at UQ’s School of Biological Sciences, said the outcome of a penalty shot was determined by a complex interaction between the shooter and the goalkeeper.

“Usually, a player’s performance is constrained by biomechanical trade-offs but each player has a range of strategies to overcome these,” Professor Wilson said.

“For example, if a shooter kicks at a high speed, accuracy is decreased, and if a goalkeeper moves early, the probability they’ll move in the correct direction is reduced.”

He said every player, including international stars like Cristiano Ronaldo and Lionel Messi, had a range of kicking speeds and areas of the goal in which they were naturally better or worse.

Hummingbird flight could provide insights for biomimicry in aerial vehicles

Hummingbirds have extreme aerial agility and flight forms, which is why many drones and other aerial vehicles are designed to mimic hummingbird movement. Using a novel modeling method, researchers gained new insights into how hummingbirds produce wing movement, which could lead to design improvements in flying robots.
Photo Credit: Zdeněk Macháček

Hummingbirds occupy a unique place in nature: They fly like insects but have the musculoskeletal system of birds. According to Bo Cheng, the Kenneth K. and Olivia J. Kuo Early Career Associate Professor in Mechanical Engineering at Penn State, hummingbirds have extreme aerial agility and flight forms, which is why many drones and other aerial vehicles are designed to mimic hummingbird movement. Using a novel modeling method, Cheng and his team of researchers gained new insights into how hummingbirds produce wing movement, which could lead to design improvements in flying robots.

Their results were published this week in the Proceedings of Royal Society B.

“We essentially reverse-engineered the inner working of the wing musculoskeletal system — how the muscles and skeleton work in hummingbirds to flap the wings,” said first author and Penn State mechanical engineering graduate student Suyash Agrawal. “The traditional methods have mostly focused on measuring activity of a bird or insect when they are in natural flight or in an artificial environment where flight-like conditions are simulated. But most insects and, among birds specifically, hummingbirds are very small. The data that we can get from those measurements are limited.”