Deciphering Catalysts: Unveiling Structure-Activity Correlations

The standard research paradigm uncovers the structure-property-activity relationships for the electrochemical CO2 reduction reaction (CO2RR) over SnO2. This picture illustrates the surface reconstruction induced by oxygen vacancies (1/1 ML coverage) and surface-active species (Sn layer) accountable for selective HCOOH production.
Illustration Credit: ©Hao Li et al.

In a new step towards combating climate change and transitioning to sustainable solutions, a group of researchers has developed a research paradigm that makes it easier to decipher the relationship between catalyst structures and their reactions.

Details of the researchers' breakthrough were published in the journal Angewandte Chemie.

Understanding how a catalyst's surface affects its activity can aid the design of efficient catalyst structures for specific reactivity requirements. However, grasping the mechanisms behind this relationship is no straightforward task given the complicated interface microenvironment of electrocatalysts.

Keeping the immune system in check

Image Credit: © Julian Nüchel, Center for Biochemistry Cologne

Researchers from the UoC’s Center for Biochemistry at the Faculty of Medicine and the UoC CECAD Cluster of Excellence in Aging Research have discovered that an excessive immune response can be prevented by the intramembrane protease RHBDL4. In a study now published in Nature Communications under the title ‘RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling’, a previously unknown regulatory mechanism is described: The cleavage of a cargo receptor by a so-called intramembrane protease reduces the localization of a central immune receptor on the cell surface and thereby the risk of an overreaction of the immune system.

Intramembrane proteases are reactive proteins that reside in the cell membranes. They form a special group of proteases because they cut proteins within cellular membranes. Many of these unusual proteases have not yet been sufficiently characterized and only a few of the molecules they can cleave – the so-called substrates – and thus their functions are known. One of these intramembrane proteases is RHBDL4. It is located in the endoplasmic reticulum, a large intracellular membrane system that is responsible, among other things, for the correct folding of newly synthesized proteins that are fed into the secretory route.

Marine algae implants could boost crop yields

Discovery could lead to more sustainable food supply
Photo Credit: Oktavianus Mulyadi

Scientists have discovered the gene that enables marine algae to make a unique type of chlorophyll. They successfully implanted this gene in a land plant, paving the way for better crop yields on less land. 

Finding the gene solves a long-standing mystery amongst scientists about the molecular pathways that allow the algae to manufacture this chlorophyll and survive. 

“Marine algae produce half of all the oxygen we breathe, even more than plants on land. And they feed huge food webs, fish that get eaten by mammals and humans,” said UC Riverside assistant professor of bioengineering and lead study author Tingting Xiang. “Despite their global significance, we did not understand the genetic basis for the algae’s survival, until now.”

The study, published in Current Biology, also documents another first-of-its-kind achievement: demonstrating that a land plant could produce the marine chlorophyll. Tobacco plants were used for this experiment, but in theory, any land plant may be able to incorporate the marine algae gene, allowing them to absorb a fuller spectrum of light and achieve better growth. 

Completely recycled viscose for the first time

Edvin Bågenholm-Ruuth
Photo Credit: Courtesy of Lund University

At present, viscose textiles are made of biomass from the forest, and there is no such thing as fully recycled viscose. Researchers at Lund University in Sweden have now succeeded in making new viscose – from worn-out cotton sheets.

Old textiles around the world end up at the rubbish tip and are often burned. In Sweden, they are generally burned to produce district heating. Extensive development work is being conducted to give old clothes and textiles a worthier ending. 

The planet really needs recycled textiles, as it takes a lot of energy, water and land to cultivate cotton and other plant sources for textiles. 

However, there are many challenges.

“Cellulose chains, the main component in plant fibers, are complex and long. Cotton textiles are also intensively treated with dyes, protective agents and other chemicals. And then there is all the ingrained grime in the form of skin flakes and fats,” says Edvin Bågenholm-Ruuth, doctoral student in chemical engineering at Lund University. 

Unveiling Inaoside A: An Antioxidant Derived from Mushrooms

Discovering a new antioxidant compound, Inaoside A from Laetiporus cremeiporus
Image credit: Atsushi Kawamura from Shinshu University, Japan

Natural products have unique chemical structures and biological activities and can play a pivotal role in advancing pharmaceutical science. In a pioneering study, researchers from Shinshu University discovered Inaoside A, an antioxidant derived from Laetiporus cremeiporus mushrooms. This breakthrough sheds light on the potential of mushrooms as a source of therapeutic bioactive compounds.

The search for novel bioactive compounds from natural sources has gained considerable momentum in recent years due to the need for new therapeutic agents to combat various health challenges. Among a diverse array of natural products, mushrooms have emerged as a rich reservoir of bioactive molecules with potential pharmaceutical and nutraceutical applications. The genus Laetiporus has attracted attention for its extracts exhibiting antimicrobial, antioxidant, and antithrombin bioactivities. The species Laetiporus cremeiporus, spread across East Asia, has also been reported to show antioxidant properties. However, the identification and characterization of specific antioxidant compounds from this species have not been conducted.

In a groundbreakng study, researchers led by Assistant Professor Atsushi Kawamura from the Department of Biomolecular Innovation, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, along with Hidefumi Makabe from the Department of Agriculture, Graduate School of Science and Technology, Shinshu University, and Akiyoshi Yamada from the Department of Mountain Ecosystem, Institute for Mountain Science, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, recently discovered the antioxidant compound derived from L. cremeiporus.

Gene discovered that can protect against severe muscle disease

The researchers behind the study. Front row from the left: Hanna Nord, Fatima Pedrosa Domellöf, Jingxia Liu. Rear row: Abraha Kahsay, Nils Dennhag, Jonas von Hofsten
Photo Credit: Per Stål

A specific gene may play a key role in new treatments that prevent muscle in the body from breaking down in serious muscle diseases. This is shown in a new study at Umeå University, Sweden. Protein expressed by the gene naturally prevents the muscles around the eye from being affected when other muscles in the body are affected by muscular dystrophies. In the study the gene is expressed in all muscles. The effects were that muscular dystrophy was alleviated throughout the body.

"You could say that the eye muscles function both as an eye-opener for understanding the disease and as a door opener to a treatment for the whole body," says Fatima Pedrosa Domellöf, professor of eye diseases at Umeå University and one of the study's authors.

Muscular dystrophies are a group of congenital genetic diseases that affect muscle tissue and often lead to severe disability and greatly reduced life expectancy. Despite intensive research, there are still no effective treatments for patients suffering from muscular dystrophy.

Decomposition under the microscope

Lara Indra photographically documenting an animal cadaver. Attached to the tree trunk and behind the researcher are camera traps; an insect trap is positioned to the left.
Photo Credit: Sandra Lösch / Dept. of Anthropology, IRM, University of Bern

Researchers at the University of Bern have investigated the process of decomposition on pig carcasses left in nature. The researchers discovered that the previous standard method for assessing decomposition in Switzerland needs to be adapted – with an impact on forensic analysis. The method presented by the researchers aims to better determine the post-mortem interval.

A dead body decomposes with the help of various organisms – such as intestinal bacteria, flies, maggots and beetles. This makes it difficult to establish the post-mortem interval of cadavers in forensics: the more advanced the decomposition, the harder it is to determine the time of death. Therefore, various methods have the goal of correlating the degree of decomposition with the postmortem interval. With respect to this, the body is divided into three areas – the head and neck, the trunk and the extremities – and its condition is assessed using a point value system. The findings from the three areas are then added together, resulting in the total body score (TBS). 

Researchers provide unprecedented view into aerosol formation in Earth’s lower atmosphere

Researchers identified evidence of Criegee intermediate oligomerization in the Amazon rainforest.
 Image Credit: Argonne National Laboratory

Eighty-five percent of the Earth’s air resides in the lowest layer of its atmosphere, or troposphere. Yet, major gaps remain in our understanding of the atmospheric chemistry that drives changes in the troposphere’s composition.

One especially important gap in knowledge is the formation and prevalence of secondary organic aerosols (SOAs), which impact the planet’s radiation balance, air quality and human health. But that gap is closing — due to the groundbreaking discoveries of an international team of researchers led by the U.S. Department of Energy’s (DOE) Argonne National Laboratory, Sandia National Laboratories and NASA’s Jet Propulsion Laboratory (JPL).

The scientists detail their findings in a new paper published in Nature Geosciences. 

The team focused on a class of compounds known as Criegee intermediates (CIs). Researchers suspect that CIs play a critical role in the formation of SOAs when they combine via a process called oligomerization. But no one had ever directly identified the chemical signatures of this process in the field — until now.

Can ‘Super Volcanoes’ Cool the Earth in a Major Way? A New Study Suggests No.

Quizapu Volcano, Chile
Photo Credit: Kevin Krajick / Earth Institute

Scientific Frontline: "At a Glance" Summary

• Main Discovery: Volcanic super-eruptions likely cause significantly less global cooling than previously estimated, with temperature drops probably not exceeding 1.5°C (2.7°F) even for the most powerful events.
• Methodology: Researchers from NASA’s Goddard Institute for Space Studies utilized advanced computer modeling to simulate climate responses to super-eruptions, specifically varying the diameter of microscopic sulfate particles injected into the stratosphere.
• Key Data: Previous estimates suggested cooling of 2°C to 8°C (3.6°F to 14.4°F), but new simulations align more closely with the 1991 Mount Pinatubo eruption, which caused a 0.5°C (1°F) drop; a super-eruption requires releasing over 1,000 cubic kilometers of magma.
• Significance: The findings explain the lack of archaeological or geological evidence for global-scale biological catastrophes following historical super-eruptions, such as the Toba event 74,000 years ago.
• Future Application: The study highlights the high level of uncertainty regarding aerosol particle behavior, suggesting that intentional geoengineering via stratospheric aerosol injection remains a non-viable climate mitigation strategy for the foreseeable future.
• Branch of Science: Earth Science, Volcanology, and Climate Modeling.
• Additional Detail: Sulfate particles influence temperature through two counteracting mechanisms: reflecting incoming solar radiation to cause cooling and trapping outgoing thermal energy to create a greenhouse effect.

Earliest-yet Alzheimer’s biomarker found in mouse model could point to new targets

Illinois graduate student Yeeun Yook, left, and professor Nien-Pei Tsai worked with their team to find the earliest marker of Alzheimer’s disease yet reported in the brains of mice. The work could create new targets for early detection or treatment options.
Photo Credit: Fred Zwicky

A surge of a neural-specific protein in the brain is the earliest-yet biomarker for Alzheimer’s disease, report University of Illinois Urbana-Champaign researchers studying a mouse model of the disease. Furthermore, the increased protein activity leads to seizures associated with the earliest stages of neurodegeneration, and inhibiting the protein in the mice slowed the onset and progression of seizure activity. 

The neural-specific protein, PSD-95, could pose a new target for Alzheimer’s research, early diagnosis and treatment, said study leader Nien-Pei Tsai, an Illinois professor of molecular and integrative physiology. 

Tsai’s group studies mice that make more of the proteins that form amyloid-beta, which progressively aggregates in Alzheimer’s disease to form plaques in the brain that hamper neural activity. However, in the new work, the group focused on a time frame much earlier in the mouse lifespan than others have studied – when no other markers or abnormalities have been reported, Tsai said.