The integrity of the blood-brain barrier depends on a protein that is altered in some neurodegenerative diseases

From left to right, Pilar Villacampa, Víctor Arribas and Eloi Montañez.
Photo Credit: Courtesy of University of Barcelona

Defects in the blood vessel network of the central nervous system have been linked to early symptoms of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). It is this complex vascular network that provides the necessary nutrients, especially glucose and oxygen to activate all neuronal functions. Now, a study led by the University of Barcelona and the Bellvitge Biomedical Research Institute (IBIDELL) reveals that the TDP-43 protein is essential for forming a stable and mature blood vessel network in the central nervous system.

According to the study the TDP-43 protein is also critical in maintaining the integrity of the blood-brain barrier, which prevents toxins and pathogens from reaching the central nervous system.

The project is led by Professor Eloi Montañez, from the Faculty of Medicine and Health Sciences of the University of Barcelona and IDIBELL, and involves teams from the Faculty of Biology and the Institute of Biomedicine of the UB (IBUB), the Josep Carreras Leukemia Research Institute, and the National Centre for Genomic Analysis (CNAG-CRG).

Rethinking galactic origins through heavy-element mapping challenges conventional theory

Galactic gas shows varying heavy element distribution: blue indicates scarcity, red indicates richness. Heavy elements are less abundant in gas than Galaxy.
Image Credit: T. Hayakawa/Y.Fukui, Nagoya University

A groundbreaking study of the origins of intermediate-velocity clouds (IVCs) challenges a 20-year-old theory and suggests a new era of deep-space research. Researchers at Nagoya University in Japan discovered that IVCs have much lower heavy elements than previously reported. Rather than the materials being constantly recycled like water in a fountain, their findings suggest that the particles that make the clouds originated outside our galaxy. The group published their findings in Monthly Notices of the Royal Astronomical Society. 

IVCs are a type of interstellar cloud characterized by their velocity. They are found at altitudes of thousands of light years away throughout the Milky Way. Gas clouds are important because they are sources of elements that enable star formation and the creation of planetary systems. 

In the conventional model, elements are released back into the interstellar medium when the stars die in events called supernovae. This material is then reincorporated into the gas clouds. According to this model, the heavy elements in IVCs are generated through nuclear fusion reactions and supernova explosions within our galaxy. 

New research on tungsten unlocks potential for improving fusion materials

Through a combination of modeling and state-of-the-art experimental techniques, researchers shed light on the complex behavior of phonons in tungsten. This advancement could lead to the development of more efficient and resilient fusion reactor materials.
Image Credit: Courtesy of SLAC National Accelerator Laboratory

In the pursuit of clean and endless energy, nuclear fusion is a promising frontier. But in fusion reactors, where scientists attempt to make energy by fusing atoms together, mimicking the sun's power generation process, things can get extremely hot. To overcome this, researchers have been diving deep into the science of heat management, focusing on a special metal called tungsten.

New research, led by scientists at the Department of Energy’s SLAC National Accelerator Laboratory, highlights tungsten's potential to significantly improve fusion reactor technology based on new findings about its ability to conduct heat. This advancement could accelerate the development of more efficient and resilient fusion reactor materials. Their results were published today in Science Advances.

"What excites us is the potential of our findings to influence the design of artificial materials for fusion and other energy applications," said collaborator Siegfried Glenzer, director of the High Energy Density Division at SLAC. “Our work demonstrates the capability to probe materials at the atomic scale, providing valuable data for further research and development."

Marine heat waves disrupt the ocean food web in the northeast Pacific Ocean

Pyrosomes.
Photo Credit: Mark Farley, Hatfield Marine Science Center, Oregon State University.

Marine heat waves in the northeast Pacific Ocean create ongoing and complex disruptions of the ocean food web that may benefit some species but threaten the future of many others, a new study has shown.

The study, just published in the journal Nature Communications, is the first of its kind to examine the impacts of marine heat waves on the entire ocean ecosystem in the northern California Current, the span of waters along the West Coast from Washington to Northern California.

The researchers found that the biggest beneficiary of marine heat waves is gelatinous zooplankton – predominantly cylindrical-shaped pyrosomes that explode in numbers following a marine heat wave and shift how energy moves throughout the food web, said lead author Dylan Gomes, who worked on the study as a postdoctoral scholar with Oregon State University’s Marine Mammal Institute.

“If you look at single species interactions, you’re likely to miss a lot,” Gomes said. “The natural effects of a disturbance are not necessarily going to be straightforward and linear. What this showed us is that these heat waves impact every predator and prey in the ecosystem through direct and indirect pathways.”

The project was a collaboration by Oregon State University and the National Oceanic and Atmospheric Administration. Joshua Stewart, an assistant professor with the Marine Mammal Institute, mentored Gomes and co-authored the paper.

Scientists reveal the first unconventional superconductor that can be found in mineral form in nature

A miassite crystal grown by Paul Canfield.
Photo Credit: Paul Canfield

Scientists from Ames National Laboratory have identified the first unconventional superconductor with a chemical composition also found in nature. Miassite is one of only four minerals found in nature that act as a superconductor when grown in the lab. The team’s investigation of miassite revealed that it is an unconventional superconductor with properties similar to high-temperature superconductors. Their findings further scientists’ understanding of this type of superconductivity, which could lead to more sustainable and economical superconductor-based technology in the future.

Superconductivity is when a material can conduct electricity without energy loss. Superconductors have applications including medical MRI machines, power cables, and quantum computers. Conventional superconductors are well understood but have low critical temperatures. The critical temperature is the highest temperature at which a material acts as a superconductor.

In the 1980s, scientists discovered unconventional superconductors, many of which have much higher critical temperatures. According to Ruslan Prozorov, a scientist at Ames Lab, all these materials are grown in the lab. This fact has led to the general belief that unconventional superconductivity is not a natural phenomenon.

Prozorov explained that it is difficult to find superconductors in nature because most superconducting elements and compounds are metals and tend to react with other elements, like oxygen. He said that miassite (Rh17S15) is an interesting mineral for several reasons, one of which is its complex chemical formula. “Intuitively, you think that this is something which is produced deliberately during a focused search, and it cannot possibly exist in nature,” said Prozorov, “But it turns out it does.”

It's in the Blood: Donor Diets Can Trigger Allergic Reactions in Blood Recipients

Photo Credit: Aman Chaturvedi

Blood transfusions are often life-saving procedures in various medical settings. They are required not only after severe blood loss due to surgery or trauma but also as standard treatment for certain blood disorders like anemia and sickle cell disease. However, blood transfusions can have serious side effects, with allergic transfusion reactions (ATRs) being particularly prevalent among children. Although scientists believe ATRs are caused by immunoglobulin E (IgE)-mediated type 1 allergy (or “immediate hypersensitivity”), the responsible allergens are not always known.

Against this backdrop, a research team composed of Dr. Ryu Yanagisawa of Shinshu University Hospital, Japan, alongside Dr. Minoru Tozuka and Dr. Yasunori Ito from Nagano Children's Hospital, Japan, set out to find more answers. In their latest study, published online in the journal Allergy, the researchers focused their attention on what might have appeared to be an unlikely suspect. Dr. Yanagisawa, wo led the study at the University’s Division of Blood Transfusion, explains: “In our previous study, we found that pediatric patients with food allergies were characteristically more prone to ATRs. Considering that food allergies are also more prevalent in children, we decided to investigate whether the food the donor ate before giving blood could be associated with the development of ATRs in children with food allergies.”

Satellites for quantum communications

Tobias Vogl investigates single photon sources in 2D materials in an experimental setup
Photo Credit: Jens Meyer / University of Jena

Through steady advances in the development of quantum computers and their ever-improving performance, it will be possible in the future to crack our current encryption processes. To address this challenge, researchers at the Technical University of Munich (TUM) are participating in an international research consortium to develop encryption methods that will apply physical laws to prevent the interception of messages. To safeguard communications over long distances, the QUICK³ space mission will deploy satellites.

How can it be ensured that data transmitted through the internet can be read only by the intended recipient? At present our data are encrypted with mathematical methods that rely on the idea that the factorization of large numbers is a difficult task. With the increasing power of quantum computers, however, these mathematical codes will probably no longer be secure in the future.

Ultra-short light pulses enable high-precision "artificial nose"

Hongtao Hu and Vinzenz Stummer
Photo Credit: Courtesy of Technische Universität Wien

A new spectroscopy method has been developed at TU Wien: Using a series of laser pulses, chemical analyses can be carried out much faster and more precisely than before.

Whether you want to analyze environmental samples in nature or monitor a chemical experiment, you often need highly sensitive sensors that can "sniff out" even tiny traces of a certain gas with extreme accuracy. Variants of Raman spectroscopy are often used for this purpose: Different molecules react in very characteristic ways to light of different wavelengths. If you irradiate a sample with the appropriate light and measure exactly how the light is modified by the sample, you can find out whether the sample contains a certain gas or not.

However, scientists at TU Wien (Vienna) have now taken a significant step forward in this area: a new method has been developed to generate and precisely control suitable light for such experiments. This not only enables much greater accuracy than before; the method also works without moving parts and is therefore much faster than the best technologies to date. The method has now been published in the journal Light: Science and Applications.

Is life based on a seeming violation of Newton’s law in molecular interactions?

Interactions between molecules that are not equal and opposite, a seeming violation of Newton’s third law of motion, can occur naturally according to new research. A kinase enzyme adds a chemical modification to other molecules, resulting in a phosphorylated protein. Phosphatase enzymes remove the modifications, such that the kinases create products that are acted upon by phosphatases and vice versa. Researchers demonstrated that the kinase is attracted to the phosphatase, but the phosphatase is repelled by the kinase, in what is called a non-reciprocal interaction.
Illustration Credit: Niladri Sekhar Mandal / Pennsylvania State University
(CC BY-NC-ND 4.0 DEED)

It turns out that every action may not have an equal and opposite reaction, despite what Newton’s third law of motion says, according to new research conducted by a team from Penn State and the University of Maine. The finding could offer insight into how certain molecular interactions could have evolved in a pre-life world.

The work was published in the journal Chem, and the researchers said this is the first demonstration of the mechanism by which these interactions occur at the molecular level. Last year’s discovery by researchers at Kyoto University that sperm movement does not cause an opposite reaction in its environment as it moves provided an example of a seeming violation of Newton’s third law of motion, but it did not address the mechanism.

“We all have heard the phrase ‘every action has an equal and opposite reaction,’ to describe Newton’s third law of motion, but we see examples that seemingly violate this every day, especially in the behavior of complex living systems small and large where there is constant input of energy,” said Ayusman Sen, Verne M. Willaman Professor of Chemistry in the Eberly College of Science at Penn State and one of the research team leaders. “An example at the larger scale is that a predator is attracted to its prey, but the prey is repelled by the predator. This type of interaction is called non-reciprocal, and we were interested to see if it also occurred in the much simpler interactions among molecules with constant energy input.”

Scientists develop a rapid gene-editing screen to find effects of cancer mutations

Using a variant of CRISPR genome-editing known as prime editing, MIT researchers have developed a method to screen cancer-associated genetic mutations much more easily and quickly than any existing approach. This illustration, by Samuel Gould’s brother Owen Gould, is an artistic interpretation of the research and the idea of “rewriting the genome,” explains Samuel.
Illustration Credit: Owen Gould
(CC BY-NC-ND 4.0 DEED)

Tumors can carry mutations in hundreds of different genes, and each of those genes may be mutated in different ways — some mutations simply replace one DNA nucleotide with another, while others insert or delete larger sections of DNA.

Until now, there has been no way to quickly and easily screen each of those mutations in their natural setting to see what role they may play in the development, progression, and treatment response of a tumor. Using a variant of CRISPR genome-editing known as prime editing, MIT researchers have now come up with a way to screen those mutations much more easily.

The researchers demonstrated their technique by screening cells with more than 1,000 different mutations of the tumor suppressor gene p53, all of which have been seen in cancer patients. This method, which is easier and faster than any existing approach, and edits the genome rather than introducing an artificial version of the mutant gene, revealed that some p53 mutations are more harmful than previously thought.

The researchers say this technique could also be applied to many other cancer genes, and could eventually be used for precision medicine, to determine how an individual patient’s tumor will respond to a particular treatment.

“In one experiment, you can generate thousands of genotypes that are seen in cancer patients, and immediately test whether one or more of those genotypes are sensitive or resistant to any type of therapy that you’re interested in using,” says Francisco Sanchez-Rivera, an MIT assistant professor of biology, a member of the Koch Institute for Integrative Cancer Research, and the senior author of the study.

MIT graduate student Samuel Gould is the lead author of the paper, which appears today in Nature Biotechnology.