Engineered “natural killer” cells could help fight cancer

Caption:A new study identifies genetic modifications that make “natural killer” cells more effective at destroying cancer cells.
Image Credit: NIAID
(CC BY-NC-ND 4.0)

One of the newest weapons that scientists have developed against cancer is a type of engineered immune cell known as CAR-NK (natural killer) cells. Similar to CAR-T cells, these cells can be programmed to attack cancer cells.

MIT and Harvard Medical School researchers have now come up with a new way to engineer CAR-NK cells that makes them much less likely to be rejected by the patient’s immune system, which is a common drawback of this type of treatment.

The new advance may also make it easier to develop “off-the-shelf” CAR-NK cells that could be given to patients as soon as they are diagnosed. Traditional approaches to engineering CAR-NK or CAR-T cells usually take several weeks.

“This enables us to do one-step engineering of CAR-NK cells that can avoid rejection by host T cells and other immune cells. And, they kill cancer cells better and they’re safer,” says Jianzhu Chen, an MIT professor of biology, a member of the Koch Institute for Integrative Cancer Research,and one of the senior authors of the study.

Engineers Develop Solid Lubricant to Replace Toxic Materials in Farming

Photo Credit: Courtesy of North Carolina State University

Researchers have developed a new class of nontoxic, biodegradable solid lubricants that can be used to facilitate seed dispersal using modern farming equipment, with the goal of replacing existing lubricants that pose human and environmental toxicity concerns. The researchers have also developed an analytical model that can be used to evaluate candidate materials for future lubricant technologies.

Modern farming makes use of various machines to accurately and efficiently plant seeds in the ground. However, it can be difficult to prevent the seeds from jamming in these machines. To keep the seeds flowing smoothly, farmers use solid lubricants that prevent the seeds from clumping up or sticking together. Unfortunately, commercially available lubricants make use of talc or microplastics, and can pose threats to farmers, farmland and pollinators.

“Lubricants are essential to modern farming, but existing approaches are contributing to toxicity in our farmlands that affect farmer health, soil health and pollinators that are essential to our food supply,” says Dhanush Udayashankara Jamadgni, co-lead author of a paper on the work and a Ph.D. student at North Carolina State University. “We’ve developed a new class of safe solid lubricants that are effective and nontoxic.”

SwRI develops technology to deploy stabilized solar arrays, enabling spacecraft docking

Southwest Research Institute (SwRI) has developed technology that enables spacecraft to utilize precision pointing algorithms for attitude control. SwRI is currently integrating the Parallelogram Synchronized Truss Assembly (PaSTA) technology to stabilize deployed solar arrays on the Astroscale U.S. Refueler.
Image Credit: Southwest Research Institute

Southwest Research Institute (SwRI) has developed technology to stiffen deployable structures on spacecraft, enabling autonomous spacecraft docking operations. SwRI is currently integrating the Parallelogram Synchronized Truss Assembly (PaSTA) technology with solar arrays on the Astroscale U.S. Refueler spacecraft The team is also designing two different deployable booms using PaSTA technology for another spacecraft SwRI is developing.

The Astroscale U.S. Refueler, a 300-kilogram spacecraft, will be the first to conduct hydrazine refueling operations above geostationary orbit for the United States Space Force (USSF) and will be the first-ever on-orbit refueling mission supporting a U.S. Department of War asset. SwRI has been contracted by Astroscale U.S. to build, integrate and test the refueler for the USSF. The spacecraft requires precision pointing to dock with other vehicles in space, which necessitates a stiff deployable solar array to power its movements.

The hidden highways of the sky mapped

Photo Credit: Björn Malmhagen

High above us, the atmosphere is teeming with life. Birds, bats and insects share the airspace, but divide it into different lanes of traffic. New research from Lund University in Sweden reveals how the atmosphere is an ecosystem, with complex ecological processes that affect how animals move between different altitude levels.

We often consider the air as simply a void – but it is in fact alive and vital. In a new study, researchers in Lund, the Netherlands and the USA introduce a framework for understanding the air as a habitat, just like a forest or ocean. The study highlights how environmental factors and interaction between species affect how animals are distributed in the aerial habitat.

“It concerns not only where animals fly, but also why. Wind, temperature and air pressure are factors, as is the location of other animals. It’s a dynamic environment that requires adaptation,” explains Cecilia Nilsson, researcher in biology at Lund University.

Easter Island’s statues actually “walked” – and physics backs it up

A research team including Binghamton University archaeologist Carl Lipo has confirmed via 3D modeling and field experiments that the ancient people of Rapa Nui "walked" the iconic moai statues.
 Photo Credit: Carl Lipo

For years, researchers have puzzled over how the ancient people of Rapa Nui did the seemingly impossible and moved their iconic moai statues. Using a combination of physics, 3D modeling and on-the-ground experiments, a team including faculty at Binghamton University, State University of New York, has confirmed that the statues actually walked – with a little rope and remarkably few people.

Studying nearly 1,000 moai statues, Binghamton University Professor of Anthropology Carl Lipo and the University of Arizona’s Terry Hunt found that the people of Rapa Nui likely used rope and “walked” the giant statues in a zig-zag motion along carefully designed roads.

Volcanic ash may enhance phytoplankton growth in the ocean over 100 km away

Nishinoshima Island, located in the Ogasawara Islands of Japan, is home to an active volcano. Ash from volcanic eruptions there in 2020 could have led to a temporary surge in phytoplankton levels in the seawater 130 km away.
Photo Credit: Ogasawara Village Tourism Bureau

A research group in Japan has suggested that ash released from volcanic eruptions on Nishinoshima Island—part of Japan's Ogasawara Islands—led to a temporary surge in phytoplankton levels in the seawater around Mukojima Island, which is located 130 km northeast of Nishinoshima and is also part of the Ogasawara Islands.

Mukojima lies within the subtropical gyre, a region known for low nutrient and low chlorophyll conditions. The study indicates that ash from the Nishinoshima eruptions was transported by wind and ocean currents to the waters around Mukojima, serving as a nutrient source for phytoplankton growth in that area.

Animations of wildlife tracking data help explore animal movements

Researchers found that understanding environmental context is key to interpreting future animal patterns.
Photo Credit: Nick Fewings

Researchers have developed new software for exploring and communicating animal movements in the wild. 

This suite of open-source tools, called ECODATA, was designed to support the analysis and visualization of complex datasets, as valuable observations about animal movement are often made by analyzing massive amounts of wildlife tracking data. 

Their tool accomplishes this by creating animations that help ecologists study animal movement, such as how extreme weather conditions or seasonal vegetation growth might influence a species’ normal activities, said Gil Bohrer, co-author of the study and a professor in civil engineering and geodetic engineering at The Ohio State University.

“We’re not creating new information, but we are taking data that ecologists typically find hard to utilize and making it easy and accessible,” said Bohrer. “This can help users understand an ecosystem and quickly identify what’s going on, or test a good hypothesis they have.”

Cascadia and San Andreas faults may be seismically linked

Chris Goldfinger
Photo Credit: Courtesy of Oregon State University

Two fault systems on North America’s West Coast – the Cascadia subduction zone and the San Andreas fault – may be synchronized, with earthquakes on one fault potentially triggering seismic events on the other, a new study.

“We’re used to hearing the ‘Big One’ – Cascadia – being this catastrophic huge thing,” said Chris Goldfinger Link is external, a marine geologist at Oregon State University and lead author of the study. “It turns out it’s not the worst-case scenario.”

Goldfinger and a team of researchers drilled deep-sea sediment cores representing 3,100 years of geologic history, and analyzed layers known as turbidites that are deposited by underwater landslides often triggered by earthquakes. They compared turbidite layers in cores from both fault systems and found similarities in timing and structure, suggesting the seismic synchronization between the faults.

In most cases, it’s difficult to determine the time separation between the Cascadia subduction zone and northern San Andreas fault ruptures, but Goldfinger said there are three instances in the past 1,500 years, including a most recent one from 1700, when the researchers believe the ruptures were just minutes to hours apart.

Clinical trial marks key milestone in fight against antibiotic resistance

Infections with antibiotic-resistant bacteria cause a significant burden of disease worldwide.
Photo Credit: Scientific Frontline / AI Generated

An international clinical trial, led by The University of Queensland, has been hailed as a significant step forward in the global challenge of antibiotic resistance.

UQ researchers have led the first randomized trial across 6 countries to examine a new antibiotic, cefiderocol, in the treatment of life-threatening, drug-resistant infections.

Associate Professor Patrick Harris, of UQ’s Centre for Clinical Research, said the drug was found to be effective and safe in treating bloodstream infections.

"The study is the first randomized controlled trial to specifically examine the use of cefiderocol in bloodstream infections and sepsis," he said.

“With increasing global antimicrobial resistance, there is a need for the development of new antibiotics.’’

DNA nanospring measures cellular motor power

Experimental design for the force measurement of KIF1A.
An inert protein known as KIF5B serves as the anchor from which KIF1A pulls the nanospring. As with more familiar springs, the extended length correlates with the force being applied. But in this case, the DNA nanospring is also labeled with fluorescent molecules which give away how far it stretches to make visualization of KIF1A’s motile strength possible.
Image Credit: ©2025 Hayashi et al
(CC BY-ND 4.0)

Cells all require the transport of materials to maintain their function. In nerve cells, a tiny motor made of protein called KIF1A is responsible for that. Mutations in this protein can lead to neurological disorders, including difficulties in walking, intellectual impairment and nerve degradation. It’s known that mutations in KIF1A also result in a weakened motor performance, but this has been difficult to measure so far. Researchers including those from the University of Tokyo and the National Institute of Information and Communications Technology (NICT) in Japan have measured changes in the force of KIF1A using a nanospring, a tiny, coiled structure, made of DNA which could lead to improved diagnosis of diseases related to the protein’s mutations.