When ovarian cancer alters the abdominal cavity

Metastases from ovarian cancer in the abdominal cavity: Cancer cells alter the tissue of the omentum in such a way that it supports their spread.
Image Credit: Scientific Frontline / stock image

Ovarian cancer often forms secondary tumors, especially in a certain tissue in the abdominal cavity known as the omentum. Researchers from the University of Basel and University Hospital Basel have investigated what happens when the cancer “hijacks” this organ. It is hoped their findings will lead to more successful treatments. 

Ovarian cancer often goes undetected for a long time. In seven out of 10 patients, the tumor has already formed secondary tumors in the abdominal cavity at the time of diagnosis. These metastases are particularly common in a tissue called the omentum, also known as the peritoneal apron. This organ is located in front of the intestine, performs protective and immune functions, and harbors fat cells. 

“In advanced ovarian cancer, the question arises as to whether, in addition to the visible tumors and metastases, the omentum should also be completely removed as a preventive measure in order to reduce the recurrence of tumors,” explains Dr. Francis Jacob from the Department of Biomedicine at the University of Basel and the University Hospital Basel. 

New research may help scientists predict when a humid heat wave will break

Caption:MIT scientists have identified a key atmospheric condition that determines how hot and humid midlatitude regions like the Midwest can become — and how intense related storms may be.
Image Credit: Scientific Frontline / stock image

A long stretch of humid heat followed by intense thunderstorms is a weather pattern historically seen mostly in and around the tropics. But climate change is making humid heat waves and extreme storms more common in traditionally temperate midlatitude regions such as the midwestern U.S., which has seen episodes of unusually high heat and humidity in recent summers.

Now, MIT scientists have identified a key condition in the atmosphere that determines how hot and humid a midlatitude region can get, and how intense related storms can become. The results may help climate scientists gauge a region’s risk for humid heat waves and extreme storms as the world continues to warm.

In a study appearing this week in the journal Science Advances, the MIT team reports that a region’s maximum humid heat and storm intensity are limited by the strength of an “atmospheric inversion”— a weather condition in which a layer of warm air settles over cooler air.

Synchronising ultrashort X-ray pulses

At the ATHOS beamline of SwissFEL, PSI researchers demonstrated a technique known as mode-locking, which allows fully coherent, ultrashort X-ray pulses to be produced. In the photo, several undulator modules are visible (blue); between each pair are magnetic chicanes used to delay the electrons.
Photo Credit: © Paul Scherrer Institute PSI/Markus Fischer

Scientists at the Paul Scherrer Institute PSI have, for the first time, demonstrated a technique that synchronises ultrashort X-ray pulses at the X-ray free-electron laser SwissFEL. This achievement opens new possibilities for observing ultrafast atomic and molecular processes with attosecond precision.

Scrutinising fast atomic and molecular processes in action requires bright and short X-ray pulses – a task in which free-electron lasers such as SwissFEL excel. However, within these X-ray pulses the light is internally disordered: its temporal structure is randomly distributed and varies from shot to shot. This limits the accuracy of certain experiments.

To tame this inherent randomness, a team of PSI researchers has succeeded in implementing a technique known as mode-locking to generate trains of pulses that are coherent in time. “We can now obtain fully ordered pulses in time and frequency in a very controlled manner,” says accelerator physicist Eduard Prat, who led the study, published in Physical Review Letters. Selected by the journal as Editor’s Suggestion, the study, funded by the EU/ERC project “HERO”, represents a significant step towards the generation of tailored attosecond X-ray pulses and a range of new experiments that are only possible with precisely timed, synchronized light pulses.

A Clear Signal Emerging from Quantum Noise

Surprising signals can arise from the coupling of light particles.
Image Credit: © Oliver Diekmann

Researchers at TU Wien and the Okinawa Institute of Science and Technology (OIST) have demonstrated an unexpected effect: in a quantum system that is highly disordered, coherent microwave radiation can suddenly emerge. 

Two candles emit twice as much light as one. And ten candles have ten times the intensity. This rule seems completely trivial—but in the quantum world it can be broken. When quantum particles are excited to a higher-energy state, they can emit light as they relax back to a lower-energy state. However, when many such quantum particles are coupled together, they can collectively generate a light pulse that is far stronger than the sum of individual contributions. The pulse intensity scales with the square of the number of particles—this phenomenon is known as superradiance. It is a form of collective emission in which all quantum particles in the system release energy almost instantaneously and, so to speak, “in lockstep.” 

TU Wien and the Okinawa Institute of Science and Technology (Japan) have now discovered a different, completely unexpected manifestation of this phenomenon. They observed superradiance in irregular diamonds and found that after the initial superradiant pulse, a series of additional pulses follows, emitting further radiation in a coherent and perfectly regular manner. This is about as surprising as if the uncoordinated chirping of many crickets were suddenly to merge into a single, synchronized bang. 

WizFile

Image Credit: Scientific Frontline

In the modern digital ecosystem, the local file system often becomes a chaotic sprawling archive. As storage drives grow larger and file counts swell into the millions, the native Windows Search function frequently struggles—plagued by slow indexing speeds, high resource consumption, and sluggish result retrieval. This latency breaks the workflow of professionals who need immediate access to their data.

WizFile enters this arena as a high-performance alternative designed to eliminate the wait. Developed by Antibody Software, it positions itself as an "extremely fast file finder" that bypasses traditional OS bottlenecks to deliver instant results. This review examines the technology, feature set, and overall utility of WizFile to determine if it truly solves the problem of file search latency on Windows.

What Is: The Capitalocene

"Anthropocene" names a symptom; "Capitalocene" names the disease.
Image Credit: Scientific Frontline

At a Glance Summary

• The Core Concept: A theoretical alternative to the "Anthropocene," arguing that the current ecological crisis is not caused by "Humanity" as a species, but specifically by the political and economic dynamics of capitalism.
• Key Distinction: While the Anthropocene suggests humans biologically altered the planet, the Capitalocene argues that a specific historical system (capitalism) organized nature to produce the crisis. It reframes the problem from "too many people" to "the way capital accumulates."
• Origin: Coined in 2009 by Andreas Malm; expanded significantly by sociologist Jason W. Moore and feminist scholar Donna Haraway.

Major Frameworks

• World-Ecology (Moore): Capitalism is not just an economy but a way of organizing nature ("The Oikeios"). It relies on the "Four Cheaps" (Labor, Food, Energy, Raw Materials) to function. Dates the crisis to the 1450s.
• Fossil Capital (Malm): Focuses on the shift to coal and steam in the 19th century, arguing steam was adopted not for efficiency, but as a weapon of class war to control labor.
• Why It Matters: Proponents argue that naming the "disease" (Capitalism) rather than the "symptom" (Anthropocene) is crucial for finding political solutions to climate change, rather than relying on geo-engineering or population control.

Canine Ocular Melanosis

Pathophysiology, genomic architecture, clinical progression, and therapeutic management of canine ocular melanosis
Image Credit: Scientific Frontline

In the discipline of veterinary ophthalmology, few conditions present as complex a challenge as Canine Ocular Melanosis (OM). Predominantly affecting the Cairn Terrier, yet not exclusive to this breed. This hereditary disorder is characterized by a relentless, progressive infiltration of pigmented cells within the ocular tissues, leading to severe morbidity through the development of intractable secondary glaucoma. Historically and colloquially referred to as "pigmentary glaucoma," this terminology has largely been abandoned in the academic literature in favor of "ocular melanosis" to more accurately reflect the underlying pathological process: a primary proliferation and migration of melanocytes, rather than a passive dispersion of pigment granules as seen in human pigmentary glaucoma. The disease represents a significant welfare concern due to the chronic pain associated with ocular hypertension and the eventual, often bilateral, loss of vision. Furthermore, its entrenched status within the Cairn Terrier gene pool, driven by an autosomal dominant mode of inheritance and a late age of onset, poses a profound dilemma for breeders and geneticists alike.  

First ancient human herpesvirus genomes document their deep history with humans

Laboratory technician and one of the authors in the contamination-controlled ancient DNA laboratory at the University of Tartu extracting tiny amounts of DNA from centuries-old skeletons.
Photo Credit: Courtesy of University of Tartu

For the first time, scientists have reconstructed ancient genomes of Human betaherpesvirus 6A and 6B (HHV-6A/B) from archaeological human remains more than two millennia old. The study, led by the University of Vienna and University of Tartu (Estonia) and published in Science Advances, confirms that these viruses have been evolving with and within humans since at least the Iron Age. The findings trace the long history of HHV-6 integration into human chromosomes and suggest that HHV-6A lost this ability early on. 

HHV-6B infects about 90 percent of children by the age of two and is best known as the cause of roseola infantum – or "sixth disease" – the leading cause of febrile seizures in young children. Together with its close relative HHV-6A, it belongs to a group of widespread human herpesviruses that typically establish lifelong, latent infections after an initial mild illness in early childhood. What makes them exceptional is their ability to integrate into human chromosomes – a feature that allows the virus to remain dormant and, in rare cases, to be inherited as part of the host's own genome. Such inherited viral copies occur in roughly one percent of people today. While earlier studies had hypothesized that these integrations were ancient, the new data from this study provide the first direct genomic proof. 

MicroBooNE finds no evidence for a sterile neutrino

Members of the MicroBooNE collaboration pose in front of Wilson Hall with a 3D-printed model of the MicroBooNE detector. The collaboration consists of 193 scientists from 40 institutions.
Photo Credit: Dan Svoboda, Fermilab

Scientists on the MicroBooNE experiment further ruled out the possibility of one sterile neutrino as an explanation for results from previous experiments. In the latest MicroBooNE result, the collaboration used one detector and two beams to study neutrino behavior, ruling out the single sterile neutrino model with 95% certainty.

Scientists are closing the door on one explanation for a neutrino mystery that has plagued them for decades.

An international collaboration of scientists working on the MicroBooNE experiment at the U.S. Department of Energy’s Fermi National Accelerator Laboratory announced that they have found no evidence for a fourth type of neutrino. The paper was published today in Nature.

Scientists discover what drives California's worst fire years

Two natural resource specialists walk through an area of Redwood Mountain Grove burned in the KNP Complex Fire in California’s Sierra Nevada Mountains to evaluate fire effects.
Photo Credit: National Park Service

What makes one fire season worse than another in fire-prone parts of the world like California is poorly understood, but in a new study, scientists at the University of California, Irvine reveal how clusters of lightning-ignited fires called fire complexes are the chief drivers of the most destructive fire years. It’s a finding that could help agencies better manage such fires when they occur.

“Nobody has ever looked into these kinds of fires before,” said Rebecca Scholten, a postdoctoral fellow in Earth system science and lead author of the Science Advances study. “We theorized that when two or more fires in a fire complex merge, they would just burn themselves out. But we found the opposite – the fires grow worse.”