. Scientific Frontline

Thursday, December 8, 2022

Say Hello to the Toughest Material on Earth

Microscopy-generated images showing the path of a fracture and accompanying crystal structure deformation in the CrCoNi alloy at nanometer scale during stress testing at 20 kelvin (-424 F). The fracture is propagating from left to right.
Image Credit: Robert Ritchie/Berkeley Lab

Scientists have measured the highest toughness ever recorded, of any material, while investigating a metallic alloy made of chromium, cobalt, and nickel (CrCoNi). Not only is the metal extremely ductile – which, in materials science, means highly malleable – and impressively strong (meaning it resists permanent deformation), its strength and ductility improve as it gets colder. This runs counter to most other materials in existence.

The team, led by researchers from Lawrence Berkeley National Laboratory (Berkeley Lab) and Oak Ridge National Laboratory, published a study describing their record-breaking findings in Science. “When you design structural materials, you want them to be strong but also ductile and resistant to fracture,” said project co-lead Easo George, the Governor’s Chair for Advanced Alloy Theory and Development at ORNL and the University of Tennessee. “Typically, it’s a compromise between these properties. But this material is both, and instead of becoming brittle at low temperatures, it gets tougher.”

CrCoNi is a subset of a class of metals called high entropy alloys (HEAs). All the alloys in use today contain a high proportion of one element with lower amounts of additional elements added, but HEAs are made of an equal mix of each constituent element. These balanced atomic recipes appear to bestow some of these materials with an extraordinarily high combination of strength and ductility when stressed, which together make up what is termed “toughness.” HEAs have been a hot area of research since they were first developed about 20 years ago, but the technology required to push the materials to their limits in extreme tests was not available until recently.

Argentine ants will do anything for sugar, but they won’t do this

 An Argentine ant tending aphids, plant parasites that secrete a sugar-rich substance the ants consume.
 Photo Credit: UCLA/Noa Pinter-Wollman

It might seem like common sense that a starving animal is more likely to take dangerous risks to obtain food than one with a full belly. But new research from UCLA shows that groups of Argentine ants, who forage boldly when they’re well fed, exercise far more caution when they’ve been deprived of carbohydrates and the risks from competitors are high.

This counterintuitive foraging strategy might contribute to the success of these insects, known as Linepithema humile, an invasive species that displaces native ant populations in California and elsewhere and has become a significant agricultural pest, the researchers said.

Their findings, published in the journal Current Zoology, suggest that the unwillingness of Argentine ants to expose themselves to danger when weakened by hunger could possibly give them a competitive edge over other species by helping to preserve their colonies’ foraging capabilities.

“While not foraging may lead to a reduction in food stores when those stores are already low, foraging in a high-risk environment exposes the colony to potential loss of foragers,” said the study’s senior author, Noa Pinter-Wollman, a UCLA professor of ecology and evolutionary biology. “So reduced foraging could be interpreted as individual foragers not taking unnecessary risks.”

Researcher Aims to Uncover Plant Invasions in the Tropics

Invasive plants are invading all major ecosystems across Central America compromising the conservation of native species.
Photo Credit: Julissa Rojas-Sandoval

Invasive species of plants have a knack for settling in new settings and making big changes to an ecosystem, even leading to extinctions of native species.

Assistant Research Professor in UConn’s Institute of the Environment Julissa Rojas-Sandoval explains that invasive plants are non-native species that have been introduced into new areas generally as a result of human activities, and that they are actively spreading, causing harm to the environment, the economy, and human health. Invasive plants may have significant long-term implications for the conservation of native biodiversity, but to combat the problem, we need to know which plants are invasive, where they’re from, and how they got there.

Rojas-Sandoval leads an international collaboration including researchers from all Central American countries, working together to compile the most comprehensive databases of invasive plant species in Central America. The collaboration is called FINCA: Flora Introduced and Naturalized in Central America, and their first paper was published this week in Biological Invasions.

The collaboration arose to meet a need, says Rojas-Sandoval. “While we have a good understanding of the processes and mechanisms of plant invasions in temperate regions, there is a huge gap in our knowledge about biological invasions in the tropics, and this lack of information is limiting our ability to respond to invasive plants.”

The Superpowers of the Female Locust

Elongation of the body of the female locust while laying eggs in the ground
Illustration Credit: Tel Aviv University

Every mother will do anything to know that her offspring are in a safe place. The female locust, however, takes it to a whole new level: A new Tel Aviv University study has discovered that these females have superpowers. The female locust’s central nervous system has elastic properties, allowing her to stretch up to two or three times her original length when laying her eggs in the ground, without causing any irreparable damage.

“We are not aware of a similar ability in almost any living creature,” say the researchers. “Nerves in the human nervous system, for example, can stretch only up to 30% without tearing or being permanently damaged. In the future, these findings may contribute to new developments in the field of regenerative medicine, as a basis for nerve restoration and the development of synthetic tissues.”

“The superpower of the locust is almost something out of science fiction. There are only two other known examples in nature of a similar phenomenon: the tongue of the sperm whale, and a certain type of sea snail whose nervous systems are able to extend significantly due to an accordion-like mechanism they have." Prof. Amir Ayali

Environmental DNA uncovers a 2-million-year-old ecosystem in Greenland

Reconstruction of the Kap København formation two-million years ago, in a time where the temperature was significantly warmer than northernmost Greenland today.
Illustration Credit: Beth Zaiken.

Scientific Frontline: "At a Glance" Summary

  • Main Discovery: Researchers recovered the oldest environmental DNA (eDNA) on record, unveiling a 2-million-year-old ecosystem in northern Greenland populated by mastodons, reindeer, and poplar trees.
  • Methodology: The team employed shotgun sequencing on sediment samples from the Kap København Formation and utilized beryllium and aluminum isotope analysis to precisely date the geologic layers.
  • Key Data: The biological material dates back 2 million years, originating from a period when annual temperatures were 11 to 19 degrees Celsius higher than current values, and yielded five times as many plant varieties as previous ancient sediment studies.
  • Significance: This discovery confirms that a highly diverse boreal forest community, including large mammals, thrived in what is now a polar desert, creating a biological composition with no modern analogue.
  • Future Application: These findings provide a critical baseline for predicting long-term ecological shifts due to modern global warming and suggest that detailed genetic records may survive in other high-Arctic localities.
  • Branch of Science: Paleoclimatology and Ancient Genomics.
  • Additional Detail: The detection of mastodon DNA marks the first evidence of these extinct proboscideans ranging as far north as Greenland, significantly expanding their known paleogeographic distribution.

Mekong Delta will continue to be at risk for severe flooding

Mekong River Delta
Photo Credit: Tsuyoshi Watanabe

Reef corals provide an accurate, high-resolution record of the influence of the El Niño Southern Oscillation on rainfall, flooding and droughts in the Mekong River Delta, Vietnam.

The Mekong River Delta is the agricultural heartland of Vietnam; it is affected by droughts and flooding, which have become more severe in recent years. If severe weather events can be more accurately predicted, risk assessments in the regions can be improved. This, in turn, will reduce the negative effects of floods and droughts in the region.

A team led by Tsuyoshi Watanabe at Hokkaido University has revealed the clearest picture yet of how the El Niño Southern Oscillation (ENSO) affected rainfall in the Mekong Delta over the last hundred years. Their findings were published in the journal Scientific Reports. They correlated water salinity data from reef coral samples with historical weather records and uncovered that the ENSO has caused seasons of heavy and light rainfall, resulting in patterns of both flooding and droughts, respectively.

The ENSO occurs in the central and Eastern tropical Pacific Ocean, in irregular cycles of two to seven years. It consists of the El Niño (warming of the ocean surface), La Niña (cooling of the ocean surface) and neutral (neither warming, nor cooling).

Common medicine can stop the transmission of HIV infection from mother to child

The risk of transmission of HIV infection from mother to child has been reduced in resource-poor countries.
Photo Credit: Antony Trivet

Antiviral drugs almost completely reduce the risk of mothers passing on HIV infection to their children, even in a low-income country with a high HIV incidence such as Tanzania, according to a new study in The Lancet HIV by researchers from Karolinska Institutet. The discovery raises hopes of achieving the World Health Organization’s goal of eliminating the spread of infection from mother to child.

Only 159 infants were infected

The women were followed for 18 months after giving birth when most of them had stopped breastfeeding. When the researchers examined the mothers’ children, they discovered that only 159 of the more than 13,000 infants had been infected with HIV by the age of 1.5 years. Taking into account the margin of error, this means a risk of 1.4 per cent.

Wednesday, December 7, 2022

Wearable sensor could guide precision drug dosing

 The sensor uses microneedles that are made by cutting down clinical-grade acupuncture needles.
Image Credit: Emaminejad Lab/UCLA

For some of the powerful drugs used to fight infection and cancer, there’s only a small difference between a healing dose and a dose that’s large enough to cause dangerous side effects. But predicting that margin is a persistent challenge because different people react differently to medications — even to the same dose.

Currently, doctors can calibrate the amount of medication they administer in part by drawing blood to test the amount of medicine in a patient’s body. But results from those tests often take a day to process and only measure dosage at one or two moments in time, so they don’t help much when determining how to adjust dosage amounts in real time.

Now, a UCLA-led research team has developed a wearable patch that uses inexpensive microneedles to analyze the fluid between cells less than a millimeter underneath the skin and continuously record concentrations of medicine in the body. The technology could be a step toward improving doctors’ ability to administer precise medication doses.

In a study published in Science Advances, the investigators tested the system in rats that had been treated with antibiotics. Using data taken by the device within about 15 minutes after the medication was administered, the researchers reliably forecast how much of that drug would be effectively delivered to the animal’s system in total.

Brookhaven Lab to Lead New 'Saturated Glue' Theory Collaboration

Gluons at the Speed of Light
Gluons are always popping in and out of existence like blinking fireflies. But when nuclei or protons are accelerated to high energies, the gluons inside appear to multiply. That's because time operates in weird ways near the speed of light. The "blinking" appears to slow down, which makes the gluons linger longer. Energetic particle collisions can help physicists study this gluon-dominated state and, guided by new approaches to nuclear theory, search for signs of gluon saturation.
Illustration Credit: Brookhaven National Laboratory

The U.S. Department of Energy (DOE) has announced funding for a new Topical Theory Collaboration to be led by DOE’s Brookhaven National Laboratory that will aid in the discovery and exploration of a saturated state of gluons. These aptly named particles carry the nuclear strong force, acting as the ‘glue’ that holds together quarks, the building blocks of all visible matter. By understanding gluons’ ability to split and recombine and potentially reach a state of saturation, scientists hope to gain deeper insight into the strong force and the role gluons play in generating the mass, spin, and other properties of hadrons—composite particles made of quarks, such as the protons and neutrons of atomic nuclei.

The SatURated GluE (SURGE) Topical Theory Collaboration aims to develop calculations and a theoretical framework for discovering this unique saturated form of gluonic matter. Such a saturated state is predicted by the theory of quantum chromodynamics (QCD) to be observable in particles accelerated to high energies in particle colliders such as the Relativistic Heavy Ion Collider (RHIC) at Brookhaven Lab, the Large Hadron Collider (LHC) at Europe’s CERN laboratory, and the future Electron-Ion Collider (EIC) at Brookhaven.

Using light to manipulate neuron excitability

MIT and Harvard University researchers have devised a way to achieve long-term changes in neuron activity. With their new strategy, they can use light exposure to change the electrical capacitance of the neurons’ membranes, which alters their excitability (how strongly or weakly they respond to electrical signals).
Photo Credit: SFLORG stock image

Nearly 20 years ago, scientists developed ways to stimulate or silence neurons by shining light on them. This technique, known as optogenetics, allows researchers to discover the functions of specific neurons and how they communicate with other neurons to form circuits.

Building on that technique, MIT and Harvard University researchers have now devised a way to achieve longer-term changes in neuron activity. With their new strategy, they can use light exposure to change the electrical capacitance of the neurons’ membranes, which alters their excitability (how strongly or weakly they respond to electrical and physiological signals).

Changes in neuron excitability have been linked to many processes in the brain, including learning and aging, and have also been observed in some brain disorders, including Alzheimer’s disease.

“This new tool is designed to tune neuron excitability up and down in a light-controllable and long-term manner, which will enable scientists to directly establish the causality between the excitability of various neuron types and animal behaviors,” says Xiao Wang, the Thomas D. and Virginia Cabot Assistant Professor of Chemistry at MIT, and a member of the Broad Institute of MIT and Harvard. “Future application of our approach in disease models will tell whether fine-tuning neuron excitability could help reset abnormal brain circuits to normal.”

Jawbone may represent earliest presence of humans in Europe


For over a century, one of the earliest human fossils ever discovered in Spain has been long considered a Neandertal. However, new analysis from an international research team, including scientists at Binghamton University, State University of New York, dismantles this century-long interpretation, demonstrating that this fossil is not a Neandertal; rather, it may actually represent the earliest presence of Homo sapiens ever documented in Europe.

In 1887, a fossil mandible was discovered during quarrying activities in the town of Banyoles, Spain, and has been studied by different researchers over the past century. The Banyoles fossil likely dates to between approximately 45,000-65,000 years ago, at a time when Europe was occupied by Neandertals, and most researchers have generally linked it to this species.

“The mandible has been studied throughout the past century and was long considered to be a Neandertal based on its age and location, and the fact that it lacks one of the diagnostic features of Homo sapiens: a chin,” said Binghamton University graduate student Brian Keeling.

The new study relied on virtual techniques, including CT scanning of the original fossil. This was used to virtually reconstruct missing parts of the fossil, and then to generate a 3D model to be analyzed on the computer.

Many genes linked to alcohol and tobacco use are shared among diverse ancestries

Penn State College of Medicine researchers co-led a large genetic study that identified more than 2,300 genes predicting alcohol and tobacco use. They said that many of these genes were similar among people with diverse ancestries.
Photo Credit: Pavel Danilyuk

Penn State researchers co-led a large genetic study that identified more than 2,300 genes predicting alcohol and tobacco use after analyzing data from more than 3.4 million people. They said a majority of these genes were similar among people with European, African, American and Asian ancestries.

Alcohol and tobacco use are associated with approximately 15% and 5% of deaths worldwide, respectively, and are linked with chronic conditions like cancer and heart disease. Although the environment and culture can affect a person’s use and the likelihood of becoming addicted to these substances, genetics is also a contributing factor, according to Penn State College of Medicine researchers. They helped identify around 400 genes that are associated with certain alcohol and tobacco use behaviors in people in a prior research study.

“We’ve now identified more than 1,900 additional genes that are associated with alcohol and tobacco use behaviors,” said Dajiang Liu, professor and vice chair for research in the Department of Public Health Sciences. “A fifth of the samples used in our analysis were from non-European ancestries, which increases the relevance of these findings to a diverse population.”

It’s colossal: Creating the world’s largest dilution refrigerator

Colossus will offer 5 cubic meters of space and cool components to around 0.01K.
Photo Credit: Ryan Postel, Fermilab

While the refrigerator in your kitchen gets cold enough to prevent your leftovers from spoiling, dilution refrigerators used for quantum computing research cool devices near the coldest physical temperature possible. Now at the U.S. Department of Energy’s Fermi National Accelerator Laboratory, researchers are building Colossus: It will be the largest, most powerful refrigerator at millikelvin temperatures ever created.

Fermilab is known for its massive experiments, and Colossus will fit right in. Researchers from the Fermilab-hosted Superconducting Quantum Materials and Systems Center need lots of room at cold temperatures to achieve their goal of building a state-of-the-art quantum computer.

Unlike a kitchen refrigerator, which compresses gases called refrigerants to cool food, a dilution refrigerator uses a mixture of helium isotopes to create temperatures close to absolute zero, or zero kelvin: the coldest temperature imaginable in physics, which is physically impossible to reach.

“With the cooling power and volume that Colossus will provide, SQMS researchers will have unprecedented space for our future quantum computer and many other quantum computing and physics experiments,” said Matt Hollister, the lead technical expert on this project. “Colossus is named after the first electronic programmable computer, which was constructed in the 1940s for codebreaking. It was a historic milestone in the history of computing and seemed like an appropriate name for the size of our new refrigerator.”

New branch on tree of life includes ‘lions of the microbial world’

On the left is a starving provoran. On the right, it has engulfed its prey.
Photo Credit: Tikhonenkov, Mikhailov, Gawryluk, Belyaev, Mathur, Karpov, Zagumyonnyi, Borodina, Prokina, Mylnikov, Aleoshin, and Keeling, Nature

There’s a new branch on the tree of life and it’s made up of predators that nibble their prey to death.

These microbial predators fall into two groups, one of which researchers have dubbed “nibblerids” because they, well, nibble chunks off their prey using tooth-like structures. The other group, nebulids, eat their prey whole. And both comprise a new ancient branch on the tree of life called “Provora,” according to a paper published today in the journal Nature.

Microbial lions

Like lions, cheetahs, and more familiar predators, these microbes are numerically rare but important to the ecosystem, says senior author Dr. Patrick Keeling, professor in the UBC department of botany. “Imagine if you were an alien and sampled the Serengeti: you would get a lot of plants and maybe a gazelle, but no lions. But lions do matter, even if they are rare. These are lions of the microbial world.”

Using water samples from marine habitats around the world, including the coral reefs of Curaçao, sediment from the Black and Red seas, and water from the northeast Pacific and Arctic oceans, the researchers discovered new microbes. “I noticed that in some water samples there were tiny organisms with two flagella, or tails, that convulsively spun in place or swam very quickly. Thus began my hunt for these microbes,” said first author Dr. Denis Tikhonenkov, senior researcher at the Institute for Biology of Inland Waters of the Russian Academy of Sciences.

Surprise kilonova upends established understanding of long gamma-ray bursts

This Gemini North image, superimposed on an image taken with the Hubble Space Telescope, shows the telltale near-infrared afterglow of a kilonova produced by a long GRB (GRB 211211A). This discovery challenges the prevailing theory that long GRBs exclusively come from supernovae, the end-of-life explosions of massive stars.
Image Credit: International Gemini Observatory/NOIRLab/NSF/AURA/M. Zamani; NASA/ESA

For nearly two decades, astrophysicists have believed that long gamma-ray bursts (GRBs) resulted solely from the collapse of massive stars. Now, a new study upends that long-established and long-accepted belief.

Led by Northwestern University, a team of astrophysicists has uncovered new evidence that at least some long GRBs can result from neutron star mergers, which were previously believed to produce only short GRBs.

After detecting a 50-second-long GRB in December 2021, the team began searching for the long GRB’s afterglow, an incredibly luminous and fast-fading burst of light that often precedes a supernova. But, instead, they uncovered evidence of a kilonova, a rare event that only occurs after the merger of a neutron star with another compact object (either another neutron star or a black hole).

In addition to challenging long-established beliefs about how long GRBs are formed, the new discovery also leads to new insights into the mysterious formation of the heaviest elements in the universe.

The research was published today (Dec. 7) in the journal Nature.

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