. Scientific Frontline: Fossil fuels responsible for heart arrhythmias in mammals

Wednesday, November 1, 2023

Fossil fuels responsible for heart arrhythmias in mammals

Photo Credit: Pixabay

One of the most common byproducts of the burning of fossil fuels, phenanthrene, causes heart arrhythmias in mice, proving for the first time it is toxic to mammals, new research has discovered.

The study, led by The University of Manchester in collaboration with the University of Bristol and Moscow State University, and funded by the British Heart Foundation, is published today in the journal Environmental Health Perspectives.

Thanks to earlier work by one of the lead authors Professor Holly Shiels from Manchester in conjunction with scientists at the University of Bristol, Moscow State University, National Oceanic and Atmospheric Association (NOAA) and Stanford University, phenanthrene's toxicity to the hearts of fish and crustaceans (crayfish) has been well established.

But now the team has discovered the change also occurs in healthy mouse hearts when directly exposed to phenanthrene, mimicking what happens when we breathe in pollution.

Professor Holly Shiels said: "We've known that phenanthrene is causally linked to cardiotoxicity in fish for many years - scientists recognized this following the disastrous impact of the Exxon Valdez oil disaster in Alaska in 1989.

"But we now know this same effect occurs in mammals, and we are also able to show its causal mechanism."

Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) that is present in crude oil and emitted into the air when fossil fuels are burnt.

"It is widely known that PAH's in general are bad for human health, but no one really studied the impact of the lower molecular weight PAH’s" added Professor Shiels.

Dr Sana Yaar, a British Heart Foundation funded PhD student at The University of Manchester, and one of the lead authors on the study, said: "Similar effects in humans could have serious health consequences which is why we need greater regulatory attention of this ubiquitous pollutant generated from fossil-fuel combustion."

Phenanthrene is one of the compounds produced when fossil fuel is burned; it is present in the gas phase of air pollution and also adheres to the surface of particulate matter (PM).

It can be inhaled into the lung and then translocated into the bloodstream, eventually finding its way to the heart. Epidemiological evidence has long shown a positive association between PM2.5 concentration and the incidence of arrhythmias and both PM and diesel particles have been shown to trigger arrhythmias in rodents.

"Our findings suggest phenanthrene could be involved in these pathologies" said Professor Shiels.

In the study, when phenanthrene was applied to an isolated mouse heart, it caused monophasic tachycardia, which is when the heart starts to beat too quickly.

Tachycardia is a form of arrhythmia common in people who have scarring caused by a heart attack or past heart disease.

The researchers were able isolate single heart muscle cells known as myocytes to understand how electrical dysfunction arrhythmias were achieved.

They showed that phenanthrene disrupts the contractile and electrical function of the mouse heart by blocking ion channels required for synchronous beating of the heart. 

Jules Hancox, Professor of Cardiac Electrophysiology in the School of Physiology, Pharmacology & Neuroscience at the University of Bristol and co-author, added: "Our study provides proof of concept that phenanthrene exposure can be proarrhythmic.

"To understand the risk this poses to humans, more information is now needed on the levels phenanthrene can reach in the heart following occupational or environmental exposure."

Co-author Ellie England and British Heart Foundation funded PhD student from The University of Manchester, said: "If the effects of phenanthrene shown here for mice extend to humans, it could be particularly dangerous to people with existing heart problems, including the elderly.  Unfortunately, the authorities do not routinely measure the amount of PAHs, or more specifically, phenanthrene, in the air.

"We think this is a mistake, as individuals who are vulnerable to heart disease would benefit from knowing the dangers of inhaling or ingesting phenanthrene."

She added: "If monitoring was in place there’s much doctors and public health officials could do to help vulnerable people reduce the risk of cardiotoxicity resulting from phenanthrene exposure.

"For example, at risk groups could stay indoors when there’s a spike in pollution, use air purifiers and avoid busier streets."

Professor Shiels explained: "As combustion engine technology improves, PM from car exhaust is reducing in many cities and that is beneficial to human health.

"But what many people don't realize is that fossil fuel combustion also produces ultrafine PM, which has a greater capacity to enter the blood stream due to its small size, is rarely monitored.  And even electric cars that increase tire wear particle formation to their heavy weight, also impact our health. 

"That is why we should be routinely monitoring for phenanthrene and other PAHs in the air."

Funding: British Heart Foundation

Published in journalEnvironmental Health Perspectives (to be released today)

Authors: Sana Yaar, Ellie England, Jules C. Hancox, Holly A. Shiels

Source/CreditUniversity of Bristol

Reference Number: en110123_02

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