A Glimpse into the Dog’s Mind: A New Study Reveals How Dogs Think of Their Toys

Many dog lovers want to know what goes on in their furry friends’ minds. Now scientists are finally getting closer to the answer. In a new study just published in the journal of Animal Cognition, researchers from the Family Dog Project (Eötvös Loránd University, University, Budapest) found out that dogs have a “multi-modal mental image” of their familiar objects. This means that, when thinking about an object, dogs imagine the object’s different sensory features. For instance, the way it looks or the way it smells.

The group of scientists assumed that the senses dogs use to identify objects, such as their toys, reflect the way the objects are represented in their minds. “If we can understand which senses dogs use while searching for a toy, this may reveal how they think about it” explains Shany Dror, one of the leading researchers of this study. “When dogs use olfaction or sight while searching for a toy, this indicates that they know how that toy smells or looks like”.

In previous studies, the researchers discovered that only a few uniquely gifted dogs can learn the names of objects. “These Gifted Word Learner dogs give us a glimpse into their minds, and we can discover what they think about when we ask them - Where is your Teddy Bear? – “explains Dr. Andrea Sommese, the second leading researcher.

Good news on blocking a virus considered a global threat

Illustration of the Hendra virus

Scientists have reported good news on the pandemic preparedness front: A cocktail of four manufactured antibodies is effective at neutralizing a virus from the Henipavirus family, a group of pathogens considered to be a global biosecurity threat.

The study focused on protection against a recently identified variant of the Hendra virus, which, along with Nipah virus, has been responsible for deadly animal and human infection outbreaks in the Eastern Hemisphere. The 2011 movie Contagion depicts a fictional viral outbreak traced to an infected pig that is modeled on the Nipah virus.

The Hendra variant, identified in two fatally diseased horses and sick bats in Australia, featured dramatic genetic changes from the original virus – which created a sense of urgency among scientists to learn how existing countermeasures stack up against the restructured pathogen.

Researchers screened and determined in cell studies that several previously developed monoclonal antibodies designed to neutralize the original virus are also effective against the variant. The team also designed an additional antibody that could join three others in a powerful cocktail that would leave the virus with minimal ability to further mutate its way out of antibody recognition.

IA leads the charge against multiple sclerosis

MRI image in false colors of a brain hemisphere from an MS patient (affected areas are shown in red).
 Credit: Govind Bhagavatheeshwaran, Daniel Reich / NINDS / NIH

Artificial intelligence may enable earlier diagnosis of Multiple Sclerosis, an incurable disease that attacks the central nervous system. This could improve the efficacy of treatments designed to slow its progression.

An autoimmune disease, multiple sclerosis (MS) is characterized by a breakdown of myelin, the membrane that protects the axons of neurons. Communication within the nervous system is gradually disrupted, causing increasingly severe motor and neurological damage. Although multiple sclerosis is currently incurable, treatments are available to relieve certain symptoms, particularly if the disease is discovered early; unfortunately, however, it tends to be diagnosed at a later stage.

Scientists Have Found Neurons that Control Some Symptoms of Sickness

During an infection, inflammatory signals activate immune-sensitive neurons (genetically labeled in red) in the ventral medial preoptic area (VMPO) leading to the induction of fever and other sickness behaviors. All cells are labeled with a nuclear stain (blue).
Credit: Courtesy of Dulac Lab/HHMI at Harvard University

Feeling ill is about both the body and the brain. Now scientists have identified a group of neurons in mice that has ultimate control over symptoms such as fever and behaviors like seeking out warmth.

Fevers, chills, an appetite that vanishes – we can tell when we’re getting sick. Many people chalk these symptoms of illness up to the immune system fighting off infection. But there’s another player involved when we feel woefully under the weather.

“All of this is orchestrated by the brain,” says neurobiologist Catherine Dulac, who is a Howard Hughes Medical Institute Investigator at Harvard University. Now research from Dulac’s team, published in Nature, pins this broad response on a previously uncharacterized population of neurons in the brain.

How exactly the brain serves as an infection ringleader has been unclear. Earlier research had identified receptors in the brain that were required for animals to develop a fever. But fever is only part of the story. One of the bigger mysteries is: Where does ultimate control for the symptoms and behaviors associated with sickness lie?

Dulac, her postdoctoral fellow, Jessica A. Osterhout, and colleagues injected mice with molecules that mimic bacterial or viral infections to investigate that question. As the mice’s immune systems reacted to these inflammatory molecules, the researchers homed in on which neurons jumped into action. The team watched neurons’ gene expression through single-cell RNA sequencing and mapped the whereabouts of those neurons using a visualization technique called MERFISH, which was developed in the lab of HHMI Investigator Xiaowei Zhuang at Harvard, a collaborator in this work.

One in 500 men carry extra sex chromosome, putting them at higher risk of several common diseases

In a study published in Genetics in Medicine, researchers analyzed genetic data collected on over 200,000 UK men aged 40-70 from UK Biobank, a biomedical database and research resource containing anonymized genetic, lifestyle and health information from half a million UK participants. They found 356 men who carried either an extra X chromosome or an extra Y chromosome.

Sex chromosomes determine our biological sex. Men typically have one X and one Y chromosome, while women have two Xs. However, some men also have an extra X or Y chromosome – XXY or XYY.

Without a genetic test, it may not be immediately obvious. Men with extra X chromosomes are sometimes identified during investigations of delayed puberty and infertility; however, most are unaware that they have this condition. Men with an extra Y chromosome tend to be taller as boys and adults, but otherwise they have no distinctive physical features.

In today’s study, the researchers identified 213 men with an extra X chromosome and 143 men with an extra Y chromosome. As the participants in UK Biobank tend to be ‘healthier’ than the general population, this suggests that around one in 500 men may carry an extra X or Y chromosome.

Only a small minority of these men had a diagnosis of sex chromosome abnormality on their medical records or by self-report: fewer than one in four (23%) men with XXY and only one of the 143 XYY men (0.7%) had a known diagnosis.

By linking genetic data to routine health records, the team found that men with XXY have much higher chances of reproductive problems, including a three-fold higher risk of delayed puberty and a four-fold higher risk of being childless. These men also had significantly lower blood concentrations of testosterone, the natural male hormone. Men with XYY appeared to have a normal reproductive function.

Seeking COVID’s Kryptonite

Photos of the setup. Left: A closeup of the interior of the box containing the laser-to-fiber-optic coupling system. Center: The laser system in the hallway outside the door to BSL-3. Right: A closeup of the experimental setup inside BSL-3, including the chamber the housed the samples of SARS-CoV-2.
 Credit: NIST

To disinfect a surface, you can illuminate it with a blast of ultraviolet (UV) light, which is bluer than the human eye can see. But to specifically inactivate SARS-CoV-2, the virus that causes COVID-19, which wavelengths are best? And how much radiation is enough?

Answering those questions requires scientists to overcome two main obstacles. First, they need to separate the virus completely from extraneous substances in the environment. Second, they need to illuminate the virus with a single wavelength of UV light at a time, with minimal changes to the experimental setup between tests.

A recent collaboration between the National Institute of Standards and Technology (NIST) and the National Biodefense Analysis and Countermeasures Center (NBACC), a U.S. Department of Homeland Security Science and Technology Directorate laboratory, overcame both these obstacles and completed what may be the most thorough test ever conducted of how several different UV and visible wavelengths affect SARS-CoV-2.

In a new paper published this week in Applied Optics, the collaborators describe their novel system for projecting a single wavelength of light at a time onto a sample of COVID-19 virus in a secure laboratory. Classified as Biosafety Level 3 (BSL-3), the lab is designed for studying microbes that are potentially lethal when inhaled. Their experiment tested more wavelengths of UV and visible light than any other study with the virus that causes COVID-19 to date.

Genetic analysis of tree confirms what Indigenous people of Borneo knew

The pingan tree’s fruit (left) is distinct from the lumok tree’s (right), but Western scientists misclassified the two trees as one species for almost two centuries.
Credit: left, Elias Ednie; right, Elliot Gardner

A study led by Northwestern University plant biologists has determined that a species of fruit-bearing tree found in Borneo and the Philippines, long considered by Western botanists to be a single species, is actually two genetically distinct species.

The findings confirm what the Iban people, who are indigenous to Borneo, already knew from experience: The tree has two different varieties, which they call lumok and pingan, distinguished by their fruit size and shape.

The researchers conducted a genetic analysis of Artocarpus odoratissimus, a single species in current Linnaean taxonomy, first described to western science by a Spanish botanist close to 200 years ago. Throughout the scientific process, the team engaged with Indigenous people to combine their knowledge with DNA data.

The study, which includes Malaysian scientists and Iban field botanists as authors, was published this week in the journal Current Biology.

Anti-Aging Clues Lurk in Lysosomes, the Recycling Centers of the Cell

HHMI Investigator Meng Wang is studying the secrets to longevity. Her team has shown how the lysosome plays a role in aging.
Credit: Anthony Rathbun/AP Images for HHMI

For decades, biology students have learned that lysosomes – tiny sacs found within nearly all cells – had a singular task: to gobble up bits of foreign material and worn-out cell parts. The aim? To break them down for recycling.

But that lesson might soon need revising. Now, scientists are learning that molecules produced during the recycling process can also serve as signals that talk to other parts of the body.

These signals seem to play a role in determining how and when organisms grow old. Cells in different organs and tissues around the body send signals to one another constantly, says Meng Wang, an HHMI Investigator at Baylor College of Medicine. “When we’re young, everything is connected and communicating. But as we age, some of these connections are lost and function declines.”

Wang has spent the past seven years exploring the link between longevity and the signals lysosomes produce. Her team previously discovered that such signaling occurs within cells. Now, they have found evidence that the anti-aging messages are transmitted between cells too, and among different tissues, Wang and her colleagues reported in a preprint on bioRxiv.org and later on June 9, 2022, in the journal Nature Cell Biology. The results suggest that lysosome signals help coordinate the body’s aging process – and prolong the lives of some organisms.

Invasive Insect that Kills Grapes Could Reach California Wine Region by 2027

The invasive insect, the spotted lanternfly.
Credit: U.S. Department of Agriculture.

The spotted lanternfly, an invasive insect that can kill grapevines and damage other crops, has a chance of first reaching the wine-producing counties of California in five years, according to a new analysis from North Carolina State University researchers.

In the study published in Communications Biology, researchers used a computer simulation tool to predict the timing of the spread of the spotted lanternfly, Lycorma delicatula, across the United States if efforts to control its spread are stopped. They predicted there is a high probability of the insect spreading to North Carolina by 2027, and a chance of the insect first reaching California’s grape-producing counties that same year.

“This is a big concern for grape growers; it could lead to billions of dollars of losses in the agricultural sector,” said the study’s lead author Chris Jones, research scholar with the NC State Center for Geospatial Analytics. “With this study, we have a baseline that we can use to evaluate the effect of different management strategies.”

The spotted lanternfly is native to Asia. It was first identified in the United States in Pennsylvania in 2014. Since then, it has spread to at least 11 other states. The invasive insect can damage or destroy commercially valuable crops such as grapes, apples, almonds, walnuts, cherries, hops, and peaches, as well as certain trees. It kills plants by directly feeding on them, and can also damage them by leaving behind a residue known as “honeydew” that helps mold grow. California, which produces 82% of the nation’s grapes, has been identified along with Washington state as a “highly suitable” climate for the spotted lanternfly.

Multi-scale imaging confirms protein’s role in neuronal structure, dynamics

A whole, live cell time-lapse image (2.5 min) of a neuron expressing fluorescently tagged actin (green) and cofilin (red).
Credit: Penn State College of Medicine.

Protein structures are typically determined by studying them in their purified form, outside of the busy inner workings of the cell, and because of this, their biological relevance is often called into question. In a new study by Penn State College of Medicine researchers, the long-observed protein structure cofilactin, a form of the filamentous protein actin that contains numerous connections to cofilin proteins, was shown to be a major component of neuronal growth cone filopodia — small dynamic “antennae” at the tips of growing neurons.

“The effects of cofilin on actin structure and its physical properties have been studied for more than 20 years, but now we can confidently see that this structural alteration serves some biological function in the cell,” said Matt Swulius, assistant professor of biochemistry and molecular biology. “We’re still trying to determine the mechanistic details of its function, but we have strong evidence that cofilactin regulates the flexibility of searching filopodia.”

According to Swulius, understanding how filopodial dynamics are controlled at the molecular level could open therapeutic avenues into nerve regeneration as well as some developmental diseases. His lab is studying how the proteins fascin and cofilin function together to regulate the structure and movement of neuronal filopodia as they navigate their environment to eventually form cellular connections.

Human skin can be damaged by exposure to thirdhand smoke and electronic cigarette spills

Prue Talbot (left) and her former graduate student Giovanna Pozuelos.
Credit: UCR/Stan Lim

A University of California, Riverside, study has found that dermal exposure to nicotine concentrations found in thirdhand smoke, or THS, and electronic cigarette spills may damage the skin.

THS, of which nicotine is a major component, is created when exhaled smoke and smoke emanating from the tip of burning cigarettes settles on surfaces such as clothing, hair, furniture, and cars. Not strictly smoke, THS refers to the residues left behind by smoking. Electronic cigarette spills are e-liquid spills that may occur by leaky electronic cigarette products or when consumers and vendors mix e-liquids for refillable electronic cigarettes.

Study results appear in Atmosphere, a journal.

“We found dermal contact with nicotine may impair wound healing, increase susceptibility to skin infections due to a decrease in immune response, and cause oxidative stress in skin cells,” said Giovanna Pozuelos, who graduated earlier this year from UC Riverside with a doctoral degree in cell, molecular, and developmental biology.

The study was performed using EpiDermTM, a 3D model of the human epidermis, and cultured human keratinocytes. Keratinocytes are epidermal cells that produce keratin, the protein found in hair and fingernails. The researchers exposed EpiDermTM for 24 hours to different nicotine concentrations typically found in THS environments and electronic cigarette spills. The researchers then proceeded to identify processes and pathways altered by the exposure. They investigated nicotine’s effect on cellular organelles, mitochondria, and peroxisomes — organelles containing enzymes involved in many metabolic reactions.

International team visualizes properties of plant cell walls at nanoscale

Scattering-type scanning near-field optical microscopy, a nondestructive technique in which the tip of the probe of a microscope scatters pulses of light to generate a picture of a sample, allowed the team to obtain insights into the composition of plant cell walls.
Credit: Ali Passian/ORNL, U.S. Dept. of Energy

To optimize biomaterials for reliable, cost-effective paper production, building construction, and biofuel development, researchers often study the structure of plant cells using techniques such as freezing plant samples or placing them in a vacuum. These methods provide valuable data but often cause permanent damage to the samples.

A team of physicists including Ali Passian, a research scientist at the Department of Energy’s Oak Ridge National Laboratory, and researchers from the French National Centre for Scientific Research, or CNRS, used state-of-the-art microscopy and spectroscopy methods to provide nondestructive alternatives. Using a technique called scattering-type scanning near-field optical microscopy, the team examined the composition of cell walls from young poplar trees without damaging the samples.

But the team still had other obstacles to overcome. Although plant cell walls are notoriously difficult to navigate due to the presence of complex polymers such as microfibrils — thin threads of biomass that Passian describes as a maze of intertwined spaghetti strings — the team reached a resolution better than 20 nanometers, or about a thousand times smaller than a strand of human hair. This detailed view allowed the researchers to detect optical properties of plant cell materials for the first time across regions large and small, even down to the width of a single microfibril. Their results were published in Communications Materials.

Common drug-resistant superbug develops fast resistance to 'last resort' antibiotic

Pseudomonas under a microscope
Credit: Sean Booth

New research has found that Pseudomonas bacterium develops resistance much faster than usual to a common ‘last-resort’ antibiotic.

A study published today in Cell Reports reveals how populations of a bacterium called Pseudomonas respond to being treated with Colistin, a 'last resort' antibiotic for patients who have developed multi-drug resistant infections.

Antibiotics play a key role in human health by helping to combat bacterial infection, but bacteria can evolve resistance to antibiotics patients rely on. Antibiotic-resistant infections now cause >1 million deaths worldwide per year.

With a small number of ‘last-resort’ antibiotics available, researchers from the University of Oxford are investigating the processes that drive the rise, and fall, of resistance in common bacterial pathogen populations, which is key to tackling the increase in antimicrobial resistance (AMR).

New Study Deepens Understanding of How Animals See, and What Colors

 Researchers determined that animals adapted to land see more colors than animals adapted to water. Animals adapted to open terrestrial habitats see a wider range of colors than animals adapted to forests.
 Credit: Artwork by Matt Murphy

Gathering vision data for hundreds of vertebrates and invertebrates, U of A biologists have deepened scientists’ understanding of animal vision, including the colors they see.

Researchers have determined that animals adapted to land are able to see more colors than animals adapted to water. Animals adapted to open terrestrial habitats see a wider range of colors than animals adapted to forests.

However, evolutionary history — primarily the difference between vertebrates and invertebrates — significantly influences which colors a species sees. Invertebrates see shorter wavelengths of light, compared to vertebrates.

Biological sciences doctoral student Matt Murphy and assistant professor Erica Westerman recently published these findings in Proceedings of the Royal Society B, a top British scientific journal. Their article, “Evolutionary history limits species’ ability to match color sensitivity to available habitat light,” explains how environment, evolution and, to some extent, genetic composition influence how and what colors animals see.

Copper makes seed pods explode

A stiff polymer called lignin (stained red) is deposited in a precise pattern in the cell walls of exploding seed pods. Researchers identified three laccase enzymes required to form this lignin. No lignin forms in the cell wall (stained blue) when all three genes are knocked out by CRISPR/Cas9 gene editing. 
Credit: Miguel Pérez Antón

Plants have evolved numerous strategies to spread their seeds widely. Some scatter their seeds to the wind, while others tempt animals and birds to eat their seed-filled fruits. And a few rare plants – such as the popping cress Cardamine hirsuta – have evolved exploding seed pods that propel their seeds in all directions. In their new study published in PNAS, Angela Hay and colleagues – from the Max Planck Institute for Plant Breeding Research in Cologne, Germany – investigate what genes control the mechanical structure of these exploding seed pods. Their findings show that a key micronutrient – copper – is essential for laying down a precise pattern of lignin in the seed pods. Lignin is an abundant plant polymer found in lignocellulose, the main structural material in plants. It is present in plant cells walls and is responsible for making wood stiff.

C. hirsuta seed pods consist of two, long valves. When the seeds are ready for dispersal, these valves rapidly separate and coil back, firing seeds out across a large area. The secret to these pods explosive nature is their unique mechanical design, which features three stiff rods of lignin connected by hinges. These hinges are crucial for the explosive release of potential energy stored in the pod. To create these hinged structures, lignin is deposited in a precise pattern in a single layer of seed pod cells, called endocarpb.

How animals reach their correct size

The development of hundreds of C. elegans individuals growing in micro-chambers was recorded with time-lapse microscopy.
Credit: Towbin Lab

Adults of the same species usually differ very little in their size. A team from the University of Bern and the Friedrich Miescher Institute for Biomedical Research (FMI) in Basel has now discovered a mechanism that ensures such size uniformity. The research using nematodes showed that the speed of growth determines the speed of a genetic clock that times development. Thereby, individuals that grow slowly are given more time to grow and can reach the same adult body size.

By and large, individuals of the same species grow to the same size. This uniformity in size is astounding, since intrinsic randomness in developmental processes and in environmental conditions produce substantial differences in how fast individuals grow. Moreover, because animal growth is often exponential, even small differences in growth can amplify to large differences in size. How do animals nevertheless make sure to reach the correct size?

Analysis of huntsman spiders reveals patterns of social behavior

 The Australian huntsman (Delena gloriosa) and her plastered egg sac.
Credit: Linda S. Rayor

A new study of huntsman spiders links evolutionary lineages with life history traits, providing patterns for predicting social behaviors in other less-studied species. Sociality is very rare in spiders – only five out of close to 1,300 huntsman species are known to exhibit social behaviors.

The study, “Huntsman Spider Phylogeny Informs Evolution of Life History, Egg Sacs and Morphology,” published in the journal Molecular Phylogenetics and Evolution, was part of the undergraduate thesis of lead author Jacob Gorneau ’20.

It represents the broadest and most in-depth phylogeny of huntsman spiders – a tree-like diagram showing evolutionary relatedness among groups of organisms – while incorporating extensive biology and life history data for each species. Compared with solitary species, the findings reveal, the social species live in larger permanent family group retreats until the offspring are up to a year old, have egg sacs plastered to surfaces so they can’t be moved and begin foraging later in their development.

“The social species are doing something different than all the other solitary species,” said Linda Rayor, the paper’s senior author and a senior research associate in the Department of Entomology in the College of Agriculture and Life Sciences (CALS).

Scientists use robots to reveal how predatory fish cope with unpredictable prey

Scientists at the University of Bristol have demonstrated how predators overcome their preys’ erratic behavior by adapting their own during the hunt.

The study, published today in scientific journal PNAS, challenges the well-held theory that behaving unpredictably helps animals survive encounters with predators.

Instead of simply fleeing directly away from a predator, many prey species from across the animal kingdom choose to escape in a surprisingly wide range of directions. Scientists have long suspected that this unpredictability helps them evade capture by keeping predators guessing about the prey’s next move.

By studying how real predatory fish (blue acara cichlids) attack robotic prey, researchers from Bristol’s School of Biological Sciences were able to experimentally test this idea. Rather than confirming that unpredictable escape tactics are beneficial to prey, the new research suggests that predators can neutralize this strategy by flexibly adjusting their own behavior.

Fish Cannibalism Rare in Wild

X-ray image of an adult female Bahamas mosquitofish where a fish she had eaten can be seen inside of her, revealing an occurrence of cannibalism.
Credit: Brian Langerhans

Mosquitofish and guppies, though known to be cannibalistic in captivity, are extremely unlikely to be cannibals in wild settings, and the rare instances of cannibalism in these fish are likely due to strong competition for food. The findings, from a new study led by U.S. and U.K. researchers, could have implications not only for fish enthusiasts and scientists who use mosquitofish as models for ecological and evolutionary studies, but could also help explain the causes and frequency of cannibalism in other animals.

Cannibalism, preying on and eating other individuals of your own species, is a peculiar behavior, featuring prominently in human mythology and fiction. But how common is it in nature, and why would organisms' resort to such an extreme course of action just to get a meal?

Brian Langerhans, associate professor of biology at North Carolina State University, and Rüdiger Riesch, senior lecturer in evolutionary biology at Royal Holloway University of London, decided to find out by looking at over a decade’s worth of data gained from almost 12,000 fish across 17 species in the wild.

Primates and non-primates differ in the construction of the nerve cells

The researchers worked exclusively with archived fabrics and preparations, including preparations that have been and are used for the training of students for decades.
Credit: RUB, Kramer

Using high-resolution microscopy, an international research team was able to significantly expand knowledge about the development of nerve cells of various types.

Researcher of the Development Neurobiology Working Group at the Ruhr University Bochum (RUB) around Prof. Dr. In cooperation with partners from Mannheim, Jülich, Linz, Austria, and La Laguna, Spain, Petra Wahle have shown that primates and non-primates differ in the architecture of their cortical neurons. The differences lie in where the nerve cell originates from the extension called Axon, which is responsible for the transmission of electrical potential. The team reports in the journal eLife.

When the axon comes out of the dendrite

So far, it was considered textbook knowledge that, with a few exceptions, this axon arises from the cell body of the nerve cell. However, the axon can also arise from a dendrite. Dendrites are processes that collect synaptic inputs. The phenomenon was described with the name "Axon carrying dendrite", in German "Axon-bearing dendrite".