Seaweed molecules used to improve outcomes for bypass surgery

Researchers use material made from seaweed to modify synthetic blood vessels
Photo Credit: Oleksandr Sushko

Researchers are using a natural material derived from seaweed to promote vascular cell growth, prevent blood clots and improve the performance of synthetic vascular grafts used in heart bypass surgery.

The new approach, developed and tested at the University of Waterloo, is especially important in cases involving small artificial blood vessels - those less than six millimeters in diameter - which are prone to clots that can develop into full blockages.

“There is a crucial need to develop synthetic vascular graft materials that will increase the rate of long-term functions,” said Dr. Evelyn Yim, a chemical engineering professor and University Research Chair who leads the project.

Researchers added a material called fucoidan, which is made from seaweed, to modify synthetic blood vessels. Fucoidan has a structure similar to heparin, a drug used as an anticoagulant.

Masks can put cognitive performance in check

The study found that while masks had a negative impact, the effect subsided over time. 
Photo Credit: Alena Beliaeva

Wearing a face mask can temporarily disrupt decision-making in some situations according to University of Queensland research.

Dr David Smerdon from UQ’s School of Economics analyzed almost three million chess moves played by more than eight thousand people in 18 countries before and during the COVID-19 pandemic and found wearing a mask substantially reduced the average quality of player decisions.

“The decrease in performance was due to the annoyance caused by the masks rather than a physiological mechanism, but people adapted to the distraction over time,” Dr Smerdon said.

“The data showed masks were more likely to decrease performance in situations where there was a demanding mental task with a high working memory load.

“This is something to keep in mind for occupations in the STEM fields of science, technology, engineering and mathematics as well as other professions that demand a high level of working memory such as language interpreters, performers, waiters and teachers.”

Detecting dark matter with quantum computers

Akash Dixit works on a team that uses quantum computers to look for dark matter. Here, Dixit holds a microwave cavity containing a superconducting qubit. The cavity has holes in its side in the same way the screen on a microwave oven door has holes; the holes are simply too small for microwaves to escape.
Photo Credit: Ryan Postel, Fermilab

Dark matter makes up about 27% of the matter and energy budget in the universe, but scientists do not know much about it. They do know that it is cold, meaning that the particles that make up dark matter are slow-moving. It is also difficult to detect dark matter directly because it does not interact with light. However, scientists at the U.S. Department of Energy’s Fermi National Accelerator Laboratory have found a way to look for dark matter using quantum computers.

Aaron Chou, a senior scientist at Fermilab, works on detecting dark matter through quantum science. As part of DOE’s Office of High Energy Physics QuantISED program, he has developed a way to use qubits, the main component of quantum computing systems, to detect single photons produced by dark matter in the presence of a strong magnetic field.

How to Edit the Genes of Nature’s Master Manipulators

Scientists are using CRISPR to engineer the viruses that evolved to engineer bacteria
Illustration Credit: Davian Ho

CRISPR, the Nobel Prize-winning gene editing technology, is poised to have a profound impact on the fields of microbiology and medicine yet again.

A team led by CRISPR pioneer Jennifer Doudna and her longtime collaborator Jill Banfield has developed a clever tool to edit the genomes of bacteria-infecting viruses called bacteriophages using a rare form of CRISPR. The ability to easily engineer custom-designed phages – which has long eluded the research community – could help researchers control microbiomes without antibiotics or harsh chemicals, and treat dangerous drug-resistant infections. A paper describing the work was recently published in Nature Microbiology.

“Bacteriophages are some of the most abundant and diverse biological entities on Earth. Unlike prior approaches, this editing strategy works against the tremendous genetic diversity of bacteriophages,” said first author Benjamin Adler, a postdoctoral fellow in Doudna’s lab. “There are so many exciting directions here – discovery is literally at our fingertips!”

Bacteriophages, also simply called phages, insert their genetic material into bacterial cells using a syringe-like apparatus, then hijack the protein-building machinery of their hosts in order to reproduce themselves – usually killing the bacteria in the process. (They’re harmless to other organisms, including us humans, even though electron microscopy images have revealed that they look like sinister alien spaceships.)

New Quantum Light Source Paves the Way to a Quantum Internet

A molybdenum ditelluride material (blue and yellow lattice) just atoms thick connects telecom-wavelength quantum emitters to optical fibers with minimal loss. The devices generate single photons (red) when triggered by optical signals (green).
Image Credit: Courtesy of Huan Zhao, Center for Integrated Nanotechnologies, Los Alamos National Laboratory

Conventional light sources for fiber-optic telecommunications emit many photons at the same time. Photons are particles of light that move as waves. In today’s telecommunication networks, information is transmitted by modulating the properties of light waves traveling in optical fibers, similar to how radio waves are modulated in AM and FM channels. In quantum communication, however, information is encoded in the phase of a single photon—the photon’s position in the wave in which it travels. This makes it possible to connect quantum sensors in a network spanning great distances and to connect quantum computers together. Researchers recently produced single-photon sources with operating wavelengths compatible with existing fiber communication networks. They did so by placing molybdenum ditelluride semiconductor layers just atoms thick on top of an array of nano-size pillars. This is the first time that researchers have demonstrated this type of tunable light sources suited to use in telecommunications systems.

Scientists invent pioneering technique to construct rare molecules

Bahamaolide A is a polyketide natural product with potent antifungal activity, which was isolated from bacteria cultured from a sediment sample collected at North Cat Cay in the Bahamas and has now been synthesized in the chemical laboratory for the first time.
Image Credit: University of Bristol and Wikimedia Commons

Scientists have created a much faster way to make certain complex molecules, which are widely used by pharmaceuticals for antibiotics and anti-fungal medicines.

The first-of-its-kind discovery by chemists at the University of Bristol has the potential to speed up the production of such drugs, making them cheaper and more accessible.

The breakthrough, published in Nature Chemistry, marks the culmination of a five-year research project which has finally cracked how to reconstruct in a laboratory a particularly complex molecule, from the family of molecules known as polyketides.

Lead author Sheenagh Aiken, a PhD student at the university’s School of Chemistry when the work was completed, said: “It’s an exciting discovery, which could bring important benefits for the pharmaceutical industry and public health.

Measuring times in billionths of a billionth of a second

Explanation by Prof Igor Litvinyuk and Prof Robert Sang. 

Video Credit: Griffith University

How fast do electrons inside a molecule move? Well, it is so fast that it takes them just a few attoseconds (1 as = 10-18 s or one billionth of billionth of a second) to jump from one atom to another. Blink and you missed it – millions of billions of times. So, measuring such ultrafast processes is a daunting task.

Scientists at the Australian Attosecond Science Facility and the Centre for Quantum Dynamics of Griffith University in Brisbane Australia, led by Professor Robert Sang and Professor Igor Litvinyuk have developed a novel interferometric technique capable of measuring time delays with zeptosecond (a trillionth of a billionth of a second) resolution.

They have used this technique to measure the time delay between extreme ultraviolet light pulses emitted by two different isotopes of hydrogen molecules – H2 and D2 – interacting with intense infrared laser pulses.

This delay was found to be less than three attoseconds (one quintillionth of a second long) and is caused by slightly different motions of the lighter and heavier nuclei.

This study has been published in Ultrafast Science, a new Science Partner Journal.

Business Professors Solve Century-old Math Problem

Illustration Credit: Yesenia Carrero /UConn

These professors made a ridiculously hard logistics problem easy to solve. In the process, they smashed a basic tenet of computer theory. And now they’re offering a $10,000 prize to anyone who can show they’re wrong.

“You have many choices to make. What’s your best choice, given limited resources, to maximize your profit?” asks Moustapha Diaby, an associate professor of operations management in UConn’s School of Business.

It may be the basic question of life in a capitalist society. It’s also the basic question behind operations research, a field of study that blossomed in the 1940s. One of operations research’s basic insights is that linear programming, which is part of a broader technique called “constrained optimization,” can answer these common business questions, says Diaby.

Imagine, for example, that you run an oil refinery. You need to decide how much gasoline (g) and diesel fuel (d) to make from each barrel of oil in order to maximize your profit. If you make a $3 profit per gallon of gas, and $5 per gallon of diesel, the objective of the optimization problem would be to maximize 3g + 5d.

Ural Chemists Improved Material for Fuel Cells

Scientists were able to identify the optimal amount of iron administered.
Photo Credit: Ilya Safarov

Chemists at Ural Federal University and the Institute of High-Temperature Electrochemistry, Ural Branch of the Russian Academy of Sciences have improved a material for high-performance electrochemical devices. Such materials are used as electrodes in solid oxide fuel cells (SOFC) or proton-ceramic fuel cells (PCFC). Scientists proposed the infiltration method as a simple and affordable way to improve electrochemical performance. Their method increased the conductivity of this material, consequently improving the performance (increased power) of fuel cells. The change now makes the reaction go faster. The material and method are described in the journal Catalysts.

In the course of their research, chemists introduced iron into the basic barium cerate-zirconate, which means that they added iron ions to the complex oxide perovskites. In this way they were able to obtain a high level of mixed ion-electron conductivity, which is necessary for good electrodes. Similar materials exist today, but scientists around the world are trying to optimize them-improving their properties to increase efficiency.

New findings on neuronal activities in the sensorimotor cortex

Neurons from layer 5 of the motor cortex stained with a fluorescent dye.
Image Credit: Ilka Diester

An interdisciplinary research team at the University of Freiburg has found important clues about the functioning of the sensorimotor cortex. The new findings on neuronal activities in this brain area could be helpful for the further development and use of so-called neuroprostheses. These have an interface with the nervous system and are intended to help compensate for neuronal dysfunctions. "Our results will contribute to the improvement of neuroprosthetic approaches while shortening the training period of patients with prostheses,” says neurobiologist Prof. Dr. Ilka Diester from the Faculty of Biology at the University of Freiburg. The results have just been published in the journal Nature Communications.

Understanding the brain under more natural conditions

The research project also involved the working groups of computer scientist Prof. Dr. Thomas Brox from the University of Freiburg and neuroscientist Prof. Dr. Daniel Durstewitz from the Central Institute of Mental Health in Mannheim. The team found evidence of conserved structures of neuronal activity in the sensorimotor cortex of freely moving rats. The electrophysiological recordings across the entire bilateral sensorimotor cortex allow conclusions about the respective contributions of the premotor, motor and sensory areas. In particular, the researchers found a clear gradient for a contralateral bias, i.e. for movements of the opposite half of the body, from anterior to posterior regions.