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| Marcela Pekna och Milos Pekny, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg. Photo Credits: Milos Pekny, Ylva Pekny |
An effective treatment for most stroke victims — even those who, today, are unable to gain access to care within the first few hours. This is the goal of an experimental method that has been tested with great success in an international study headed by the University of Gothenburg.
The work now published in the Journal of Clinical Investigation is a multicenter study in which researchers at the Universities of Gothenburg and Cologne implemented parallel testing of an experimental stroke treatment on mice. The study was conducted in collaboration with researchers at the Czech Academy of Sciences.
By giving mice a molecule, the complement peptide C3a, in nasal drops, the scientists saw them recover motor function faster and better after stroke compared with mice that had received nasal drops with placebo. These results confirm and extend a previous study at the University of Gothenburg and the current study design further strengthens their credibility.
“We see the same positive effects in experiments done in Sweden and in Germany, which makes the results much more robust,” says Marcela Pekna, Professor of Neuroimmunology at Sahlgrenska Academy, University of Gothenburg, who led the study.

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