. Scientific Frontline

Wednesday, June 14, 2023

Alcohol harm reduction can also reduce other substance use

Photo Credit: cottonbro studio

Quitting alcohol or drugs was not a top priority for people experiencing homelessness in a harm reduction treatment study, yet participants still reduced their use of both.

A different approach than traditional abstinence-based programs, harm reduction treatment for alcohol use disorder, also called HaRT-A, has patients set their own goals. In a study of 308 people experiencing homelessness, the participants receiving harm reduction treatment set goals of meeting basic needs and improving quality of life well above quitting alcohol and other substances.

Yet harm reduction treatment still led to more reduced use compared to a control group who received regular services. The findings are detailed in the Journal of Addiction Medicine.

“It’s a good reminder that all people have the same basic goals: we all want to be safer, healthier and happier, and when we help people experiencing homelessness achieve those goals, they might end up doing the things that treatment providers want them to do anyway,” said Susan Collins, a Washington State University psychology professor and the study’s senior author. “They might end up cutting down their use; they might end up quitting, but it’s on their own terms and their own timeline, so it’s more sustainable.”

Collins and first author Nicki Mostofi analyzed data from an earlier clinical study focused on harm reduction and alcohol use. That study involved people with alcohol use disorder from three Seattle homeless shelters who were divided into different groups: one received harm reduction treatment alone, another treatment with naltrexone which reduces alcohol cravings, and a third group had the treatment and a placebo. A fourth control group received traditional services.

Towards the New-Space Era with Foldable Phased-Array Transmitters for Small Satellites

A foldable phased-array transmitter for LEO satellites By varying the number of liquid crystal polymer layers, the proposed design incorporates foldable creases, contributing to a smaller form factor and lower weight.
Photo Credit: Courtesy of Tokyo Institute of Technology

A new design for a foldable phased-array transmitter can help make satellites lightweight, smaller, and cost-efficient to launch, report scientists at Tokyo Tech. The transmitter is made of stacked layers of liquid crystal polymer and incorporates flexible creases, which provide flexibility and deployability. The new design could make research and implementation of space technologies more accessible to private companies and startups.

By varying the number of liquid crystal polymer layers, the proposed design incorporates foldable creases, contributing to a smaller form factor and lower weight.

There has been a recent shift in the space industry towards what is now called the "new-space era." The term refers to how space is no longer dominated exclusively by government agencies such as NASA but has instead become a playground for many private companies and startups interested in exploring and deploying space technologies. While this opens up a vast ocean of possibilities for space research, exploration, and telecommunications, launching satellites remains an expensive endeavor.

In general, low earth orbit (LEO) satellites are both low cost and low latency. However, modern antenna designs for LEO satellites are heavy, leading to a trade-off between making satellites compact and achieving a large antenna aperture for better performance. Such issues increase launch costs significantly and are regarded as major hurdles to overcome in the new-space era.

A marine mystery: finding the link between climate change and sea sponge loss

The latest findings suggest that thermal stress disturbs sponge-microbes symbiosis, which likely causes the sponge to die.
Photo Credit: Heidi Luter.

Microbes could hold the key to explaining how climate change affects sea sponges, warn scientists from UNSW Sydney. 

Sea sponges are essential to marine ecosystems. They play critical roles in the ocean, as they provide shelter and food to a plethora of marine creatures, recycle nutrients by filtering thousands of liters of sea water daily, and are hosts to microbes that may be the key to some of the most pressing medical challenges we face today. 

Now, scientists from UNSW have discovered that when a tropical sea sponge is exposed to warmer temperatures, it loses an important microbe, which could explain why the sponge tissue dies.  

The latest study, published in ISME Communications, has revealed that by exposing sea sponges to a temperature increase of 3°C, one essential microbe abandons the sponge, potentially causing tissue poisoning.   

The collaboration between researchers from UNSW, Heidi Luter from the Australian Institute of Marine Science and James Bell from the Victoria University of Wellington, has added an important piece to the puzzle on the impact of climate change on sponge populations around the world. 

Paleontologists Discovered Unique Remains of Paleogene Reptiles in the Urals

Rare remains have been found in the Sverdlovsk and Kurgan Regions
Photo Credit: Courtesy of Ural Federal University

At the river Miass (Kurgan Region) paleontologists of the Ural Branch of the Institute of Ecology of Animals and Plants of the Russian Academy of Sciences and the Ural Federal University discovered rare for the Urals and Siberia finds - vertebrae of a sea snake and a piece of a turtle shell. Approximate dating of bones - 45-35 million years, but the exact figures have not yet been established. The findings were sent to the Paleontological Institute of the Russian Academy of Sciences in Moscow for further research.

"This is the second such unique find, and we were lucky to study both of them. The fact is that fossil remains of Paleogene snakes from the territory of Western and Eastern Europe, the Caucasus, and Central Asia are quite well described, but such finds are not known in the Urals and Western Siberia. Last year we managed to find a vertebra of a sea snake on the Dernei River in the Sverdlovsk Region. This year, our friend and paleontology enthusiast Alexey Sofrygin showed us a snake vertebra from a new spot - the Miass River. Unfortunately, we did not find any other vertebrae when we conducted a complete study of the Miass River sediments. However, we did find a piece of a turtle shell. This is also an extremely rare find," says Dmitry Gimranov, Head of Research, Senior Researcher at the Laboratory of Natural Science Methods in Humanities of the Ural Federal University.

Light pollution confuses coastal woodlouse

A woodlouse underwater.
Photo Credit: Martin Stjernstedt

Artificial night-time light confuses a color-changing coastal woodlouse, new research shows.

The sea slater is an inch-long woodlouse that lives around the high-tide line and is common in the UK and Europe.

Sea slaters forage at night and can change color to blend in and conceal themselves from predators.

The new study, by the University of Exeter, tested the effects of a single-point light source (which casts clear shadows) and “diffuse” light (similar to “skyglow” found near towns and cities).

While the single light did not interfere with the sea slaters’ camouflage, diffuse light caused them to turn paler while hiding on a dark background – making them more visible.

“With night skies getting brighter worldwide, it’s important to understand how this will affect the natural world,” said Kathryn Bullough, who led the study as part of her masters at the Centre for Ecology and Conservation on Exeter’s Penryn Campus in Cornwall.

“We know artificial light causes all sorts of negative effects for animals and plants, but our results show that shadow-casting light can have very different impacts to diffuse skyglow, even when both have the same overall brightness.

New insights into the origin of food sharing among humans

Chimpanzees Gremlin and son Grendel, begging for food, at Gombe National Park, Tanzania.
Photo Credit: Courtesy of University of Minnesota

As humans evolved to hunt, gather and share food, cooperation provided a key to our success as a species. While chimpanzees and other primates sometimes share food, humans stand out. As hunter-gatherers — the subsistence strategy that all humans followed until the invention of agriculture — our survival depended on daily sharing of food between unrelated adult males and females. 

While hunter-gatherers today depend heavily on hunting and cooking, long before these activities became important for our ancestors, species such as Australopithecus extracted foods such as roots, tubers and nuts. Since hunter-gatherers and nonhuman primates tend to share foods that are large, valuable and divisible, these nutrient-dense foods are likely candidates for sharing, and may have been susceptible to theft by hungry group members. 

In new research published in the Proceedings of the National Academy of Sciences (PNAS), a team led by College of Biological Sciences Professor Michael Wilson developed a conceptual and mathematical model of the evolution of food production and sharing in early human ancestors. The interdisciplinary team included an economist, a theoretical biologist, an anthropologist and a primatologist. 

A Novel Technique to Observe Colloidal Particle Degradation in Real Time

Height images of nanoplastics degrading in real time, captured using high-speed atomic force microscopy. The left side shows a particle containing water, and the right side shows a water-free particle.
Image Credit: Daisuke Suzuki from Shinshu University

Researchers develop an innovative approach using atomic force microscopy to shed light on the degradation of colloidal particles

Degradation of colloidal particles is a common occurrence in nature, be it removal of waste products from cells or the natural degradation of polymers, such as plastics, in the environment. Nanoplastics are a major environmental concern, but little is known about how they are created from plastics over time. Researchers from Shinshu University have now developed a novel approach that utilizes high-speed atomic force microscopy to observe, in real time, the course of degradation of colloidal particles.

In the early 2000s, scientists from the UK made a worrisome discovery that the oceans are teeming with small particles of plastic (less than one millimeter in length) due to the continuous degradation of plastic waste. These microscopic particles of plastic have become a major environmental concern. Scientists classify these small particles as either microplastics or nanoplastics based on their size; the latter term is used exclusively for particles smaller than one micrometer.

New way of identifying proteins supports drug development

The illustration shows how different areas of PRC2 protein (the one on the right side) binds to survivin. The color pixel diagram shows binding strength to survivin. The bright pink pixels are the strongest binders.
Illustration Credit: Atsarina Larasati Anindya

All living cells contain proteins with different functions, depending on the type of cell. Researchers at the University of Gothenburg have discovered a way to identify proteins without even looking at their structure. Their method is faster, easier and more reliable than previous methods.

Currently, the general view is that each protein’s structure is what controls its function in cells. The atomic sequences, meaning how the atoms are arranged in the proteins, create the protein’s structure and shape. But there are many proteins that lack a well-defined structure.

Researcher Gergely Katona has developed a new method where proteins are scanned based on the number of amino acids (or the number of different atoms) they contain in order to identify them and their function instead of identifying them based on their structure. With this scanning method, the researchers were able to predict relatively reliably which combination of amino acids is needed to bind to the protein survivin. The outcome was a reliability of about 80 per cent, which is better than when you use the protein’s primary structures for identification. The results are now published in the scientific journal iScience.

Tuesday, June 13, 2023

AI helps show how the brain’s fluids flow

A video shows a perivascular space (area within white lines) into which the researchers injected tiny particles. The particles (shown as moving dots) are trailed by lines which indicate their direction. Having measured the position and velocity of the particles over time, the team then integrated this 2D video with physics-informed neural networks to create an unprecedented high-resolution, 3D look at the brain’s fluid flow system.
Video Credit: Douglas Kelley

New research targets diseases including Alzheimer’s.

A new artificial intelligence-based technique for measuring fluid flow around the brain’s blood vessels could have big implications for developing treatments for diseases such as Alzheimer’s.

The perivascular spaces that surround cerebral blood vessels transport water-like fluids around the brain and help sweep away waste. Alterations in the fluid flow are linked to neurological conditions, including Alzheimer’s, small vessel disease, strokes, and traumatic brain injuries but are difficult to measure in vivo.

A multidisciplinary team of mechanical engineers, neuroscientists, and computer scientists led by University of Rochester Associate Professor Douglas Kelley developed novel AI velocimetry measurements to accurately calculate brain fluid flow. The results are outlined in a study published by Proceedings of the National Academy of Sciences.

Next Generation Experimental Aircraft Becomes NASA’s Newest X-Plane

The X-66A is the X-plane specifically aimed at helping the United States achieve the goal of net-zero greenhouse gas emissions by 2050. To build the X-66A, Boeing will work with NASA to modify an MD-90 aircraft, shortening the fuselage and replacing its wings and engines. The resulting demonstrator aircraft will have long, thin wings with engines mounted underneath and a set of aerodynamic trusses for support. The design, which Boeing submitted for NASA’s Sustainable Flight Demonstrator project, is known as a Transonic Truss-Braced Wing.
Full Size Image
Image Credits: NASA

NASA and Boeing said Monday the aircraft produced through the agency’s Sustainable Flight Demonstrator project has been designated by the U.S. Air Force as the X-66A.

The new X-plane seeks to inform a potential new generation of more sustainable single-aisle aircraft – the workhorse of passenger airlines around the world. Working with NASA, Boeing will build, test, and fly a full-scale demonstrator aircraft with extra-long, thin wings stabilized by diagonal struts, known as a Transonic Truss-Braced Wing concept.

“At NASA, our eyes are not just focused on stars but also fixated on the sky. The Sustainable Flight Demonstrator builds on NASA’s world-leading efforts in aeronautics as well climate,” said NASA Administrator Bill Nelson. “The X-66A will help shape the future of aviation, a new era where aircraft are greener, cleaner, and quieter, and create new possibilities for the flying public and American industry alike.”

The X-66A is the first X-plane specifically focused on helping the United States achieve the goal of net-zero aviation greenhouse gas emissions, which was articulated in the White House’s U.S. Aviation Climate Action Plan.

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