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| L-DOPA, a precursor of the neurotransmitter dopamine, makes humans wait longer for rewards, as new research addresses gaps in earlier studies Photo Credit: Tim Mossholder |
A research team from the University of Cologne conducted one of the most comprehensive studies on dopamine and decision-making in humans so far, providing evidence for effects of the former on the latter. Dopamine is a neurotransmitter involved in several functions, including motivation and reward. The team at the Psychology Department led by Dr Elke Smith and Professor Dr Jan Peters found that L-DOPA, a precursor of dopamine that increases dopamine levels in the brain, slightly increased the study participants’ willingness to wait for larger delayed rewards, decreasing impulsivity by about a 20 percent compared to placebo. This modest effect challenges some earlier influential findings from much smaller studies, which had found that L-DOPA increased impulsive choices. The study “Dopamine and temporal discounting: revisiting pharmacology and individual differences” has appeared in the Journal of Neuroscience.




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