‘Back to the Future’ to Forecast the Fate of a Dead Florida Coral Reef

Alex Modys, Ph.D., diving at the coral death assemblage in Pompano Ridge and digging up a subfossil coral, Orbicella annularis.
Photo Credit: Anton Olenik, Ph.D., Florida Atlantic University

Rising temperatures and disease outbreaks are decimating coral reefs throughout the tropics. Evidence suggests that higher latitude marine environments may provide crucial refuges for many at-risk, temperature-sensitive coral species. However, how coral populations expand into new areas and sustain themselves over time is constrained by the limited scope of modern observations. 

What can thousands of years of history tell us about what lies ahead for coral reef communities? A lot. In a new study, Florida Atlantic University researchers and collaborators provide geological insights into coral range expansions by reconstructing the composition of a Late Holocene-aged subfossil coral death assemblage in an unusual location in Southeast Florida and comparing it to modern reefs throughout the region. 

Located off one of the most densely populated and urbanized coastlines in the continental United States, the Late Holocene coral death assemblage known as “Pompano Ridge,” records a northward range expansion of tropical coral communities that occurred during a period of regional climate warming more than 2,000 years ago.

Could this happen again in the face of climate change? Going “back to the future,” this study offers a unique glimpse into what was once a vibrant coral reef assemblage and explores if history can repeat itself.

‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention

Photo Credit: Angiola Harry

Everyone has BRCA1 and BRCA2 genes, but mutations in these genes - which can be inherited - increase the risk of breast and ovarian cancer.

The study found that the immune cells in breast tissue of healthy women carrying BRCA1 or BRCA2 gene mutations show signs of malfunction known as ‘exhaustion’. This suggests that the immune cells can’t clear out damaged breast cells, which can eventually develop into breast cancer.

This is the first time that ‘exhausted’ immune cells have been reported in non-cancerous breast tissues at such scale - normally these cells are only found in late-stage tumors.

The results raise the possibility of using existing immunotherapy drugs as early intervention to prevent breast cancer developing, in carriers of BRCA1 and BRCA2 gene mutations.

The researchers have received a ‘Biology to Prevention Award’ from Cancer Research UK to trial this preventative approach in mice. If effective, this will pave the way to a pilot clinical trial in women carrying BRCA gene mutations.

“Our results suggest that in carriers of BRCA mutations, the immune system is failing to kill off damaged breast cells - which in turn seem to be working to keep these immune cells at bay,” said Professor Walid Khaled in the University of Cambridge’s Department of Pharmacology and Wellcome-MRC Cambridge Stem Cell Institute, senior author of the report.

Magnetic Avalanche Triggered by Quantum Effects

Christopher Simon holds a crystal of lithium holmium yttrium fluoride.
Photo Credit: Lance Hayashida/Caltech

Iron screws and other so-called ferromagnetic materials are made up of atoms with electrons that act like little magnets. Normally, the orientations of the magnets are aligned within one region of the material but are not aligned from one region to the next. Think of groups of tourists in Times Square pointing to different billboards all around them. But when a magnetic field is applied, the orientations of the magnets, or spins, in the different regions line up and the material becomes fully magnetized. This would be like the packs of tourists all turning to point at the same sign.

The process of spins lining up, however, does not happen all at once. Rather, when the magnetic field is applied, different regions, or so-called domains, influence others nearby, and the changes spread across the material in a clumpy fashion. Scientists often compare this effect to an avalanche of snow, where one small lump of snow starts falling, pushing on other nearby lumps, until the entire mountainside of snow is tumbling down in the same direction.

Cats with MDR1 mutation at risk of severe reactions to popular medication

Photo Credit: Zhang Kaiyv

More than half a million cats in the United States could be at risk of a severe or even fatal neurological reaction to the active ingredient in some top-selling parasite preventatives for felines.

While the ingredient, eprinomectin, which is found in products like NexGard COMBO and Centragard, appears safe and effective for the significant majority of cats when used at label doses, a study conducted by Washington State University’s Program for Individualized Medicine identified a risk of severe adverse effects in cats with the MDR1 genetic mutation. Genetically affected cats lack a protective mechanism that prevents certain drugs, including eprinomectin, from entering the brain and causing serious neurological toxicity.

“Almost every week we receive reports about someone’s pet cat having serious reactions to eprinomectin. This is not an issue with the drug itself — the problem lies in the genes of 1% of cats. That is a sizable number considering there are over 60 million pet cats in the U.S., and we’re trying to increase general awareness of these risks,” said Dr. Katrina Mealey, a WSU veterinarian and pharmacologist who led the research.

Patients with delirium more likely to develop dementia

Professor Ruth Hubbard interacting with a patient.
Photo Credit: The University of Queensland

University of Queensland researchers have found older patients who experience delirium are three times more likely to develop dementia.

Professor Ruth Hubbard from UQ’s Centre for Health Services Research (CHSR) said the study also found that every episode of delirium increased the chance of developing dementia by 20 per cent.

“Delirium is an acute confusional state which particularly impacts older people and can have long term detrimental effects on patients,” Professor Hubbard said.

“Our study found that it is also strongly linked to dementia.”

The researchers analyzed a cohort of more than 110,000 patients from New South Wales hospitals over five years.

Lead author and CHSR research fellow, Dr Emily Gordon, said more than 55,000 patients who had experienced delirium were compared to patients who had not.

Rice study identifies protein responsible for gas vesicle clustering in bacteria

Zongru Li (left) and George Lu
Photo Credit: Anna Stafford/Rice University

Gas vesicles are hollow structures made of protein found in the cells of certain microorganisms, and researchers at Rice University believe they can be programmed for use in biomedical applications.

“Inside cells, gas vesicles are packed in a beautiful honeycomb pattern. How this pattern is formed has never been thoroughly understood. We are presenting the first identification of a protein that can regulate this patterning, and we believe this will be a milestone in molecular microbiology,” said George Lu, assistant professor of bioengineering and a Cancer Prevention and Research Institute of Texas scholar.

Lu and colleagues have published their findings in a paper published in Nature Microbiology. The lead author is Zongru Li, a fourth-year bioengineering doctoral student in Lu’s Laboratory for Synthetic Macromolecular Assemblies.

“Gas vesicles are cylindrical tubes closed by conical end caps,” Li said. “They provide buoyancy within the cells of their native hosts.”

Largest ice shelf in Antarctica lurches forward once or twice each day

A side view of the Ross Ice Shelf, the largest ice shelf in Antarctica. Washington University in St. Louis seismologist Doug Wiens discovered that unexpected movements of the Ross Ice Shelf are triggered by the sudden slipping of parts of the Willans Ice Stream.
Photo Credit: Lin Padgham
(CC BY 2.0.)

In Antarctica, heavy glaciers are always on the move. Conveyor belts of ice known as ice streams are the corridors of faster flow that carry most of the vast glaciers’ ice and sediment debris out toward the ocean.

One such ice stream jostles the entire Ross Ice Shelf out of place at least once daily, according to new research from Washington University in St. Louis.

This finding is significant because of the scale of the Ross Ice Shelf: It is the largest ice shelf in Antarctica, about the same size as the country of France.

“We found that the whole shelf suddenly moves about 6 to 8 centimeters (or 3 inches) once or twice a day, triggered by a slip on an ice stream that flows into the ice shelf,” said Doug Wiens, the Robert S. Brookings Distinguished Professor of earth, environmental and planetary science​s in Arts & Sciences. “These sudden movements could potentially play a role in triggering icequakes and fractures in the ice shelf.”

The Ross Ice Shelf is a floating lip of ice that extends out over the ocean from inland glaciers.

Risk factors for faster aging in the brain revealed in new study

Governments have been urged to act decisively before 2035 to ensure global warming can be kept below 2°C by 2100.
Photo Credit: Nöel Puebla

Researchers from the Nuffield Department of Clinical Neurosciences at the University of Oxford have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.

The researchers had previously identified a ‘weak spot’ in the brain, which is a specific network of higher-order regions that not only develop later during adolescence, but also show earlier degeneration in old age. They showed that this brain network is also particularly vulnerable to schizophrenia and Alzheimer’s disease.

In this new study, published in Nature Communications, they investigated the genetic and modifiable influences on these fragile brain regions by looking at the brain scans of 40,000 UK Biobank participants aged over 45.

The researchers examined 161 risk factors for dementia, and ranked their impact on this vulnerable brain network, over and above the natural effects of age. They classified these so-called ‘modifiable’ risk factors − as they can potentially be changed throughout life to reduce the risk of dementia − into 15 broad categories: blood pressure, cholesterol, diabetes, weight, alcohol consumption, smoking, depressive mood, inflammation, pollution, hearing, sleep, socialization, diet, physical activity, and education.

Not unique to humans but uniquely human: researchers identify factor involved in brain expansion in humans

A microscopy image of a human brain organoid.
Image Credit: © Janine Hoffmann

What makes us human? According to neurobiologists it is our neocortex. This outer layer of the brain is rich in neurons and lets us do abstract thinking, create art, and speak complex languages. An international team led by Dr. Mareike Albert at the Center for Regenerative Therapies Dresden (CRTD) of TUD Dresden University of Technology has identified a new factor that might have contributed to neocortex expansion in humans. The results were published in the EMBO Journal.

The neocortex is the characteristic folded outer layer of the brain that resembles a walnut. It is responsible for higher cognitive functions such as abstract thinking, art, and language. “The neocortex is the most recently evolved part of the brain,” says Dr. Mareike Albert, research group leader at the CRTD. “All mammals have a neocortex, but it varies in size and complexity. Human and primate neocortices have folds while, for example, mice have a completely smooth neocortex, without any creases.”

The folds characteristic of the human brain increases the surface area of the neocortex. The human neocortex has a greater number of neurons that support complex cognitive functions.

The molecular mechanisms driving neocortex evolution are still largely unknown. “Which genes are responsible for inter-species differences in neocortex size? What factors have contributed to brain expansion in humans? Answering these questions is crucial to understanding human brain development and potentially addressing mental health disorders,” explains Dr. Albert.

Liquid crystal nanoparticles supercharge antibiotics for cystic fibrosis

Image Credit: Copilot Dall E-3 AI generated

Cystic fibrosis is the most common, life-limiting genetic condition in Australia. It affects the lungs, digestive system, and reproductive system, producing excess mucus, infections, and blockages.

Now, thanks to a $500,000 grant from Brandon BioCatalyst's CUREator incubator, through their CSIRO-funded Minimizing Antimicrobial Resistance Stream, University of South Australia researchers are advancing the development of liquid crystal nanoparticle-formulated antibiotics to more accurately target and eliminate difficult-to-cure lung infections in people with cystic fibrosis.

Funded by the Medical Research Future Fund CUREator provides grant funding to support the development of Australian biomedical research and innovations.

The study will use a patent-protected platform technology, invented by UniSA’s Centre for Pharmaceutical Innovation to establish new therapies for cystic fibrosis sufferers. UniSA will also work with the Cystic Fibrosis Airways Research Group at the Women’s and Children’s Hospital to advance the platform.

True trans visibility requires better data

The influential book Invisible Women articulates some of the countless ways in which women are missing from the data we use to understand the world, including the testing of many drugs, consideration of how best to support refugees, and others. The book is powerful, because it shines a light into how, by missing women out, we (unintentionally) do harm.

This trans visibility day, we’ve been thinking about whether a similar book could be written for trans people, and have had to conclude that it could not. Trans people and their experiences are so missing from the datasets that shape social science that we cannot even begin to fully understand the extent of their absence, and how this affects their lives.

Trans identities are missing from our datasets, meaning that their experiences in a number of domains cannot be studied quantitatively. The way in which many of our datasets are constructed reinforces a cis-normative understanding of the world, where people are pushed into the false binary of describing themselves as either male or female. Even less desirably, their gender is often assumed by the person administering the dataset, or worse, lumped into the amorphous category of “other” – literally othering survey respondents with a trans or non-binary identity.

Unleashing Disordered Rocksalt Oxides as Cathodes for Rechargeable Magnesium Batteries

Schematics of the battery and present cathode material. The present material contains many metal elements as cations thanks to the effect of the high configurational entropy.
Illustration Credit: ©Tohoku University

Researchers at Tohoku University have made a groundbreaking advancement in battery technology, developing a novel cathode material for rechargeable magnesium batteries (RMBs) that enables efficient charging and discharging even at low temperatures. This innovative material, leveraging an enhanced rock-salt structure, promises to usher in a new era of energy storage solutions that are more affordable, safer, and higher in capacity.

Details of the findings were published in the Journal of Materials Chemistry. 

The study showcases a considerable improvement in magnesium (Mg) diffusion within a rock-salt structure, a critical advancement since the denseness of atoms in this configuration had previously impeded Mg migration. By introducing a strategic mixture of seven different metallic elements, the research team created a crystal structure abundant in stable cation vacancies, facilitating easier Mg insertion and extraction.

This represents the first utilization of rocksalt oxide as a cathode material for RMBs. The high-entropy strategy employed by the researchers allowed the cation defects to activate the rocksalt oxide cathode.

New Method Developed to Isolate HIV Particles

The image shows PNF-coated magnetic microbeads that bind HIV particles to their surface.
Image Credit: Torsten John

Researchers at Leipzig University and Ulm University have developed a new method to isolate HIV from samples more easily, potentially making it easier to detect infection with the virus. They focus on peptide nanofibrils (PNFs) on magnetic microparticles, a promising tool and hybrid material for targeted binding and separation of viral particles. They have published their new findings in the journal Advanced Functional Materials.

“The presented method makes it possible to efficiently capture, isolate and concentrate virus particles, which may improve the sensitivity of existing diagnostic tools and analytical tests,” says Professor Bernd Abel of the Institute of Technical Chemistry at Leipzig University. The nanofibrils used – small, needle-like structures – are based on the EF-C peptide, which was first described in 2013 by Professor Jan Münch from Ulm University and Ulm University Medical Center. EF-C is a peptide consisting of twelve amino acids that forms nanoscale fibrils almost instantaneously when dissolved in polar solvents. These can also be applied to magnetic particles. “Using the EF-C peptide as an example, our work shows how peptide fibrils on magnetic particles can have a completely new functionality – the more or less selective binding of viruses. Originally, fibrils of this kind were more likely to be associated with neurodegenerative diseases,” adds Dr Torsten John, co-first author of the study and former doctoral researcher under Professor Abel at Leipzig University. He is now a junior researcher at the Max Planck Institute for Polymer Research in Mainz, Germany.

Key Ocean Current Contains a Warning on Climate

Scientists extracted a 5.3 million-year record of the Antarctic Circumpolar Current by drilling sediment cores in the Earth’s most remote waters. Here, the drill ship JOIDES Resolution makes its way through the far southeast Pacific.
Photo Credit: Gisela Winckler

It carries more than 100 times as much water as all the world’s rivers combined. It reaches from the ocean’s surface to its bottom, and measures as much as 2,000 kilometers across. It connects the Indian, Atlantic and Pacific oceans, and plays a key role in regulating global climate. Continuously swirling around the southernmost continent, the Antarctic Circumpolar Current is by far the world’s most powerful and consequential mover of water. In recent decades it has been speeding up, but scientists have been unsure whether that is connected to human-induced global warming, and whether the current might offset or amplify some of warming’s effects.

In a new study, an international research team used sediment cores from the planet’s roughest and most remote waters to chart the ACC’s relationship to climate over the last 5.3 million years. Their key discovery: During past natural climate swings, the current has moved in tandem with Earth’s temperature, slowing down during cold times and gaining speed in warm ones―speedups that abetted major losses of Antarctica’s ice. This suggests that today’s speedup will continue as human-induced warming proceeds. That could hasten the wasting of Antarctica’s ice, increase sea levels, and possibly affect the ocean’s ability to absorb carbon from the atmosphere.

“This is the mightiest and fastest current on the planet. It is arguably the most important current of the Earth climate system,” said study coauthor Gisela Winckler, a geochemist at Columbia University’s Lamont-Doherty Earth Observatory who co-led the sediment sampling expedition. The study “implies that the retreat or collapse of Antarctic ice is mechanistically linked to enhanced ACC flow, a scenario we are observing today under global warming,” she said.

New Nanoceramics Could Help Improve Smartphone and TV Displays

Nanoceramics are strong because they are made under high pressure.
Photo Credit: Anna Marinovich

Scientists from the Ural Federal University, together with colleagues from India and the Ural Branch of the Russian Academy of Sciences, have developed a nanoceramic that glows in three main colors - red, green, and blue. The new material is extremely strong because it is created under high pressure. Scientists believe that the characteristics of the new nanoceramics - luminescence, strength, and transparency - will be useful for creating screens with improved brightness and detail for smartphones, televisions, and other devices. The scientists published detailed information about the new nanoceramics and their properties in the journal Applied Materials Today. 

"We obtained optically transparent nanoceramics capable of luminescing in red, green, and blue colors. This was made possible by adding carbon particles that act as carbon nanodots. During the synthesis process, the carbon components are encapsulated between the ceramic particles, creating defects on their surface. We believe that these defects create several energy levels in the carbon nanodots, allowing the material to glow in different colors in the visible spectrum", explains Arseny Kiryakov, the co-author of the work, Associate Professor of the UrFU Department of Physical Techniques and Devices for Quality Control.