Gene-edited calf may reduce reliance on antimicrobials against cattle disease

 Brian Vander Ley, associate professor in the University of Nebraska–Lincoln’s School of Veterinary Medicine and Biomedical Sciences, works with Ginger, a Gir cow gene-edited with resistance to bovine viral diarrhea virus.
Photo Credit: Craig Chandler | University Communication and Marketing

Cattle worldwide face major health threats from a highly infectious viral disease that decades of vaccinations and other precautions have failed to contain. Federal, private-sector and Husker scientists are collaborating on a new line of defense, by producing a gene-edited calf resistant to the virus.

If follow-up research confirms its efficacy, the gene-editing approach offers long-term potential to reduce antimicrobial and antibiotic use in the cattle industry.

The bovine viral diarrhea virus devastates the bovine immune system and can cause severe respiratory and intestinal harm to infected beef and dairy cattle, said veterinary epidemiologist Brian Vander Ley, an associate professor in the University of Nebraska–Lincoln’s School of Veterinary Medicine and Biomedical Sciences.

In utero calves are especially vulnerable to infection. If they survive, they can remain infected for life, repeatedly spreading the virus to other cattle.

“They show up as normal cattle but really, they’re shedding a tremendous amount of virus. They’re the ‘Typhoid Marys’ of BVDV spread,” said Vander Ley, assistant director of UNL’s Great Plains Veterinary Educational Center in Clay Center.

Cost-effective and Non-toxic Substance Helps in the Extraction of Noble Metals

The new technology will help extract valuable components from complex raw materials.
Photo Credit: Rodion Narudinov

Scientists of the Ural Federal University have found a "solvent" (surfactant), lignosulfonate, which facilitates the transfer of noble metals into solution. Lignosulfonate is a waste product of pulp and paper industry, which is cheap and non-toxic. The scientists have effectively solved two serious problems at once: using a waste product along with processing ores and concentrates. The researchers published a description of the solvent's mechanism of action in the scientific journal Langmuir.

"We investigated the mechanism of action of a very complex surfactant that is at the same time a humectant, dispersant and stabilizer in terms of the surface of the ore concentrate. Lignosulfonate has been used in autoclave metal extraction technologies since the 1970s. However, its efficiency has not been sufficiently studied and the mechanism of action has not been subjectively investigated. Taking into account the fact that today different types of ores are processed, the use of lignosulfonate for processing becomes even more important," says Tatyana Lugovitskaya, co-author of the research, Assistant Professor Researcher of the UrFU Department of Non-Ferrous Metallurgy.

Clinically relevant deficiency of the “bonding hormone” oxytocin demonstrated

The hormones oxytocin and vasopressin are produced in the same area of the brain and are also very similar in structure. This is why disorders that cause vasopressin deficiency could also affect the neurons that produce oxytocin
Image Credit: Colin Behrens

The hormone oxytocin is important for social interaction and to control emotions. A deficiency of this hormone has previously been assumed, for example, in people with autism, but has never been proven. Now, for the first time, researchers from the University of Basel and the University Hospital of Basel have succeeded in demonstrating a deficiency of oxytocin in patients with a deficiency of vasopressin caused by a disease of the pituitary gland. This finding could be key to developing new therapeutic approaches.

The hormones oxytocin and vasopressin are produced in the same area of the brain and are also very similar in structure. Patients with a rare deficiency of vasopressin cannot concentrate their urine and lose liters of water as a result. In order to compensate for this loss, they are obliged to drink up to 10 liters or more per day.

With a nasal spray or a tablet containing synthetically produced vasopressin, these symptoms can usually be treated without any problems. However, even with this treatment, many patients report anxiety, have trouble with social interactions or demonstrate impaired emotional awareness.

Putting the STING into cancer immunotherapy

Belcher and Hammond Lab researchers developed a cancer vaccine that could make checkpoint blockade therapies more effective for more patients.
Illustration Credit: Bendta Schroeder

Immune checkpoint blockade therapies have been revolutionary in the treatment of some cancer types, emerging as one of the most promising treatments for diseases such as melanoma, colon cancer, and non-small cell lung cancer.  

While in some cases checkpoint blockade therapies elicit a strong immune response that clears tumors, checkpoint inhibitors do not work for all tumor types or all patients. Moreover, some patients who do experience an initial benefit from these therapies see their cancers recur. Only a small minority of patients treated with checkpoint blockade therapies see lasting benefits. Researchers have developed various combination therapy strategies to overcome resistance to checkpoint blockade therapies, with the STING pathway emerging as one of the most attractive lines of inquiry.  

In a study appearing in Advanced Healthcare Materials, a team of MIT researchers engineered a therapeutic cancer vaccine capable of restoring STING signaling and eliminating the majority of tumors in mouse models of colon cancer and melanoma, with minimal side effects. The vaccine also inhibited metastasis in a breast cancer mouse model and prevented the recurrence of tumors in cured mice. 

More research is needed to spread the benefits of electric vehicles equitably

Researchers should focus on equity issues surrounding the spread of electrical vehicles, according to a study by Penn State researchers
Photo Credit: Michael Fousert

Electric vehicles, or EVs, promise to reduce carbon emissions and serve as a tool to help mitigate climate change, but a team of Penn State researchers report there has been little research to determine how equitable the benefits of EVs are and, in fact, whether the technology may unfairly harm some areas and populations.

In a study, the researchers only found 48 papers out of a pool of 9,838 studies that explicitly addressed equity issues of EVs, said Wei Peng, assistant professor of international affairs and civil and environmental engineering, Peng added that the small percentage of papers that addressed equity was telling in itself.

“During that screening process, we began to learn what is over-studied and what is understudied,” said Peng, who is also an associate of the Institute for Computational and Data Sciences. “We highlighted in our paper what we saw as the most understudied: making equity more explicit as research and, second, we saw a need to focus on those emerging markets and parts of the developing world where EVs are going to be more important.”

Unlike vehicles powered by gasoline or diesel fuel, which produce carbon and other chemicals during the combustion process, the electric motors that drive the wheels of an EV do not produce tailpipe emissions. EV owners charge the batteries that are stored on board the EV, rather than add fuel.

New Sensors with the HOTS for Extreme Missions

High Operational Temperature Sensors (HOTS)
Graphic Credit: Defense Advanced Research Projects Agency

Modern technologies are laden with sensors – a now-customary fact of life in much of the world. On smart watches and phones, and in cars and homes, sensors help monitor health, adjust various settings for comfort, and warn of potential dangers. More widely, sensors are deployed across countless commercial and defense systems, including in the oil and gas sector, the automotive industry, alternative energy sources, geothermal applications, and aviation and aerospace.

In these broader industrial contexts, the capabilities of sensors can be inhibited by thermal limitations. A sensor may theoretically be able to process inputs such as speed, pressure, or the integrity of a mechanical component, but inside a turbine engine, temperatures far exceed what any existing sensor can withstand.

DARPA’s new High Operational Temperature Sensors (HOTS) program will work toward developing microelectronic sensor technologies capable of high-bandwidth, high-dynamic-range sensing at extreme temperatures.

Study reveals set of brain regions that control complex sequences of movement

The findings in mice have the potential to advance treatment of some brain injuries and illnesses
Photo Credit: Kanashi

In a novel set of experiments with mice trained to do a sequence of movements and "change course" at the spur of the moment, Johns Hopkins scientists report they have identified areas of the animals' brains that interact to control the ability to perform complex, sequential movements, as well as to help the mice rebound when their movements are interrupted without warning.

The research, they say, could one day help scientists find ways to target those regions in people and restore motor function caused by injury or illness.

Based on brain activity measurements of the specially trained rodents, the investigators found that three main areas of the cortex have distinct roles in how the mice navigate through a sequence of movements: the premotor, primary motor, and primary somatosensory areas. All are on the top layers of the mammals' brains and arranged in a fundamentally similar fashion in people.

The team concluded that the primary motor and primary somatosensory areas are involved in controlling the immediate movements of the mice in real time, while the premotor area appears to control an entire planned sequence of movements, as well as how the mice react and adjust when the sequence is unexpectedly disrupted.

Scientists Discover Fire Records Embedded Within Sand Dunes

An illustration showing how charcoal layers accumulate in dune foot-slope deposits.
Full size image
Image Credit: Nicholas Patton / Desert Research Institute

Knowing how the frequency and intensity of wildfires has changed over time offers scientists a glimpse into Earth’s past landscapes, as well as an understanding of future climate change impacts. To reconstruct fire records, researchers rely heavily on sediment records from lake beds, but this means that fire histories from arid regions are often overlooked. Now, a new study shows that sand dunes can serve as repositories of fire history and aid in expanding scientific understanding of fire regimes around the world.

Published May 11 in Quaternary Research, the study is the first to examine sedimentary records preserved in foot-slope deposits of sand dunes. The research team, led by Nicholas Patton, Ph.D., a postdoctoral researcher now at DRI, studied four sand dunes at the Cooloola Sand Mass in Australia. Australia is one of the world’s most fire-prone landscapes, with a long history of both natural and cultural burning, and vast expanses without lakes or ponds to gather sedimentary records from. The researchers aimed to prove that these sand dune deposits could be used to reconstruct reliable, multi-millennial fire histories. These previously unrecognized archives could potentially be used in arid regions around the world to fill knowledge gaps in places where fire shapes the landscape.

New therapy helps immune system eradicate brain tumors

Professor Anna Dimberg.
Photo Credit: Mikael Wallerstedt

Researchers from Uppsala University have developed a method that helps immune cells exit from blood vessels into the tumor and kill cancer cells. The aim is to improve the treatment of aggressive brain tumors. The study has been published in the journal Cancer Cell.

Glioblastoma is an aggressive brain tumor that lacks efficient treatment. This is in part due to the ability of the tumor to suppress or evade the body´s natural anti-cancer immune response. Immunotherapy, using checkpoint inhibitors, aims to reactivate our immune system against cancer. However, for this type of treatment to be effective, specific immune cells known as killer T cells are required to be present within the tumor.

Unfortunately, blood vessels in brain cancer are dysfunctional and act as a barrier, preventing killer T cells from reaching the tumor. As a result, this form of immunotherapy, which is effective against many forms of cancer, is ineffective against brain cancers.

Help the killer T cells

In the new study, the Uppsala researchers have developed a method to help the killer T cells reach the tumors and fight cancer cells. They used a viral vector that specifically infected the blood vessels in the brain and enabled them to produce a factor called LIGHT. This altered the function of the tumor vessels, increasing their ability to transport T cells from the blood into the tumor tissue.

Ultralow temperature terahertz microscope capabilities enable better quantum technology

Terahertz microscope with cryogenic insert.
Image Credit: Courtesy of Ames National Laboratory

A team of scientists from the Department of Energy’s Ames National Laboratory have developed a way to collect terahertz imaging data on materials under extreme magnetic and cryogenic conditions. They accomplished their work with a new scanning probe microscope. 

This microscope was recently developed at Ames Lab. The team used the ultralow temperature terahertz microscope to take measurements on superconductors and topological semimetals. These materials were exposed to high magnetic fields and temperatures below liquid helium (below 4.2 Kelvins or -452 degrees Fahrenheit).

According to Jigang Wang, a scientist at Ames Lab, professor of Physics and Astronomy at Iowa State University, and the team leader, the team has been improving their terahertz microscope since it was first completed in 2019. “We have improved the resolution in terms of the space, time and energy,” said Wang. “We have also simultaneously improved operation to very low temperatures and high magnetic fields.”