Special probes improve ultrasound imaging in obese patients

Edited image from the publication: scan of the liver of an obese patient. The image quality of the standard ultrasound probe (left) is significantly poorer than that of the high-performance probes (center and left).
Image Credit: Heintz et.al. 2023, Scientific Reports

Ultrasound is used to diagnose many diseases in the abdominal cavity. A new study conducted at the University of Leipzig Medical Center and supported by the Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG) shows that obesity affects the quality of ultrasound scans of the liver and kidneys. It also shows that the use of high-performance ultrasound probes can improve the anatomical depiction in these patients. The findings have been published in the journal Scientific Reports.

Ultrasound of the abdominal organs is a central diagnostic tool and is recommended as the first-line approach for many medical conditions. Compared with other imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI), ultrasound is readily available, avoids unnecessary radiation exposure and can be used in almost every case. However, the accuracy of this method is usually limited in obese individuals because the imaging quality of anatomical structures is impaired. To date, the degree of obesity at which ultrasound diagnostics are no longer sufficiently precise has not been sufficiently researched.

Study indicates majority of endangered greater glider habitat in QLD unprotected

Greater Glider (Petauroides volans) in a Eucalypt taken by Sam Horton in South East Queensland for the Wildlife Queensland and the Glider Network
Photo Credit: Samrhorton
(CC BY-SA 4.0 DEED)

Researchers at Griffith University have discovered that the majority of critical habitat and movement pathways for southern greater gliders in Queensland lie outside of protected areas.

Dr Patrick Norman and Professor Brendan Mackey used cutting-edge technology to map mature forests to identify potential habitat and corridors that were essential for the survival of the endangered species. It is only these 200+-year-old forests in which tree hollows large enough to support the cat-sized gliders occurred.

Worryingly, the researchers discovered that most of the important remaining glider habitat in the state occurred within privately owned, lease owned land and state forest, leaving it vulnerable to logging, clearing and other threats.

The emotional function of dreams is not the same everywhere

The study by the UNIGE and the University of Toronto shows that there is a strong link between our socio-cultural life and the function of dreams.
Photo Credit: Maeghan Smulders

Why do we dream? A product of our brain’s neurophysiology, dreaming is a complex experience that can take on many emotional tones and simulate reality to varying degrees. As a result, there is still no clear answer to this question. A study led by the universities of Geneva (UNIGE) and Toronto, and the Geneva University Hospitals (HUG), compared the dreams of two forager communities, in Tanzania and the Democratic Republic of Congo, with those of individuals living in Europe and North America. It showed that the first two groups produced more threatening, but also more cathartic and socially-oriented dreams than the Western groups. These results, to be read in Scientific Reports, show how strong the links are between the socio-cultural environment and the function of dreams.

Dreaming is a hallucinatory experience common to all human beings. It occurs most often during the paradoxical phase of sleep, known as the Rapid Eye Movement (REM) phase. However, it can occur at any sleep stage. What are the physiological, emotional or cultural functions of dreams? Does it regulate our emotions? Does it prepare us to deal with a specific situation? Recent theories suggest that during a "functional" dream, the individual simulates more threatening and/or social situations, which would have an evolutionary advantage in promoting adapted behavior to real-life situations.

Photonic Crystals Bend Light as Though It Were Under the Influence of Gravity

The experimental set-up of beam trajectory in a DPC.
Photo Credit ©K. Kitamura et.al

A collaborative group of researchers has manipulated the behavior of light as if it were under the influence of gravity. The findings, which were published in the journal Physical Review A on September 28, 2023, have far-reaching implications for the world of optics and materials science, and bear significance for the development of 6G communications.

Albert Einstein's theory of relativity has long established that the trajectory of electromagnetic waves--including light and terahertz electromagnetic waves--can be deflected by gravitational fields.

Photonic Crystals Bend Light as Though It Were Under the Influence of Gravity--i.e., pseudogravity--is possible by deforming crystals in the lower normalized energy (or frequency) region.

"We set out to explore whether lattice distortion in photonic crystals can produce pseudogravity effects," said Professor Kyoko Kitamura from Tohoku University's Graduate School of Engineering.

Marine bacteria take a bite at plastic pollution

Plastic waste in the ocean is becoming a pressing issue.
Image Credit: rawpixel

A bacterium that can degrade the common polymer polybutylene succinate (PBS), which naturally biodegrades to only a limited extent in marine environments, could lead to improved ways to recycle this polymer. The bacterium’s potential, and its enzyme molecule that breaks down PBS, was discovered by researchers at Hokkaido University, working with colleagues at the Mitsubishi Chemical Group in Japan. The team published their results in the journal Environmental Microbiology.

PBS is generally regarded as an eco-friendly polymer due to its biodegradability when discarded on land and exposed to the atmosphere. This has led to its increasing use since the early 1990s in industrial plastics, including mulching films, compostable bags and catering packaging. But many discarded plastics eventually find their way into the sea, and unfortunately PBS does not biodegrade well in that environment.

“Plastic pollution in the ocean is a global problem and we need to tackle it by gaining new understanding of plastic behavior in that environment, and new technologies to deal with the pollution,” says Tomoo Sawabe, leader of the research team at Hokkaido University’s Faculty of Fisheries Sciences.

Sexism and poorer parenting: Auckland study suggests a link

Professor Nickola Overall (top left) with researchers Dr Annette Henderson, Dr Rachel Low, Dr Valerie Chang, Dr Caitlin McRae and Dr Nina Waddell.
Photo Credit: Courtesy of University of Auckland

Fathers and mothers who believe men should hold the power and authority in society and the family were less responsive to their children during family interactions, according to University of Auckland research.

The study was the first of its type.

“For decades, sexism has been known to predict negative behaviors toward women, from discrimination to violence,” says lead author Professor Nickola Overall, of Waipapa Taumata Rau, University of Auckland. “Our study suggests the effects flow through to poorer parenting.”

Video-recording family groups in the laboratory, researchers assessed parents’ responsiveness, including warmth, involvement, engagement, and sensitivity toward their children.

The less responsive parents – both mothers and fathers – had disclosed higher levels of “hostile sexism,” an academic term for attitudes favoring male authority and antagonism toward women who challenge men’s social power.

Extinct fish is alive and well

‘Extinct’ houting from the collection of the Natural History Museum London.
Photo Credit: Ymke Winkel

The houting, a fish species that lived in North Sea estuaries and is officially extinct, turns out to be alive and well. Researchers from the University of Amsterdam and the Natural History Museum London extracted DNA from multiple houtings conserved in the museum, up to 250+ years old. Next they compared the DNA of these museum fish with DNA from various currently occurring sibling species. The biologists found hardly any genetic difference between houting and a species called European whitefish. Since this species is still common, houting also isn’t extinct.

In a recent publication in the journal BMC Ecology and Evolution, the researchers describe how they isolated mitochondrial DNA from the fish. They even managed to obtain a small piece of DNA from a dried North Sea houting from 1754 that was used by Linnaeus for the official species description. Next, they used the DNA to create a phylogenetic tree, in which all examined houting (Coregonus oxyrinchus) ended up in the same group as the European whitefish (Coregonus lavaretus).

Thousands of programmable DNA-cutters found in algae, snails, and other organisms

Amoeba proteus with pseudopodia, cytoplasm often with truncated bipyramidal crystals
Image Credit: SmallRex
(CC BY-SA 4.0 DEED)

A diverse set of species, from snails to algae to amoebas, make programmable DNA-cutting enzymes called Fanzors — and a new study from scientists at MIT’s McGovern Institute for Brain Research has identified thousands of them. Fanzors are RNA-guided enzymes that can be programmed to cut DNA at specific sites, much like the bacterial enzymes that power the widely used gene-editing system known as CRISPR. The newly recognized diversity of natural Fanzor enzymes, reported in the journal Science Advances, gives scientists an extensive set of programmable enzymes that might be adapted into new tools for research or medicine.

“RNA-guided biology is what lets you make programmable tools that are really easy to use. So, the more we can find, the better,” says McGovern Fellow Omar Abudayyeh, who led the research with McGovern Fellow Jonathan Gootenberg.

CRISPR, an ancient bacterial defense system, has made it clear how useful RNA-guided enzymes can be when they are adapted for use in the lab. CRISPR-based genome editing tools developed by MIT professor and McGovern investigator Feng Zhang, Abudayyeh, Gootenberg, and others have changed the way scientists modify DNA, accelerating research and enabling the development of many experimental gene therapies.

Females less likely to heal from ACL injuries than males

An analysis of genes expressed by healing rabbit ligaments may lead to a better understanding of ACL injury prevention and treatment in humans, according to Penn State researchers.
Photo Credit: Nicolas Hoizey

Injuries of the anterior cruciate ligament (ACL), located in the knee, are typically thought to be caused by acute traumatic events, such as sudden twists. Led by Penn State researchers, new work analyzing an animal model of ACLs suggests that such injuries can also occur as a result of chronic overuse, specifically due to a reduced ability to repair microtraumas associated with overuse. Importantly, the team said, females also are less able to heal from these microtraumas than males, which may explain why females are two to eight times more likely to tear their ACL ligaments than males.

“ACL tears are one of the most common injuries, affecting more than 200,000 people in the U.S. each year, and women are known to be particularly susceptible,” said principal investigator Spencer Szczesny, associate professor of biomedical engineering and of orthopedics and rehabilitation at Penn State. “While recent research suggests that chronic overuse can lead to ACL injuries, until now, no one had investigated the differential biological response of female and male ACLs to applied force.”

A New Method for Assessing the Microbiome of the Human Gut

A technique called 'bead beating.'
Photo Credit: Courtesy of California Institute of Technology

The gut microbiome—the population and variety of bacteria within the intestine—is thought to influence a number of behavioral and disease traits in humans. Most obviously, it affects intestinal health. Cancer, inflammatory bowel disease, and celiac disease, for example, are all affected by the gut microbiome. But recent research at Caltech and other research centers has identified connections between the gut microbiome and diseases such as Parkinson's disease and multiple sclerosis as well as links between the gut microbiome and the presence of autistic behaviors, anxious behaviors, and a propensity to binge-eat sweets. (Most of this work has been done in the laboratory of Sarkis Mazmanian, Caltech's Luis B. and Nelly Soux Professor of Microbiology, who works mainly on mouse models.)

Looking directly at the human gut and the bacteria that make this space their home is often performed with sequencing—a process that analyzes the DNA sequences that make up each organism. However, this process is difficult in the intestine largely because the amount of microbial DNA in the gut is miniscule in comparison to the amount of host DNA. In intestinal tissue, roughly 99.99 percent of the DNA present is from the host organism; only 0.01 percent is microbial DNA.

However powerful the effects of these microbes, it is hard to understand their role without knowing their composition. Microbiome studies often rely on studies of feces and saliva, but these are quite different from the ecosystem of the gut itself.