Trees are in trouble

 The trees in this lush, temperate forest in the Cascade Range of Washington are likely less resistant to drought than their counterparts in drier regions to the south.
Photo Credit Joan Dudney

This holiday season brings surprising news about your Christmas tree. Scientists just discovered that globally, trees growing in wetter regions are more sensitive to drought. That means if your tree hails from a more humid clime, it’s likely been spoiled for generations.

Scientists have long debated whether arid conditions make trees more or less resilient to drought. It seems intuitive that trees living at their biological limits will be most vulnerable to climate change, since even just a little extra stress could tip them past the brink. On the other hand, these populations have adapted to a harsher setting, so they might be more capable of withstanding a drought.

According to a new study in the journal Science by researchers at UC Santa Barbara and UC Davis, greater water availability could “spoil” trees by reducing their adaptations to drought. “And that’s really critical to understand when we’re thinking about the global vulnerability of forest carbon stocks and forest health,” said ecologist Joan Dudney, an assistant professor at UCSB’s Bren School of Environmental Science & Management and in the Environmental Studies Program. “You don’t want to be a ‘spoiled’ tree when facing a major drought.”

Clues to preventing Alzheimer’s come from patient who, despite genetics, evaded disease

A woman who never developed Alzheimer's despite a strong genetic predisposition may hold the key to stopping the disease in its tracks. Studying the woman's unique complement of genetic mutations, researchers at Washington University School of Medicine in St. Louis have found clues that could help cut the link between the early, asymptomatic stage and the late stage, when cognitive decline sets in.
Image Credit: AartlistDesign

Alzheimer’s disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life. But one member of that family evaded what had seemed would be fate: Despite inheriting the genetic defect that caused her relatives to develop dementia in their 40s, she stayed cognitively healthy into her 70s.

Researchers at Washington University School of Medicine in St. Louis now think they know why. A previous study had reported that, unlike her relatives, the woman carried two copies of a rare variant of the APOE gene known as the Christchurch mutation. In this study, researchers used genetically modified mice to show that the Christchurch mutation severs the link between the early phase of Alzheimer’s disease, when a protein called amyloid beta builds up in the brain, and the late phase, when another protein called tau accumulates and cognitive decline sets in. So the woman stayed mentally sharp for decades, even as her brain filled with massive amounts of amyloid. The findings, published in the journal Cell, suggest a new approach to preventing Alzheimer’s dementia.

New treatment for deadly uterine cancer

left to right, Dr Asmerom Sengal, Professor Pamela Pollock.
Photo Credit: Courtesy of Queensland University of Technology

QUT scientists have discovered a promising new therapy for a deadly type of endometrial cancer that has a poor prognosis if the cancer spreads or returns after initial treatment, a plight that affects 15-20 per cent of endometrial cancer patients.

• Testing of new drug inhibited uterine tumor cell growth in lab and mice models

• The drug blocks the receptor of the growth factor in tumors that is associated with a low survival rate

• The inhibitor also reduced the tumors blood vessel formation

Dr Asmerom Sengal and Associate Professor Pamela Pollock from QUT’s School of Biomedical Sciences, published their research in Nature Precision Oncology with a recommendation that the strength of their findings indicated they should proceed to patient trials.

Dr Asmerom said endometrial cancer confined within the uterus could be cured with surgery however, if it had spread to the abdomen and other organs patients had limited treatment options.

“Previously, we found women with endometrial cancer who have an incorrect growth factor receptor called fibroblast growth factor receptor 2c (FGFR2c) on the tumor cell surface have a poor survival rate,” Dr Asmerom said.

Cutting-edge Biodiversity Models Will Help Assess Nature's Vital Contributions to People

Photo Credit: Pixabay

People depend on nature in a multitude of ways. Crop pollination, pest management, storm buffering, and carbon capturing are all part of nature's contributions to people (NCP). But these contributions are subject to change - species that make vital contributions may migrate or even go extinct due to climate change or habitat loss. Forecasting these changes is challenging, but also essential to ensure that humans are adequately prepared to respond.

Part of what makes this so challenging is that current NCP estimates typically rely on data incorporating the physical environment and omit information on species. Given that biodiversity is a cornerstone of NCP, many scientists recognize that biodiversity information can help us better assess the current and future state of NCP.

In a new opinion paper published in Trends in Ecology and Evolution, lead author Jamie M. Kass, associate professor and head of the Macroecology Lab at Tohoku University's Graduate School of Life Sciences, and an international team of colleagues argue that recent advances in biodiversity modeling and mapping have great potential for improving NCP estimates.

The 'one-pot' nanosheet method catalyzing a green energy revolution

Illustration Credit: Minoru Osada

A research group from the Institute for Future Materials and Systems at Nagoya University in Japan has developed a new “one-pot” method to make nanosheets using less rare metals. Their discovery should allow for the energy-making process to be more eco-friendly. The journal ACS Nano published the study.

Producing clean energy is important because it helps reduce global warming and contributes to building a carbon-neutral society. A potential source of clean energy uses hydrogen catalysts, such as palladium (Pd). Industries use Pd in electrolysis to separate water into hydrogen and oxygen. Afterward, the hydrogen in fuel cells is used to create electricity. The only byproduct is water. 

Pd is commonly used in a spherical ‘nanoparticle’ form for catalyst use. However, a flatter, thinner surface would use fewer precious metals and increase the available surface area for the reaction.

Minoru Osada at Nagoya University and his research group have developed a new way to make Pd nanosheets. They named it the "one-pot method" because it can be done in a single glass bottle. The resulting sheets were so thin (1~2 nm) that they can be compared to the size of a single molecule or DNA strand.

Women with PCOS can stress less about fertility

Photo Credit: Mart Production

Researchers from The University of Queensland have found that women with polycystic ovary syndrome (PCOS) respond well to fertility treatments and have the same birth rate as women without the condition.  

Dr Katrina Moss from UQ’s School of Public Health said the findings should offer some reassurance for women with PCOS who are concerned about their fertility.

“We studied 1109 women who were using fertility treatments and found no difference in births between the women with and without PCOS or between those on different treatment paths,” Dr Moss said.

“More women with PCOS used fertility treatment – 38 per cent compared to 13 per cent of women without PCOS, but the birth rate was equivalent, so women with PCOS were not disadvantaged.”

PCOS affects around 1 in 10 Australian women, causing irregular or absent ovulation making it difficult to fall pregnant.

Clinical practice guidelines recommend a stepped treatment for PCOS-related infertility – ovulation induction (OI) followed by intrauterine insemination (IUI) and finally, IVF.

Increased risk of heart rhythm disruption after COVID-19

Ioannis Katsoularis
Photo Credit: Klas Sjöberg

Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation. This is shown in a new study at Umeå University, Sweden, which is one of the largest studies of its kind in the world.

"The results underline the importance of both being vaccinated against COVID-19 and that the healthcare system identifies people at increased risk of this type of complications, so that the correct diagnosis is made and appropriate treatment is started in time," says Ioannis Katsoularis, first author of the study and cardiologist at University Hospital of Northern Sweden in Umeå.

The researchers were able to show that those who had been ill with COVID-19 could also suffer from heart rhythm disturbances, both in the form of so-called tachycardias, when the heart ha rate is high, and bradyarrhythmias, when the heart is slow so that a pacemaker is sometimes needed.  

The study shows that the risk of atrial fibrillation and flutter was increased up to two months after infection. In the first month, the risk was twelve times greater than for people who did not suffer from COVID-19infection.

Scientists Have Developed a Powder Model for 3D Printing Magnets

Nanocrystalline materials can serve as raw materials for 3D printing permanent magnets.
Photo Credit: Oksana Meleshchuk

Scientists of the Ural Federal University have described the processes of magnetization reversal of nanocrystalline alloys used as raw materials for 3D printing of magnetic systems. The description of the research and the results have been published in the Journal of Magnetism and Magnetic Materials. 

Permanent magnets are products made of hard magnetic materials capable of maintaining the state of magnetization for a long time. They are used as autonomous sources of magnetic field to convert mechanical energy into electrical energy and vice versa. Applications of permanent magnets include robotics, magnetic resonance imaging, production of wind generators, electric motors, mobile phones, high-quality speakers, home appliances, and hard disk drives.

The use of permanent magnets makes it possible to reduce the dimensions of some products and increase their efficiency. The development of power engineering and robotics, miniaturization of high-tech devices, and electric and hybrid vehicles require an annual increase in the production of permanent magnets and at the same time improvement of their magnetic properties. At the same time, one of the most important tasks in the production of permanent magnets is to increase their coercivity (the value of the external magnetic field strength required for complete demagnetization of a ferro- or ferrimagnetic substance).

Protein study could one day advance Parkinson’s, breast cancer care

Jonathan Pruneda, Ph.D., led a study to explore how a form of the common protein ubiquitin is modified during an infection with illness-causing bacteria. With further research, his study's findings could lead to improved care for Parkinson's disease and breast cancer.
Photo Credit: OHSU/Christine Torres Hicks

New research from Oregon Health & Science University could one day lead to therapies that prevent or treat diseases and infections tied to a protein that’s found in all human cells.

A study published today in the journal Molecular Cell describes how the protein ubiquitin is modified during a bacterial infection. The study details the steps taken to create a form of the protein known as lysine 6 polyubiquitin, where a long chain of ubiquitin molecules are linked through the amino acid lysine. This form of ubiquitin helps cells communicate by sending a molecular message — communication that remains poorly understood.

Previous research has indicated that this form of ubiquitin may be linked to the development of Parkinson’s disease and breast cancer. However, the details of how lysine 6 polyubiquitin is formed or how it is involved in disease aren’t yet clear.

To explore this, OHSU scientists turned their attention to illness-causing bacteria and how they manipulate lysine 6 polyubiquitin during infection. Researchers isolated enzymes used by E. coli and Salmonella to cause food poisoning and other illnesses, and observed how the enzymes interacted with ubiquitin.

Allured by Night Light

Skyglow — how bright the night sky is because of artificial light — is a top predictor of where large numbers of migrating birds are going to stop and rest during their migrations across the U.S.
Image Credit: Jeffrey C. Chase

Billions of migrating birds take flight across North America each fall and spring, heading south to their wintering grounds or north to their breeding grounds. 

Most of these birds are songbirds and they’re on the move at night. At times during their long migration, they need to stop, rest and refuel before they take off again. But instead of landing in their typical habitats such as forests or wetlands, artificial light is drawing them within and around cities. 

That’s a problem, said Jeff Buler, a University of Delaware professor of wildlife ecology, because light pollution can be an “ecological trap” for birds. 

“It lures them into cities where they’re at greater risk of colliding with buildings or mortality from other sources like feral cats,” Buler said. 

New research published in the journal Nature Communications finds that skyglow — how bright the night sky is because of artificial light — is a top predictor of where large numbers of migrating birds are going to stop and rest during their migrations across the U.S.

The study, which uses bird stopover data from 2016 to 2020, is a collaboration between UD’s Buler and researchers at Colorado State University, the National Park Service, the Cornell Lab of Ornithology, Princeton University, University of Massachusetts Amherst and Michigan State University. The research was supported with funding from NASA and the National Science Foundation.