Case report shows promising results using transcranial magnetic stimulation for post-stroke ataxia

Image Credit: UCLA| Health et al. Cerebellum. October 21, 2023

In a new case report, researchers at UCLA Health describe promising results using repetitive transcranial magnetic stimulation (rTMS) in the management of post-stroke cerebellar ataxia, a debilitating condition marked by impaired coordination and balance.

Cerebellar ataxia describes a group of neurological disorders that affect coordination, balance, and control of muscle movements. It results from damage or dysfunction of the cerebellum, a part of the brain responsible for coordinating voluntary movements. Ataxia can manifest as unsteady walking, difficulties with fine motor skills, and problems with speech, among other symptoms. The severity of ataxia can vary from mild to severe, and treatments often aim to manage symptoms and improve a person's quality of life as treatment options are limited.

Writing in The Cerebellum, researchers led by Evan Hy Einstein, Department of Psychiatry & Biobehavioral Sciences at the UCLA David Geffen School of Medicine, report on the case of a 58-year-old male who had experienced a cerebellar hemorrhage approximately 12 years previously. Despite intensive rehabilitation, symptoms such as slow and unsteady gait, balance issues, and urinary incontinence persisted over the years. The patient sought consultation for potential rTMS treatment. His primary complaints focused on his slow and unsteady gait, along with challenges related to balance and stability. The decision was made to employ bilateral cerebellar rTMS, representing an innovative approach to address the condition.

How Huntington’s Disease Begins Before Symptoms Appear

A microglia cell (shown in green) and corticostriatal synapses (purple) from a patient with Huntington’s disease.
Image Credit: Dan Wilton

A new study led by researchers at Boston Children’s Hospital and Harvard Medical School reveals how the process of Huntington’s disease begins well before symptoms appear — and shows that in mice, the process can be blocked to prevent cognitive problems related to Huntington’s.

If the findings hold true in humans, they raise the possibility of intervening early in the disease in people who carry the Huntington’s gene mutation.

The work, published in Nature Medicine, also could shed light on other neurodegenerative disorders.

The team found in patient tissue samples and mouse models that two players in the immune system — complement proteins and microglia — are activated very early in Huntington’s, leading to loss of synapses in the brain before cognitive and motor symptoms emerge. The researchers revealed how and where the synapses are lost.

The findings corroborate a potential treatment that’s currently in clinical trials for the disease.

The study was led by senior author Beth Stevens, HMS associate professor of neurology at Boston Children’s, and first author Dan Wilton, HMS research fellow in neurology in the Stevens lab.

Cathode active materials for lithium-ion batteries could be produced at low temperatures

Reaction pathway of the hydroflux process to form layered lithium cobalt oxide (LiCoO2) at 300 °C.
Full Size Image
 Illustration Credit: Masaki Matsui

Lithium-ion batteries (LIB) are the most commonly used type of battery in consumer electronics and electric vehicles. Lithium cobalt oxide (LiCoO2) is the compound used for the cathode in LIB for handheld electronics. Traditionally, the synthesis of this compound requires temperatures over 800°C and takes 10 to 20 hours to complete.

A team of researchers at Hokkaido University and Kobe University, led by Professor Masaki Matsui at Hokkaido University’s Faculty of Science, have developed a new method to synthesize lithium cobalt oxide at temperatures as low as 300°C and durations as short as 30 minutes. Their findings were published in the journal Inorganic Chemistry.

“Lithium cobalt oxide can typically be synthesized in two forms,” Matsui explains. “One form is layered rocksalt structure, called the high-temperature phase, and the other form is spinel-framework structure, called the low-temperature phase. The layered LiCoO2 is used in Li-ion batteries.”

Scientists from UNSW Sydney reveal biases in the field of coral reef research

Photo Credit: Vincent Rivaud

Analysis of the literature revealed authors from countries with large coral reef systems, such as The Maldives, Papua New Guinea and Indonesia, are underrepresented. 

Coral reefs support approximately 25 per cent of marine species, and are essential to coastal economies, such as the fishing and tourism industries, to name a few. But coral reefs worldwide are at risk due to climate change and are on the brink of collapse. 

The global decline of coral reefs has encouraged extensive research. Now, scientists from UNSW Sydney have assessed the current landscape of coral health research to reveal biases in the field.  

The team discovered that most papers on coral reef research are published from within the US and Australia, while researchers from countries with large coral reefs, such as The Maldives and Papua New Guinea, are underrepresented. As these reefs are also on the brink of collapse, the UNSW research team emphasizes the importance of local experts to be included. 

They also identified key topic areas that are underrepresented within the existing literature, including coral bioerosion and the microbiome, both of which are important to paint a more complete picture of the state of our reefs.  

Preventing Airborne Infection without Impeding Communication with Ions and Electric Field

Figure 1.
Novel device for preventing airborne infection The design (a) and schematic (b) of the mechanism of the device for capturing infectious droplets and aerosols without hindering communication. The negatively charged ions attach to the droplets and the electric field guides them to the collecting electrode.
Illustration Credit: Courtesy of Tokyo Institute of Technology

A novel device developed by Tokyo Tech researchers in a new study utilizes ions and an electric field to effectively capture infectious droplets and aerosols, while letting light and sound pass through to allow communication. The innovation is significant in the wake of the COVID-19 pandemic, since it shows promise in preventing airborne infection while facilitating communication.

Airborne infections, such as H1N1 influenza, SARS, and COVID-19, are spread by aerosols and airborne droplets. While droplet/aerosol transmission can be prevented using acrylic partitions or, as with the COVID-19 pandemic, by imposing lockdowns in severe cases, these countermeasures can significantly impede communication. This, in turn, can lead to unintended consequences.

For instance, lockdown measures during the COVID-19 pandemic led to severe economic losses as well as a rise in cases of mental illness like depression and suicide around the world. Therefore, as we prepare for a potential future pandemic, it is necessary to develop more sustainable countermeasures that do not disrupt economic activities and daily face-to-face interactions.

To this end, a research team including Kaito Kanda, a graduate student at Tokyo Institute of Technology (Tokyo Tech) at the time of research, Assistant Professor Tetsuya Yamada, from the Institute of Innovative Research at Tokyo Tech, and Professor Takeo Fujiwara from Tokyo Medical and Dental University (TMDU) and Chiba University researchers, has now developed a device that successfully captures droplets and aerosols while allowing the transmission of light and sound for effective communication.

Small but mighty: the hidden power of broccoli sprouts

The study revealed that the total polysulfide content of broccoli sprouts was significantly higher than that of mature broccoli   
Photo Credit: Osaka Metropolitan University

Broccoli sprouts have been discovered to contain seven times more polysulfides than mature broccoli

Scientists investigated how germination impacts the polysulfide content and composition of broccoli sprouts

Remember when your parents used to say, “Eat your greens, they are good for you”? Well, they were really onto something. Several studies have shown that higher intakes of cruciferous vegetables like broccoli, one of the most widely consumed vegetables in the United States, are associated with reduced risks of diseases such as diabetes and cancer, thanks to their organosulfur compounds, such as glucosinolates and isothiocyanates that exhibit a broad spectrum of bioactivities including antioxidant activity. However, few studies have focused on the endogenous content of polysulfide in broccoli sprouts.

A research team led by Assistant Professor Shingo Kasamatsu and Professor Hideshi Ihara of the Graduate School of Science at Osaka Metropolitan University, investigated the amount of polysulfides in broccoli sprouts during the process of their germination and growth. Building upon their previous work, the research team demonstrated the abundance of polysulfide molecules in cruciferous vegetables.

Treating the inflamed intestinal wall locally

For their self-forming gel, the researchers chose a lipid that is well tolerated and safe for use in humans. It is a fluid material at room temperature and can be administered as an enema into the inflamed area of the colon. There, at body temperature, it forms a viscous and sticky gel and remains adherent for at least six hours, gradually releasing the active ingredient.
Illustration Credit: © University of Bern, Marianna Carone

Treatment of the chronic inflammatory bowel disease ulcerative colitis often produces unsatisfactory results. Researchers at the University of Bern have now developed a lipid gel that is administered directly to the inflamed part of the intestine, where it remains and releases its active substance evenly. This could result in a new, targeted therapy approach with fewer side effects.

For diseases that affect a specific organ or tissue, a drug is usually most effective and well-tolerated if it is administered exactly where it is supposed to work in the body. If it is swallowed or injected, it distributes throughout the body, thus increasing the risk of side effects.

Researchers from the Department of Chemistry, Biochemistry and Pharmaceutical Sciences and the Institute of Tissue Medicine and Pathology at the University of Bern, together with colleagues from the University Hospital Zurich, have developed a self-forming, viscous lipid gel to deliver anti-inflammatory drugs directly to the wall of the colon or rectum. Thanks to this innovation, patients with ulcerative colitis, a chronic inflammation of the terminal part of the intestine, could be helped in a more targeted way and with fewer side effects.

UrFU Scientists Registered a Meteorite Weighing Almost 300 Kilograms

Kapustin Yar meteorite
Photo Credit: Courtesy of Ural Federal University

Scientists from the Institute of Geology and Mineralogy of the Siberian Branch of the Russian Academy of Sciences and the Extra Terra Consortium laboratory of UrFU have registered a new meteorite (chondrite) in the Meteoritical Bulletin Database of the International Meteoritical Society. The chondrite was named "Kapustin Yar" (Capustin Yar). It was one of 29 L/LL6 class meteorites found on Earth and the heaviest of the group.

"The total weight of the meteorite is 276.5 kg. The main mass is still in Volgograd, fragments - in Novosibirsk and Moscow. The largest sample of meteorite measuring 48×60×50 cm has an angular and slightly rounded shape. Its surface is partially covered with fusion crust, which is also characteristic of smaller fragments. The name "Kapustin Yar" was given by the gunnery range of the same name in the Astrakhan region, because near the place of the meteorite fall and around this test site there are no residential settlements. So far, the Kapustin Yar chondrite is the third meteorite found in the Astrakhan region," says Viktor Sharygin, a senior researcher at the Extra Terra Consortium laboratory of UrFU.

Preventing collateral damage in cancer treatment

The Electronic Polymer Dosimeter for Radiotherapy, created by a team at Sandia National Laboratories.
 Photo Credit: Spencer Toy

Using a simple concept and a patented Sandia sensor that detects radioactive materials, a team at Sandia National Laboratories has developed a patch to stop damage to healthy tissue during proton radiotherapy, one of the best tools to target certain cancerous tumors.

“This is an important need, especially among pediatric patients,” said Patrick Doty, one of the creators of the patch. Proton radiation therapy is used to send a high dose of radiation into a specific area of the body to disrupt and destroy tumor cells, but the radiation also kills nearby healthy cells. The goal is to be as precise as possible when targeting the radiation, but human movement is an issue especially when dealing with children.

“If you breathe, you move. When your heart beats, you move. You can’t stop those types of motions. And kids are wiggly. You can’t keep them still for long,” Doty said. “Sometimes doctors must resort to general anesthesia and the treatments sometimes go day after day for six weeks. Imagine going to the hospital and having to be put under every day for weeks. That is not good for anyone, but it’s especially bad for kids.”

Researchers probe molten rock to crack Earth’s deepest secrets

Deep inside rocky planets like Earth, the behavior of iron can greatly affect the properties of molten rock materials: properties that influenced how Earth formed and evolved. Scientists used powerful lasers and ultrafast X-rays to recreate the extreme conditions in these molten rock materials, called silicate melts, and measure properties of iron. 
Illustration Credit: Greg Stewart/SLAC National Accelerator Laboratory

Deep inside rocky planets like Earth, the behavior of iron can greatly affect the properties of molten rock materials: properties that influenced how Earth formed and evolved. 

In fact, the evolution of our entire planet may be driven by the microscopic quantum state of these iron atoms. One special feature of iron is its “spin state,” which is a quantum property of the electrons in each iron atom that drives their magnetic behavior and reactivity in chemical reactions. Changes in the spin state can influence whether iron prefers to be in the molten rock or in solid form and how well the molten rock conducts electricity.

Until now, it’s been challenging to recreate the extreme conditions in these molten rock materials, called silicate melts, to measure the spin state of iron. Using powerful lasers and ultrafast X-rays, an international team of researchers at the Department of Energy’s SLAC National Accelerator Laboratory, Stanford University, Universite ́ Grenoble Alpes, Laboratoire pour l’Utilisation des Lasers Intenses (LULI), and Arizona State University overcame this challenge. They showed that at extremely high pressures and temperatures, the iron in silicate melts mostly has a low-spin state, meaning its electrons stay closer to the center and pair up in their energy levels, making the iron less magnetic and more stable.

Genomic Stability: A Double-Edged Sword for Sharks

The adult pair of epaulette sharks from the study.
Photo Credit: Frank J. Tulenko

Sharks have existed for millions of years, rarely develop cancer, and react sensitively to ecological changes. An international study led by Würzburg scientists shows that one explanation lies in the fish's genes.

Sharks have been populating the oceans for about 400 to 500 million years. While our planet and many of its inhabitants have undergone massive changes several times during this period, this basal group of vertebrates has remained somewhat constant. Their body shape and biology has hardly changed since then.

An international research team from Germany, Australia, Sweden, and the USA has now discovered the reason for this. They found that sharks have the lowest mutation rate between generations ever recorded in vertebrates.

The study was led and coordinated by the research group of Senior Professor Manfred Schartl at the Department of Developmental Biochemistry of the Julius-Maximilians-Universität Würzburg (JMU).

It has now been published in the journal Nature Communications.

Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery

John Heymach, M.D., Ph.D., chair of Thoracic/Head & Neck Medical Oncology at MD Anderson.
Photo Credit: Courtesy of University of Texas MD Anderson Cancer Center

A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to results of a Phase III trial reported by researchers at The University of Texas MD Anderson Cancer Center.

The findings, published today in the New England Journal of Medicine, were first presented at the American Association for Cancer Research (AACR) Annual Meeting 2023.

The AEGEAN trial evaluated durvalumab given perioperatively, meaning therapy is given both before and after surgery. Participants on the trial received either pre-surgical (neoadjuvant) durvalumab and platinum-based chemotherapy followed by post-surgical (adjuvant) durvalumab or neoadjuvant placebo and chemotherapy followed by adjuvant placebo.

AEGEAN was the first Phase III trial investigating perioperative immunotherapy in patients with resectable NSCLC to report positive outcomes, and these data add to the growing evidence supporting the benefits of both neoadjuvant and adjuvant immunotherapy for these patients

Research shows climate change boosts likelihood of toxin releases from algal blooms in American lakes

 

Blue-green algae scums washing up on shore of Milford Reservior, Kansas, in 2017.
Photo Credit: Ted Harris

A broad analysis of lake water quality across the United States reveals human-driven climate change is increasing risks of high toxin concentrations from algal blooms in U.S. lakes, posing increasing hazards to people and wild and domestic animals, including dogs.

The investigation, recently published as the cover story in Nature Water, relies on data from lake-water samples from 2,804 U.S. lakes collected between 2007 and 2017 by the Environmental Protection Agency.

The authors, including a researcher at the University of Kansas, use the EPA’s data to predict the likelihood that a toxin called microcystin, produced by some blue-green algal species, will spike above water quality thresholds in the years ahead. Microcystin can damage the liver in humans and can kill wild and domestic animals.

UConn Health Researchers Find that Youthful Proteins Help Nerves Regrow

Three sections of optic nerve were injured by crushing (the white diamond on the far left of each nerve marks the crush point.) The lower two nerves each express genes (Rpl7 or Rpl7a) newly identified by the Trakhtenberg lab as promoting nerve axon regeneration. The axons carry the bright green dye. The insets to the right show how much more axon regrowth is occurring in the nerves that express the regeneration genes, and how no regrowth happens in the normal control (top).
Image Credit: Courtesy of Trakhtenberg Lab/UConn Health

Damaged nerves of the brain, eye, and spinal cord cannot grow back. But specific gene therapies might be able to change this, leading to treatments for paralysis and other forms of nerve damage, UConn Health researchers report in the October issue of Experimental Neurology.

Axons are the long arms of nerve cells that reach from our extremities to our spinal cord, and from our eye to our brain. Injuries that smash or sever axons—and often the large bundles of axons that we commonly call nerves—can cause paralysis, blindness, lack of sexual function, or other devastating outcomes. Most of the time, these central nervous system axons don’t repair themselves, and we have no good treatments for this.

Axons fail to regenerate for several reasons. Some of them have to do with the environment the axon grows in, but another reason is that the ability to grow is lost as the nervous system matures during and after birth. The loss of key proteins prevents regrowth once an organism matures, reports a team of researchers at UConn School of Medicine.

BNP Peptide a Culprit in Eczema

Image Credit: Freepik

Researchers from North Carolina State University have pinpointed a particular peptide’s role in activating atopic dermatitis, or eczema. The work could lead to more effective treatments for the condition.

Atopic dermatitis (AD) is a skin condition characterized by itching, irritated and thickened skin at the site of the irritation. The brain natriuretic peptide (BNP) is a peptide, or short chain of amino acids, that is elevated in patients with AD.

“BNP is expressed in sensory neurons, the neurons responsible for conveying sensation to the brain via the spinal cord,” says Santosh Mishra, associate professor of molecular biomedical sciences at NC State and corresponding author of the work. “We know from previous work that BNP helps translate the sensation of itch from the skin to the brain. In this work we wanted to see if BNP was involved in activating AD.”

In a chemically induced mouse model of AD, the researchers saw that mice without BNP did not exhibit the thickened or irritated skin commonly associated with AD, and their itching was reduced compared with control mice who did have BNP.