When healing turns harmful: adrenal support cells tied to cancer origin

Image Credit: Scientific Frontline / AI generated

A new study from Karolinska Institutet, shows that support cells in the adrenal gland can regenerate hormone-producing tissue after birth. The same cells may also act as a starting point for adrenal tumors, offering new insights into cancer development and potential treatment strategies.

“We found that these glial-like cells not only help maintain healthy tissue but, in some paragangliomas, also carry the same tumor-initiating genetic event,” explains Susanne Schlisio, group leader at the Department of Oncology-Pathology and last author of the study. 

“In tumors with germline VHL mutations, subsets of these support cells showed loss of chromosome 3p, the ‘second hit’ leading to VHL inactivation. This suggests they may be the origin of certain tumors,” says Dr. Michael Mints, docent at the same department and co-corresponding author of the study.

In a surprising discovery, scientists find tiny loops in the genomes of dividing cells

MIT experiments have revealed the existence of “microcompartments,” shown in yellow, within the 3D structure of the genome. These compartments are formed by tiny loops that may play a role in gene regulation.
Illustration Credit: Ed Banigan, edited by MIT News
(CC BY-NC-ND 4.0)

Before cells can divide, they first need to replicate all of their chromosomes, so that each of the daughter cells can receive a full set of genetic material. Until now, scientists had believed that as division occurs, the genome loses the distinctive 3D internal structure that it typically forms.

Once division is complete, it was thought, the genome gradually regains that complex, globular structure, which plays an essential role in controlling which genes are turned on in a given cell.

However, a new study from MIT shows that in fact, this picture is not fully accurate. Using a higher-resolution genome mapping technique, the research team discovered that small 3D loops connecting regulatory elements and genes persist in the genome during cell division, or mitosis.

“This study really helps to clarify how we should think about mitosis. In the past, mitosis was thought of as a blank slate, with no transcription and no structure related to gene activity. And we now know that that’s not quite the case,” says Anders Sejr Hansen, an associate professor of biological engineering at MIT. “What we see is that there’s always structure. It never goes away.”

New study finds large fluctuations in sea level occurred throughout the last ice age, a significant shift in understanding of past climate

Photo Credit: Michael Chen

Large changes in global sea level, fueled by fluctuations in ice sheet growth and decay, occurred throughout the last ice age, rather than just toward the end of that period, a study published this week in the journal Science has found.

The findings represent a significant change in researchers’ understanding of how the Pleistocene – the geological period from about 2.6 million to 11,700 years ago and commonly known as the last ice age – developed, said Peter Clark Link is external, a paleoclimatologist at Oregon State University and the study’s lead author.

“This is a paradigm shift in our understanding of the history of the ice age,” said Clark, a university distinguished professor in OSU’s College of Earth, Ocean, and Atmospheric Sciences.

During the last ice age, Earth experienced cycles of dramatic shifts in global sea level caused by the formation and melting of large ice sheets over northern areas of North America and Eurasia. These changes are recorded in the shell remains of microscopic marine organisms called foraminifera, which are found in ocean sediment and collected by drilling cores, giving scientists an important record of past climate history.

Muscle wasting reversed in patients with rheumatoid arthritis

Photo Credit: Roger Vaughan

Patients with rheumatoid arthritis increased their leg muscle volume when treated with an anti-rheumatic drug, offering new hope for improved muscle health.

Publishing in the prestigious journal, The Lancet Rheumatology, the team from Newcastle University and The Newcastle upon Tyne Hospitals NHS Foundation Trust describe how 15 patients were given Tofacitinib, a Janus kinase (JAK) inhibitor used to treat RA, as part of an experimental medicine study. After 6 months their leg muscles increased in size, particularly in the thigh.  

Sarcopenia is a progressive, age-related musculoskeletal disease characterized by the loss of muscle mass, strength, and physical performance, increasing the risk of falls, fractures, physical disability, and mortality. Currently there are no medicines approved to reverse this muscle-wasting disease. It is commonly seen in patients with rheumatoid arthritis where chronic inflammation contributes to the loss of muscle mass and strength.

Hotter does mean wetter

How rising temperatures will affect rainfall in Japan.
Illustration Credit: KyotoU / Takemi lab

Around the world, we are already witnessing the detrimental effects of climate change, which we know will only become more severe. Extreme weather events such as heavy rainfall, tropical cyclones, and heat waves are projected to intensify, and this will negatively impact both human society and natural ecosystems.

Assessing how climate change affects extreme weather is important not only from a scientific point of view, but also from a practical perspective. It is critical that we start adapting to climate change and mitigating the effects of potential disasters.

This situation has motivated a team of researchers at Kyoto University to investigate how climate change -- in particular, rising temperatures -- affects precipitation in Japan. The team has focused on heavy rainfall patterns and what kind of atmospheric conditions influence their characteristics.

The Many FACES of Lipid Research

Subcellular lipid distributions (magenta) in mitochondria (green) revealed using FACES and super-resolution structure illuminated microscopy.
Image Credit: William Moore

Lipids are fatty molecules that play critical roles in cell function, including membrane structure, energy storage and nutrient absorption. Most lipids are made in a cell organelle called the endoplasmic reticulum, but specific lipid types are shuttled around to different parts of the cell depending on their purpose. Each organelle serves a specific role in a cell and has its own unique mixture of lipids called a lipidome.

Scientists have long wanted to get a closer look at the movement of lipids around a cell, but because organelles are so close together – often only tens of nanometers apart – it’s tough to visualize with traditional light microscopy, which only has resolutions up to 250 nanometers.

Now researchers at the University of California San Diego have unveiled a new technology with the power to see cells in unprecedented detail. The tool, called fluorogen-activating coincidence encounter sensing (FACES), was developed in Associate Professor of Biochemistry & Molecular Biophysics Itay Budin’s lab. This work appears in Nature Chemical Biology.

Helping farmers, boosting biofuels

Doug Collins and Teal Potter, co-authors on the new paper, stand in a field of triticale. The cover crop was grown to study its viability as a biofuel source.
Photo Credit: Chad Kruger/WSU

New research has found cover crops that are viable in Washington’s normal “off season” don’t hurt the soil and can be sold as a biofuel source.

After harvest, farmland often sits fallow and unused until growers seed in the next crop. Soil can erode, weeds can take root, and farmers don’t make any money during that time. Cover crops can eliminate or reduce some of those issues, but many farmers have concerns about their effects on soil quality, a reduced growing window for their primary crop, and the inability to sell the cover crop.

In a paper recently published in the journal Biomass and Bioenergy, a team led by Washington State University scientists looked at four cover crops grown for multiple years in western and central Washington fields. Two showed promising results.

“Molecular bodyguard” helps infections persist

Joram Waititu and Kemal Avican working together in the Avican Lab at the Department of Molecular Biology, Umeå University.
Photo Credit: Gabrielle Beans

Researchers at Umeå University have identified a key molecular player that helps bacteria survive the hostile environment inside the body. Their study reveals how the protein RfaH acts as a protective shield for bacterial genes — and points to new strategies for fighting persistent infections.

“The human body is a very stressful place for bacteria,” says Kemal Avican research group leader at Department of Molecular Biology and Icelab at Umeå University and leader of the study. “During infection, the immune system attacks, nutrients are scarce, and microbes are exposed to bile salts, acids and heat. We looked at how RfaH helps bacteria deal with that stress by turning on the right survival genes at the right time.”

Persistent bacterial infections pose a major challenge in medicine: bacteria can linger in the body long after acute symptoms fade, evading immune defenses and surviving antibiotic treatment. In diseases like tuberculosis, this leads to relapse and makes treatment difficult.

Combination of pre- and probiotics offers superior anti-inflammatory benefits compared with omega-3 or prebiotic alone

Photo Credit: Cosmin Ursea

A new study, led by experts at the University of Nottingham, has found that combining certain types of dietary supplements is more effective than single prebiotics or omega-3 in supporting immune and metabolic health, which could lower the risk of conditions linked to chronic inflammation.

The findings of the study, which are published in the Journal of Translational Medicine, show that a synbiotic - a combination of naturally fermented kefir and a diverse prebiotic fiber mix - produces the most powerful anti-inflammatory effects among the three common dietary supplements tested.

The kefir and prebiotic mix were provided by Chuckling Goat Ltd. It contains a mx of naturally occurring probiotic bacteria and yeasts, which form during the traditional fermentation of goat’s milk with live kefir grains. These grains are living cultures that house dozens of beneficial microbial species.

Why women's brains face higher risk: scientists pinpoint X-chromosome gene behind MS and Alzheimer's

Image Credit: Scientific Frontline / AI generated

New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain, offering insight into why women are disproportionately affected by conditions such as Alzheimer’s disease and multiple sclerosis as well as offering a potential target for intervention. 

The study published in the journal Science Translational Medicine, used a mouse model of multiple sclerosis to identify a gene on the X chromosome that drives inflammation in brain immune cells, known as microglia. Because females have two X chromosomes, as opposed to only one in males, they get a “double dose” of inflammation, which plays a major role in aging, Alzheimer’s disease and multiple sclerosis.  

When the gene, known as Kdm6a, and its associated protein were deactivated, the multiple sclerosis-like disease and neuropathology were both ameliorated with high significance in female mice.