How mosquito-borne viruses breach the brain’s defenses

Stem cell-derived blood-brain barrier cells.
Image Credit: Pablo Alvarez/Li Lab 

Mosquito-borne viruses can cause more than fevers and joint pain. In severe cases, they invade the brain, leading to seizures, encephalitis, lasting memory loss and sometimes death. But thanks to a new UCLA study, researchers have uncovered how some of these viruses breach the brain’s defenses — and point toward ways of keeping them out.

The research, published in Cell Reports, focuses on Sindbis virus, a relatively mild pathogen that scientists use as a safe stand-in for more dangerous mosquito-borne viruses such as chikungunya. 

Using a stem cell-based model of the human blood-brain barrier, developed with collaborators from Florida State University, the UCLA team compared two closely related Sindbis strains — one brain-invading and one not — and found that small changes in viral surface proteins called glycoproteins dictate whether the virus can cross.

The team discovered that the invasive strain grips just one or two specific proteins on blood-brain barrier cells, turning those proteins into doorways that let the virus inside. By contrast, the non-invasive strain spreads its efforts across many receptors and is far less successful.

Innovative transistors for quantum chips

Walter Weber, Masiar Sistani and Andreas Fuchsberger
Photo Credit: Technische Universität Wien

The smaller electronic components become, the more complex their manufacture becomes. This has been a major problem for the chip industry for years. At TU Wien, researchers have now succeeded for the first time in manufacturing a silicon-germanium (SiGe) transistor using an alternative approach that will not only enable smaller dimensions in the future, but will also be faster, require less energy and function at extremely low temperatures, which is important for quantum chips.

The key trick lies in the oxide layer that insulates the semiconductor: it is doped and produces a long-range effect that extends into the semiconductor. The technology was developed by TU Wien (Vienna), JKU Linz and Bergakademie Freiberg.

Scientists visualize atomic structures in moiré materials

On the left is an artistic depiction of a twisted double layer forming a moiré pattern created by overlapping 2D sheets; each layer’s structure is shown separately on the right.
Image Credit: Sumner Harris/ORNL, U.S. Dept. of Energy

Researchers with the Department of Energy’s Oak Ridge National Laboratory and the University of Tennessee, Knoxville, have created an innovative method to visualize and analyze atomic structures within specially designed, ultrathin bilayer 2D materials. When precisely aligned at an angle, these materials exhibit unique properties that could lead to advancements in quantum computing, superconductors and ultraefficient electronics.

These developments bolster U.S. leadership in materials innovation, energy technologies and secure communication, and they lay the groundwork for a future defined by leading-edge progress.

Solar fuel conundrum nears a solution

 

Transition-metal complexes are promising light harvesters. Petter Persson, Zehan Yao and Neus Allande Calvet are getting closer to a breakthrough
Photo Credit: Johan Joelsson

Solar energy stored in the form of fuel is something scientists hope could partially replace fossil fuels in the future. Researchers at Lund University in Sweden may have solved a long-standing problem that has hindered the development of sustainable solar fuels. If solar energy can be used more efficiently using iron-based systems, this could pave the way for cheaper solar fuels.

“We can now see previously hidden mechanisms that would allow iron-based molecules to transfer charge more efficiently to acceptor molecules. This could effectively remove one of the biggest obstacles to producing solar fuels using common metals,” says Petter Persson, a chemistry researcher at Lund University.

An intense search for new ways to produce environmentally friendly fuels is underway. These could help phase out the fossil fuels that currently dominate global energy. One promising strategy is to develop catalysts that utilize solar energy to produce fuels such as green hydrogen.

In recent years, significant progress has been made in this area, including the development of solar-powered catalysts based on iron and other common elements. Despite these achievements, the conversion of energy from solar to fuel has proved too inefficient in the iron-based systems.

Deaths Rose in Emergency Rooms After Hospitals Were Acquired by Private Equity

Researchers linked the increase in mortality to cuts in salary and staffing levels.
Photo Credit: Sungmin Cho

Patient death rates increased in the emergency departments of U.S. hospitals acquired by private equity firms compared to similar hospitals not acquired by private equity, according to a nationwide study of hundreds of hospitals conducted by researchers at Harvard Medical School, the University of Pittsburgh, and the University of Chicago.

The results, published Sept. 23 in Annals of Internal Medicine, offer more concrete evidence that this for-profit ownership model of health care has led to higher patient mortality.

The federally funded study also found that private equity hospitals experienced large cuts in staffing and salaries, which the researchers propose is the likely explanation for the increase in patient deaths.

“Staffing cuts are one of the common strategies used to generate financial returns for the firm and its investors,” said senior author Zirui Song, associate professor of health care policy in the Blavatnik Institute at HMS and HMS associate professor of medicine at Massachusetts General Hospital, who has published extensively on the implications of private equity in health care.

Koala stress linked to disease threat

Many koalas in the study were successfully treated for Chlamydia before being released back into the wild.
Photo Credit: Currumbin Wildlife Hospital

Researchers have revealed a clear relationship between stress and increased disease risk in koalas in South East Queensland and on the New South Wales North Coast.

A study led by Dr Michaela Blyton at The University of Queensland measured and tracked the level of koala retrovirus (KoRV) in groups of captive and wild koalas.

“We wanted to see what happened to their KoRV loads over time and how it related to chlamydial infection and levels of the stress hormones cortisol and corticosterone in their feces,” Dr Blyton said.

“Virus load likely weakens the immune system, so those with a higher KoRV load are more at risk of diseases such as Chlamydia which can cause blindness, infertility and death.

“Poor quality or disappearing habitat may increase stress and the koalas with higher average cortisol levels had higher average KoRV loads.

Wildfire Smoke May Lead to Thousands More U.S Deaths

Mammoth Mountain in California’s Sierra Nevada Range on September 8, 2025. The photo reveals significant haze and smog, much of that the result of continual wildfires in the state.
Photo Credit: Marshall Burke.

A study led by Stony Brook University faculty and published in Nature projects that smoke exposure from wildfires in the coming decades toward 2050 could result in tens of thousands of excess deaths in the United States.

This projection, by a national team of investigators led by Stony Brook’s Minghao Qiu, is based on research that assesses wildfire activity in an increasingly dry and warming climate.

Wildfires have significantly increased in recent years, often in the western U.S. but also in other regions. Warmer, drier conditions are increasing the scope, damage, and exposures to people from wildfires. The study details the use of historical data from wildfires and smoke pollution, along with statistical models and machine learning tools to estimate deaths caused by exposure to smoke particulates in climate change scenarios.

Deaths from wildfire smoke result from inhaling a complex mix of chemicals. Wildfires can expose large numbers of people to these toxic pollutants for days or weeks at a time, contributing to deaths up to three years after the initial exposure, according to the study.

Rivers in the Sky, Arctic Warming, and What this Means for the Greenland Ice Sheet

Photo Credit: Beau Mori

 “Atmospheric rivers” are large-scale extreme weather systems that are making headlines more frequently. When viewed in satellite images, they appear just as described – like rivers in the sky. Though they are often reported in places like California, these weather systems have the potential to bring high heat and dump disastrous amounts of precipitation on areas throughout the mid and high latitudes.

A team of researchers, including UConn Department of Earth Sciences associate professor Clay Tabor and Ph.D. student Joseph Schnaubelt, looked at how atmospheric rivers impacted the Greenland Ice Sheet in the past to get a better understanding of how these weather systems may enhance melting in the Arctic as the climate continues to warm. Their results are published in AGU Advances.

An important question that paleoclimate scientists like Schnaubelt and Tabor are trying to answer is how the Arctic will respond to climate change, and for this they focused deep into the past on a time called the Last Interglacial, between 130,000 and 115,000 years ago.

“Earth goes through glacial cycles, and the Last Interglacial was the last time the Arctic was warmer than present day,” says Schnaubelt. “We know that that’s the direction we’re headed toward, and we wanted to see how atmospheric rivers impacted the Greenland Ice Sheet.”

New Diagnostic Tool Developed at Dana-Farber Revolutionizes Acute Leukemia Diagnosis

Volker Hovestadt, PhD
Assistant Professor, Pediatrics, Harvard Medical School Independent Investigator/Assistant Professor, Department of Pediatric Oncology, Dana-Farber Cancer Institute
Photo Credit: Courtesy of Dana-Farber Cancer Institute

Researchers at Dana-Farber Cancer Institute have developed a groundbreaking diagnostic tool that could transform the way acute leukemia is identified and treated. The tool, called MARLIN (Methylation- and AI-guided Rapid Leukemia Subtype Inference), uses DNA methylation patterns and machine learning to classify acute leukemia with speed and accuracy. This tool has the potential to significantly improve patient care by allowing faster and more precise treatment decisions.

Acute leukemia is an aggressive blood cancer that requires accurate diagnosis to guide treatment. Current diagnostic methods, which rely on a combination of molecular and cytogenetic tests, often take days or even weeks to complete. MARLIN, however, can provide results in as little as two hours from the time of biopsy. By providing rapid and detailed insights into leukemia subtypes, MARLIN could enable clinicians to make treatment decisions sooner and with more complete information.

Turning Plastic Waste into Fuel

Ali Kamali, a doctoral candidate in chemical and biomolecular engineering, inspects a sample of liquid fuel created from plastics.
Photo Credit: Kathy F. Atkinson

Plastics are valued for their durability, but that quality also makes it difficult to break down. Tiny pieces of debris known as microplastics persist in soil, water and air and threaten ecosystems and human health. Traditional recycling reprocesses plastics to make new products, but each time this is done, the material becomes lower in quality due to contamination and degradation of the polymers in plastics. Moreover, recycling alone cannot keep pace with the growing volume of global plastic waste.

Now, a University of Delaware-led research team has developed a new type of catalyst that enhances conversion of plastic waste into liquid fuels more quickly and with fewer undesired byproducts than current methods. Published in the journal Chem Catalysis, the pilot-stage work helps pave the way toward energy-efficient methods for plastic upcycling, reducing plastic pollution and promoting sustainable fuel production.

“Instead of letting plastics pile up as waste, upcycling treats them like solid fuels that can be transformed into useful liquid fuels and chemicals, offering a faster, more efficient and environmentally friendly solution,” said senior author Dongxia Liu, the Robert K. Grasseli Professor of Chemical and Biomolecular Engineering at UD’s College of Engineering.

Mammograms may benefit women well into their 80s, UCLA study finds

UCLA Health radiologist Dr. Tiffany Chan reviews a mammogram.
Photo Credit: Milo Mitchell/UCLA Health

For many older women, the question of whether to continue breast cancer screening has been uncertain. While most guidelines recommend mammograms up to age 74, advice for women 75 and older has been less clear. Now, a new study from researchers at the UCLA Health Jonsson Comprehensive Cancer Center suggests that regular mammograms may still offer significant benefits for women in their 80s.

The study is published in the Annals of Surgical Oncology, found that women in their 80s who get regular mammograms are more likely to have breast cancer detected early, need less aggressive treatment and live longer.

“When cancer is found on screening, it is often early stage,” said Dr. Nimmi Kapoor, an associate professor of surgery at the David Geffen School of Medicine at UCLA and senior author of the study. “In postmenopausal women with the most common hormone-sensitive breast cancers, we can often omit sentinel lymph node biopsy, chemotherapy, and sometimes even radiation. Screening is especially important in this era of de-escalation because early detection allows us to safely reduce the intensity of treatment while still achieving excellent outcomes.”

Space-based nuclear detonation detection mission endures

Visual safety observers Debra Yzquierdo, left, and Naomi Baros watch the skies for aircraft atop an observation platform.
Photo Credit: Craig Fritz

Roughly 12,550 miles above Earth, a constellation of U.S. global positioning satellites orbits the planet. GPS satellites also carry a sophisticated system designed to detect above ground nuclear detonations anytime, anywhere.

The Global Burst Detection system, developed by Sandia and Los Alamos national laboratories, carries a suite of sensors and instruments capable of identifying signals from nuclear detonations and providing real-time information to the U.S. military and government.

The final system in the current block of eight systems launched into space in May 2025. Meanwhile, the next series, scheduled for initial deployment in 2027, already has several units completed and ready to be integrated with host satellites.

This mission has endured for more than 60 years at the Labs. Teams of engineers, scientists and technologists work a decade ahead to develop new complex technologies that can withstand the harsh space environment while countering evolving threats.

Hostile hoots make robins eat less at night

At night, the little robin is extra vigilant
Photo Credit: Johan Nilsson

The sound of tawny owls makes young European robins eat less during their southward migration. A new study from Lund University in Sweden shows how the threat from nocturnal predators affects the birds’ behaviour – and by extension their survival.

When young robins embark on their first southward migration in the autumn, they make regular stops along the way to rest and replenish their energy reserves. However, each stop entails a risk – predators may be lurking nearby. 

In an article in the Journal of Animal Ecology, a research team has established that migrating birds are not only aware of threats around them, but also adapt their behaviour based on which predator calls they hear.

Boreal plants spread into the arctic tundra

The Grövelsjö mountains in the northern corner of Dalarna are home to the largest colonisation of boreal species on the bare mountains.
Photo Credit: Tage Vowles

A new international study involving researchers from the University of Gothenburg shows that vegetation in the Arctic is changing rapidly as species from nearby forests spread into the tundra. This change is occurring in half of the 1,100 areas studied and is mainly driven by species that already exist in the transition zone between forest and tundra.

In an increasingly warmer world, the Arctic tundra is becoming more forestlike. This process, known as borealisation, is particularly widespread in Eurasia and in Arctic mountain regions, where the distance to the boreal (northern) forest is shorter. Many species of grasses and shrubs that can live in both the tundra and the forest are gaining ground in the tundra. This is shown by a new large-scale study of 1,100 sampling sites across the entire Arctic biome.

New type of time crystals discovered

Time crystal 
Correlations between quantum particles result in a rhythmic signal – without the need for an external beat to set the tempo.
Image Credit: © TU Wien

Nature has many rhythms: the seasons result from the Earth's movement around the sun; the ticking of a pendulum clock results from the oscillation of its pendulum. These phenomena can be understood with very simple equations.

However, regular rhythms can also arise in a completely different way – by themselves, without an external clock, through the complex interaction of many particles. Instead of uniform disorder, a fixed rhythm emerges – this is referred to as a ‘time crystal’. Calculations by TU Wien (Vienna) now show that such time crystals can also be generated in a completely different way than previously thought. The quantum physical correlations between the particles, which were previously thought to be harmful for the emergence of such phenomena, can actually stabilize time crystals. This is a surprising new insight into the quantum physics of many-particle systems.