Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome — a cell’s complete set of DNA — is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.
Researchers at Washington University School of Medicine in St. Louis has identified a previously unknown signaling pathway cells use to protect their DNA while it is being copied. The findings, published in the journal Molecular Cell, suggest that targeting this pathway potentially could boost the potency of cancer therapeutics.
“A cell that can’t protect its genome is going to die,” said senior author Zhongsheng You, a professor of cell biology and physiology. “This entire pathway we found exists to protect the genome so the cell can survive in the face of replication stress. By combining inhibitors of this pathway with chemotherapy drugs that target the DNA replication process, we potentially could make such drugs more effective.”