Scientists develop an efficient method of producing proteins from E. coli

Proteins are synthesized through two processes involving DNA: transcription, which converts DNA into mRNA; and translation, where ribosomes read the mRNA and sequentially link amino acids to form proteins. This image illustrates the translation process accelerated to produce proteins more efficiently.
 Image Credit: Teruyo Ojima-Kato

Proteins sourced from microorganisms are attracting attention for their potential in biomanufacturing a variety of products, including pharmaceuticals, industrial enzymes, and diagnostic antibodies. These proteins can also be used for converting resources into biofuels and bioplastics, which could serve as viable alternatives to petroleum-based fuels and products. Therefore, efficiently producing microbial proteins could make a significant contribution to sustainable manufacturing.

Producing proteins from Escherichia coli (E. coli) has become popular due to its cost-effectiveness and efficiency. However, yields of protein production in E. coli may be reduced depending on the specific gene sequence of the target protein.

How unlocking ‘sticky’ chemistry may lead to better, cleaner fuels

Chemistry powered by renewable electricity offers a promising route to produce sustainable fuels and chemicals.
Photo Credit: Chokniti Khongchum

In a new study, chemists have developed a novel framework for determining how effectively carbon monoxide sticks to the surface of a catalyst during conversion from carbon dioxide. 

This stickiness, known as carbon monoxide (CO) adsorption energy, is a property that can often decide the final product of a chemical reaction. Using a widely accessible advanced electroanalytical technique, researchers found that the strength of this energy actually relies on a mix of reaction factors, including the type of catalyst material, applied voltage, and the surface’s structure.

This is a major step for the field, as gaining a better understanding of how CO adsorption works in real-time can help scientists search for innovative ways to recycle its counterpart, carbon dioxide, into useful fuel products, like methanol and ethanol. By designing better catalysts, these new insights could be used to accelerate the development of cleaner technologies that support a more sustainable future, said Zhihao Cui, lead author of the study and a postdoctoral student in chemistry at The Ohio State University.

New observation method improves outlook for lithium metal battery

Stacey Bent (left), professor of chemical engineering and of energy science and engineering, Sanzeeda Baig Shuchi (right), chemical engineering PhD student, and Yi Cui (not pictured), professor of materials science and engineering and of energy science and engineering, led the research team that discovered a way to more accurately analyze key chemistries for rechargeable batteries and possibly many other chemistry applications.
Photo Credit: Bill Rivard

Stanford researchers developed a flash-freezing observation method that reveals battery chemistry without altering it, providing new insights to enhance lithium metal batteries.

In science and everyday life, the act of observing or measuring something sometimes changes the thing being observed or measured. You may have experienced this “observer effect” when you measured the pressure of a tire and some air escaped, changing the tire pressure. In investigations of materials involved in critical chemical reactions, scientists can hit the materials with an X-ray beam to reveal details about composition and activity, but that measurement can cause chemical reactions that change the materials. Such changes may have significantly hampered scientists learning how to improve – among many other things – rechargeable batteries.

To address this, Stanford University researchers have developed a new twist to an X-ray technique. They applied their new approach by observing key battery chemistries, and it left the observed battery materials unchanged and did not introduce additional chemical reactions. In doing so, they have advanced knowledge for developing rechargeable lithium metal batteries. This type of battery packs a lot of energy and can be recharged very quickly, but it short-circuits and fails after recharging a handful of times. The new study, published today in Nature, also could advance the understanding of other types of batteries and many materials unrelated to batteries.

Scientists discover clean and green way to recycle Teflon®

The Newcastle research team (L-R): Dr Matthew Hopkinson, Dr Roly Armstrong and Matthew Lowe.
Photo Credit: Courtesy of Newcastle University

New research demonstrates a simple, eco-friendly method to break down Teflon® – one of the world’s most durable plastics – into useful chemical building blocks.

Scientists from Newcastle University and the University of Birmingham have developed a clean and energy-efficient way to recycle Teflon® (PTFE), a material best known for its use in non-stick coatings and other applications that demand high chemical and thermal stability.

The researchers discovered that waste Teflon® can be broken down and repurposed using only sodium metal and mechanical energy – movement by shaking - at room temperature and without toxic solvents.

Publishing their findings today (22 October) in the Journal of the American Chemical Society (JACS), researchers reveal a low-energy, waste-free alternative to conventional fluorine recycling.

New AI Model for Drug Design Brings More Physics to Bear in Predictions

This illustration shows the mesh of anchoring points the team obtained by discretizing the manifold, an estimation of the distribution of atoms and the probable locations of electrons in the molecule. This is important because, as the authors note in the new paper, treating atoms as solid points "does not fully reflect the spatial extent that real atoms occupy in three-dimensional space."
Image Credit: Liu et al./PNAS

When machine learning is used to suggest new potential scientific insights or directions, algorithms sometimes offer solutions that are not physically sound. Take for example AlphaFold, the AI system that predicts the complex ways in which amino acid chains will fold into 3D protein structures. The system sometimes suggests "unphysical" folds—configurations that are implausible based on the laws of physics—especially when asked to predict the folds for chains that are significantly different from its training data. To limit this type of unphysical result in the realm of drug design, Anima Anandkumar, Bren Professor of Computing and Mathematical Sciences at Caltech, and her colleagues have introduced a new machine learning model called NucleusDiff, which incorporates a simple physical idea into its training, greatly improving the algorithm's performance.

Unmasking the Culprits of Battery Failure with a Graphene Mesosponge

Photo Credit: Roberto Sorin

To successfully meet the United Nations' Sustainable Development Goals (SDGs), we need significant breakthroughs in clean and efficient energy technologies. Central to this effort is the development of next-generation energy storage systems that can contribute towards our global goal of carbon neutrality. Among many possible candidates, high-energy-density batteries have drawn particular attention, as they are expected to power future electric vehicles, grid-scale renewable energy storage, and other sustainable applications.

Lithium-oxygen (Li-O2) batteries stand out due to their exceptionally high theoretical energy density, which far exceeds that of conventional lithium-ion batteries. Despite this potential, their practical application has been limited by poor cycle life and rapid degradation. Understanding the root causes of this instability is a critical step toward realizing a sustainable and innovative energy future.

Helping farmers, boosting biofuels

Doug Collins and Teal Potter, co-authors on the new paper, stand in a field of triticale. The cover crop was grown to study its viability as a biofuel source.
Photo Credit: Chad Kruger/WSU

New research has found cover crops that are viable in Washington’s normal “off season” don’t hurt the soil and can be sold as a biofuel source.

After harvest, farmland often sits fallow and unused until growers seed in the next crop. Soil can erode, weeds can take root, and farmers don’t make any money during that time. Cover crops can eliminate or reduce some of those issues, but many farmers have concerns about their effects on soil quality, a reduced growing window for their primary crop, and the inability to sell the cover crop.

In a paper recently published in the journal Biomass and Bioenergy, a team led by Washington State University scientists looked at four cover crops grown for multiple years in western and central Washington fields. Two showed promising results.

Binding power of trapped water demonstrated for the first time

Water molecules are a driving force in the formation of molecular bonds, such as in proteins.
Image Credit: INT, KIT

Water is everywhere – it covers most of the earth, circulates in the human body and can be found in even the smallest molecular niches. But what happens if water does not flow freely but is trapped in such structures? Researchers at the Karlsruhe Institute of Technology (KIT) and Constructor University in Bremen have proven for the first time that "locked" water can influence its environment and strengthen the bond between molecules. This finding could open new avenues for the development of drugs and materials.

Some of the water on Earth is found in tiny nooks and crannies – enclosed in molecular pockets, such as protein binding sites or synthetic receptors. Whether this water behaves neutrally in the presence of other molecules or influences their binding has so far been controversial. "Water molecules usually interact most strongly with each other. However, experimental data showed that water behaves unusually in such narrow pockets", says Dr. Frank Biedermann from KIT's Institute of Nanotechnology. "We have now been able to provide the theoretical basis for these observations and prove that the water in the molecular pockets is energetically tense."

Russian Physicists Found a Way to Speed Up the Process of Developing Solar Panels

According to Ivan Zhidkov, this method allows for the quick selection of only promising materials.
 Photo Credit: Rodion Narudinov

Physicists at Ural Federal University and their colleagues from the Institute of Problems of Chemical Physics of the Russian Academy of Science (IPCP RAS) have found a way to significantly reduce the thousands of hours required for developing perovskite solar panel technology. Scientists have proposed a method that allows us  to determine in a few hours whether solar panels will fail quickly or if the development is promising with a potentially long service life. The test results were published in the journal Physica B: Condensed Matter.

Perovskite films are promising energy converters for various photoelectronic devices, such as solar cells, LEDs, and photodetectors. They have excellent optoelectronic properties and can be grown relatively easily at a low production cost.

Extra Silver Atom Sparks Breakthrough in Photoluminescence of Silver Nanoclusters

Structural architectures of anion-templated (a) Ag78 and (b) Ag79 NCs. Hydrogen atoms are omitted for clarity.
Image Credit: ©Yuichi Negishi et al.

A team of researchers from Tohoku University, Tokyo University of Science, and the Institute for Molecular Science have uncovered how the precise addition of a single silver (Ag) atom can dramatically transform the light-emitting properties of high-nuclear Ag nanoclusters (NCs). The study reports a remarkable 77-fold increase in photoluminescence (PL) quantum yield (QY) at room temperature - a milestone that paves the way for practical applications in optoelectronics and sensing technologies. The findings were published in the Journal of the American Chemical Society.

Photoluminescence quantum yield is an important metric used to evaluate the efficiency of photoluminescence, which is how well a material can absorb energy and convert it into light. Improving PLQY positively impacts technology such as OLEDs in TV screens.

Microwaves for energy-efficient chemical reactions

Microwave reactions.
Ideally the microwave reactions can be driven by green energy, in which case the system could help reduce carbon dioxide by converting it into other useful chemicals.
Image Credit: ©2025 Kishimoto et al.
(CC BY-ND 4.0)

Some industrial processes used to create useful chemicals require heat, but heating methods are often inefficient, partly because they heat a greater volume of space than they really need to. Researchers including those from the University of Tokyo devised a way to limit heating to the specific areas required in such situations. Their technique uses microwaves, not unlike those used in home microwave ovens, to excite specific elements dispersed in the materials to be heated. Their system proved to be around 4.5 times more efficient than current methods.

While there’s more to climate change than power generation and carbon dioxide (CO2), reducing the need for the former and the output of the latter are critical matters that science and engineering strive to tackle. Under the broad banner of green transformation, Lecturer Fuminao Kishimoto from the Department of Chemical System Engineering at the University of Tokyo and his team explore ways to improve things like industrial processes. Their latest development could impact on some industries involved in chemical synthesis and may have some other positive offshoots. And their underlying idea is relatively straightforward.

Chemists create red fluorescent dyes that may enable clearer biomedical imaging

Caption:MIT chemists have created a fluorescent, boron-containing molecule that is stable when exposed to air and can emit light in the red and near-infrared range. The dye can be made into crystals (shown in these images), films, or powders. The images at top were taken in ambient light and the images at bottom in UV light.
Image Credit: Courtesy of the researchers
(CC BY-NC-ND 4.0)

MIT chemists have designed a new type of fluorescent molecule that they hope could be used for applications such as generating clearer images of tumors.

The new dye is based on a borenium ion — a positively charged form of boron that can emit light in the red to near-infrared range. Until recently, these ions have been too unstable to be used for imaging or other biomedical applications.

In a study appearing today in Nature Chemistry, the researchers showed that they could stabilize borenium ions by attaching them to a ligand. This approach allowed them to create borenium-containing films, powders, and crystals, all of which emit and absorb light in the red and near-infrared range.

That is important because near-IR light is easier to see when imaging structures deep within tissues, which could allow for clearer images of tumors and other structures in the body.

“One of the reasons why we focus on red to near-IR is because those types of dyes penetrate the body and tissue much better than light in the UV and visible range. Stability and brightness of those red dyes are the challenges that we tried to overcome in this study,” says Robert Gilliard, the Novartis Professor of Chemistry at MIT and the senior author of the study.

Rapid flash Joule heating technique unlocks efficient rare‑earth element recovery from electronic waste

The research team’s method uses flash Joule heating.
Photo Credit: Jeff Fitlow/Rice University.

A team of researchers including Rice University’s James Tour and Shichen Xu has developed an ultrafast, one-step method to recover rare earth elements (REEs) from discarded magnets using an innovative approach that offers significant environmental and economic benefits over traditional recycling methods. Their study was published in the Proceedings of the National Academy of Sciences Sept. 29, 2025.

Conventional rare earth recycling is energy-heavy and creates toxic waste. The research team’s method uses flash Joule heating (FJH), which rapidly raises material temperatures to thousands of degrees within milliseconds, and chlorine gas to extract REEs from magnet waste in seconds without needing water or acids. The breakthrough supports U.S. efforts to boost domestic mineral supplies.

“We’ve demonstrated that we can recover rare earth elements from electronic waste in seconds with minimal environmental footprint,” said Tour, the T.T. and W.F. Chao Professor of Chemistry, professor of materials science and nanoengineering and study corresponding author. “It’s the kind of leap forward we need to secure a resilient and circular supply chain.”

Layered Cobalt Catalyst Reimagines Pigment as a Pathway for Carbon Dioxide Recycling

Comparison of the structure and performance of the multilayer CoPc/KB core-shell hybrid in this work with previous single-layer molecular Pc-based catalysts for CO2-to-CO electroreduction.
Image Credit: ©Hiroshi Yabu et. al.

Researchers at the Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, have introduced a new approach for electrochemical carbon dioxide (CO₂) reduction. By designing multilayer cobalt phthalocyanine (CoPc)/carbon core-shell structures, the team has demonstrated a catalyst architecture that makes CO₂ conversion into carbon monoxide (CO) both stable and efficient.

The study combined large-scale data analysis and artificial intelligence (AI) to screen 220 molecular candidates. Cobalt phthalocyanine - widely known as a blue pigment - emerged as the most effective option for selective CO production. This discovery became the basis for constructing electrodes optimized for CO₂ utilization.

"We wanted to move beyond conventional thinking that isolated molecules perform best," said Hiroshi Yabu, a professor at the (WPI-AIMR) who led the research. "Instead, our results show that stacking these molecules in ordered layers produces a much stronger catalytic effect."

Solar fuel conundrum nears a solution

 

Transition-metal complexes are promising light harvesters. Petter Persson, Zehan Yao and Neus Allande Calvet are getting closer to a breakthrough
Photo Credit: Johan Joelsson

Solar energy stored in the form of fuel is something scientists hope could partially replace fossil fuels in the future. Researchers at Lund University in Sweden may have solved a long-standing problem that has hindered the development of sustainable solar fuels. If solar energy can be used more efficiently using iron-based systems, this could pave the way for cheaper solar fuels.

“We can now see previously hidden mechanisms that would allow iron-based molecules to transfer charge more efficiently to acceptor molecules. This could effectively remove one of the biggest obstacles to producing solar fuels using common metals,” says Petter Persson, a chemistry researcher at Lund University.

An intense search for new ways to produce environmentally friendly fuels is underway. These could help phase out the fossil fuels that currently dominate global energy. One promising strategy is to develop catalysts that utilize solar energy to produce fuels such as green hydrogen.

In recent years, significant progress has been made in this area, including the development of solar-powered catalysts based on iron and other common elements. Despite these achievements, the conversion of energy from solar to fuel has proved too inefficient in the iron-based systems.

Turning Plastic Waste into Fuel

Ali Kamali, a doctoral candidate in chemical and biomolecular engineering, inspects a sample of liquid fuel created from plastics.
Photo Credit: Kathy F. Atkinson

Plastics are valued for their durability, but that quality also makes it difficult to break down. Tiny pieces of debris known as microplastics persist in soil, water and air and threaten ecosystems and human health. Traditional recycling reprocesses plastics to make new products, but each time this is done, the material becomes lower in quality due to contamination and degradation of the polymers in plastics. Moreover, recycling alone cannot keep pace with the growing volume of global plastic waste.

Now, a University of Delaware-led research team has developed a new type of catalyst that enhances conversion of plastic waste into liquid fuels more quickly and with fewer undesired byproducts than current methods. Published in the journal Chem Catalysis, the pilot-stage work helps pave the way toward energy-efficient methods for plastic upcycling, reducing plastic pollution and promoting sustainable fuel production.

“Instead of letting plastics pile up as waste, upcycling treats them like solid fuels that can be transformed into useful liquid fuels and chemicals, offering a faster, more efficient and environmentally friendly solution,” said senior author Dongxia Liu, the Robert K. Grasseli Professor of Chemical and Biomolecular Engineering at UD’s College of Engineering.

Ice dissolves iron faster than liquid water

When ice freezes and thaws repeatedly, chemical reactions are fuelled that can have significant impact on ecosystems. The photo was taken in Stordalen, Abisko.
Photo Credit: Jean-François Boily

Ice can dissolve iron minerals more effectively than liquid water, according to a new study from Umeå University. The discovery could help explain why many Arctic rivers are now turning rusty orange as permafrost thaws in a warming climate.

The study, recently published in the scientific journal PNAS, shows that ice at minus ten degrees Celsius releases more iron from common minerals than liquid water at four degrees Celsius. This challenges the long-held belief that frozen environments slow down chemical reactions.

“It may sound counterintuitive, but ice is not a passive frozen block,” says Jean-François Boily, Professor at Umeå University and co-author of the study. “Freezing creates microscopic pockets of liquid water between ice crystals. These act like chemical reactors, where compounds become concentrated and extremely acidic. This means they can react with iron minerals even at temperatures as low as minus 30 degrees Celsius.”

Greener rocket fuels on the horizon

SpaceX Falcon Heavy Launch
Photo Credit: SpaceX

Studying safer, cheaper rocket and missile fuels that could reduce health and environmental risks is the focus of a new $800,000 grant awarded to the University of Hawaiʻi at Mānoa Department of Chemistry by the U.S. Air Force Office of Scientific Research. The project will be led by principal investigator Professor Rui Sun with co-principal investigator Professor Ralf I. Kaiser.

The grant falls under a broader push toward green chemistry—designing chemical products and processes that reduce or eliminate hazardous substances. Current propellants can be expensive and toxic, creating risks during manufacture, storage and transport. The research seeks to help lower costs for space exploration while reducing risks to workers and communities.

Rice scientists create tiny, water-based reactors for green chemistry

Researchers at Rice, including Ying Chen and Angel Martí, have developed a new method for performing chemical reactions using water instead of toxic solvents.
Photo Credit: Jeff Fitlow/Rice University.

Researchers at Rice University have developed a new method for performing chemical reactions using water instead of toxic solvents. The scientists created microscopic reactors capable of driving light-powered chemical processes by designing metal complex surfactants (MeCSs) that self-assemble into nanoscale spheres called micelles. This innovation could drastically reduce pollution in industries including pharmaceuticals and materials science, where harmful organic solvents are often necessary.

The new micellar technology represents a step forward in sustainable chemistry. These self-assembled micelles form in water, where their hydrophobic cores provide a unique environment for reactions, even with materials that are typically insoluble in water. The research team led by Angel Martí, professor and chair of chemistry at Rice, demonstrated that this system can efficiently perform photocatalytic reactions while eliminating the need for hazardous substances. The study was published in Chemical Science Feb. 10.

“Our findings show how powerful molecular design can be in tackling chemical sustainability challenges while maintaining high chemical performance,” Martí said. “We’ve created a tool that could transform how chemical reactions are performed, reducing environmental harm while increasing efficiency.”

UCLA researchers find high levels of the industrial chemical BTMPS in fentanyl

Image Credit: Colin Davis

A UCLA research team has found that drugs being sold as fentanyl contain high amounts of the industrial chemical bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate, or BTMPS. This new substance of concern emerged in the illicit drug supply nearly simultaneously in multiple U.S. locations from coast-to-coast.

From June through October 2024, the team quantitatively tested samples of drugs sold as fentanyl that had high levels of the chemical, which belongs to a class of compounds called hindered amine light stabilizers and has a variety of applications including as a sealant, adhesive, and additive to plastics. 

The paper is published in the peer-reviewed journal JAMA.

“The emergence of BTMPS is much more sudden than previous changes in the illicit drug supply, and the geographic range where it was detected nearly simultaneously suggests it may be added at a high level in the supply chain,” said study lead Chelsea Shover, an assistant professor-in-residence at the David Geffen School of Medicine at UCLA. “This is concerning because BTMPS is not approved for human consumption, and animal studies have shown serious health effects such as cardiotoxicity and ocular damage, and sudden death at certain doses.”