Why the "gut brain" plays a central role for allergies

This tissue section, taken from the intestine of a mouse unable to produce the neuropeptide VIP, clearly shows the striking frequency with which certain cell types occur on the intestine's surface. These include villous cells (red), mucus-producing goblet cells (yellow), Paneth cells (pink) and stem cells (green).
Image Credit: © Charité | Luisa Barleben

The intestinal nervous system, often referred to as the "gut brain", is essential in controlling digestion and maintaining the intestinal barrier. This protective layer, made up of the intestinal mucosa, immune cells and the microbiome, shields the body from the contents of the gut. Its effectiveness depends on the delicate balance among these components. If this balance is disrupted, inflammation, allergies, or chronic intestinal diseases can arise. The intestinal mucosa serves as the body’s primary defense against pathogens. While previous studies have shown that the intestinal nervous system is involved in immune responses in addition to digestion, its role in the development of intestinal epithelial cells has remained largely unclear until now. 

Ichthyology: In-Depth Description

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Ichthyology is the specialized branch of zoology devoted to the scientific study of fish, encompassing all three major groups: jawless fish (Agnatha), cartilaginous fish (Chondrichthyes), and bony fish (Osteichthyes). This discipline investigates the biology, morphology, taxonomy, evolution, and behavioral patterns of the most diverse group of vertebrates on Earth, ranging from microscopic species to massive biological entities like whale sharks.

Stroke scientists gather more evidence for presence of ‘gut-brain axis’

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Research on mice by scientists at The University of Manchester has shed new light on why the guts’ immune system changes after a stroke and how it might contribute to gastro-intestinal problems. 

Published in Brain, Behavior and Immunity, the study adds to the emerging idea of the “gut-brain axis” – in which scientists suggest allows communication between the two organs in both health and disease. 

The study casts more light on the biology of stroke, a life-threatening medical emergency that disrupts blood flow to parts of the brain often causing long-term effects to mobility and cognition. 

Stroke patients are also at risk of secondary bacterial infections and often exhibit gastrointestinal symptoms including difficulty swallowing and constipation. 

Genetics: In-Depth Description

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Genetics is the branch of biology concerned with the study of genes, genetic variation, and heredity in organisms. It seeks to understand the molecular mechanisms by which traits are passed from parents to offspring, how the genetic code directs biological functions, and how variations in this code drive evolution and disease. At its core, genetics is the study of biological information: how it is stored, copied, translated, and mutated.

Consciousness as the foundation – new theory of the nature of reality

Maria Strømme, Professor of Materials Science.
Inset Photo Credit: Courtesy of Uppsala University

Consciousness is fundamental; only thereafter do time, space and matter arise. This is the starting point for a new theoretical model of the nature of reality, presented by Maria Strømme, Professor of Materials Science at Uppsala University, in the scientific journal AIP Advances. The article has been selected as the best paper of the issue and featured on the cover. 

Strømme, who normally conducts research in nanotechnology, here takes a major leap from the smallest scales to the very largest – and proposes an entirely new theory of the origin of the universe. The article presents a framework in which consciousness is not viewed as a byproduct of brain activity, but as a fundamental field underlying everything we experience – matter, space, time, and life itself. 

Untreated sleep apnea raises risk of Parkinson’s

 A new study involving millions of electronic health records reveals that untreated obstructive sleep apnea raises the risk of Parkinson’s disease.
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New research reveals that people with untreated obstructive sleep apnea have a higher risk of developing Parkinson’s disease. However, they can significantly reduce the risk by improving the quality of their sleep by using continuous positive airway pressure, or CPAP.

The study, which published today in the journal JAMA Neurology, examined electronic health records covering more than 11 million U.S. military veterans who received care through the Department of Veterans Affairs between 1999 and 2022.

The research was led by Oregon Health & Science University and the Portland VA Health Care System.

Parkinson’s is a neurodegenerative condition that affects an estimated 1 million people nationwide, with the risk rising incrementally year by year for people over age 60.

Humpback Whales Are Making a Comeback – Here’s One Reason Why

Photo Credit: © Olga Filatova/SDU

When SDU whale researcher Olga Filatova set off on her first field trip in 2000, she spent five years looking for whales before she saw a humpback. 

“It was incredibly rare to spot one back then. Today, we see them almost every day when we’re in the field,” she says. “We don’t know exactly how many humpbacks there are now, but definitely many more than when I started.” 

A cautious estimate from the Endangered Species Coalition puts today’s population at around 80,000—up from just 10,000 at their lowest point. That makes humpbacks one of the great success stories of conservation. 

New clues to why some animals live longer

Sika Zheng
Photo Credit: Courtesy of University of California, Riverside

A collaborative study by scientists at the University of California, Riverside, and University of Southern California reports on how a process known as alternative splicing, often described as “editing” the genetic recipe, may help explain why some mammals live far longer than others.

Published in Nature Communications, the study, which compared alternative RNA processing in 26 mammal species with maximum lifespans ranging from 2.2 to 37 years (>16-fold differences), found that changes in how genes are spliced, more than just how active they are, play a key role in determining maximum lifespan.

Particle accelerator waste could help produce cancer-fighting materials

Photo Credit: Courtesy of University of York

Energy that would normally go to waste inside powerful particle accelerators could be used to create valuable medical isotopes, scientists have found. 

The next step is to explore how the method could be scaled up to deliver clinically use 

Researchers at the University of York have shown that intense radiation captured in particle accelerator “beam dumps” could be repurposed to produce materials used in cancer therapy.  

Scientists have now found a way to make those leftover photons do a second job, without affecting the main physics experiments. 

A beam of photons designed to investigate things like the matter that makes up our universe, could at the same time, be used to create useful medical isotopes in the diagnosis and treatment of cancer. 

Blood protein profiles can predict mortality

Photo Credit: Akram Huseyn

Elevated levels of five proteins in our blood can help predict risk of mortality, a new study from the University of Surrey finds. Scientists believe the proteins (PLAUR, SERPINA3, CRIM1, DDR1 and LTBP2), that play key roles in the development of diseases such as cancer and inflammation, may also contribute to the risk of dying. Findings could help clinicians identify individuals most at risk from mortality and lead to earlier medical interventions.   

The study also discovered 392 proteins associated with an increased risk of death within a 5-year timeframe and a further 377 proteins associated with dying within 10 years, even when adjusting for health and lifestyle factors, such as smoking or pre-existing disease diagnoses. Proteins perform a wide range of essential functions in the body and are vital for growth, development, and the structure of every cell.