It Doesn’t Matter Much Which Fiber You Choose – Just Get More Fiber!

There are lots of choices on the drug store shelves, but which fiber supplement is the right one for you? All of them help, say Duke researchers.
Credit: Duke photo

That huge array of dietary fiber supplements in the drugstore or grocery aisle can be overwhelming to a consumer. They make all sorts of health claims too, not being subject to FDA review and approval. So how do you know which supplement works and would be best for you?

A rigorous examination of the gut microbes of study participants who were fed three different kinds of supplements in different sequences concludes that people who had been eating the least amount of fiber before the study showed the greatest benefit from supplements, regardless of which ones they consumed.

“The people who responded the best had been eating the least fiber to start with,” said study leader Lawrence David, an associate professor of molecular genetics and microbiology at Duke University.

The benefit of dietary fiber isn’t just the easier pooping that advertisers tout. Fermentable fiber -- dietary carbohydrates that the human gut cannot process on its own but some bacteria can digest -- is also an essential source of nutrients that your gut microbes need to stay healthy.

“We’ve evolved to depend on nutrients that our microbiomes produce for us,” said Zack Holmes, former PhD student in the David lab and co-author on two new papers about fiber. “But with recent shifts in diet away from fiber-rich foods, we’ve stopped feeding our microbes what they need.”

New DNA repair-kit successfully fixes hereditary disease in patient-derived cells

Image of patient derived podocyte kidney cells repaired with novel baculovirus-vectored approach pioneered by the Berger team. Podocin (colored in green) is restored to the cell surface as in healthy podocytes.
Credit: Dr Francesco Aulicino, University of Bristol

Genetic mutations which cause a debilitating hereditary kidney disease affecting children and young adults have been fixed in patient-derived kidney cells using a potentially game-changing DNA repair kit. The advance, developed by University of Bristol scientists, is published in Nucleic Acids Research.

In this new study, the international team describe how they created a DNA repair vehicle to genetically fix faulty podocin, a common genetic cause of inheritable Steroid Resistant Nephrotic Syndrome (SRNS).

Podocin is a protein normally located on the surface of specialized kidney cells and essential for kidney function. Faulty podocin, however, remains stuck inside the cell and never makes it to the surface, terminally damaging the podocytes. Since the disease cannot be cured with medications, gene therapy which repairs the genetic mutations causing the faulty podocin offers hope for patients.

Typically, human viruses have been utilized in gene therapy applications to carry out genetic repairs. These are used as a ‘Trojan Horse’ to enter cells carrying the errors. Currently dominating systems include lentivirus (LV), adenovirus (AV) and adeno-associated virus (AAV), which are all relatively harmless viruses that readily infect humans. However, these viruses all share the same limitation in that they are restricted in space within their viral shells. This in turn constrains the amount of cargo they can deliver, namely the DNA kit required for efficient genetic repair, which significantly limits the scope of their application in gene therapy.

COVID vaccine patch fights variants better than needles

A vaccine patch
Credit: University of Queensland

A needle-free vaccine patch could better fight COVID-19 variants, such as Omicron and Delta, than a traditional needle vaccine according to a University of Queensland study in mice.

The research, conducted in partnership with Brisbane biotechnology company Vaxxas, tested the Hexapro SARS-CoV-2 spike vaccine using the Vaxxas high-density microarray patch (HD-MAP) technology, and the results found the patch was far more effective at neutralizing COVID-19 variants.

UQ’s Dr Christopher McMillan said the vaccine patch appeared to counteract new variants more effectively than the current SARs-CoV-2 vaccine delivered by injection.

“The high-density microarray patch is a vaccine delivery platform that precisely delivers the vaccine into the layers of the skin which are rich in immune cells,” Dr McMillan said.

"We found that vaccination via a patch was approximately 11 times more effective at combatting the Omicron variant when compared with the same vaccine administered via a needle."

He said the results extended further than just the Hexapro vaccine.

How elephants adapt to human development in cities versus farm life

Resized Image using AI by SFLORG
Source: Radboud University Nijmegen

The movement of elephants through wildlife corridors is directly impacted by differing forms of human pressures and development, new research by Elephants Without Borders (EWB) and Radboud University shows. Their study, published today in Frontiers in Conservation, is the first that takes an in-depth look at how varying land-use affects elephants and their use of wildlife corridors.

From 2012 to 2019, the researchers monitored elephants' movements through six wildlife corridors using of motion-detected camera traps in two different human-dominated landscapes: the townships of Kasane and Kazungula, and the farming villages of the Chobe Enclave, both located in the Chobe District.

The study shows that various land-use seemingly affects when elephants use wildlife corridors on an hourly basis. Elephants in agricultural areas largely moved through the corridors predominantly nocturnally, when humans are less active, compared to the urban corridors, where humans and elephants actively mostly overlap.

Carbon Removal Using ‘Blue Carbon’ Habitats “Uncertain and Unreliable”

Restoring coastal vegetation – so called ‘blue carbon’ habitats – may not be the nature-based climate solution it is claimed to be, according to a new study.

In their analysis researchers from the University of East Anglia (UEA), the French Centre National de la Recherche Scientifique (CNRS) and the OACIS initiative of the Prince Albert II of Monaco Foundation, challenge the widely held view that restoring areas such as mangroves, saltmarsh and seagrass can remove large amounts of carbon dioxide (CO2) from the atmosphere.

The findings of their review, published today in the journal Frontiers in Climate, identify seven reasons why carbon accounting for coastal ecosystems is not only extremely challenging but risky.

These include the high variability in carbon burial rates, vulnerability to future climate change, and fluxes of methane and nitrous oxide. The authors, who also looked at information on restoration costs, warn that extra measurements can reduce these risks, but would mean much higher costs.

However, they stress that blue carbon habitats should still be protected and, where possible, restored, as they have benefits for climate adaptation, coastal protection, food provision and biodiversity conservation.

Lead author Dr Phil Williamson, honorary reader in UEA’s School of Environmental Sciences, said: “We have looked into the processes involved in carbon removal and there are just too many uncertainties. The expected climate benefits from blue carbon ecosystem restoration may be achieved, yet it seems more likely they will fall seriously short.

New rabies vaccine candidate demonstrates promising immune response and safety

Artist's impression of the rabies virus
Source: University of Oxford

Researchers from the University of Oxford have today reported new findings from a Phase 1 clinical trial studying the immune response and safety of their newly-developed single shot rabies vaccine, ChAdOx2 RabG - with promising results identified.

The RAB001 trial was conducted at the University and is the first time the novel rabies vaccine has been used in human volunteers. The aim of the study was to look at safety and measure immune responses from the vaccine by analyzing levels of rabies neutralizing antibodies – a powerful marker of successful rabies vaccination.

In their findings (published in The Lancet Microbe), the researchers reported that 12 volunteers were recruited into the study in total, with three receiving a low dose, three receiving a medium dose and six receiving a high dose of ChAdOx2 RabG. Strong immune responses against rabies were generated by the vaccine, with all volunteers who received a medium or high dose developing levels of rabies neutralizing antibodies above the World Health Organization protective threshold (0.5 International Units / ml) within two months.

No serious adverse events or safety concerns were reported during the trial. Expected levels of common short-lived vaccine side effects such as soreness at the injection area or feverishness were observed in volunteers, mainly in the medium- and higher-dose groups.

Additionally, the researchers assessed longer term immune responses. Six of the seven middle- and high-dose recipients who returned for an additional follow-up one year after vaccination maintained neutralizing antibody levels above the protective threshold, demonstrating that the immune response from the vaccine persists over time.

Coming wave of opioid overdoses 'will be worse than ever been before'

Source/Credit: Northwestern University

Over the past 21 years of opioid overdose deaths—from prescription drugs to heroin to synthetic and semisynthetic opioids such as fentanyl—geography has played a role in where opioid-involved overdose deaths have occurred, reports a new Northwestern Medicine study.

"For the first time, there is a convergence and escalation of acceleration rates for every type of rural and urban county.”

Lori Post

Director of the Buehler Center for Health Policy and Economics, Northwestern University Feinberg School of Medicine

But the coming wave will not discriminate between rural and urban areas, the study findings suggest. Every type of county—from the most rural to the most urban—is predicted to see dramatic increases in deaths from opioid-involved overdoses. The reason opioid overdoses have reached historical highs comes from combining synthetic opioids with stimulants such as cocaine and methamphetamines, a lethal cocktail that is hard to reverse during an overdose, the study authors said.

“I'm sounding the alarm because, for the first time, there is a convergence and escalation of acceleration rates for every type of rural and urban county,” said corresponding author Lori Post, director of the Buehler Center for Health Policy and Economics at Northwestern University Feinberg School of Medicine. “Not only is the death rate from an opioid at an all-time high, but the acceleration of that death rate signals explosive exponential growth that is even larger than an already historic high.”

MIT engineers develop stickers that can see inside the body

Ultrasound imaging is a safe and noninvasive window into the body’s workings, providing clinicians with live images of a patient’s internal organs. To capture these images, trained technicians manipulate ultrasound wands and probes to direct sound waves into the body. These waves reflect back out to produce high-resolution images of a patient’s heart, lungs, and other deep organs.

Currently, ultrasound imaging requires bulky and specialized equipment available only in hospitals and doctor’s offices. But a new design by MIT engineers might make the technology as wearable and accessible as buying Band-Aids at the pharmacy.

In a paper appearing today in Science, the engineers present the design for a new ultrasound sticker — a stamp-sized device that sticks to skin and can provide continuous ultrasound imaging of internal organs for 48 hours.

The researchers applied the stickers to volunteers and showed the devices produced live, high-resolution images of major blood vessels and deeper organs such as the heart, lungs, and stomach. The stickers maintained a strong adhesion and captured changes in underlying organs as volunteers performed various activities, including sitting, standing, jogging, and biking.

The current design requires connecting the stickers to instruments that translate the reflected sound waves into images. The researchers point out that even in their current form, the stickers could have immediate applications: For instance, the devices could be applied to patients in the hospital, similar to heart-monitoring EKG stickers, and could continuously image internal organs without requiring a technician to hold a probe in place for long periods of time.

Boeing, U.S. Air Force Celebrate 50 Years of F-15 Innovation

F-15 Tower flyby
Credit: Boeing

On July 27, 1972, the Boeing [NYSE: BA] F-15 flew for the first time with Chief Test Pilot Irv Burrows at the controls. Fifty years later, the undefeated F-15 continues to evolve and add advanced capability to the U.S. Air Force fighter fleet.

“Boeing is proud of the F-15’s proven performance and of our shared legacy on this platform with the U.S. Air Force and operators around the world,” said Prat Kumar, vice president of F-15 Programs. “With its unrivaled combat performance, five decades-long production run and continuous evolution, the F-15 has a remarkable history and continues today to be a critical asset for U.S. and allied forces. And with the development of new, advanced capabilities and the evolution of the F-15EX, the best is yet to come.”

Boeing’s F-15 program was initiated at the request of the U.S. Air Force, which needed a fighter jet designed to maintain the country’s air superiority. Through its variants, the F-15 has also served that mission internationally with numerous global customers including Japan, Israel, Saudi Arabia, Singapore, South Korea and Qatar.

Creating an “Adult-like” Mature Human Cardiac Tissue

Heart muscle structure, computer illustration. Heart muscle is composed of spindle-shaped cells grouped in irregular bundles. Boundaries between individual cells are faintly visible here. Each cell contains one nucleus, visible as a dark stained spot. Cardiac muscle is a specialized muscle tissue that can contract regularly and continuously without tiring.

Researchers in the Biomedical Engineering Department at UConn have developed a new cardiac cell-derived platform that closely mimics the human heart, unlocking potential for more thorough preclinical drug development and testing, and model for cardiac diseases.

The research, published in Cell Reports by Assistant Professor Kshitiz in collaboration with Dr. Junaid Afzal in the cardiology department at the University of California San Francisco, presents a method that accelerates maturation of human cardiac cells towards a state suitable enough to be a surrogate for preclinical drug testing.

“There is a very strong need to create human cardiac constructs for all sorts of applications. Small animal models just do not recapitulate human heart biology, and human samples are scarce,” says Kshitiz. “This matters because all drugs need to be tested for their toxicity to heart. It is widely believed that a large number of them unnecessarily fail clinical trials because we do not have human samples to test them with.”

Kshitiz and Afzal first identified the need to create a mature human cardiac tissue during their time together at Johns Hopkins Medicine.