Bat urine reveals extended range for new Hendra virus variant

Source/Credit: Griffith University

Griffith University researchers have discovered a new Hendra virus variant that may pass to horses and humans much more widely across Australia than previously known.

Published in Emerging Infectious Disease, the variant was detected in the urine of black and grey-headed flying foxes across an extended geographical distribution from mid-north coast NSW to southeast Queensland.

The new Hendra virus variant (HeV-g2) was recently discovered in samples from a horse that died in 2015 with acute illness and was previously detected in flying fox organs.

“Detection of the novel Hendra variant in urine is important, as contact with infected flying fox urine is how horses can become infected,” said lead researcher Dr Alison Peel, from the Centre for Planetary Health and Food Security.

“Our study, by revealing associations with particular flying fox species, helps to identify the variant’s distribution in these animals and the risk of spill-over into horses and subsequently humans.

Dog coronavirus jumps to humans, with a protein shift

N-terminus: The end of a peptide or protein primary structure in which the amino acid residue is not part of a peptide bond. The terminal group is often (but not always) an amine or ammonium cation.

Cornell researchers have identified a shift that occurs in canine coronavirus that points to a possible pattern of change found in other coronaviruses and which may provide clues to how they transmit to humans from animals.

A new canine coronavirus was first identified in two Malaysian human patients who developed pneumonia in 2017-18. A group of other scientists isolated the canine coronavirus, sequenced it and published their findings in 2021.

Now, a team led by Cornell and Temple University researchers has identified a pattern that occurs in a terminus of the canine coronavirus spike protein – the area of the virus that facilitates entry into a host cell: The virus shifts from infecting both the intestines and respiratory system of the animal host to infecting only the respiratory system in a human host.

The researchers identified a change in the terminus – known as the N terminus – a region of the molecule with alterations also detected in another coronavirus, which jumped from bats to humans, where it causes a common cold.

Fermilab is home to a new baby bison!

This year, Fermilab is expecting up to 20 new calves.
Credit: Ryan Postel, Fermilab

World-class particle physics research isn’t the only thing Fermilab is known for. The iconic sight of the Midwestern bison graces the acres of prairie land surrounding the lab, beckoning visitors from across the country. On April 13, baby bison season officially began at the lab, a sure sign spring is truly on its way. The first calf of the year was born in the morning, and we’re pleased to announce that both mother and baby are doing well.

 Currently, the herd comprises 32 bison — 30 females and two bulls. The bulls are changed out periodically to maintain the herd’s health and genetic diversity.

This year, Fermilab is expecting up to 20 new calves. For a front-seat view of the bison, visit Fermilab’s new bison cam to glimpse the activities of the mighty herd.

Robert Wilson, Fermilab’s first director, established the bison herd in 1969 as a symbol of the history of the Midwestern prairie and the laboratory’s pioneering research at the cutting-edge of particle physics.

New study defines spread of SARS-CoV-2 in white-tailed deer

White-Tailed Deer
Credit: Heidi-Ann Fourkiller / SFLORG

North American white-tailed deer – shown in 2021 surveys of five states to have SARS-CoV-2 infection rates of up to 40% – shed and transmit the virus for up to five days once infected, according to a new study.

“It’s a relatively short window of time in which the infected animals are shedding and are able to transmit the virus,” said Dr. Diego Diel, associate professor in the Department of Population Medicine and Diagnostic Sciences and director of the Virology Laboratory at the College of Veterinary Medicine’s Animal Health Diagnostic Center. “However, the virus is very efficient at transmitting to white-tailed-deer entering contact with infected animals.”

The study, “From Deer-to-Deer: SARS-CoV-2 is Efficiently Transmitted and Presents Broad Tissue Tropism and Replication Sites in White-Tailed Deer,” which published online on March 21 in PLOS Pathogens, also identified that the virus develops and replicates in the deer’s respiratory tract, lymphoid tissues – including tonsils and several lymph nodes – and in central nervous system tissues.

“Virus replication in the upper respiratory tract – especially the nasal turbinates [nose structures] - is comparable with what is observed in humans and in other animals that are susceptible to the infection,” Diel said, “and I think that’s probably one of the reasons why the virus transmits so efficiently.” As with humans, the virus spreads between deer through nasal and oral secretions and aerosols.

Viagra promising as treatment for canine eating disorder

Cake, a beagle mix, who suffers from the eating disorder known as megaesophagus, sits in specialized chair known as a Bailey chair, at the WSU Veterinary Teaching Hospital. Bailey chairs allow dogs with megaesophagus to better digest their food.
Credit: Washington State University

Sildenafil, the generic version of the drug known as Viagra, could be the long-awaited remedy for a group of dogs with a rare disorder called megaesophagus.

The condition involves an enlargement of the esophagus and a loss of the organ’s ability to move food to the stomach, which leaves food bottling up in the lower esophagus. If left untreated, many animals regurgitate their food and aspirate food into their lungs, causing aspiration pneumonia.

“The literature tells us that many dogs with the disease die from aspiration pneumonia or are humanely euthanized due to poor quality of life within eight months of diagnosis,” said Dr. Jillian Haines, a veterinarian at Washington State University who co-led the study.

Liquid sildenafil was shown to relax the smooth muscle of the lower esophagus so it will open to let food pass to the stomach. Besides some rare gastrointestinal irritation, there are no side effects to dogs at the dose used in the study. While sildenafil is most known to treat erectile dysfunction, the drug is also used to treat elevated pulmonary blood pressure in dogs and humans.

Notches on lions’ teeth reveal poaching in Zambia’s conservation areas

UCLA biologist Paula White displays two leopard skulls.
Credit: Paula White

In a hunting camp in Zambia more than a decade ago, UCLA biologist Paula White puzzled over the heavy skull of a trophy-hunted lion. Zambia permits limited hunting in certain areas to help fund its national conservation program, and White had gained permission to examine the trophy skulls and hides to evaluate how hunting was affecting conservation efforts.

This particular skull had a pronounced horizontal V-shaped notch on one of the canine teeth — a marking White had never seen before from natural wear. Over the next few months, she began noticing similar notches on other lions’ teeth.

It wasn’t until three years later, when she visited lions bred in captivity and saw them gnawing on a wire fence, that it clicked: The tooth notches in wild lions resulted from the animals chewing their way out of wire snares — noose-like traps set by poachers. The sheer number of notched teeth she’d seen suggested that such traps, illegal in conservation areas, were injuring far more lions than experts had estimated.

“It was an odd mix of thrilling to figure out the cause of the notches and horrifying to realize that so many animals had been entangled in a snare at some point in their lives,” said White, director of the Zambia Lion Project and a senior research fellow with the Center for Tropical Research at UCLA’s Institute of the Environment and Sustainability.

Microbes help hibernating animals recycle nutrients, maintain muscle through winter

Like many hibernators, thirteen-lined ground squirrels retain muscle tone and healthy gut microbiomes through hibernation even though they aren’t eating or moving around. Their success at rest may help humans make long space voyages.
Credit: Rob Streiffer

To get through a long winter without food, hibernating animals — like the 13-lined ground squirrel — can slow their metabolism by as much as 99 percent, but they still need important nutrients like proteins to maintain muscles while they hibernate. A new study from the University of Wisconsin–Madison shows that hibernating ground squirrels get help from microbes in their guts.

The discovery could help people with muscle-wasting disorders and even astronauts on extended space voyages.

“The longer any animal doesn’t exercise, bones and muscles start to atrophy and lose mass and function,” says Hannah Carey, an emeritus professor in the UW–Madison School of Veterinary Medicine and co-author of the new study, published today (Jan. 27) in the journal Science. “Without any dietary protein coming in, hibernators need another way to get what their muscles need.”

One source of nitrogen, a vital building block for amino acids and proteins, accumulates in the bodies of all animals (including humans) as urea, a component of urine. The researchers knew that urea that moved into the squirrels’ digestive tract could be broken down by some gut microbes, which also need nitrogen for their own proteins. But the researchers wanted to see if some of that urea nitrogen freed up by the microbes was also being incorporated into the squirrels’ bodies.

Overweight dogs respond well to high-protein, high-fiber diet

Overfed dogs experience some of the same maladies associated with overweight and obesity in humans. A new study finds that overweight dogs also benefit from a high-protein, high-fiber weight loss regimen. 
Photo by www.pixel.la, CC0 1.0 Universal Public Domain Dedication

A study of overweight dogs fed a reduced calorie, high-protein, high-fiber diet for 24 weeks found that the dogs’ body composition and inflammatory markers changed over time in ways that parallel the positive changes seen in humans on similar diets. The dogs achieved a healthier weight without losing too much muscle mass, and their serum triglycerides, insulin and inflammatory markers all decreased with weight loss.

All such changes are beneficial, said University of Illinois Urbana-Champaign animal sciences professor Kelly Swanson, who led the new research.

Mange Outbreak Decimated a Wild Vicuña Population in Argentina

A family of vicuñas prepares to rest for the night in Argentina's San Guillermo National Park before the 2014 mange outbreak that wiped out the local population.
Credit: Hebe del Valle Ferreyra

Mange has decimated the population of wild vicuñas and guanacos in an Argentinian national park that was created to conserve them, according to a study from the Administration of National Parks in Argentina and the University of California, Davis.

The findings, published today in the journal PLOS ONE, suggest domestic llamas introduced to the site may have been the source of the outbreak. Cascading consequences for local predator and scavenger species are expected.

A lone vicuña stands amid the grasslands in Argentina’s
San Guillermo National Park following a mange epidemic.
Credit: Hebe del Valle Ferreyra

Vicuñas and guanacos are species of wild camelids native to Argentina, Chile, Bolivia, Ecuador and Peru, where the vicuña is the national animal.

The study investigated the impacts and origins of the outbreak, which began in 2014 in San Guillermo National Park.

Between 2013 and the onset of the study in 2017, populations of guanaco and vicuña were down 95% and 98%, respectively. Nearly three-quarters more were lost between 2017-18 alone. By 2019, researchers could no longer find either animal during the study surveys.

“This part of Argentina used to be the Serengeti of the wild camelids,” said corresponding author Marcela Uhart, who directs the Karen C. Drayer Wildlife Health Center’s Latin America Program, within the UC Davis School of Veterinary Medicine and its One Health Institute. “Now you go and it’s empty, and whoever is there is mangy. This disease is not novel. We know mange. It’s a common mite. But significant outbreaks are happening in several wildlife species around the world.”

Dog brains can distinguish between languages

Credit: Photo: Eniko Kubinyi

"Some years ago I moved from Mexico to Hungary to join the Neuroethology of Communication Lab at the Department of Ethology, Eötvös Loránd University for my postdoctoral research. My dog, Kun-kun, came with me. Before, I had only talked to him in Spanish. So I was wondering whether Kun-kun noticed that people in Budapest spoke a different language, Hungarian.” — says Laura V. Cuaya, first author of the study. “We know that people, even preverbal human infants, notice the difference. But maybe dogs do not bother. After all, we never draw our dogs' attention to how a specific language sounds. We designed a brain imaging study to find this out.

Kun-kun and 17 other dogs were trained to lay motionless in a brain scanner, where we played them speech excerpts of The Little Prince in Spanish and Hungarian. All dogs had heard only one of the two languages from their owners, so this way we could compare a highly familiar language to a completely unfamiliar one. We also played dogs scrambled versions of these excerpts, which sound completely unnatural, to test whether they detect the difference between speech and non-speech at all.”

When comparing brain responses to speech and non-speech, researchers found distinct activity patterns in dogs’ primary auditory cortex. This distinction was there independently from whether the stimuli originated from the familiar or the unfamiliar language. There was, however, no evidence that dog brains would have a neural preference for speech over non-speech.

"Dog brains, like human brains, can distinguish between speech and non-speech.

Robust approach needed to reduce risk of disease transmission between humans and wild animals

Credit: Pixabay

The threat of disease transmission from conservationists moving wild animals between habitats or back into the wild needs to be urgently assessed to minimize risk. Experts at the University of Birmingham are calling on local and national health authorities and wildlife managers to adopt a robust approach.

In a new paper, published in Frontiers in Veterinary Science, researchers in the University’s College of Life and Environmental Sciences, collaborating with Wildlife Impact and other sector partners, have highlighted the issues using the example of translocated orangutans in Indonesia.

All three species of orangutans in Indonesia are listed as Critically Endangered, and moving animals between habitats is a fairly common practice as demands for agriculture, mining, and other natural resource use puts pressure on the forests they inhabit. Interactions and conflict between humans and orangutans sharing the same habitats also contributes to the complex problems facing these rare species across their range.

During the covid 19 pandemic, the team identified instances of orangutans being released who had been in direct contact or proximity to humans without any protective equipment. In some cases, formerly captive orangutans were released after long periods of contact and potential exposure to human diseases.

The team’s results suggest that there is a potential problem of pathogen transmission between humans and animals which needs to be properly understood and managed.

Compounds from soybeans may improve animal health

The sprouting soybeans, in front, have been inoculated with a pathogen to trigger production of glyceollins, which have antimicrobial properties. Scaling up these lab experiments at the POET Bioproducts Institute may lead to soybeans that are rich in glyceollins being integrated into animal feed to help prevent disease and reduce the need for antibiotics.

Antimicrobial compounds that soybean plants produce when threatened by insects, diseases and even drought may help animals stay healthy, thereby reducing the need for antibiotics.

“When a soybean is attacked by a pathogen, the plant produces phytochemicals called glyceollins as a defense mechanism,” explained assistant professor Bishnu Karki of South Dakota State University’s Department of Biology and Microbiology. Her research group has identified pathogens and lab-scale processes to trigger production of glyceollins and begun assessing soybean varieties to see which produce higher levels of the antimicrobial compounds.

“Animals, such as pigs and poultry, already consume diets high in soybeans and could benefit from the phytochemical’s antimicrobial properties,” Karki said, pointing out scientists are studying the impact of glyceollins on human health, specifically in relation to cancer, inflammation and cardiovascular diseases.

Karki’s research is supported by U.S. Department of Agriculture Hatch Act funding through the South Dakota Agricultural Experiment Station. Two master’s students and several undergraduates have also worked on the project.

Common Household Noises May Be Stressing Your Dog

Researchers at the University of California, Davis, have found that people may not recognize that their dog is stressed when exposed to common household noises. While it’s well established that sudden loud noises, such as fireworks or thunderstorms, commonly trigger a dog’s anxiety, a new study finds even common noises, such as a vacuum or microwave, can be a trigger. The study was published in Frontiers in Veterinary Science.

The research found that high-frequency, intermittent noises such as the battery warning of a smoke detector are more likely to cause a dog anxiety, rather than low-frequency, continuous noise.

“We know that there are a lot of dogs that have noise sensitivities, but we underestimate their fearfulness to noise we consider normal because many dog owners can’t read body language,” said lead author Emma Grigg, a research associate and lecturer at the UC Davis School of Veterinary Medicine.

Signs of anxiety

Some common signs of a dog’s anxiety include cringing, trembling or retreating, but owners may be less able to identify signs of fear or anxiety when behaviors are more subtle. For example, stressed dogs could pant, lick their lips, turn their head away or even stiffen their body. Sometimes their ears will turn back, and their head will lower below their shoulders. Grigg suggests owners better educate themselves on anxiety-related behavior.

Researchers conducted a survey of 386 dog owners about their dogs’ responses to household sounds and examined recorded dog behaviors and human reactions from 62 videos available online. The study found that owners not only underestimated their dogs’ fearfulness, but the majority of people in videos responded with amusement rather than concern over their dog’s welfare.

Ways to make equestrian sport safer for horses and riders

Photo by Jean van der Meulen from Pexels

In the first study of horse falls for over 20 years, University of Bristol academics have identified some simple interventions to reduce the risk of injury in equestrian sport - making it safer for both horses and riders.

The study pinpointed characteristics associated with an increased risk of falls in eventing, such as higher-level events, longer courses, more starters at cross-country phase and less experienced horses and athletes.

Identifying these risk factors allows riders and event organizers to assess the level of risk for individual horse, rider and event combinations. The study, published in the Equine Veterinary Journal, recommends simple mitigations such as adjusting minimum eligibility requirements (MERs) to ensure horses and riders always compete at a level appropriate to their ability.

Led by Bristol Veterinary School’s Dr. Euan Bennet and Professor Tim Parkin, with Dr Heather Cameron-Whytock of Nottingham Trent University, and funded by Federation Equestre Internationale (FEI), it is the first large scale study using a global data set of every FEI eventing competition over an 11-year period.

The smarter the bird, the more mental stimulation it needs in captivity, a study has found

African grey parrot Photo by Magda Ehlers from Pexels

Researchers have discovered that intelligent birds have unique welfare needs in captivity.

These findings may apply to other brainy captive creatures including great apes, elephants and whales, said the head of the research group, Dr. Georgia Mason, Director of the University of Guelph’s Campbell Centre for the Study of Animal Welfare.

“This study provides the first empirical evidence that intelligent animals can struggle in captivity,” said Dr Mason, a professor in the Department of Integrative Biology. "Our findings could help pet owners identify which species may be more challenging to cater for as pets, because of their welfare requirements” added one of the lead authors, Dr Emma Mellor from the University of Bristol.

The study, also conducted by other researchers at University of Bristol and Utrecht University in the Netherlands, revealed for the first time that this issue can in particular hinder large-brained parrots’ in confinement.

Published recently in Proceedings of the Royal Society B, the study highlights cognitive stimulation and foods that require more complicated physical handling as ways to improve care of birds.

The researchers examined two main data sources. One was an early 1990s survey on captive breeding success involving more than 30,000 birds in the United States. The team also ran an online survey involving almost 1,400 pet parrots in 50 species for stereotypic behavior: repetitive abnormal activity such as biting at cage bars, chewing or even pulling out feathers, and swaying, bouncing or route pacing in cages.

Cartilage Resurfacing Implant Reduces Pain, Restores Hip Joint Function in Dogs

 

Chinni Credit: Heidi-Ann Fourkiller

A textile-based implant containing cartilage derived from stem cells reduced pain and restored hip joint function to baseline levels in a study of dogs with symptoms of moderate osteoarthritis. The study, led by researchers at North Carolina State University, Washington University in St. Louis and Cytex Therapeutics Inc., could be a significant first step toward preventative, less invasive joint resurfacing in dogs and humans.

In humans – and in dogs – a single, millimeter-thick layer of cartilage can mean the difference between an active lifestyle or painful osteoarthritis. That tiny cap of cartilage is what protects joint surfaces and allows the bones to glide over one another smoothly. Age or joint injury can cause the cartilage to degrade, leading to osteoarthritis and progressive joint pain.

“One of the holy grails of orthopedics is to replace cartilage, but there hasn’t been an effective way to do it,” says Duncan Lascelles, professor of surgery and translational pain research and management at NC State and co-corresponding author of the research. “Most of the focus is on replacing or restoring the cartilage surface with artificial materials, but regenerating cartilage isn’t possible right now. And many of the artificial products in use don’t integrate with the body.”

Farshid Guilak, the Mildred B. Simon Professor of Orthopedic Surgery at Washington University and Shriners Hospitals for Children, along with Bradley Estes and Frank Moutos, founded Cytex Therapeutics to develop an implant that could replace damaged or missing cartilage. The implant is made using a unique combination of manufacturing techniques that result in a part textile, part 3D-printed structure, which can be seeded with the patient’s own stem cells.

Koala killer being passed to joeys from mum

 

A deadly koala virus that can cause immune depletion and cancer, known as koala retrovirus, is being transferred to joeys from their mothers, according to University of Queensland scientists.

Associate Professor Keith Chappell, from UQ’s School of Chemistry and Molecular Biosciences, said the virus predisposes koala to chlamydia and other disease, and was having a large impact on wild koala populations across Queensland and New South Wales.

“Koala retrovirus – also known as KoRV – and associated diseases are another threat facing koalas, along with climate change and habitat loss.

“The virus causes immune depletion, likely making it much harder for koalas to cope with these other, already-detrimental environmental stressors.

“All northern koalas share a single highly conserved version of KoRV that is integrated into the koala genome, however until now, we weren’t certain how other disease-causing variants are spread.

“By sequencing variations of the virus DNA in 109 captive koalas, we finally revealed how the virus spreads – from mother to joey.

“It seems that transmission between mother and joey likely occurs due to close proximity, via a joey’s exposure to a mother’s potentially infectious fluids, like their milk.

“Mothers were sharing their virus variants three times more than fathers, suggesting this is the dominant pathway of spread for the virus.

“And, unlike other diseases affecting koalas like chlamydia, there’s no evidence of sexual transmission.”

The 109 koalas were housed in two sites in south-east Queensland, helping identify a total of 421 unique koala retrovirus sequences.

Collaborator and lead author, PhD candidate Briony Joyce said the research may lead to a re-think in how conservation plans are executed.

“This work will be highly informative for koala conservation, as it suggests that captive breeding programs focused on mothers that have a low amount of retrovirus variants, could result in healthier animals for release,” Ms Joyce said.

“Also, we propose that antiretroviral treatment – if shown to be safe in koala and effective against KoRV – could be used specifically in mothers during breeding seasons to prevent transmission.

“This work helps pave the way for evidence-based conservation, increasing koala resilience to help them cope with a changing and challenging environment.

“We must do everything we can to ensure the survival of this culturally important species.”

Source/Credit: University of Queensland

vet090721_01

From racehorse to therapy horse

 

Photo by Jennifer Murray from Pexels

A new study will examine the selection, training and welfare of thoroughbred horses as they transition from racetrack to therapy horse. The pioneering project, led by academics at the University of Bristol’s Veterinary School in collaboration with Racing to Relate, will develop a recognized global welfare standard for former racehorses who are moving into Equine Assisted Therapy (EAT).

Thoroughbreds are recognized for their sensitivity and this project will provide a research-based approach to retraining them for therapy work. EAT careers could include work with a diverse group of people, from veterans and disabled children to those struggling with mental health issues. The research, which is funded by the John Pearce Foundation, is the first of its kind to study EAT across many countries and will look at practices in the UK, USA, France and Ireland, to understand the impact of EAT on the horses.

Claire Neveux, Bristol Vet School PhD student for the project, said: "I have worked with thoroughbreds for about 20 years, mainly with broodmares and young horses, and I have always been amazed by their high reactivity and sensitivity. I'm also fascinated by the human-horse relationship. I had a few opportunities to participate in Equine Assisted Therapy programs as an intern during my graduate studies. That's why, when I met Jennifer Twomey from Racing to Relate, I took the opportunity to be part of this pioneering and collaborative project, and I'm thrilled to contribute to this research. I'm convinced that a better understanding of the thoroughbred personality traits and suitability of horses for EAT is essential for equine and human welfare."

The main aim of the research is to create a create a global standard for selection and training, to help the racing industry to improve welfare support for off-track racehorses going into a career in EAT. The research will help industry and stakeholders to improve Thoroughbred welfare through a successful transition to their new career in EAT.

Little research has been carried out on the welfare of horses within EAT programs, and especially on the impact it may have on their wellbeing. In particular, this research will analyze the educational process for all horses within the EAT sector, to gain a clearer picture of why and how horses are selected for particular roles. The aim is to fully understand the current selection and training methods within the sector and identify specific characteristics of the thoroughbred, which are suited to a career in EAT. The study will also explore details of the life and routine of equines within EAT, examining existing perceptions and considerations of horse welfare.

Dr Mathilde Valenchon, Research Fellow at the Bristol Vet School and co-supervisor of the PhD project, added: "I am delighted we successfully developed this research project to understand and facilitate the involvement of ex-racehorses in EAT activities. I have been studying equine behaviour, cognition and welfare for the past 12 years. I have always been impressed by the thoroughbred's sensitivity and adaptability. I am thrilled to contribute to a better knowledge of their suitability for EAT and the development of standards, as this will significantly and positively impact the horses' welfare, as well as people’s. I am especially proud that our research includes the horse's perspective."

Dr Siobhan Mullan, Senior Research Fellow at Bristol Vet School, and co-supervisor of the PhD project, said: "Thoroughbred horses involved in EAT programs are performing a really special and valuable role in society, and yet little formal research has been done to understand how to optimize their welfare throughout their transition from racehorse to therapy horse and in the course of their new career. I'm heartened by the interest around the world in using the results of our research to develop standards which will have a long-lasting impact on horse welfare."

Source/Credit: University of Bristol

vs090621_01