Stress levels sky high for families of neurodiverse kids

Almost 80 per cent of caregivers experienced poor wellbeing, high levels of stress and poor mental health
Photo Credit: Jordan Whitt

New Curtin University-led research has found caregivers of neurodivergent children are more likely to experience clinically significant levels of stress, poor mental health, financial hardship, and negative relationships.

The research, published in the Journal of Autism and Developmental Disorders, explored the health and wellbeing of caregivers of children living with neurological conditions such as autism spectrum disorder, attention deficit/ hyperactive disorder (ADHD), cerebral palsy, and learning disabilities, and whether current support services were sufficient to meet their needs.

Lead researcher Dr Ben Milbourn, from the Curtin School of Allied Health, said children diagnosed with neurodevelopmental conditions often require significant levels of support from their caregivers and meeting their emotional, physical, social and learning needs can be challenging.

NIH scientists discover a rare neurological disease involving cellular recycling

Image Credit: Raman Oza

A new disease could provide insights into how the cell’s recycling system contributes to a healthy brain.

Researchers at the National Institutes of Health have discovered a new neurological condition characterized by issues with motor coordination and speech. They report their findings in npj Genomic Medicine.

Scientists from NIH’s National Human Genome Research Institute (NHGRI) and Undiagnosed Diseases Program (UDP) identified three children with the condition, two siblings and an unrelated child. The three children all had issues with motor coordination and speech, and one child had abnormalities in the cerebellum, the part of the brain involved in complex movement among other functions. Additionally, the children all had mutations in both copies of the ATG4D gene.

ATG4D aids in the cellular housekeeping process called autophagy, which cells use to break down and recycle damaged proteins and other defective pieces of the cell to stay healthy. Autophagy is a fundamental process used by cells throughout the body, but neurons are particularly dependent on autophagy for survival. However, little is known about how ATG4D contributes to healthy neurons.

The first inclination of ATG4D’s effects on brain health came from a 2015 study in which researchers identified a genetic neurological disease among Lagotto Romagnolo dogs, an Italian breed known for their fluffy coats and truffle-hunting abilities. The affected dogs had abnormal behavior, atrophy of the cerebellum, issues with motor coordination and eye movement and ATG4D mutations.

How protein-rich droplets form

Martina Havenith-Newen has gained new insights by combining two methods.
Photo Credit: © RUB, Marquard

Terahertz spectroscopy can be used to explain the spontaneous formation of protein-rich droplets, which may lead to neurodegenerative diseases.

With the help of a new method, terahertz calometry, it is a research team of the Bochum Cluster of Excellence Ruhr Explores Solvation RESOLV succeeded in re-examining the spontaneous phase separation into a protein-rich and a low-protein phase in one solution. It is believed that the protein-rich droplets favor the formation of neurotoxic protein aggregates - a starting point for neurodegenerative diseases. The researchers around Prof. Dr. Martina Havenith, holder of the Chair for Physical Chemistry II at the Ruhr University Bochum, reports in the Journal of Physical Chemistry Letters from 6. February 2023.

Molecular level and time resolution in the picosecond range

The study is based on the work in the Terahertz-Calorimetry project, which was funded by the European Research Council with an Advanced Grant. "The visionary idea in the project was to marry two powerful techniques in physical chemistry - laser spectroscopy and calorimetry -" explains Grantee Martina Havenith.

Disrupted flow of brain fluid may underlie neurodevelopmental disorders

The addition of a magenta tracer molecule illustrates the flow of fluid around the brain, revealing that neurons in the hippocampus (cyan), the brain’s memory center, are awash in fluid. Researchers at Washington University School of Medicine in St. Louis have discovered that this fluid flows to areas critical for normal brain development and function, suggesting that disruptions to its circulation may play an underrecognized role in neurodevelopmental disorders.
Photo Credit: Shelei Pan and Peter Yang/School of Medicine

The brain floats in a sea of fluid that cushions it against injury, supplies it with nutrients and carries away waste. Disruptions to the normal ebb and flow of the fluid have been linked to neurological conditions including Alzheimer’s disease and hydrocephalus, a disorder involving excess fluid around the brain.

Researchers at Washington University School of Medicine in St. Louis created a new technique for tracking circulation patterns of fluid through the brain and discovered, in rodents, that it flows to areas critical for normal brain development and function. Further, the scientists found that circulation appears abnormal in young rats with hydrocephalus, a condition associated with cognitive deficits in children.

The findings, available online in Nature Communications, suggest that the fluid that bathes the brain — known as cerebrospinal fluid — may play an underrecognized role in normal brain development and neurodevelopmental disorders.

Mushrooms magnify memory by boosting nerve growth

Lion's mane mushroom
Photo Credit: Kier... in Sight

Researchers from The University of Queensland have discovered an active compound from an edible mushroom that boosts nerve growth and enhances memory.

Professor Frederic Meunier from the Queensland Brain Institute said the team had identified new active compounds from the mushroom, Hericium erinaceus.

“Extracts from these so-called ‘lion’s mane’ mushrooms have been used in traditional medicine in Asian countries for centuries, but we wanted to scientifically determine their potential effect on brain cells,” Professor Meunier said.

“Pre-clinical testing found the lion’s mane mushroom had a significant impact on the growth of brain cells and improving memory.

“Laboratory tests measured the neurotrophic effects of compounds isolated from Hericium erinaceus on cultured brain cells, and surprisingly we found that the active compounds promote neuron projections, extending and connecting to other neurons.

New approach puts brain scans on the witness stand in trademark disputes

Research shows how neuroscience could reduce bias, revolutionize intellectual property law
Image Credit: creative commons

Imagine you’re browsing the toothpaste aisle and see next to Colgate a new brand called Colddate, packaged in a box with similar colors and designs. “You might think this is clearly a copycat brand,” said Ming Hsu, William Halford Jr. Family Chair in Marketing at the Haas School of Business, UC Berkeley.

Yet in a real-life trademark infringement case involving these two brands, Colgate-Palmolive lost the suit, with the judge saying they were “similar” but not “substantially indistinguishable.”

There are often different opinions between judges and juries in trademark cases about how similar the brands in question actually are, leading to large inconsistencies in the application of the law. In a paper published February 8 in the journal Science Advances, Hsu and colleagues propose a more scientific measure through the use of brain scans—employing functional magnetic resonance imaging (fMRI) along with a specialized technique called repetition suppression (RS).

“Asking the brain, not a person, could reduce—if not eliminate—these inconsistencies,” said lead author Zhihao Zhang, a former Berkeley Haas postdoctoral researcher now on the faculty of the Darden School of Business, University of Virginia. The study’s other authors include Dr. Andrew Kayser of UC San Francisco, Femke van Horen of Vrije University Amsterdam, and Mark Bartholomew of University at Buffalo Law School.

Study finds much still not known about cognitive decline

Why do some elderly people keep their cognitive ability much longer than others? Scientists still have much to learn.
Photo Credit: Alexandra Lowenthal

The risk factors linked to cognitive decline in older adults explain a surprisingly modest amount about the large variation in mental abilities between older people, according to a new national study.

Researchers found that the factors most commonly associated with cognitive functioning – including socioeconomic status, education and race – explained only 38% of the variation in functioning among Americans at age 54.

Health behaviors such as avoiding obesity and smoking and participating in vigorous exercise had only very small effects on functioning by the time people reached their mid-50s.

In addition, the factors studied explained only 5.6% of the variation in how quickly cognitive functioning declined in people between age 54 and 85.

Researchers identify the neurons that synchronize female preferences with male courtship songs in fruit flies

Researchers discovered the strength of the response of a specific component of the auditory neuron circuit (shown in green) partly explain the fruit flies’ preferences for specific rhythms.
Image Credit: Takuro S. Ohashi 

When it comes to courtship, it is important to ensure that one is interacting with a member of the same species. Animals use multiple sensory systems to confirm that potential mates are indeed suitable, with acoustic communication playing an important role in their decision making.   

Although these differences have previously been reported at the behavioral level, it is not known how the neuronal circuitry underlying this decision-making has diverged between species. Now, in a new publication in Scientific Reports, a research group at Nagoya University in Japan has investigated how the auditory processing pathway has evolved and diverged between fruit fly species.  

Males of several species of Drosophila (fruit flies), which are regularly used in neuroscience research, vibrate their wings rhythmically during courtship, producing a courtship song. The temporal components of these songs differ between species, allowing female flies to distinguish between potential mates. 

HudsonAlpha scientists make new discovery linked to Alzheimer’s disease

Senior Scientist Lindsay Rizzardi, PhD
Photo Credit: Courtesy of HudsonAlpha

HudsonAlpha scientists identify transcription factors that may be involved in altered gene expression seen in Alzheimer’s disease

The human brain contains many types of cells that work together to ensure it functions properly. As arguably the most important organ in the human body, if something goes amiss with any brain cells or their connections to other cells, varying levels of neurological dysfunction can occur. Many neurological disorders arise from damage to brain cells due to a build-up of misfolded or aggregated proteins in the brain, like the tau protein and the amyloid-beta protein. Specific genes contain the instructions cells need for producing proteins. Changes to those genes can affect the protein production cycle, causing a change in the amount of protein produced or the conformation or quality of that protein. 

Alterations to the DNA code itself are only one of the ways that protein production can go awry. A class of proteins called transcription factors are a key component of how genes are expressed, causing a protein product to be made at higher or lower amounts than needed. These transcription factors act without changing the genetic makeup of the gene. These factors bind to DNA and recruit repressors or activators like RNA polymerase that coordinate DNA transcription and, ultimately, translation into a protein. 

Learning with all your senses: Multimodal enrichment as the optimal learning strategy of the future

Illustration Credit: John Hain

Neuroscientist Katharina von Kriegstein from Technische Universität Dresden and Brian Mathias from the University of Aberdeen have compiled extensive interdisciplinary findings from neuroscience, psychology, computer modelling and education on the topic of "learning" in a recent review article in the journal Trends in Cognitive Sciences. The results of the interdisciplinary review reveal the mechanisms the brain uses to achieve improved learning outcome by combining multiple senses or movements in learning. This kind of learning outcome applies to a wide variety of domains, such as letter and vocabulary acquisition, reading, mathematics, music, and spatial orientation.

Many educational approaches assume that integrating complementary sensory and motor information into the learning experience can enhance learning, for example gestures help in learning new vocabulary in foreign language classes. In her recent publication, neuroscientist Katharina von Kriegstein from Technische Universität Dresden and Brian Mathias of the University of Aberdeen summarize these methods under the term "multimodal enrichment." This means enrichment with multiple senses and movement. Numerous current scientific studies prove that multimodal enrichment can enhance learning outcomes. Experiments in classrooms show similar results.

A new tool for examining processes in the cerebellum

The Bochum research team: Bianca Preissing, Lennard Rohr, Ida Siveke and Tatjana Surdin (from left)
Photo Credit: © RUB, Marquard

Light can start a signal cascade in the cerebellum. This also illuminates processes that play an important role in cerebellar diseases.

Processes in the cerebellum are involved in various diseases that affect motor learning. A new tool developed by a Bochum working group helps to investigate this better: a light-activated protein that is coupled with part of an exciting receptor. Thanks to this optogenetic tool, light can activate a signaling pathway in the nerve cells of the cerebellum and observe its effects. So, the group around Dr. Ida Siveke from the working group of Prof. Dr. Stefan Herlitze at the Ruhr University Bochum show that the signal path is involved in cerebellar-controlled motor learning. The researchers report in the iSience journal.

How sound waves trigger immune responses to cancer in mice

The 700kHz, 260-element histotripsy ultrasound array transducer used in Prof. Xu’s lab.
Photo Credit: Marcin Szczepanski/Lead Multimedia Storyteller, Michigan Engineering

Technique pioneered at the University of Michigan could improve outcomes for cancer and neurological conditions

When noninvasive sound waves break apart tumors, they trigger an immune response in mice. By breaking down the cell wall “cloak,” the treatment exposes cancer cell markers that had previously been hidden from the body’s defenses, researchers at the University of Michigan have shown.

The technique developed at Michigan, known as histotripsy, offers a two-prong approach to attacking cancers: the physical destruction of tumors via sound waves and the kickstarting of the body’s immune response. It could potentially offer medical professionals a treatment option for patients without the harmful side effects of radiation and chemotherapy.

Until now, researchers didn’t understand how histotripsy was activating the immune system. A study from last spring showed that histotripsy breaks down liver tumors in rats, leading to the complete disappearance of the tumor even when sound waves are applied to only 50% to 75% of the mass. The immune response also prevented further spread, with no evidence of recurrence or metastases in more than 80% of the animals.

Common heart medicine is linked to a reduced risk of committing violent crimes

Yasmina Molero.
Photo Credit: Niklas Faye-Wevle Samuelson

Beta blockers, commonly used to treat heart disease and high blood pressure, can be linked to a reduced risk of committing violent crimes. It shows a new registry study from Karolinska Institutet and the University of Oxford published in the journal PLOS Medicine.

Beta blockers lower blood pressure by blocking the effect of hormones like adrenaline. The medicine is used to treat a variety of conditions including high blood pressure, cardiovascular events, heart failure and anxiety. It has also been suggested to work for clinical depression and aggression, but some studies have found a link to increased suicidal tendencies and the results are contradictory.

In the current study, the researchers investigated the relationship between beta blockers and hospitalization for mental illness, suicidal tendencies, suicide and reports of violent crime. They studied 1.4 million individuals in Sweden and compared periods with and without beta blockers in the same individual over an eight-year period (2006-2013). In this way, the researchers were able to control factors that can affect relationships, such as genetics or disease history.

Periods of medication were associated with a 13 percent lower risk of being charged with violent crime. Since it is an observational study, conclusions about causation should be interpreted with caution.

One way to deal with aggression

- If the results are confirmed in other studies, including randomized controlled trials, beta blocks may be considered as a way to manage aggression in individuals with psychiatric diagnoses, say Yasmina Molero, researchers at Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics at Karolinska Institutet.

Use of beta-blockers was also linked to eight percent lower risk of hospitalization due to mental illness and eight percent increased risk of being treated for suicidal tendencies or dying in suicide. However, these relationships were inconsistent.

- The risk of hospitalization and suicidal tendencies varied depending on psychiatric diagnosis and previous mental health problems, but also on the severity and type of heart problems that the beta blockers were used to treat. This indicates that there are no links between beta blockers and these outcomes, says Yasmina Molero.

Heart problems are associated with depression

Previous research has linked serious heart events to an increased risk of depression and suicide. This may indicate that the mental disorders and other disabilities associated with serious heart problems, rather than the treatment with beta blockers, increase the risk of serious mental illness, according to the researchers.

Funding: The study was funded by the Wellcome Trust, Forte, the American Foundation for Suicide Prevention and the Karolinska Institutet's funds. Co-author Henrik Larsson has received grants from Shire Pharmaceuticals, Medice Speaker Fees, Shire / Takeda Pharmaceuticals and Evolan Pharma as well as sponsorship for a conference on adhd from Shire / Takeda Pharmaceuticals, all outside the current study.

Published in journal: PLOS Medicine

Source/Credit: Karolinska Institutet

Reference Number: ns013123_02

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Focused ultrasound mediated liquid biopsy in a tauopathy mouse model

Hong Chen and her collaborators found that using focused-ultrasound-mediated liquid biopsy in a mouse model released more tau proteins and another biomarker for neurodegenerative disorders into the blood than without the intervention. This noninvasive method could facilitate diagnosis of neurodegenerative disorders.
Illustration Credit: Chen lab

Several progressive neurodegenerative disorders, including Alzheimer’s disease, are defined by having tau proteins in the brain. Researchers are seeking to identify the mechanisms behind these tau proteins to develop treatments, however, their efforts to detect biomarkers in blood has been hampered by the protective blood-brain barrier.

At Washington University in St. Louis, new research from the lab of Hong Chen, associate professor of biomedical engineering in the McKelvey School of Engineering and of radiation oncology in the School of Medicine, and collaborators found that using focused-ultrasound-mediated liquid biopsy in a mouse model released more tau proteins and another biomarker into the blood than without the intervention. This noninvasive method could facilitate diagnosis of neurodegenerative disorders, the researchers said.

The method, known as sonobiopsy, uses focused ultrasound to target a precise location in the brain. Once located, the researchers inject microbubbles into the blood that travel to the ultrasound-targeted tissue and pulsate, which safely opens the blood-brain barrier. The temporary openings allow biomarkers, such as tau proteins and neurofilament light chain protein (NfL), both indicative of neurodegenerative disorders, to pass through the blood-brain barrier and release into the blood.

An action plan to prevent Alzheimer’s disease

As the population ages, the number of people with Alzheimer’s disease in Europe will double by 2050.
Image Credit: Gerd Altmann

A task force led by UNIGE and HUG is laying the foundations for a preventive protocol.

Memory loss, behavioral changes, cognitive deficits: Alzheimer’s disease leads to a dramatic loss of autonomy for those affected and has a heavy impact on health costs. Its prevention has become a real social challenge. An international task force, led by the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG), is setting out guidelines for innovative services to prevent Alzheimer’s disease. These will soon be an integral part of second-generation memory clinics. These guidelines are detailed in an article published in the Lancet Regional Health - Europe.

With 10 million people affected in Europe, Alzheimer’s disease is the most common neurodegenerative disease. It is characterized by progressive disabling memory loss and cognitive deficits caused by an accumulation of toxic proteins in the brain. Its social and economic impact is considerable. On a global scale, it is estimated to be worth around USD 1,500 billion per year* and in Switzerland CHF 11.8 billion per year**.

Not just mood swings but premenstrual depression

The scientists took images of the womens’ brain with positron emission tomography (PET) at different cycle times. 
Image Credit: © MPI CBS

Researchers find serotonin transporter in the brain increased

Scientists led by Julia Sacher from Max Planck Institute for Human Cognitive and Brain Sciences and Osama Sabri from the Leipzig University Hospital have discovered in an elaborate patient study that the transport of the neurotransmitter serotonin in the brain increases in women with premenstrual dysphoric disorder (PMDD) shortly before menstruation. Their findings provide the basis for a more targeted therapy of this specific mood disorder, in which patients only have to take antidepressants for a few days.

PMS, or premenstrual syndrome, is now a familiar term to many - about 50 per cent of all women experience these symptoms a few days before onset of their menstruation. The more severe form, called premenstrual dysphoric disorder (PMDD), affects eight percent of women of childbearing age and is associated with physical symptoms such as sleep disturbances or breast pain as well as psycho-emotional symptoms, including depression, loss of control, irritability, aggressiveness and concentration problems. As a result, many women with PMDD experience disruptions in their personal and professional lives.

Researchers Unveil New Collection of Human Brain Atlases that Chart Postnatal Development

Surface-volume atlases from 2 weeks to 24 months.
Image Credit: © 2023, Ahmad et al., CCBY 4.0

Led by Pew-Thian Yap, PhD, researchers at the UNC School of Medicine created monthly infant brain atlases to help researchers analyze the developing brain in detail to investigate neurological disorders and other conditions.

Human brain atlases can be used by medical professionals to track normative trends over time and to pinpoint crucial aspects of early brain development. By using these atlases, they are able to see what typical structural and functional development looks like, making it easier for them to spot the symptoms of abnormal development, such as attention-deficit / hyperactivity disorder (ADHD), dyslexia, and cerebral palsy.

Pew-Thian Yap, PhD, professor in the UNC Department of Radiology, and colleagues in the department and the Biomedical Research Imaging Center (BRIC) have created a new collection of month-by-month infant brain atlas (IBA) that capture fine spatiotemporal details of the early developing brain.

Supplementation with amino acid serine eases neuropathy in diabetic mice

From left: Michal Handzlik and Christian Metallo
Photo Credit: Salk Institute

Approximately half of people with type 1 or type 2 diabetes experience peripheral neuropathy—weakness, numbness, and pain, primarily in the hands and feet. The condition occurs when high levels of sugar circulating in the blood damage peripheral nerves. Now, working with mice, Salk Institute researchers, in collaboration with the University of California San Diego, have identified another factor contributing to diabetes-associated peripheral neuropathy: altered amino acid metabolism.

The study, published in Nature, adds to growing evidence that some often-underappreciated, “non-essential” amino acids play important roles in the nervous system. The findings may provide a new way to identify people at high risk for peripheral neuropathy, as well as a potential treatment option. The team included UC San Diego bioengineering professor Prashant Mali, microbiome expert professor Rob Knight and pathologist Nigel A. Calcutt.

“We were surprised that dialing up and down a non-essential amino acid had such a profound effect on metabolism and diabetic complications,” says senior author Christian Metallo, a professor in Salk’s Molecular and Cell Biology Laboratory. “It just goes to show that what we think of as dogma can change under different circumstances, such as in disease conditions.”

Mechanical forces in the nervous system play a corrective role

The researchers visualized the forces acting on dendrites during pruning by measuring their lengths (blue/red) and the angles at dendritic branchpoints: A) before, B) after dendrite severing,
Image Credit: WWU - Rumpf Lab

Researchers at Münster University show in the fruit fly how mechanical tearing cuts neural connections

Nerve cells communicate with one another via long processes known as axons and dendrites, or, more generally, neurites. During development, these processes first grow and form connections with other cells, for example synapses with other nerve cells. Any neurites which are not properly linked, or are no longer needed, are removed by a corrective mechanism known as “pruning”. Such pruning processes can appear drastic, and neurites sometimes seem to be severed directly from the nerve cell. Researchers headed by Dr. Sebastian Rumpf from the Institute of Neuro- and Behavioral Biology at Münster University has now found the mechanism of neurite severing. In a study published in the Journal of Cell Biology, the team show that in sensory nerve cells of the fruit fly Drosophila melanogaster, pruning occurs through mechanical tearing.

Traffic pollution impairs brain function

fMRI shows decreased functional connectivity in the brain following exposure to traffic pollution.
Image Credit: Courtesy of University of British Columbia

First-in-the-world study suggests that even brief exposure to air pollution has rapid impacts on the brain

A new study by researchers at the University of British Columbia and the University of Victoria has shown that common levels of traffic pollution can impair human brain function in only a matter of hours.

The peer-reviewed findings, published in the journal Environmental Health, show that just two hours of exposure to diesel exhaust causes a decrease in the brain’s functional connectivity – a measure of how different areas of the brain interact and communicate with each other. The study provides the first evidence in humans, from a controlled experiment, of altered brain network connectivity induced by air pollution.

“For many decades, scientists thought the brain may be protected from the harmful effects of air pollution,” said senior study author Dr. Chris Carlsten, professor and head of respiratory medicine and the Canada Research Chair in occupational and environmental lung disease at UBC. “This study, which is the first of its kind in the world, provides fresh evidence supporting a connection between air pollution and cognition.”