Monkeypox viruses relatively stable on surfaces

Cleaning surfaces with alcohol-based disinfectant is a good protection against infection.
Photo Credit: © RUB, Marquard

The virus remains infectious on steel surfaces for up to 30 days, but can be effectively deactivated by alcoholic disinfectants.

Pockenviruses are known to remain infectious in the area for a very long time. A study by the Molecular and Medical Virology Department at the Ruhr University Bochum showed that the temperature is very important: at room temperature, it can take up to eleven days until there is no longer a reproductive monkeypox virus on a stainless-steel surface, at four degrees Celsius even up to a month. Accordingly, it is particularly important to disinfect surfaces. According to the study, alcoholic disinfectants work well against monkeypox viruses. However, hydrogen peroxide-based disinfectants are not sufficiently effective. The team reports in Journal of infectious diseases.

Weekly observation

Since 2022, the monkey pox virus has been spreading from person to person. Even if the infection is primarily due to direct physical contact, it is possible to infect yourself via contaminated surfaces, for example in the household or in hospital rooms. "Pockenviren is known to remain infectious in the area for a very long time," explains Dr. Toni Meister from the Department of Molecular and Medical Virology at Ruhr University. “So far we have not known the exact times for monkey pox."

Brain research with organoids

Section of an electroporated brain organoid of a common marmoset. Green: electroporated cells that glow green due to the green fluorescent protein; magenta: neurons; gray: nuclei.
Photo Credit: Lidiia Tynianskaia

Scientists at the German Primate Center develop effective method to genetically modify brain organoids

Primates are among the most intelligent creatures with distinct cognitive abilities. Their brains are relatively large in relation to their body stature and have a complex structure. However, how the brain has developed over the course of evolution and which genes are responsible for the high cognitive abilities is still largely unclear. The better our understanding of the role of genes in brain development, the more likely it will be that we will be able to develop treatments for serious brain diseases. 

Researchers are approaching these questions by knocking out or activating individual genes and thus drawing conclusions about their role in brain development. To avoid animal experiments as far as possible, brain organoids are used as an alternative. These three-dimensional cell structures, which are only a few millimeters in size, reflect different stages of brain development and can be genetically modified. However, such modifications are usually very complex, lengthy and costly. Researchers at the German Primate Center (DPZ) – Leibniz Institute for Primate Research in Göttingen have now succeeded in genetically manipulating brain organoids quickly and effectively. 

Deficiency causes appetite for meat

A carnivorous leaf of Triphyophyllum peltatum with glands excreting a sticky liquid to capture insect prey.
Photo Credit: Traud Winkelmann / Universität Hannover

Under certain circumstances, a rare tropical plant develops into a carnivore. A research team from the universities of Hannover and Würzburg has now deciphered the mechanism responsible for this.

Triphyophyllum peltatum is a unique plant. Native to the tropics of West Africa, the liana species is of great interest for medical and pharmaceutical research due to its constituents: In the laboratory, this show promising medically useful activities against pancreatic cancer and leukemia cells, among others, as well as against the pathogens that cause malaria and other diseases.

However, the plant species is also interesting from a botanical perspective: Triphyophyllum peltatum is the only known plant in the world that can become a carnivore under certain circumstances. Its menu then includes small insects, which it captures with the help of adhesive traps in the form of secretion drops and digests with synthesized lytic enzymes.

Sea butterfly life cycle threatened by climate change

An adult sea butterfly, a tiny free swimming sea snail.
Photo Credit: Victoria Peck – British Antarctic Survey

Shelled pteropods, commonly known as sea butterflies, are increasingly exposed to ocean changes, but some species are more vulnerable to this threat. In a new study, published this month in the journal Frontiers in Marine Science, British Antarctic Survey (BAS) scientists examining pteropod life cycles in the Southern Ocean have found that some species might be more vulnerable to this threat due to different timings of their life cycle.

Sea butterflies are tiny, free-swimming sea snails, which are an important part of the marine ecosystem. They are also vulnerable to climate change as their shells are sensitive to ocean acidification. Now, a team of researchers led by BAS has examined the life cycles of two free-swimming sea snail species. They found that one is less vulnerable to changes in the Southern Ocean than the other, which could affect the sea snails on a population level and in turn impact the marine ecosystem.

The world’s oceans absorb approximately a quarter of all carbon dioxide (CO2) emissions. During absorption, CO2 reacts with seawater and oceanic pH levels fall. This is known as ocean acidification and results in lower carbon ion concentrations. Certain ocean inhabitants use carbon ions to build and sustain their shells. Pteropods, which are important components of the marine ecosystem, are among them.

Butterflies on the decline

According to the analysis of the scientists, the orange tip (Anthocharis cardamines) is the only butterfly species in Europe for which a significant increase can be recorded.
Photo Credit: Ulrike Schäfer

Research shows that the numbers of butterflies in meadows and pastures of Europe are in a continuous decline. A new EU regulation aims to stop this trend.

Grassland butterflies will soon play an even greater role in EU nature conservation legislation. Based on the occurrences and population trends of butterflies, the member states are supposed to document the progress they have made in implementing the planned "Nature Restoration Law". The Butterfly Grassland Indicator, recently calculated for the eighth time by European foundation "Butterfly Conservation Europe", is to be used for this. This analysis, which also includes data and expertise from many volunteers in Germany - coordinated by experts from the Helmholtz Centre for Environmental Research (UFZ) in Halle - shows an urgent need for action. This is because the situation of grassland butterflies in Europe has deteriorated considerably since the first calculations in 1990.

The diagnosis sounds worrying: More than 80% of habitats in the EU are currently considered vulnerable. This has negative consequences on their functional capability and thus the services they provide for humans. In order to counter this, the European Commission has proposed a new set of rules. This "Nature Restoration Law" is one of the key elements of the EU Biodiversity Strategy 2030 to be published this May. It defines binding targets for the entire EU for the renaturation of various ecosystems. Two years after the regulation enters into force, member states must submit plans on how they intend to meet these targets. They must also document the success of their measures.

Latest research provides SwRI scientists close-up views of energetic particle jets ejected from the sun

Southwest Research Institute (SwRI) scientists observed the first close-up views of the source of jets of energetic particles expelled from the Sun. The high-resolution images of the solar event were provided by ESA and NASA Solar Orbiter, a Sun-observing satellite launched in 2020.
Image Credit: Courtesy of SwRI

Southwest Research Institute (SwRI) scientists observed the first close-ups of a source of energetic particles expelled from the Sun, viewing them from just half an astronomical unit (AU), or about 46.5 million miles. The high-resolution images of the solar event were provided by ESA’s Solar Orbiter, a Sun-observing satellite launched in 2020.

“In 2022, the Solar Orbiter detected six recurrent energetic ion injections. Particles emanated along the jets, a signature of magnetic reconnection involving field lines open to interplanetary space,” said SwRI’s Dr. Radoslav Bucik, the lead author of a new study published this month in Astronomy & Astrophysics Letters. “The Solar Orbiter frequently detects this type of activity, but this period showed very unusual elemental compositions.”

Chemists Unravel Reaction Mechanism for Clean Energy Catalyst

Dmitry Polyansky (left) and David Grills in the pulse radiolysis lab where the research was conducted. Here, Grills programs a syringe pump that delivers the catalyst to the radiolysis cell. Polyansky adjusts the radiolysis cell inside a white insulated compartment.
Photo Credit: Brookhaven National Laboratory

Hydrogen, the simplest element on Earth, is a clean fuel that could revolutionize the energy industry. Accessing hydrogen, however, is not a simple or clean process at all. Pure hydrogen is extremely rare in nature, and practical methods to produce it currently rely on fossil fuels. But if scientists find the right chemical catalyst, one that can split the hydrogen and oxygen in water molecules apart, pure hydrogen could be produced from renewable energy sources such as solar power.

Now, scientists are one step closer to finding that catalyst. Chemists at the University of Kansas and the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory have unraveled the entire reaction mechanism for a key class of water-splitting catalysts. Their work was published today in Proceedings of the National Academy of Sciences.

“It’s very rare that you can get a complete understanding of a full catalytic cycle,” said Brookhaven chemist Dmitry Polyansky, a co-author of the paper. “These reactions go through many steps, some of which are very fast and cannot be easily observed.”

Sea anemone’s sweet efforts help reef ecosystems flourish

KAUST researchers have discovered how corals can thrive in nutrient-depleted oceans. Their study shows how sea anemones are able to recycle the essential nutrient Nitrogen.
Photo Credit: Morgan Bennett-Smith / King Abdullah University of Science and Technology

Tropical oceans are known for being low in nutrients, yet they support incredibly diverse and thriving reef ecosystems created by symbiotic cnidarians such as corals and anemones. This intriguing contradiction, referred to as the Darwin Paradox, has fascinated scientists ever since Charles Darwin first described it in 1842.

A group of researchers from KAUST conducted a study on sea anemones called Aiptasia. They found out that Aiptasia uses the sugar it gets from its partners to recycle waste in its body and survive in places where there are not many nutrients.

According to Guoxin Cui, a research scientist who worked on the project with Manuel Aranda, many studies in the past have tried to figure out where the limited nutrients in the ocean come from, especially nitrogen which is rare.

Guoxin Cui explains that some studies about coral have suggested that the partnership between coral and algae creates areas with lots of nutrients. But until now, researchers didn't fully understand how these organisms were able to create such large ecosystems.

Saturn’s rings younger than previously thought — just a few hundred million years

New research reveals that Saturn's rings are much younger than the planet itself.
Photo Credit: NASA/JPL/Space Science Institute.

Saturn’s rings are much younger than scientists once thought, according to new research from Indiana University Professor Emeritus of Astronomy Richard Durisen — and they are not here to stay.

For decades, there has been debate about the origin of Saturn’s icy rings. But according to two new studies from Durisen, published in Icarus, the rings are no more than a few hundred million years old — much younger than the planet itself, which formed 4.5 billion years ago. In fact, Durisen said the rings may well have formed when dinosaurs were still walking on the Earth.

Durisen and co-author Paul Estrada, a research scientist at NASA’s Ames Research Center in California’s Silicon Valley, also concluded that the rings will last only another few hundred million years at most.

“Our inescapable conclusion is that Saturn’s rings must be relatively young by astronomical standards, just a few hundred million years old,” Durisen said. “If you look at Saturn’s satellite system, there are other hints that something dramatic happened there in the last few hundred million years.”

Heat is the Top Cause of Exertion-Related Injuries and Fatalities for Laborers

This study is one of the first of its kind to evaluate exertion-related injuries and fatalities from word-related activities
Photo Credit: Jeriden Villegas

Dangers like working high above the ground or with heavy machinery are common hazards for laborers in industries like construction or excavation. But there’s another near-universal hazard for laborers – heat.

Margaret Morrissey, a postdoctoral fellow within UConn’s College of Agriculture, Health and Natural Resources and president of occupational safety for the Korey Stringer Institute, led a recently published study that found heat is the number one cause of exertion-related injuries and fatalities on U.S. work sites.

This work was recently published in the International Journal of Environmental Research and Public Health.

Using data reported to OSHA (Occupational Safety and Health Administration), the team found that of all injuries and fatalities, about 3% were exertion related. Of that 3%, a staggering 89% were related to heat stress.

Most species, including humans, who experience early life adversity suffer as adults. How are gorillas different?

Experienced the loss of her mother and father and the disintegration of her family group before the age of 5. Now 20, she has become a successful mother, raising three offspring.
Photo Credit: Dian Fossey Gorilla Fund

There’s something most species—from baboons to humans to horses—have in common: When they suffer serious adversity early in life, they’re more likely to experience hardship later on in life.

When researchers from the Dian Fossey Gorilla Fund and the University of Michigan decided to look at this question in gorillas, they weren’t sure what they would find.

Previous studies by the Fossey Fund revealed that young gorillas are surprisingly resilient to losing their mothers, in contrast to what has been found in many other species. But losing your mother is only one of many potential bad things that can happen to young animals.

“Assuming that you survive something that we consider early life adversity, it’s often still the case that you will be less healthy or you will have fewer kids or your lifespan will be shorter—no matter what species you are,” said Stacy Rosenbaum, U-M assistant professor of anthropology and senior author of the study. “There’s this whole range of things that happens to you that seems to just make your life worse in adulthood.”

Phage structure captured for the first time, to benefit biotech applications

Phage image
Image Credit: Dr Vicki Gold et al, Nature Communications

New insights into the structure of phages will enable researchers to develop new uses for viruses in biotechnology.

Phages are viruses that infect bacteria, which enables them to be exploited as tools in biotechnology and medicine. Now, for the first time, researchers at the University of Exeter, in collaboration with Massey University and Nanophage Technologies, New Zealand, have mapped out what a commonly-used form of phage looks like, which will help researchers design better uses in future.

One common use for phage is phage display, which is a useful tool in drug discovery. Phage display works by linking a gene fragment of interest to a phage gene that makes one of the phage coat proteins. The new coat protein with the linked protein of interest appears on the surface of the phage, where it can be assayed and tested for biological activity.

Billions of types of phages exist. Phage display often uses a type of phage known as filamentous, so called because they are long and thin, making the display of many proteins across its surface possible. Although phage display and other applications have proved successful, until now, scientists have not known what this type of phage looks like.

Combined delivery of engineered virus with immunotherapy is safe and improves outcomes in subset of patients with glioblastoma

From left to right: Frederick Lang, M.D., Juan Fueyo, M.D., and Candelaria Gomez-Manzano, M.D.
Image Credit: Courtesy of MD Anderson Cancer Center

Intratumoral delivery of an engineered oncolytic virus (DNX-2401) targeting glioblastoma (GBM) cells combined with subsequent immunotherapy was safe and improved survival outcomes in a subset of patients with recurrent GBM, according to results from a multi-institutional Phase I/II clinical trial co-led by researchers at The University of Texas MD Anderson Cancer Center and the University of Toronto.

The study, published today in Nature Medicine, met its primary safety endpoint and demonstrated the combination was well tolerated overall with no dose-limiting toxicities. The study did not meet its primary efficacy endpoint of objective response rate, but the combination achieved a 12-month overall survival (OS) rate of 52.7%, which is greater than the prespecified efficacy threshold of 20%. Three patients remained alive at 45, 48 and 60 months after treatment.

“This viral therapy is a different approach to the current standard of care,” said co-corresponding author Frederick Lang, M.D., chair of Neurosurgery. “Our previous trial demonstrated that not only does the virus act by killing cancer cells directly, it also effectively activates the innate immune system to convert these immunologically cold tumors into hot tumors. This led us to evaluate a combination with checkpoint inhibitors, which we now see can improve survival outcomes in a subset of patients.”

New priming method improves battery life, efficiency

Quan Nguyen (left), Sibani Lisa Biswal and collaborators developed a prelithiation technique that helps improve the performance of lithium-ion batteries with silicon anodes.
Photo Credit: Jeff Fitlow/Rice University

Silicon anode batteries have the potential to revolutionize energy storage capabilities, which is key to meeting climate goals and unlocking the full potential of electric vehicles.

However, the irreversible depletion of lithium ions in silicon anodes puts a major constraint on the development of next-generation lithium-ion batteries.

Scientists at Rice University’s George R. Brown School of Engineering have developed a readily scalable method to optimize prelithiation, a process that helps mitigate lithium loss and improves battery life cycles by coating silicon anodes with stabilized lithium metal particles (SLMPs).

The Rice lab of chemical and biomolecular engineer Sibani Lisa Biswal found that spray-coating the anodes with a mixture of the particles and a surfactant improves battery life by 22% to 44%. Battery cells with a greater amount of the coating initially achieved a higher stability and cycle life. However, there was a drawback: When cycled at full capacity, a larger amount of the particle coating led to more lithium trapping, causing the battery to fade more rapidly in subsequent cycles.

Gene-edited calf may reduce reliance on antimicrobials against cattle disease

 Brian Vander Ley, associate professor in the University of Nebraska–Lincoln’s School of Veterinary Medicine and Biomedical Sciences, works with Ginger, a Gir cow gene-edited with resistance to bovine viral diarrhea virus.
Photo Credit: Craig Chandler | University Communication and Marketing

Cattle worldwide face major health threats from a highly infectious viral disease that decades of vaccinations and other precautions have failed to contain. Federal, private-sector and Husker scientists are collaborating on a new line of defense, by producing a gene-edited calf resistant to the virus.

If follow-up research confirms its efficacy, the gene-editing approach offers long-term potential to reduce antimicrobial and antibiotic use in the cattle industry.

The bovine viral diarrhea virus devastates the bovine immune system and can cause severe respiratory and intestinal harm to infected beef and dairy cattle, said veterinary epidemiologist Brian Vander Ley, an associate professor in the University of Nebraska–Lincoln’s School of Veterinary Medicine and Biomedical Sciences.

In utero calves are especially vulnerable to infection. If they survive, they can remain infected for life, repeatedly spreading the virus to other cattle.

“They show up as normal cattle but really, they’re shedding a tremendous amount of virus. They’re the ‘Typhoid Marys’ of BVDV spread,” said Vander Ley, assistant director of UNL’s Great Plains Veterinary Educational Center in Clay Center.