Machine learning drives drug repurposing for neuroblastoma

Daniel Bexell leads the research group in molecular pediatric oncology, and Katarzyna Radke, first author of the study.
Photo Credit: Lund University

Using machine learning and a large volume of data on genes and existing drugs, researchers at Lund University in Sweden have identified a combination of statins and phenothiazines that is particularly promising in the treatment of the aggressive form of neuroblastoma. The results from experimental trials showed slowing of tumor growth and higher survival rates. 

The childhood cancer, neuroblastoma, affects around 15-20 children in Sweden every year. Most of them fell ill before the age of five. Neuroblastoma is characterized by, among other things, tumors that are often resistant to drug treatment, including chemotherapy. The disease exists in both mild and severe forms, and the Lund University researchers are mainly studying the aggressive form, high-risk neuroblastoma. This variant is the form of childhood cancer with the lowest survival rate. 

The Invisible Scale: Measuring AI’s Return on Energy

The Coin of Energy: Efficiency Paying for Itself
Image Credit: Scientific Frontline

In the public imagination, Artificial Intelligence is often visualized as a chatbot writing a poem or a generator creating a surreal image. This trivializes the technology and magnifies the scrutiny on its energy consumption. When AI is viewed as a toy, its electricity bill seems indefensible.

But when viewed as a scientific instrument—akin to a particle accelerator or an electron microscope—the equation shifts. The question is not "How much power does AI use?" but rather "What is the return on that energy investment?"

When measured across a single human lifetime, the dividends of AI in time, cost, and survival are staggering.

Why can’t powerful AIs learn basic multiplication?

Image Credit: Scientific Frontline / Stock image

These days, large language models can handle increasingly complex tasks, writing complex code and engaging in sophisticated reasoning. 

But when it comes to four-digit multiplication, a task taught in elementary school, even state-of-the-art systems fail. Why? 

A new paper by University of Chicago computer science Ph.D. student Xiaoyan Bai and faculty co-director of the Data Science Institute's Novel Intelligence Research Initiative Chenhao Tan finds answers by reverse-engineering failure and success.

They worked with collaborators from MIT, Harvard University, University of Waterloo and Google DeepMind to probe AI’s “jagged frontier”—a term for its capacity to excel at complex reasoning yet stumble on seemingly simple tasks.

The Quest for the Synthetic Synapse

Spike Timing" difference (Biology vs. Silicon)
Image Credit: Scientific Frontline

The modern AI revolution is built on a paradox: it is incredibly smart, but thermodynamically reckless. A large language model requires megawatts of power to function, whereas the human brain—which allows you to drive a car, debate philosophy, and regulate a heartbeat simultaneously—runs on roughly 20 watts, the equivalent of a dim lightbulb.

To close this gap, science is moving away from the "Von Neumann" architecture (where memory and processing are separate) toward Neuromorphic Computing—chips that mimic the physical structure of the brain. This report analyzes how close we are to building a "synthetic synapse."

Tohoku University and Fujitsu Use AI to Discover Promising New Superconducting Material

The AI technology was utilized to automatically clarify causal relationships from measurement data obtained at NanoTerasu Synchrotron Light Source
Image Credit: Scientific Frontline / stock image

Tohoku University and Fujitsu Limited announced their successful application of AI to derive new insights into the superconductivity mechanism of a new superconducting material. Their findings demonstrate an important use case for AI technology in new materials development and suggests that the technology has the potential to accelerate research and development. This could drive innovation in various industries such as environment and energy, drug discovery and healthcare, and electronic devices.

The two parties used Fujitsu's AI platform Fujitsu Kozuchi to develop a new discovery intelligence technique to accurately estimate causal relationships. Fujitsu will begin offering a trial environment for this technology in March 2026. Furthermore, in collaboration with the Advanced Institute for Materials Research (WPI-AIMR), Tohoku University , the two parties applied this technology to data measured by angle-resolved photoemission spectroscopy (ARPES), an experimental method used in materials research to observe the state of electrons in a material, using a specific superconducting material as a sample.

AI helps explain how covert attention works and uncovers new neuron types

Image Credit: Scientific Frontline / AI generated

Shifting focus on a visual scene without moving our eyes — think driving or reading a room for the reaction to your joke — is a behavior known as covert attention. We do it all the time, but little is known about its neurophysiological foundation. Now, using convolutional neural networks (CNNs), UC Santa Barbara researchers Sudhanshu Srivastava, Miguel Eckstein and William Wang have uncovered the underpinnings of covert attention and, in the process, have found new, emergent neuron types, which they confirmed in real life using data from mouse brain studies. 

“This is a clear case of AI advancing neuroscience, cognitive sciences and psychology,” said Srivastava, a former graduate student in the lab of Eckstein, now a postdoctoral researcher at UC San Diego. 

New Artificial Intelligence Model Could Speed Rare Disease Diagnosis

A DNA strand with a highlighted area indicating a mutation
Image Credit: Scientific Frontline

Every human has tens of thousands of tiny genetic alterations in their DNA, also known as variants, that affect how cells build proteins.

Yet in a given human genome, only a few of these changes are likely to modify proteins in ways that cause disease, which raises a key question: How can scientists find the disease-causing needles in the vast haystack of genetic variants?

For years, scientists have been working on genome-wide association studies and artificial intelligence tools to tackle this question. Now, a new AI model developed by Harvard Medical School researchers and colleagues has pushed forward these efforts. The model, called popEVE, produces a score for each variant in a patient’s genome indicating its likelihood of causing disease and places variants on a continuous spectrum.

Researchers Unveil First-Ever Defense Against Cryptanalytic Attacks on AI

Image Credit: Scientific Frontline

Security researchers have developed the first functional defense mechanism capable of protecting against “cryptanalytic” attacks used to “steal” the model parameters that define how an AI system works.

“AI systems are valuable intellectual property, and cryptanalytic parameter extraction attacks are the most efficient, effective, and accurate way to ‘steal’ that intellectual property,” says Ashley Kurian, first author of a paper on the work and a Ph.D. student at North Carolina State University. “Until now, there has been no way to defend against those attacks. Our technique effectively protects against these attacks.”

“Cryptanalytic attacks are already happening, and they’re becoming more frequent and more efficient,” says Aydin Aysu, corresponding author of the paper and an associate professor of electrical and computer engineering at NC State. “We need to implement defense mechanisms now, because implementing them after an AI model’s parameters have been extracted is too late.”

Artificial Intelligence: In-Depth Description

Futuristic AI mainframe
Image Credit: Scientific Frontline / AI Generated

Artificial Intelligence (AI) is a wide-ranging branch of computer science focused on building smart machines capable of performing tasks that typically require human intelligence, such as learning, reasoning, problem-solving, perception, and language comprehension. The primary goal is not just to mimic human thought but to create systems that can learn from data, identify patterns, and make autonomous decisions to solve complex problems, often with greater speed and accuracy than humans.

Rebalancing the Gut: How AI Solved a 25-Year Crohn’s Disease Mystery

Electron micrographs show how macrophages expressing girdin neutralize pathogens by fusing phagosomes (P) with the cell’s lysosomes (L) to form phagolysosomes (PL), compartments where pathogens and cellular debris are broken down (left). This process is crucial for maintaining cellular homeostasis. In the absence of girdin, this fusion fails, allowing pathogens to evade degradation and escape neutralization (right).
Image Credit: UC San Diego Health Sciences

The human gut contains two types of macrophages, or specialized white blood cells, that have very different but equally important roles in maintaining balance in the digestive system. Inflammatory macrophages fight microbial infections, while non-inflammatory macrophages repair damaged tissue. In Crohn’s disease — a form of inflammatory bowel disease (IBD) — an imbalance between these two types of macrophages can result in chronic gut inflammation, damaging the intestinal wall and causing pain and other symptoms. 

Researchers at University of California San Diego School of Medicine have developed a new approach that integrates artificial intelligence (AI) with advanced molecular biology techniques to decode what determines whether a macrophage will become inflammatory or non-inflammatory. 

The study also resolves a longstanding mystery surrounding the role of a gene called NOD2 in this decision-making process. NOD2 was discovered in 2001 and is the first gene linked to a heightened risk for Crohn’s disease.

Researchers Explore How AI Could Shape the Future of Student Learning

Johns Hopkins study reveals the strengths and pitfalls of incorporating chatbots into middle and high school classrooms as a 'co-tutor'
Image Credit: Scientific Frontline / AI generated

As students settle into the new school year, one question looms large: How will artificial intelligence tools like ChatGPT affect their learning? Seeking answers, a team from Johns Hopkins recently introduced a chatbot into a classroom of middle and high school students to act as a co-tutor and study the impact.

The pilot study included 22 students enrolled in the Johns Hopkins Center for Talented Youth's online course Diagnosis: Be the Doctor. It involved two virtual classrooms; both were taught by the same instructor and organized similarly, except for one key difference: Students in one classroom had access to a large language model designed to act like a coach, asking Socratic-style questions as students worked through medical case studies.

New AI Model for Drug Design Brings More Physics to Bear in Predictions

This illustration shows the mesh of anchoring points the team obtained by discretizing the manifold, an estimation of the distribution of atoms and the probable locations of electrons in the molecule. This is important because, as the authors note in the new paper, treating atoms as solid points "does not fully reflect the spatial extent that real atoms occupy in three-dimensional space."
Image Credit: Liu et al./PNAS

When machine learning is used to suggest new potential scientific insights or directions, algorithms sometimes offer solutions that are not physically sound. Take for example AlphaFold, the AI system that predicts the complex ways in which amino acid chains will fold into 3D protein structures. The system sometimes suggests "unphysical" folds—configurations that are implausible based on the laws of physics—especially when asked to predict the folds for chains that are significantly different from its training data. To limit this type of unphysical result in the realm of drug design, Anima Anandkumar, Bren Professor of Computing and Mathematical Sciences at Caltech, and her colleagues have introduced a new machine learning model called NucleusDiff, which incorporates a simple physical idea into its training, greatly improving the algorithm's performance.

When Machines Learn to Feel

Changes in heart rate can provide information about physical and emotional well-being. 
Photo Credit: © RUB, Kramer

In addition to linguistic prompts, large language models can also understand, interpret, and adapt their responses to heart frequency data. Dr. Morris Gellisch, previously of Ruhr University Bochum, Germany, and now at University of Zurich, Switzerland, and Boris Burr from Ruhr University Bochum verified this in an experiment. They developed a technical interface through which the physiological data can be transmitted to the language model in real time. The AI can also account for subtle physiological signals such as changes in heart activity. This opens new doors for use in medical and care applications. The work was published in the technical journal Frontiers in Digital Health.

AI tool offers deep insight into the immune system

scHDeepInsight.
An overview of the process linking single-cell RNA input, image conversion and CNN analysis, to hierarchical immune cell classification.
Image Credit: ©2025 Tsunoda et al.
(CC BY-ND 4.0)

Researchers explore the human immune system by looking at the active components, namely the various genes and cells involved. But there is a broad range of these, and observations necessarily produce vast amounts of data. For the first time, researchers including those from the University of Tokyo built a software tool which leverages artificial intelligence to not only offer a more consistent analysis of these cells at speed but also categorizes them and aims to spot novel patterns people have not yet seen.

Our immune system is important — it’s impossible to imagine complex life existing without it. This system, comprising different kinds of cells, each playing a different role, helps to identify things that threaten our health, and take actions to defend us. They are both very effective, but also far from perfect; hence, the existence of diseases such as the notorious acquired immunodeficiency syndrome, or AIDS. And recent earth-shattering issues, such as the coronavirus pandemic, serve to highlight the importance of research around this intricate yet powerful system.

New Diagnostic Tool Developed at Dana-Farber Revolutionizes Acute Leukemia Diagnosis

Volker Hovestadt, PhD
Assistant Professor, Pediatrics, Harvard Medical School Independent Investigator/Assistant Professor, Department of Pediatric Oncology, Dana-Farber Cancer Institute
Photo Credit: Courtesy of Dana-Farber Cancer Institute

Researchers at Dana-Farber Cancer Institute have developed a groundbreaking diagnostic tool that could transform the way acute leukemia is identified and treated. The tool, called MARLIN (Methylation- and AI-guided Rapid Leukemia Subtype Inference), uses DNA methylation patterns and machine learning to classify acute leukemia with speed and accuracy. This tool has the potential to significantly improve patient care by allowing faster and more precise treatment decisions.

Acute leukemia is an aggressive blood cancer that requires accurate diagnosis to guide treatment. Current diagnostic methods, which rely on a combination of molecular and cytogenetic tests, often take days or even weeks to complete. MARLIN, however, can provide results in as little as two hours from the time of biopsy. By providing rapid and detailed insights into leukemia subtypes, MARLIN could enable clinicians to make treatment decisions sooner and with more complete information.

New tool makes generative AI models more likely to create breakthrough materials

The researchers applied their technique to generate millions of candidate materials consisting of geometric lattice structures associated with quantum properties. The kagome lattice, represented here, can support the creation of materials that could be useful for quantum computing.
Image Credit: Jose-Luis Olivares, MIT; iStock
(CC BY-NC-ND 4.0)

The artificial intelligence models that turn text into images are also useful for generating new materials. Over the last few years, generative materials models from companies like Google, Microsoft, and Meta have drawn on their training data to help researchers design tens of millions of new materials.

But when it comes to designing materials with exotic quantum properties like superconductivity or unique magnetic states, those models struggle. That’s too bad, because humans could use the help. For example, after a decade of research into a class of materials that could revolutionize quantum computing, called quantum spin liquids, only a dozen material candidates have been identified. The bottleneck means there are fewer materials to serve as the basis for technological breakthroughs.

Now, MIT researchers have developed a technique that lets popular generative materials models create promising quantum materials by following specific design rules. The rules, or constraints, steer models to create materials with unique structures that give rise to quantum properties.

“The models from these large companies generate materials optimized for stability,” says Mingda Li, MIT’s Class of 1947 Career Development Professor. “Our perspective is that’s not usually how materials science advances. We don’t need 10 million new materials to change the world. We just need one really good material.”

Improved Brain Decoder Holds Promise for Communication in People with Aphasia

Brain activity like this, measured in an fMRI machine, can be used to train a brain decoder to decipher what a person is thinking about. In this latest study, UT Austin researchers have developed a method to adapt their brain decoder to new users far faster than the original training, even when the user has difficulty comprehending language.
Image Credit: Jerry Tang/University of Texas at Austin.

People with aphasia — a brain disorder affecting about a million people in the U.S. — struggle to turn their thoughts into words and comprehend spoken language.

A pair of researchers at The University of Texas at Austin has demonstrated an AI-based tool that can translate a person’s thoughts into continuous text, without requiring the person to comprehend spoken words. And the process of training the tool on a person’s own unique patterns of brain activity takes only about an hour. This builds on the team’s earlier work creating a brain decoder that required many hours of training on a person’s brain activity as the person listened to audio stories. This latest advance suggests it may be possible, with further refinement, for brain computer interfaces to improve communication in people with aphasia.

“Being able to access semantic representations using both language and vision opens new doors for neurotechnology, especially for people who struggle to produce and comprehend language,” said Jerry Tang, a postdoctoral researcher at UT in the lab of Alex Huth and first author on a paper describing the work in Current Biology. “It gives us a way to create language-based brain computer interfaces without requiring any amount of language comprehension.”

AI unveils: Meteoroid impacts cause Mars to shake

High-resolution CaSSIS image of one of the newly discovered impact craters in Cerberus Fossae. The so-called "blast zone", i.e. the dark rays around the crater, is clearly visible.
Image Credit: © ESA/TGO/CaSSIS
(CC-BY-SA 3.0 IGO)

Meteoroid impacts create seismic waves that cause Mars to shake stronger and deeper than previously thought: This is shown by an investigation using artificial intelligence carried out by an international research team led by the University of Bern. Similarities were found between numerous meteoroid impacts on the surface of Mars and marsquakes recorded by NASA's Mars lander InSight. These findings open up a new perspective on the impact rate and seismic dynamics of the Red Planet.

Meteoroid impacts have a significant influence on the landscape evolution of solid planetary bodies in our solar system, including Mars. By studying craters – the visible remnants of these impacts – important properties of the planet and its surface can be determined. Satellite images help to constrain the formation time of impact craters and thus provide valuable information on impact rates.

A recently published study led by Dr. Valentin Bickel from the Center for Space and Habitability at the University of Bern presents the first comprehensive catalog of impacts on the Martian surface that took place near NASA's Mars lander during the InSight mission between December 2018 and December 2022. Bickel is also an InSight science team member. The study has just been published in the journal Geophysical Research Letters.

OHSU researchers use AI machine learning to map hidden molecular interactions in bacteria

Andrew Emili, Ph.D., professor of systems biology and oncological sciences, works in his lab at OHSU. Emili is part of a multi-disciplinary research team that uncovered how small molecules within bacteria interact with proteins, revealing a network of molecular connections that could improve drug discovery and cancer research.
Photo Credit: OHSU/Christine Torres Hicks

A new study from Oregon Health & Science University has uncovered how small molecules within bacteria interact with proteins, revealing a network of molecular connections that could improve drug discovery and cancer research.

The work also highlights how methods and principles learned from bacterial model systems can be applied to human cells, providing insights into how diseases like cancer emerge and how they might be treated. The results are published today in the journal Cell.

The multi-disciplinary research team, led by Andrew Emili, Ph.D., professor of systems biology and oncological sciences in the OHSU School of Medicine and OHSU Knight Cancer Institute, alongside Dima Kozakov, Ph.D., professor at Stony Brook University, studied Escherichia coli, or E. coli, a simple model organism, to map how metabolites — small molecules essential for life — interact with key proteins such as enzymes and transcription factors. These interactions control important processes such as cell growth, division and gene expression, but how exactly they influence protein function is not always clear.

Oxford researchers develop blood test to enable early detection of multiple cancers

Photo Credit: Fernando Zhiminaicela

Oxford University researchers have unveiled a new blood test, powered by machine learning, which shows real promise in detecting multiple types of cancer in their earliest stages, when the disease is hardest to detect.

Named TriOx, this innovative test analyses multiple features of DNA in the blood to identify subtle signs of cancer, which could offer a fast, sensitive and minimally invasive alternative to current detection methods.

The study, published in Nature Communications, showed that TriOx accurately detected cancer (including in its early stages) across six cancer types and reliably distinguished those people who had cancer from those that did not.

Cancers are more likely to be cured if they’re caught early, and early treatment is also much cheaper for healthcare systems. While the test is still in the development phase, it demonstrates the promise of blood-based early cancer detection, a technology that could revolutionize screening and diagnostic practices.

A team of researchers at the University of Oxford have developed a new liquid biopsy test capable of detecting six cancers at an early stage. The cancer types evaluated in this study were colorectal, esophageal, pancreatic, renal, ovarian and breast.