Children with the rare allergic condition FPIES have a clearly altered gut microbiota, according to a new study from Umeå University in which molecular biologist and associate professor Kotryna Simonyte Sjödin participated.
Photo Credit: Johanna Nordström
Scientific Frontline: "At a Glance" Summary: Gut Microbiota in FPIES
- Main Discovery: Infants diagnosed with food protein-induced enterocolitis syndrome (FPIES) exhibit a distinctly altered and atypical gut bacterial composition compared to healthy individuals, marking a clear biological association with the rare allergic disease.
- Methodology: Researchers systematically collected and analyzed stool samples from 56 children with newly diagnosed FPIES and compared the high-resolution data against samples from 43 age‑matched control children without allergies across the first year of life.
- Key Data: The FPIES cohort demonstrated significant reductions in symbiotic bacteria such as Bifidobacterium and Verrucomicrobiota, alongside an increased abundance of Bacteroides, Haemophilus, and Veillonella. Age remained the strongest overall factor influencing bacterial composition.
- Significance: The study links clinical observations with detailed microbiological data to address the current lack of reliable clinical biomarkers for FPIES, reinforcing the theory that early biological factors like gut flora composition have long-term impacts on allergic disease development.
- Future Application: The robust comparative dataset establishes a critical foundation for developing highly individualized clinical strategies aimed at the targeted diagnosis, early prevention, and therapeutic treatment of FPIES in pediatric patients.
- Branch of Science: Immunology, Microbiology, Pediatrics, Gastroenterology
- Additional Detail: Beyond the baseline bacterial disparities, researchers discovered that specific trigger foods associated with FPIES were correlated with further, distinct alterations within the gastrointestinal microbiomes of the affected children.
Children with the rare but serious allergic disease FPIES have an atypical gut microbiota compared to healthy children. This is shown in a new study from Umeå University, published in the scientific journal in the Journal of Allergy and Clinical Immunology.
Our results reveal clear differences in the gut bacterial composition of children with FPIES
“Our results reveal clear differences in the gut bacterial composition of children with FPIES, an area where knowledge has so far been limited,” says Kotryna Simonyte Sjödin, molecular biologist and associate professor at the Department of Clinical Sciences at Umeå University.
FPIES (food protein-induced enterocolitis syndrome) is a form of food allergy in which the body reacts without the usual allergy antibodies, meaning that symptoms appear more slowly and affect the gastrointestinal tract rather than causing rashes or breathing difficulties. It typically begins during infancy and can lead to severe vomiting, diarrhea, and circulatory symptoms. The underlying mechanism remains unclear.
In the new study, the researchers analyzed stool samples from 56 children with newly diagnosed FPIES and compared them with samples from 43 age‑matched children without allergies. The children were divided into three age groups covering the first year of life. The results show that age was the strongest factor influencing bacterial composition, but that FPIES itself was also clearly associated with differences in the gut microbiota.
The study found, among other things, that children with FPIES had lower levels of Bifidobacterium and Verrucomicrobiota, while bacteria such as Bacteroides, Hemophilus, and Veillonella were more abundant. Certain trigger foods for FPIES were also associated with additional changes in the gut microbiota.
“FPIES is a clinically challenging diagnosis, and today we lack reliable biomarkers. By linking clinical observations with detailed analyses of the gut microbiota, we can gradually build a more coherent picture of the disease,” says Anna Winberg, senior consultant and associate professor at the Department of Clinical Sciences at Umeå University.
The study contributes new knowledge about the connection between early gut microbiota and the development of allergic disease, strengthening the view that early biological factors can have long‑term consequences for children's health.
“This study is based on systematically collected samples at diagnosis and on high‑resolution analyses, providing a robust and comparable dataset. Over time, these findings may contribute to the development of more individualized strategies for diagnosis, prevention, or treatment, although such applications will require further research,” says Christina West, senior consultant and professor of pediatrics at the Department of Clinical Sciences at Umeå University.
Published in journal: Journal of Allergy and Clinical Immunology
Authors: Anna Winberg, MD, PhD, Kotryna Simonyté Sjödin, PhD, Magnus Öhlund, MD, and Christina E. West, MD, PhD
Source/Credit: Umeå University | Ingrid Schéle
Reference Number: imgy040226_01
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